PubMed

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

Herold KC, Brooks-Worrell B, Palmer J, Dosch HM, Peakman M, Gottlieb P, Reijonen H, Arif S, Spain LM, Thompson C, Lachin JM; Type 1 Diabetes TrialNet Research Group.

Diabetes. 2009 Nov;58(11):2588-95. Epub 2009 Aug 12.PMID: 19675135 [PubMed - in process]Related articles

Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.

Martin-Pagola A, Sisino G, Allende G, Dominguez-Bendala J, Gianani R, Reijonen H, Nepom GT, Ricordi C, Ruiz P, Sageshima J, Ciancio G, Burke GW, Pugliese A.

Diabetologia. 2008 Oct;51(10):1803-13. Epub 2008 Aug 12.PMID: 18696047 [PubMed - indexed for MEDLINE]Related articles

Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

Yang J, Danke NA, Berger D, Reichstetter S, Reijonen H, Greenbaum C, Pihoker C, James EA, Kwok WW.

J Immunol. 2006 Mar 1;176(5):2781-9.PMID: 16493034 [PubMed - indexed for MEDLINE]Related articlesFree article

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.

Oling V, Marttila J, Ilonen J, Kwok WW, Nepom G, Knip M, Simell O, Reijonen H.

J Autoimmun. 2005 Nov;25(3):235-43. Epub 2005 Nov 2. Erratum in: J Autoimmun. 2006 Aug;27(1):69. PMID: 16263242 [PubMed - indexed for MEDLINE]Related articles

Functional avidity directs T-cell fate in autoreactive CD4+ T cells.

Mallone R, Kochik SA, Reijonen H, Carson B, Ziegler SF, Kwok WW, Nepom GT.

Blood. 2005 Oct 15;106(8):2798-805. Epub 2005 Jul 19.PMID: 16030184 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.

Gebe JA, Masewicz SA, Kochik SA, Reijonen H, Nepom GT.

Eur J Immunol. 2004 Dec;34(12):3337-45.PMID: 15549775 [PubMed - indexed for MEDLINE]Related articles

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.

Reijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B, Kwok WW, Greenbaum C, Nepom GT.

Diabetes. 2004 Aug;53(8):1987-94.PMID: 15277377 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.

Mallone R, Kochik SA, Laughlin EM, Gersuk VH, Reijonen H, Kwok WW, Nepom GT.

Diabetes. 2004 Apr;53(4):971-7.PMID: 15047612 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.

Reijonen H, Kwok WW, Nepom GT.

Ann N Y Acad Sci. 2003 Nov;1005:82-7.PMID: 14679042 [PubMed - indexed for MEDLINE]Related articles

Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children.

Mrena S, Savola K, Kulmala P, Reijonen H, Ilonen J, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

J Clin Endocrinol Metab. 2003 Jun;88(6):2682-9.PMID: 12788873 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-avidity recognition by CD4+ T cells directed to self-antigens.

Gebe JA, Falk BA, Rock KA, Kochik SA, Heninger AK, Reijonen H, Kwok WW, Nepom GT.

Eur J Immunol. 2003 May;33(5):1409-17.PMID: 12731068 [PubMed - indexed for MEDLINE]Related articles

Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.

Reijonen H, Kwok WW.

Methods. 2003 Mar;29(3):282-8. Review.PMID: 12725793 [PubMed - indexed for MEDLINE]Related articles

Polycystic liver disease is genetically heterogeneous: clinical and linkage studies in eight Finnish families.

Tahvanainen P, Tahvanainen E, Reijonen H, Halme L, Kääriäinen H, Höckerstedt K.

J Hepatol. 2003 Jan;38(1):39-43.PMID: 12480558 [PubMed - indexed for MEDLINE]Related articles

Defining antigen-specific responses with human MHC class II tetramers.

Buckner JH, Holzer U, Novak EJ, Reijonen H, Kwok WW, Nepom GT.

