PubMed

The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells.

Ljubicic S, Bezzi P, Vitale N, Regazzi R.

PLoS One. 2009 Nov 5;4(11):e7770.PMID: 19890390 [PubMed - in process]Related articlesFree article

Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate.

Tomas A, Yermen B, Regazzi R, Pessin JE, Halban PA.

Traffic. 2009 Sep 28. [Epub ahead of print]PMID: 19845918 [PubMed - as supplied by publisher]Related articles

Role and therapeutic potential of microRNAs in diabetes.

Kolfschoten IG, Roggli E, Nesca V, Regazzi R.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:118-29.PMID: 19817794 [PubMed - in process]Related articles

Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure.

Plaisance V, Perret V, Favre D, Abderrahmani A, Yang JY, Widmann C, Regazzi R.

Mol Cell Endocrinol. 2009 Jun 16;305(1-2):47-55. Epub 2008 Dec 24.PMID: 19133313 [PubMed - indexed for MEDLINE]Related articles

Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes.

Marchaland J, Calì C, Voglmaier SM, Li H, Regazzi R, Edwards RH, Bezzi P.

J Neurosci. 2008 Sep 10;28(37):9122-32.PMID: 18784293 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.

Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R.

Diabetes. 2008 Oct;57(10):2728-36. Epub 2008 Jul 15.PMID: 18633110 [PubMed - indexed for MEDLINE]Related articlesFree article

SDF 1-alpha (CXCL12) triggers glutamate exocytosis from astrocytes on a millisecond time scale: imaging analysis at the single-vesicle level with TIRF microscopy.

Calì C, Marchaland J, Regazzi R, Bezzi P.

J Neuroimmunol. 2008 Jul 31;198(1-2):82-91. Epub 2008 Jun 6.PMID: 18538866 [PubMed - indexed for MEDLINE]Related articles

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.

Martin D, Allagnat F, Chaffard G, Caille D, Fukuda M, Regazzi R, Abderrahmani A, Waeber G, Meda P, Maechler P, Haefliger JA.

Diabetologia. 2008 Aug;51(8):1429-39. Epub 2008 Apr 3.PMID: 18385973 [PubMed - indexed for MEDLINE]Related articles

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway.

Ferdaoussi M, Abdelli S, Yang JY, Cornu M, Niederhauser G, Favre D, Widmann C, Regazzi R, Thorens B, Waeber G, Abderrahmani A.

Diabetes. 2008 May;57(5):1205-15. Epub 2008 Feb 5.PMID: 18252896 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc 18-1 and granuphilin collaborate during insulin granule exocytosis.

Tomas A, Meda P, Regazzi R, Pessin JE, Halban PA.

Traffic. 2008 May;9(5):813-32. Epub 2008 Jan 19.PMID: 18208509 [PubMed - indexed for MEDLINE]Related articles

Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs.

Lovis P, Gattesco S, Regazzi R.

Biol Chem. 2008 Mar;389(3):305-12.PMID: 18177263 [PubMed - indexed for MEDLINE]Related articles

Technology Insight: small, noncoding RNA molecules as tools to study and treat endocrine diseases.

Kolfschoten IG, Regazzi R.

Nat Clin Pract Endocrinol Metab. 2007 Dec;3(12):827-34. Review.PMID: 18026161 [PubMed - indexed for MEDLINE]Related articles

Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells.

Abderrahmani A, Niederhauser G, Favre D, Abdelli S, Ferdaoussi M, Yang JY, Regazzi R, Widmann C, Waeber G.

Diabetologia. 2007 Jun;50(6):1304-14. Epub 2007 Apr 17.PMID: 17437081 [PubMed - indexed for MEDLINE]Related articles

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions.

Abderrahmani A, Plaisance V, Lovis P, Regazzi R.

Biochem Soc Trans. 2006 Nov;34(Pt 5):696-700.PMID: 17052177 [PubMed - indexed for MEDLINE]Related articles

MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells.

Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R.

J Biol Chem. 2006 Sep 15;281(37):26932-42. Epub 2006 Jul 10.PMID: 16831872 [PubMed - indexed for MEDLINE]Related articlesFree article

Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis.

Cheviet S, Bezzi P, Ivarsson R, Renström E, Viertl D, Kasas S, Catsicas S, Regazzi R.

J Cell Sci. 2006 Jul 15;119(Pt 14):2912-20. Epub 2006 Jun 20.PMID: 16787939 [PubMed - indexed for MEDLINE]Related articlesFree article

ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis.

Abderrahmani A, Cheviet S, Ferdaoussi M, Coppola T, Waeber G, Regazzi R.

EMBO J. 2006 Mar 8;25(5):977-86. Epub 2006 Feb 23.PMID: 16498408 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional assays for the investigation of the role of Rab GTPase effectors in dense core granule release.

Cheviet S, Coppola T, Regazzi R.

