PubMed

Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.

Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, Ramanadham S.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E925-35. Epub 2009 Feb 10.PMID: 19208856 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation.

Carper MJ, Zhang S, Turk J, Ramanadham S.

Biochemistry. 2008 Nov 18;47(46):12241-9. Epub 2008 Oct 21.PMID: 18937505 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.

Lei X, Zhang S, Bohrer A, Ramanadham S.

J Biol Chem. 2008 Dec 12;283(50):34819-32. Epub 2008 Oct 20.PMID: 18936091 [PubMed - indexed for MEDLINE]Related articles

Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice.

Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Novack DV, Christiansen B, Tu X, Zhang S, Lei X, Turk J.

Am J Pathol. 2008 Apr;172(4):868-81. Epub 2008 Mar 18.PMID: 18349124 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus.

Carper MJ, Cade WT, Cam M, Zhang S, Shalev A, Yarasheski KE, Ramanadham S.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. Epub 2008 Jan 2.PMID: 18171911 [PubMed - indexed for MEDLINE]Related articlesFree article

The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S.

Biochemistry. 2007 Sep 4;46(35):10170-85. Epub 2007 Aug 9.PMID: 17685585 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J.

J Biol Chem. 2007 Sep 14;282(37):27100-14. Epub 2007 Jul 12.PMID: 17627946 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.

Bao S, Song H, Wohltmann M, Ramanadham S, Jin W, Bohrer A, Turk J.

J Biol Chem. 2006 Jul 28;281(30):20958-73. Epub 2006 May 27.PMID: 16732058 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of biological oxidants on the catalytic activity and structure of group VIA phospholipase A2.

Song H, Bao S, Ramanadham S, Turk J.

Biochemistry. 2006 May 23;45(20):6392-406.PMID: 16700550 [PubMed - indexed for MEDLINE]Related articlesFree article

A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols.

Song H, Ramanadham S, Bao S, Hsu FF, Turk J.

Biochemistry. 2006 Jan 24;45(3):1061-73.PMID: 16411783 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells.

Bao S, Bohrer A, Ramanadham S, Jin W, Zhang S, Turk J.

J Biol Chem. 2006 Jan 6;281(1):187-98. Epub 2005 Nov 14.PMID: 16286468 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests.

Song H, Hecimovic S, Goate A, Hsu FF, Bao S, Vidavsky I, Ramanadham S, Turk J.

J Am Soc Mass Spectrom. 2004 Dec;15(12):1780-93.PMID: 15589755 [PubMed - indexed for MEDLINE]Related articles

Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.

Wang Z, Ramanadham S, Ma ZA, Bao S, Mancuso DJ, Gross RW, Turk J.

J Biol Chem. 2005 Feb 25;280(8):6840-9. Epub 2004 Dec 2.PMID: 15576376 [PubMed - indexed for MEDLINE]Related articlesFree article

The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells.

Turk J, Ramanadham S.

Can J Physiol Pharmacol. 2004 Oct;82(10):824-32. Review.PMID: 15573142 [PubMed - indexed for MEDLINE]Related articles

Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.

Bao S, Miller DJ, Ma Z, Wohltmann M, Eng G, Ramanadham S, Moley K, Turk J.

J Biol Chem. 2004 Sep 10;279(37):38194-200. Epub 2004 Jul 12.PMID: 15252026 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells.

Bao S, Jin C, Zhang S, Turk J, Ma Z, Ramanadham S.

Diabetes. 2004 Feb;53 Suppl 1:S186-9.PMID: 14749286 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A(2) in beta-cells.

Ramanadham S, Song H, Bao S, Hsu FF, Zhang S, Ma Z, Jin C, Turk J.

Diabetes. 2004 Feb;53 Suppl 1:S179-85. Review.PMID: 14749285 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.

Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J.

Biochemistry. 2004 Feb 3;43(4):918-30.PMID: 14744135 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.

Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant GA, Newgard CB, Bao S, Ma Z, Turk J.

Biochemistry. 2003 Dec 2;42(47):13929-40.PMID: 14636061 [PubMed - indexed for MEDLINE]Related articles

Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.

Ramanadham S, Zhang S, Ma Z, Wohltmann M, Bohrer A, Hsu FF, Turk J.