J Allergy Clin Immunol. 2002 Aug;110(2):199-208. Review.PMID: 12170258 [PubMed - indexed for MEDLINE]Related articles

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.

Reijonen H, Novak EJ, Kochik S, Heninger A, Liu AW, Kwok WW, Nepom GT.

Diabetes. 2002 May;51(5):1375-82.PMID: 11978633 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.

Nepom GT, Buckner JH, Novak EJ, Reichstetter S, Reijonen H, Gebe J, Wang R, Swanson E, Kwok WW.

Arthritis Rheum. 2002 Jan;46(1):5-12. Review.PMID: 11817608 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.

Laaksonen M, Pastinen T, Sjöroos M, Kuokkanen S, Ruutiainen J, Sumelahti ML, Reijonen H, Salonen R, Wikström J, Panelius M, Partanen J, Tienari PJ, Ilonen J.

J Neuroimmunol. 2002 Jan;122(1-2):140-5.PMID: 11777553 [PubMed - indexed for MEDLINE]Related articles

Radioimmunoassay for glutamic acid decarboxylase-65.

Hao W, Daniels T, Pipeleers DG, Smismans A, Reijonen H, Nepom GT, Lernmark A.

Diabetes Technol Ther. 1999 Spring;1(1):13-20.PMID: 11475299 [PubMed - indexed for MEDLINE]Related articles

GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.

Reijonen H, Daniels TL, Lernmark A, Nepom GT.

Diabetes. 2000 Oct;49(10):1621-6.PMID: 11016444 [PubMed - indexed for MEDLINE]Related articlesFree article

Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with type 1 diabetes susceptibility. The Childhood Diabetes in Finland Study Group.

Ilonen J, Reijonen H, Green A, Reunanen A, Knip M, Simell O, Akerblom HK.

Eur J Immunogenet. 2000 Aug;27(4):225-30.PMID: 10998087 [PubMed - indexed for MEDLINE]Related articles

Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group.

Virtanen SM, Läärä E, Hyppönen E, Reijonen H, Räsänen L, Aro A, Knip M, Ilonen J, Akerblom HK.

Diabetes. 2000 Jun;49(6):912-7. Erratum in: Diabetes 2000 Sep;49(9):1617. PMID: 10866042 [PubMed - indexed for MEDLINE]Related articlesFree article

Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.

Kimpimäki T, Kulmala P, Savola K, Vähäsalo P, Reijonen H, Ilonen J, Akerblom HK, Knip M.

J Clin Endocrinol Metab. 2000 Mar;85(3):1126-32.PMID: 10720050 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.

Kulmala P, Savola K, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Tuomilehto-Wolf E, Ilonen J, Tuomilehto J, Akerblom HK, Knip M.

Diabetes. 2000 Jan;49(1):48-58.PMID: 10615949 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.

Komulainen J, Kulmala P, Savola K, Lounamaa R, Ilonen J, Reijonen H, Knip M, Akerblom HK.

Diabetes Care. 1999 Dec;22(12):1950-5.PMID: 10587824 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.

Kwok WW, Reijonen H, Falk BA, Koelle DM, Nepom GT.

Hum Immunol. 1999 Jul;60(7):619-26.PMID: 10426279 [PubMed - indexed for MEDLINE]Related articles

Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.

Reijonen H, Elliott JF, van Endert P, Nepom G.

J Immunol. 1999 Aug 1;163(3):1674-81.PMID: 10415074 [PubMed - indexed for MEDLINE]Related articlesFree article

Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.

Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Ilonen J, Akerblom HK, Knip M.

Clin Exp Immunol. 1999 Apr;116(1):78-83.PMID: 10209508 [PubMed - indexed for MEDLINE]Related articlesFree article

Distribution of insulin-dependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region.

Nejentsev S, Koskinen S, Sjöroos M, Reijonen H, Schwartz EI, Kovalchuk L, Sochnev A, Adojaan B, Podar T, Knip M, Simell O, Koskenvuo M, Akerblom HK, Ilonen J.

