PubMed

Portal vein embolization with radiolabeled polyvinyl alcohol particles in a swine model: hepatic distribution and implications for pancreatic islet cell transplantation.

Owen RJ, Mercer JR, Al-Saif F, Molinari M, Ashforth RA, Rajotte RV, Conner-Spady B, Shapiro AM.

Cardiovasc Intervent Radiol. 2009 May;32(3):499-507. Epub 2009 Mar 28.PMID: 19330373 [PubMed - indexed for MEDLINE]Related articles

Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.

Kobayashi T, Arefanian H, Harb G, Tredget EB, Rajotte RV, Korbutt GS, Rayat GR.

Cell Transplant. 2008;17(10-11):1243-56.PMID: 19181218 [PubMed - indexed for MEDLINE]Related articles

Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture.

Seeberger KL, Eshpeter A, Rajotte RV, Korbutt GS.

Lab Invest. 2009 Feb;89(2):110-21. Epub 2008 Dec 15.PMID: 19079324 [PubMed - indexed for MEDLINE]Related articles

Mouse pancreatic islets are resistant to indoleamine 2,3 dioxygenase-induced general control nonderepressible-2 kinase stress pathway and maintain normal viability and function.

Jalili RB, Forouzandeh F, Moeenrezakhanlou A, Rayat GR, Rajotte RV, Uludag H, Ghahary A.

Am J Pathol. 2009 Jan;174(1):196-205. Epub 2008 Dec 12.PMID: 19074614 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells.

Eshpeter A, Jiang J, Au M, Rajotte RV, Lu K, Lebkowski JS, Majumdar AS, Korbutt GS.

Cell Prolif. 2008 Dec;41(6):843-58.PMID: 19040565 [PubMed - indexed for MEDLINE]Related articles

Monotherapy with anti-LFA-1 monoclonal antibody promotes long-term survival of rat islet xenografts.

Tredget EB, Arefanian H, Gill RG, Rajotte RV, Rayat GR.

Cell Transplant. 2008;17(6):599-608.PMID: 18819248 [PubMed - indexed for MEDLINE]Related articles

Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.

Dufour JM, Dass B, Halley KR, Korbutt GS, Dixon DE, Rajotte RV.

Cell Transplant. 2008;17(5):525-34.PMID: 18714671 [PubMed - indexed for MEDLINE]Related articles

Moving towards clinical application.

Rajotte RV.

Xenotransplantation. 2008 Mar;15(2):113-5. No abstract available. PMID: 18447883 [PubMed - indexed for MEDLINE]Related articles

Isolation and assessment of islet quality.

Rajotte RV.

Xenotransplantation. 2008 Mar;15(2):93-5. No abstract available. PMID: 18447876 [PubMed - indexed for MEDLINE]Related articles

Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice.

Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV.

Cell Transplant. 2008;16(10):1029-38.PMID: 18351019 [PubMed - indexed for MEDLINE]Related articles

Combination of anti-CD4 with anti-LFA-1 and anti-CD154 monoclonal antibodies promotes long-term survival and function of neonatal porcine islet xenografts in spontaneously diabetic NOD mice.

Arefanian H, Tredget EB, Rajotte RV, Korbutt GS, Gill RG, Rayat GR.

Cell Transplant. 2007;16(8):787-98.PMID: 18087999 [PubMed - indexed for MEDLINE]Related articles

Long-term graft function after allogeneic islet transplantation.

Lakey JR, Kin T, Warnock GL, Shapiro AM, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA.

Cell Transplant. 2007;16(4):441-6.PMID: 17658134 [PubMed - indexed for MEDLINE]Related articles

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS.

Rev Diabet Stud. 2004 Summer;1(2):66-79. Epub 2004 Aug 10.PMID: 17491668 [PubMed]Related articlesFree article

Suppression of islet allogeneic immune response by indoleamine 2,3 dioxygenase-expressing fibroblasts.

Jalili RB, Rayat GR, Rajotte RV, Ghahary A.

J Cell Physiol. 2007 Oct;213(1):137-43.PMID: 17477384 [PubMed - indexed for MEDLINE]Related articles

Diabetes induces rapid suppression of adaptive immunity followed by homeostatic T-cell proliferation.

Luo B, Chan WF, Lord SJ, Nanji SA, Rajotte RV, Shapiro AM, Anderson CC.

Scand J Immunol. 2007 Jan;65(1):22-31.PMID: 17212763 [PubMed - indexed for MEDLINE]Related articles

Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.

Kobayashi T, Harb G, Rajotte RV, Korbutt GS, Mallett AG, Arefanian H, Mok D, Rayat GR.