Biochim Biophys Acta. 2002 Jan 30;1580(1):40-56.PMID: 11923099 [PubMed - indexed for MEDLINE]Related articles

Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.

Ma Z, Zhang S, Turk J, Ramanadham S.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E820-33.PMID: 11882502 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of phospholipid metabolism, proliferation, and secretion of stably transfected insulinoma cells that overexpress group VIA phospholipase A2.

Ma Z, Bohrer A, Wohltmann M, Ramanadham S, Hsu FF, Turk J.

Lipids. 2001 Jul;36(7):689-700.PMID: 11521967 [PubMed - indexed for MEDLINE]Related articles

A pyrrolidine-based specific inhibitor of cytosolic phospholipase A(2)alpha blocks arachidonic acid release in a variety of mammalian cells.

Ghomashchi F, Stewart A, Hefner Y, Ramanadham S, Turk J, Leslie CC, Gelb MH.

Biochim Biophys Acta. 2001 Aug 6;1513(2):160-6.PMID: 11470087 [PubMed - indexed for MEDLINE]Related articles

Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.

Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, Turk J.

J Biol Chem. 2001 Apr 20;276(16):13198-208. Epub 2001 Jan 22.PMID: 11278673 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats.

Hsu FF, Bohrer A, Wohltmann M, Ramanadham S, Ma Z, Yarasheski K, Turk J.

Lipids. 2000 Aug;35(8):839-54.PMID: 10984107 [PubMed - indexed for MEDLINE]Related articles

Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion.

Ramanadham S, Hsu F, Zhang S, Bohrer A, Ma Z, Turk J.

Biochim Biophys Acta. 2000 Apr 12;1484(2-3):251-66.PMID: 10760474 [PubMed - indexed for MEDLINE]Related articles

Electrospray ionization/mass spectrometric analyses of human promonocytic U937 cell glycerolipids and evidence that differentiation is associated with membrane lipid composition changes that facilitate phospholipase A2 activation.

Hsu FF, Ma Z, Wohltmann M, Bohrer A, Nowatzke W, Ramanadham S, Turk J.

J Biol Chem. 2000 Jun 2;275(22):16579-89.PMID: 10748096 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells.

Ramanadham S, Hsu FF, Bohrer A, Ma Z, Turk J.

J Biol Chem. 1999 May 14;274(20):13915-27.PMID: 10318801 [PubMed - indexed for MEDLINE]Related articlesFree article

Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1.

Ma Z, Wang X, Nowatzke W, Ramanadham S, Turk J.

J Biol Chem. 1999 Apr 2;274(14):9607-16.PMID: 10092647 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation of human skeletal muscle myosin heavy chain and actin for measurement of fractional synthesis rates.

Hasten DL, Morris GS, Ramanadham S, Yarasheski KE.

Am J Physiol. 1998 Dec;275(6 Pt 1):E1092-9.PMID: 9843753 [PubMed - indexed for MEDLINE]Related articlesFree article

Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes: catalysis by a protein constituent recognized by monoclonal antibodies directed against glyceraldehyde-3-phosphate dehydrogenase.

Han X, Ramanadham S, Turk J, Gross RW.

Biochim Biophys Acta. 1998 Nov 11;1414(1-2):95-107.PMID: 9804907 [PubMed - indexed for MEDLINE]Related articles

Mass spectrometric evidence that agents that cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ concentration.

Nowatzke W, Ramanadham S, Ma Z, Hsu FF, Bohrer A, Turk J.

Endocrinology. 1998 Oct;139(10):4073-85.PMID: 9751485 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and expression of a group IV cytosolic Ca2+-dependent phospholipase A2 from rat pancreatic islets. Comparison of the expressed activity with that of an islet group VI cytosolic Ca2+-independent phospholipase A2.

Ma Z, Ramanadham S, Hu Z, Turk J.

Biochim Biophys Acta. 1998 Apr 22;1391(3):384-400.PMID: 9555100 [PubMed - indexed for MEDLINE]Related articles

Type IB secretory phospholipase A2 is contained in insulin secretory granules of pancreatic islet beta-cells and is co-secreted with insulin from glucose-stimulated islets.