Tissue Antigens. 1998 Nov;52(5):473-7.PMID: 9864037 [PubMed - indexed for MEDLINE]Related articles

Time-resolved fluorometry based sandwich hybridisation assay for HLA-DQA1 typing.

Sjöroos M, Ilonen J, Reijonen H, Lövgren T.

Dis Markers. 1998 Jun;14(1):9-19.PMID: 9706458 [PubMed - indexed for MEDLINE]Related articles

Autoimmune and clinical characteristics of type I diabetes in children with different genetic risk loads defined by HLA-DQB1 alleles. Childhood Diabetes in Finland Study Group.

Komulainen J, Knip M, Sabbah E, Vähäsalo P, Lounamaa R, Akerblom HK, Reijonen H, Ilonen J.

Clin Sci (Lond). 1998 Mar;94(3):263-9.PMID: 9616260 [PubMed - indexed for MEDLINE]Related articles

Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype. Childhood Diabetes in Finland Study Group.

Saukkonen T, Virtanen SM, Karppinen M, Reijonen H, Ilonen J, Räsänen L, Akerblom HK, Savilahti E.

Diabetologia. 1998 Jan;41(1):72-8.PMID: 9498633 [PubMed - indexed for MEDLINE]Related articles

HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.

Reijonen H, Nejentsev S, Tuokko J, Koskinen S, Tuomilehto-Wolf E, Akerblom HK, Ilonen J.

Eur J Immunogenet. 1997 Oct;24(5):357-63.PMID: 9442803 [PubMed - indexed for MEDLINE]Related articles

The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302.

Nejentsev S, Reijonen H, Adojaan B, Kovalchuk L, Sochnevs A, Schwartz EI, Akerblom HK, Ilonen J.

Diabetes. 1997 Nov;46(11):1888-92.PMID: 9356041 [PubMed - indexed for MEDLINE]Related articles

Islet cell antibody seroconversion in children is temporally associated with enterovirus infections. Childhood Diabetes in Finland (DiMe) Study Group.

Hiltunen M, Hyöty H, Knip M, Ilonen J, Reijonen H, Vähäsalo P, Roivainen M, Lonnrot M, Leinikki P, Hovi T, Akerblom HK.

J Infect Dis. 1997 Mar;175(3):554-60.PMID: 9041325 [PubMed - indexed for MEDLINE]Related articles

Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood.

Pociot F, Veijola R, Johannesen J, Hansen PM, Lorenzen T, Karlsen AE, Reijonen H, Knip M, Nerup J.

J Interferon Cytokine Res. 1997 Feb;17(2):87-93.PMID: 9058314 [PubMed - indexed for MEDLINE]Related articles

Interaction of genetic and environmental factors in the pathogenesis of insulin-dependent diabetes mellitus.

Akerblom HK, Knip M, Hyöty H, Reijonen H, Virtanen S, Savilahti E, Ilonen J.

Clin Chim Acta. 1997 Jan 17;257(2):143-56. Review.PMID: 9118560 [PubMed - indexed for MEDLINE]Related articles

Increase of HLA-DRB1*0408 and -DQB1*0301 in HLA-B27 positive reactive arthritis.

Tuokko J, Reijonen H, Ilonen J, Anttila K, Nikkari S, Möttönen T, Yli-Kerttula U, Toivanen A.

Ann Rheum Dis. 1997 Jan;56(1):37-40.PMID: 9059139 [PubMed - indexed for MEDLINE]Related articlesFree article

Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.

Peterson P, Salmi H, Hyöty H, Miettinen A, Ilonen J, Reijonen H, Knip M, Akerblom HK, Krohn K.

Clin Immunol Immunopathol. 1997 Jan;82(1):37-42.PMID: 9000040 [PubMed - indexed for MEDLINE]Related articles

HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.

Veijola R, Reijonen H, Vähäsalo P, Sabbah E, Kulmala P, Ilonen J, Akerblom HK, Knip M.