Methods Enzymol. 2005;403:57-71.PMID: 16473577 [PubMed - indexed for MEDLINE]Related articles

The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor.

Abderrahmani A, Niederhauser G, Lenain V, Regazzi R, Waeber G.

FEBS Lett. 2005 Nov 7;579(27):6199-204. Epub 2005 Oct 13.PMID: 16253247 [PubMed - indexed for MEDLINE]Related articles

Myosin 5a controls insulin granule recruitment during late-phase secretion.

Ivarsson R, Jing X, Waselle L, Regazzi R, Renström E.

Traffic. 2005 Nov;6(11):1027-35.PMID: 16190983 [PubMed - indexed for MEDLINE]Related articles

Superficial and deep changes of cellular mechanical properties following cytoskeleton disassembly.

Kasas S, Wang X, Hirling H, Marsault R, Huni B, Yersin A, Regazzi R, Grenningloh G, Riederer B, Forrò L, Dietler G, Catsicas S.

Cell Motil Cytoskeleton. 2005 Oct;62(2):124-32.PMID: 16145686 [PubMed - indexed for MEDLINE]Related articles

Role of phosphoinositide signaling in the control of insulin exocytosis.

Waselle L, Gerona RR, Vitale N, Martin TF, Bader MF, Regazzi R.

Mol Endocrinol. 2005 Dec;19(12):3097-106. Epub 2005 Aug 4.PMID: 16081518 [PubMed - indexed for MEDLINE]Related articlesFree article

The Small GTPase RalA controls exocytosis of large dense core secretory granules by interacting with ARF6-dependent phospholipase D1.

Vitale N, Mawet J, Camonis J, Regazzi R, Bader MF, Chasserot-Golaz S.

J Biol Chem. 2005 Aug 19;280(33):29921-8. Epub 2005 Jun 24.PMID: 15980073 [PubMed - indexed for MEDLINE]Related articlesFree article

Noc-king out exocrine and endocrine secretion.

Cheviet S, Waselle L, Regazzi R.

Trends Cell Biol. 2004 Oct;14(10):525-8. Review.PMID: 15450973 [PubMed - indexed for MEDLINE]Related articles

Neuronal traits are required for glucose-induced insulin secretion.

Abderrahmani A, Niederhauser G, Plaisance V, Haefliger JA, Regazzi R, Waeber G.

FEBS Lett. 2004 May 7;565(1-3):133-8.PMID: 15135066 [PubMed - indexed for MEDLINE]Related articles

Complexin I regulates glucose-induced secretion in pancreatic beta-cells.

Abderrahmani A, Niederhauser G, Plaisance V, Roehrich ME, Lenain V, Coppola T, Regazzi R, Waeber G.

J Cell Sci. 2004 May 1;117(Pt 11):2239-47.PMID: 15126625 [PubMed - indexed for MEDLINE]Related articlesFree article

Reticulon 1-C/neuroendocrine-specific protein-C interacts with SNARE proteins.

Steiner P, Kulangara K, Sarria JC, Glauser L, Regazzi R, Hirling H.

J Neurochem. 2004 May;89(3):569-80.PMID: 15086514 [PubMed - indexed for MEDLINE]Related articles

The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.

Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R.

Mol Endocrinol. 2004 Jan;18(1):117-26. Epub 2003 Oct 30.PMID: 14593078 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.

Waselle L, Coppola T, Fukuda M, Iezzi M, El-Amraoui A, Petit C, Regazzi R.

Mol Biol Cell. 2003 Oct;14(10):4103-13. Epub 2003 Aug 7.PMID: 14517322 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between synaptic vesicle fusion proteins explored by atomic force microscopy.

Yersin A, Hirling H, Steiner P, Magnin S, Regazzi R, Hüni B, Huguenot P, De los Rios P, Dietler G, Catsicas S, Kasas S.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8736-41. Epub 2003 Jul 9.PMID: 12853568 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab3A and calmodulin regulate acrosomal exocytosis by mechanisms that do not require a direct interaction.

Yunes R, Tomes C, Michaut M, De Blas G, Rodriguez F, Regazzi R, Mayorga LS.

FEBS Lett. 2002 Aug 14;525(1-3):126-30.PMID: 12163174 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

Coppola T, Frantz C, Perret-Menoud V, Gattesco S, Hirling H, Regazzi R.

Mol Biol Cell. 2002 Jun;13(6):1906-15.PMID: 12058058 [PubMed - indexed for MEDLINE]Related articlesFree article

The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells.

Coppola T, Perret-Menoud V, Gattesco S, Magnin S, Pombo I, Blank U, Regazzi R.

Biochem J. 2002 Mar 1;362(Pt 2):273-9.PMID: 11853534 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of Rho GTPases and their effectors in the secretory process of PC12 cells.

Frantz C, Coppola T, Regazzi R.