Xenotransplantation. 2006 Nov;13(6):547-59.PMID: 17059582 [PubMed - indexed for MEDLINE]Related articles

Neonatal porcine islets exhibit natural resistance to hypoxia-induced apoptosis.

Emamaullee JA, Shapiro AM, Rajotte RV, Korbutt G, Elliott JF.

Transplantation. 2006 Oct 15;82(7):945-52.PMID: 17038911 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells.

Sipione S, Simmen KC, Lord SJ, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV, Bleackley RC.

J Immunol. 2006 Oct 15;177(8):5051-8.PMID: 17015688 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection.

Manji RA, Zhu LF, Nijjar NK, Rayner DC, Korbutt GS, Churchill TA, Rajotte RV, Koshal A, Ross DB.

Circulation. 2006 Jul 25;114(4):318-27. Epub 2006 Jul 10.PMID: 16831988 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.

Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangappa S, Weber CJ, Pearson TC, Rajotte RV, Larsen CP.

Nat Med. 2006 Mar;12(3):304-6. Epub 2006 Feb 26.PMID: 16501570 [PubMed - indexed for MEDLINE]Related articles

Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.

Seeberger KL, Dufour JM, Shapiro AM, Lakey JR, Rajotte RV, Korbutt GS.

Lab Invest. 2006 Feb;86(2):141-53.PMID: 16402034 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of an ectopic site for islet transplantation, using biodegradable scaffolds.

Dufour JM, Rajotte RV, Zimmerman M, Rezania A, Kin T, Dixon DE, Korbutt GS.

Tissue Eng. 2005 Sep-Oct;11(9-10):1323-31.PMID: 16259588 [PubMed - indexed for MEDLINE]Related articles

Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia.

Gustavson SM, Rajotte RV, Hunkeler D, Lakey JR, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cherrington AD.

Am J Transplant. 2005 Oct;5(10):2368-77.PMID: 16162184 [PubMed - indexed for MEDLINE]Related articles

XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.

Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF.

Diabetes. 2005 Sep;54(9):2541-8.PMID: 16123341 [PubMed - indexed for MEDLINE]Related articlesFree article

Decellularization reduces the immune response to aortic valve allografts in the rat.

Meyer SR, Nagendran J, Desai LS, Rayat GR, Churchill TA, Anderson CC, Rajotte RV, Lakey JR, Ross DB.

J Thorac Cardiovasc Surg. 2005 Aug;130(2):469-76.PMID: 16077415 [PubMed - indexed for MEDLINE]Related articles

Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.

Kin T, Korbutt GS, Kobayashi T, Dufour JM, Rajotte RV.

Diabetes. 2005 Apr;54(4):1032-9.PMID: 15793241 [PubMed - indexed for MEDLINE]Related articlesFree article

The portal immunosuppressive storm: relevance to islet transplantation?

Shapiro AM, Gallant HL, Hao EG, Lakey JR, McCready T, Rajotte RV, Yatscoff RW, Kneteman NM.

Ther Drug Monit. 2005 Feb;27(1):35-7.PMID: 15665744 [PubMed - indexed for MEDLINE]Related articles

Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis.

Dufour JM, Hamilton M, Rajotte RV, Korbutt GS.

Biol Reprod. 2005 May;72(5):1224-31. Epub 2005 Jan 19.PMID: 15659703 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.

Street CN, Lakey JR, Shapiro AM, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T, Korbutt GS.

Diabetes. 2004 Dec;53(12):3107-14.PMID: 15561940 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation.

Korbutt GS, Mallett AG, Ao Z, Flashner M, Rajotte RV.

Diabetologia. 2004 Oct;47(10):1810-8. Epub 2004 Oct 23.PMID: 15517151 [PubMed - indexed for MEDLINE]Related articles

In-situ crosslinking thermoreversible polymers for cell entrapment.

Norrie B, Jalil A, Lakey JR, Rajotte RV, Uludag H.

Adv Exp Med Biol. 2004;553:19-28. No abstract available. PMID: 15503444 [PubMed - indexed for MEDLINE]Related articles

Reassessment of the vascularization of renal subcapsular islet grafts.

Kin T, Rajotte RV, Korbutt GS.

Pancreas. 2004 Oct;29(3):e59-63.PMID: 15367895 [PubMed - indexed for MEDLINE]Related articles

Increased apoptosis in porcine cardiac xenografts perfused with human ABO plasma containing the anti-B antibody.

Manji JS, Rajotte RV, Koshal A, Manji RA.

Xenotransplantation. 2004 Jul;11(4):378-9. No abstract available. PMID: 15196134 [PubMed - indexed for MEDLINE]Related articles

Human anti-A and anti-B antibodies interact with alphaGal antibody affecting xenograft survival.