J Clin Invest. 1996 Dec 1;98(11):2489-95.PMID: 8958211 [PubMed - indexed for MEDLINE]Related articlesFree article

Disease-associated antibodies in offspring of mothers with IDDM.

Martikainen A, Saukkonen T, Kulmala PK, Reijonen H, Ilonen J, Teramo K, Koskela P, Knip M, Akerblom HK.

Diabetes. 1996 Dec;45(12):1706-10.PMID: 8922355 [PubMed - indexed for MEDLINE]Related articles

Effect of polymorphism in the insulin gene region on IDDM susceptibility and insulin secretion. The Childhood Diabetes in Finland (DiMe) Study Group.

Halminen M, Veijola R, Reijonen H, Ilonen J, Akerblom HK, Knip M.

Eur J Clin Invest. 1996 Oct;26(10):847-52.PMID: 8911856 [PubMed - indexed for MEDLINE]Related articles

Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. The Childhood Diabetes in Finland (DiMe) Study Group.

Ilonen J, Reijonen H, Herva E, Sjöroos M, Iitiä A, Lövgren T, Veijola R, Knip M, Akerblom HK.

Diabetes Care. 1996 Aug;19(8):795-800.PMID: 8842593 [PubMed - indexed for MEDLINE]Related articles

The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.

Veijola R, Knip M, Puukka R, Reijonen H, Cox DW, Ilonen J.

Am J Hum Genet. 1996 Aug;59(2):462-70.PMID: 8755935 [PubMed - indexed for MEDLINE]Related articlesFree article

Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group.

Saukkonen T, Savilahti E, Reijonen H, Ilonen J, Tuomilehto-Wolf E, Akerblom HK.

Diabet Med. 1996 May;13(5):464-70.PMID: 8737029 [PubMed - indexed for MEDLINE]Related articles

Cellular immune response to cow's milk beta-lactoglobulin in patients with newly diagnosed IDDM.

Vaarala O, Klemetti P, Savilahti E, Reijonen H, Ilonen J, Akerblom HK.

Diabetes. 1996 Feb;45(2):178-82.PMID: 8549862 [PubMed - indexed for MEDLINE]Related articles

Population-based genetic screening for IDDM susceptibility as a source of HLA-genotyped control subjects.

Ilonen J, Reijonen H, Knip M, Simell O.

Diabetologia. 1996 Jan;39(1):123. No abstract available. PMID: 8720613 [PubMed - indexed for MEDLINE]Related articles

Human leukocyte antigen identity and DQ risk alleles in autoantibody-positive siblings of children with IDDM are associated with reduced early insulin response. Childhood Diabetes in Finland (DiMe) Study Group.

Veijola R, Vähäsalo P, Tuomilehto-Wolf E, Reijonen H, Kulmala P, Ilonen J, Akerblom HK, Knip M.

Diabetes. 1995 Sep;44(9):1021-8.PMID: 7657023 [PubMed - indexed for MEDLINE]Related articles

Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.

Undlien DE, Bennett ST, Todd JA, Akselsen HE, Ikäheimo I, Reijonen H, Knip M, Thorsby E, Rønningen KS.

Diabetes. 1995 Jun;44(6):620-5.PMID: 7789624 [PubMed - indexed for MEDLINE]Related articles

Triple-label hybridization assay for type-1 diabetes-related HLA alleles.

Sjöroos M, Iitiä A, Ilonen J, Reijonen H, Lövgren T.

Biotechniques. 1995 May;18(5):870-7.PMID: 7619493 [PubMed - indexed for MEDLINE]Related articles

Effect of genetic risk load defined by HLA-DQB1 polymorphism on clinical characteristics of IDDM in children.

Veijola R, Knip M, Reijonen H, Vähäsalo P, Puukka R, Iionen J.

Eur J Clin Invest. 1995 Feb;25(2):106-12.PMID: 7737259 [PubMed - indexed for MEDLINE]Related articles