Exp Cell Res. 2002 Feb 15;273(2):119-26.PMID: 11822867 [PubMed - indexed for MEDLINE]Related articles

Rab3a controls exocytosis in cholecystokinin-secreting cells.

Gevrey JC, Laurent S, Saurin JC, Némoz-Gaillard E, Regazzi R, Chevrier AM, Chayvialle JA, Abello J.

FEBS Lett. 2001 Aug 10;503(1):19-24.PMID: 11513847 [PubMed - indexed for MEDLINE]Related articles

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.

Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R.

J Biol Chem. 2001 Aug 31;276(35):32756-62. Epub 2001 Jul 3.PMID: 11438518 [PubMed - indexed for MEDLINE]Related articlesFree article

Rabphilin dissociated from Rab3 promotes endocytosis through interaction with Rabaptin-5.

Coppola T, Hirling H, Perret-Menoud V, Gattesco S, Catsicas S, Joberty G, Macara IG, Regazzi R.

J Cell Sci. 2001 May;114(Pt 9):1757-64.PMID: 11309205 [PubMed - indexed for MEDLINE]Related articlesFree article

VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts.

Randhawa VK, Bilan PJ, Khayat ZA, Daneman N, Liu Z, Ramlal T, Volchuk A, Peng XR, Coppola T, Regazzi R, Trimble WS, Klip A.

Mol Biol Cell. 2000 Jul;11(7):2403-17.PMID: 10888677 [PubMed - indexed for MEDLINE]Related articlesFree article

Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking.

Hirling H, Steiner P, Chaperon C, Marsault R, Regazzi R, Catsicas S.

Eur J Neurosci. 2000 Jun;12(6):1913-23.PMID: 10886332 [PubMed - indexed for MEDLINE]Related articles

The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis.

Iezzi M, Regazzi R, Wollheim CB.

FEBS Lett. 2000 May 26;474(1):66-70.PMID: 10828453 [PubMed - indexed for MEDLINE]Related articles

Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis.

Coppola T, Perret-Menoud V, Lüthi S, Farnsworth CC, Glomset JA, Regazzi R.

EMBO J. 1999 Nov 1;18(21):5885-91.PMID: 10545100 [PubMed - indexed for MEDLINE]Related articlesFree article

High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiation of stimulated secretion.

Joberty G, Stabila PF, Coppola T, Macara IG, Regazzi R.

J Cell Sci. 1999 Oct;112 ( Pt 20):3579-87.PMID: 10504306 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells.

Iezzi M, Escher G, Meda P, Charollais A, Baldini G, Darchen F, Wollheim CB, Regazzi R.

Mol Endocrinol. 1999 Feb;13(2):202-12.PMID: 9973251 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of SNARE proteins in enteroendocrine cell lines and functional role of tetanus toxin-sensitive proteins in cholecystokinin release.

Némoz-Gaillard E, Bosshard A, Regazzi R, Bernard C, Cuber JC, Takahashi M, Catsicas S, Chayvialle JA, Abello J.

FEBS Lett. 1998 Mar 20;425(1):66-70.PMID: 9541008 [PubMed - indexed for MEDLINE]Related articles

SNAP-25 can self-associate to form a disulfide-linked complex.

Sadoul K, Berger A, Niemann H, Regazzi R, Catsicas S, Halban PA.

Biol Chem. 1997 Oct;378(10):1171-6.PMID: 9372187 [PubMed - indexed for MEDLINE]Related articles

SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion.

Sadoul K, Berger A, Niemann H, Weller U, Roche PA, Klip A, Trimble WS, Regazzi R, Catsicas S, Halban PA.

J Biol Chem. 1997 Dec 26;272(52):33023-7.PMID: 9407084 [PubMed - indexed for MEDLINE]Related articlesFree article

The stimulatory effect of rabphilin 3a on regulated exocytosis from insulin-secreting cells does not require an association-dissociation cycle with membranes mediated by Rab 3.

Arribas M, Regazzi R, Garcia E, Wollheim CB, De Camilli P.

Eur J Cell Biol. 1997 Nov;74(3):209-16.PMID: 9402469 [PubMed - indexed for MEDLINE]Related articles

Insulin production: from gene to granule.

Regazzi R, Verchere CB, Halban PA, Polonsky KS.

Diabetologia. 1997 Oct;40 Suppl 3:B33-8. No abstract available. PMID: 9345643 [PubMed - indexed for MEDLINE]Related articles

Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis.

Regazzi R, Sadoul K, Meda P, Kelly RB, Halban PA, Wollheim CB.

EMBO J. 1996 Dec 16;15(24):6951-9.PMID: 9003771 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells.

Regazzi R, Ravazzola M, Iezzi M, Lang J, Zahraoui A, Andereggen E, Morel P, Takai Y, Wollheim CB.

J Cell Sci. 1996 Sep;109 ( Pt 9):2265-73.PMID: 8886977 [PubMed - indexed for MEDLINE]Related articlesFree article