Manji JS, Rajotte RV, Koshal A, Manji RA.

Xenotransplantation. 2004 Jul;11(4):376-7. No abstract available. PMID: 15196133 [PubMed - indexed for MEDLINE]Related articles

Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant.

Binette TM, Seeberger KL, Lyon JG, Rajotte RV, Korbutt GS.

Am J Transplant. 2004 Jul;4(7):1051-60.PMID: 15196061 [PubMed - indexed for MEDLINE]Related articles

Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes.

Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS.

Int J Biochem Cell Biol. 2004 Apr;36(4):667-83. Review.PMID: 15010331 [PubMed - indexed for MEDLINE]Related articles

Human O red blood cells and pig-to-human xenotransplantation.

Manji RA, Rajotte RV, Arvind K.

Xenotransplantation. 2004 Jan;11(1):107. No abstract available. PMID: 14962300 [PubMed - indexed for MEDLINE]Related articles

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker.

Street CN, Lakey JR, Seeberger K, Helms L, Rajotte RV, Shapiro AM, Korbutt GS.

J Endocrinol. 2004 Feb;180(2):213-25.PMID: 14765974 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetically engineered Sertoli cells are able to survive allogeneic transplantation.

Dufour JM, Hemendinger R, Halberstadt CR, Gores P, Emerich DF, Korbutt GS, Rajotte RV.

Gene Ther. 2004 Apr;11(8):694-700.PMID: 14724669 [PubMed - indexed for MEDLINE]Related articles

Stem cells: a promising source of pancreatic islets for transplantation in type 1 diabetes.

Street CN, Rajotte RV, Korbutt GS.

Curr Top Dev Biol. 2003;58:111-36. Review.PMID: 14711014 [PubMed - indexed for MEDLINE]Related articles

Long-term survival of neonatal porcine Sertoli cells in non-immunosuppressed rats.

Dufour JM, Rajotte RV, Seeberger K, Kin T, Korbutt GS.

Xenotransplantation. 2003 Nov;10(6):577-86.PMID: 14708526 [PubMed - indexed for MEDLINE]Related articles

Harnessing the immunomodulatory properties of Sertoli cells to enable xenotransplantation in type I diabetes.

Dufour JM, Rajotte RV, Korbutt GS, Emerich DF.

Immunol Invest. 2003 Nov;32(4):275-97. Review.PMID: 14603995 [PubMed - indexed for MEDLINE]Related articles

Current status of islet cell transplantation.

Oberholzer J, Shapiro AM, Lakey JR, Ryan EA, Rajotte RV, Korbutt GS, Morel P, Kneteman NM.

Adv Surg. 2003;37:253-82. Review. No abstract available. PMID: 12953637 [PubMed - indexed for MEDLINE]Related articles

Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.

Owen RJ, Ryan EA, O'Kelly K, Lakey JR, McCarthy MC, Paty BW, Bigam DL, Kneteman NM, Korbutt GS, Rajotte RV, Shapiro AM.

Radiology. 2003 Oct;229(1):165-70. Epub 2003 Aug 27.PMID: 12944593 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunization with streptozotocin-treated NOD mouse islets inhibits the onset of autoimmune diabetes in NOD mice.

Rayat GR, Rajotte RV, Lyon JG, Dufour JM, Hacquoil BV, Korbutt GS.

J Autoimmun. 2003 Aug;21(1):11-5.PMID: 12892731 [PubMed - indexed for MEDLINE]Related articles

Immunoprotection of rat islet xenografts by cotransplantation with sertoli cells and a single injection of antilymphocyte serum.

Dufour JM, Rajotte RV, Kin T, Korbutt GS.

Transplantation. 2003 May 15;75(9):1594-6.PMID: 12792521 [PubMed - indexed for MEDLINE]Related articles

The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection.

Rayat GR, Johnson ZA, Beilke JN, Korbutt GS, Rajotte RV, Gill RG.

Diabetes. 2003 Jun;52(6):1433-40.PMID: 12765954 [PubMed - indexed for MEDLINE]Related articlesFree article

Granzyme B: a natural born killer.

Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC.

Immunol Rev. 2003 Jun;193:31-8. Review.PMID: 12752668 [PubMed - indexed for MEDLINE]Related articles

In vitro and in vivo expression of Galalpha-(1,3)Gal on porcine islet cells is age dependent.

Rayat GR, Rajotte RV, Hering BJ, Binette TM, Korbutt GS.

J Endocrinol. 2003 Apr;177(1):127-35.PMID: 12697044 [PubMed - indexed for MEDLINE]Related articlesFree article