Ramanadham S, Ma Z, Arita H, Zhang S, Turk J.

Biochim Biophys Acta. 1998 Feb 23;1390(3):301-12.PMID: 9487151 [PubMed - indexed for MEDLINE]Related articles

Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis.

Ramanadham S, Hsu FF, Bohrer A, Nowatzke W, Ma Z, Turk J.

Biochemistry. 1998 Mar 31;37(13):4553-67.PMID: 9521776 [PubMed - indexed for MEDLINE]Related articles

Effects of arachidonyltrifluoromethyl ketone on cytosolic [Ca2+] in HIT insulinoma cells.

Stickle D, Ramanadham S, Turk J.

J Lipid Mediat Cell Signal. 1997 Sep;17(1):65-70.PMID: 9302655 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism.

Ma Z, Landt M, Bohrer A, Ramanadham S, Kipnis DM, Turk J.

J Biol Chem. 1997 Jul 11;272(28):17827-35.PMID: 9211938 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin.

Ma Z, Ramanadham S, Kempe K, Chi XS, Ladenson J, Turk J.

J Biol Chem. 1997 Apr 25;272(17):11118-27.PMID: 9111008 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell lines.

Ramanadham S, Wolf MJ, Li B, Bohrer A, Turk J.

Biochim Biophys Acta. 1997 Jan 21;1344(2):153-64.PMID: 9030192 [PubMed - indexed for MEDLINE]Related articles

Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform.

Ma Z, Ramanadham S, Kempe K, Hu Z, Ladenson J, Turk J.

Biochim Biophys Acta. 1996 Aug 14;1308(2):151-63.PMID: 8764833 [PubMed - indexed for MEDLINE]Related articles

Evidence for association of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein.

Ramanadham S, Wolf MJ, Ma Z, Li B, Wang J, Gross RW, Turk J.

Biochemistry. 1996 Apr 30;35(17):5464-71.PMID: 8611537 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism.

Ma Z, Ramanadham S, Corbett JA, Bohrer A, Gross RW, McDaniel ML, Turk J.

J Biol Chem. 1996 Jan 12;271(2):1029-42.PMID: 8557627 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels.

Ferrer J, Nichols CG, Makhina EN, Salkoff L, Bernstein J, Gerhard D, Wasson J, Ramanadham S, Permutt A.

J Biol Chem. 1995 Nov 3;270(44):26086-91.PMID: 7592809 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor.

Ramanadham S, Wolf MJ, Jett PA, Gross RW, Turk J.

Biochemistry. 1994 Jun 14;33(23):7442-52.PMID: 8003509 [PubMed - indexed for MEDLINE]Related articles

omega-Conotoxin inhibits glucose- and arachidonic acid-induced rises in intracellular [Ca2+] in rat pancreatic islet beta-cells.

Ramanadham S, Turk J.

Cell Calcium. 1994 Mar;15(3):259-64.PMID: 8194105 [PubMed - indexed for MEDLINE]Related articles

Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets.

Turk J, Corbett JA, Ramanadham S, Bohrer A, McDaniel ML.

Biochem Biophys Res Commun. 1993 Dec 30;197(3):1458-64.PMID: 7904159 [PubMed - indexed for MEDLINE]Related articles

Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes.

Ramanadham S, Bohrer A, Gross RW, Turk J.

Biochemistry. 1993 Dec 14;32(49):13499-509.PMID: 8257685 [PubMed - indexed for MEDLINE]Related articles

Arachidonic acid release from aortic smooth muscle cells induced by [Arg8]vasopressin is largely mediated by calcium-independent phospholipase A2.

Lehman JJ, Brown KA, Ramanadham S, Turk J, Gross RW.

J Biol Chem. 1993 Oct 5;268(28):20713-6.PMID: 8407892 [PubMed - indexed for MEDLINE]Related articlesFree article

Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.

Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J.

Biochemistry. 1993 May 25;32(20):5339-51.PMID: 8499439 [PubMed - indexed for MEDLINE]Related articles

Amplification of insulin secretion by lipid messengers.

Turk J, Gross RW, Ramanadham S.

Diabetes. 1993 Mar;42(3):367-74. Review.PMID: 8432406 [PubMed - indexed for MEDLINE]Related articles