PubMed

A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.

Munster PN, Rubin EH, Van Belle S, Friedman E, Patterson JK, Van Dyck K, Li X, Comisar W, Chodakewitz JA, Wagner JA, Iwamoto M.

Clin Cancer Res. 2009 Nov 15;15(22):7077-84. Epub 2009 Nov 3.PMID: 19887475 [PubMed - in process]Related articles

Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial.

Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS.

JAMA. 2009 Oct 21;302(15):1651-7.PMID: 19843899 [PubMed - indexed for MEDLINE]Related articles

Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors.

Tan AR, Rubin EH, Walton DC, Shuster DE, Wong YN, Fang F, Ashworth S, Rosen LS.

Clin Cancer Res. 2009 Jun 15;15(12):4213-9. Epub 2009 Jun 9.PMID: 19509146 [PubMed - indexed for MEDLINE]Related articles

Treatment of depression after coronary artery bypass surgery: a randomized controlled trial.

Freedland KE, Skala JA, Carney RM, Rubin EH, Lustman PJ, Dávila-Román VG, Steinmeyer BC, Hogue CW Jr.

Arch Gen Psychiatry. 2009 Apr;66(4):387-96.PMID: 19349308 [PubMed - indexed for MEDLINE]Related articles

Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity.

Park HJ, Zheng H, Kulkarni D, Kerrigan J, Pungaliya P, Saleem A, Rubin EH.

Biochemistry. 2008 Dec 30;47(52):13887-96.PMID: 19053840 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic/pharmacodynamic modeling and simulation of neutropenia during phase I development of liposome-entrapped paclitaxel.

Fetterly GJ, Grasela TH, Sherman JW, Dul JL, Grahn A, Lecomte D, Fiedler-Kelly J, Damjanov N, Fishman M, Kane MP, Rubin EH, Tan AR.

Clin Cancer Res. 2008 Sep 15;14(18):5856-63.PMID: 18794097 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimal modeling for phase I design of a two drug combination-results of a phase I study of cisplatin with 9-nitrocamptothecin.

Lee SJ, Gounder M, Rubin EH, Li JM, Gu Z, Thalasila A, Loyer E, Kudelka AP, Verschraegen CF.

Invest New Drugs. 2008 Dec;26(6):541-51. Epub 2008 Jul 4.PMID: 18600301 [PubMed - indexed for MEDLINE]Related articles

Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia.

Saraiya B, Gounder M, Dutta J, Saleem A, Collazo C, Zimmerman L, Nazar A, Gharibo M, Schaar D, Lin Y, Shih W, Aisner J, Strair RK, Rubin EH.

Anticancer Drugs. 2008 Apr;19(4):411-20.PMID: 18454051 [PubMed - indexed for MEDLINE]Related articles

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH, Bieberich CJ.

J Biol Chem. 2008 Feb 22;283(8):4834-40. Epub 2007 Dec 12.PMID: 18077445 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan.

Gounder MK, Nazar AS, Saleem A, Pungaliya P, Kulkarni D, Versace R, Rubin EH.

Invest New Drugs. 2008 Jun;26(3):205-13. Epub 2007 Oct 18.PMID: 17943230 [PubMed - indexed for MEDLINE]Related articles

Phase I and pharmacokinetic study of imatinib mesylate (Gleevec) and gemcitabine in patients with refractory solid tumors.

Ali Y, Lin Y, Gharibo MM, Gounder MK, Stein MN, Lagattuta TF, Egorin MJ, Rubin EH, Poplin EA.

Clin Cancer Res. 2007 Oct 1;13(19):5876-82.PMID: 17908982 [PubMed - indexed for MEDLINE]Related articlesFree article

TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

Pungaliya P, Kulkarni D, Park HJ, Marshall H, Zheng H, Lackland H, Saleem A, Rubin EH.

J Proteome Res. 2007 Oct;6(10):3918-23. Epub 2007 Sep 6.PMID: 17803295 [PubMed - indexed for MEDLINE]Related articles

Efficacy of sertraline in prevention of depression recurrence in older versus younger adults with diabetes.

Williams MM, Clouse RE, Nix BD, Rubin EH, Sayuk GS, McGill JB, Gelenberg AJ, Ciechanowski PS, Hirsch IB, Lustman PJ.

Diabetes Care. 2007 Apr;30(4):801-6.PMID: 17392541 [PubMed - indexed for MEDLINE]Related articlesFree article

A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.

Rubin EH, Agrawal NG, Friedman EJ, Scott P, Mazina KE, Sun L, Du L, Ricker JL, Frankel SR, Gottesdiener KM, Wagner JA, Iwamoto M.

Clin Cancer Res. 2006 Dec 1;12(23):7039-45.PMID: 17145826 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics of cetuximab after administration of escalating single dosing and weekly fixed dosing in patients with solid tumors.

Tan AR, Moore DF, Hidalgo M, Doroshow JH, Poplin EA, Goodin S, Mauro D, Rubin EH.

Clin Cancer Res. 2006 Nov 1;12(21):6517-22. Epub 2006 Oct 25.PMID: 17065274 [PubMed - indexed for MEDLINE]Related articlesFree article

Post-acute dispositions of older adults hospitalized for depression.

Morrow-Howell NL, Proctor EK, Blinne WR, Rubin EH, Saunders JA, Rozario PA.

Aging Ment Health. 2006 Jul;10(4):352-61.PMID: 16798627 [PubMed - indexed for MEDLINE]Related articles

Sertraline for prevention of depression recurrence in diabetes mellitus: a randomized, double-blind, placebo-controlled trial.

Lustman PJ, Clouse RE, Nix BD, Freedland KE, Rubin EH, McGill JB, Williams MM, Gelenberg AJ, Ciechanowski PS, Hirsch IB.

Arch Gen Psychiatry. 2006 May;63(5):521-9.PMID: 16651509 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.

Desai SD, Haas AL, Wood LM, Tsai YC, Pestka S, Rubin EH, Saleem A, Nur-E-Kamal A, Liu LF.

Cancer Res. 2006 Jan 15;66(2):921-8.PMID: 16424026 [PubMed - indexed for MEDLINE]Related articlesFree article

Early-stage Alzheimer disease represents increased suicidal risk in relation to later stages.

Lim WS, Rubin EH, Coats M, Morris JC.

Alzheimer Dis Assoc Disord. 2005 Oct-Dec;19(4):214-9.PMID: 16327348 [PubMed - indexed for MEDLINE]Related articles

Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors.

Rubin EH, Rothermel J, Tesfaye F, Chen T, Hubert M, Ho YY, Hsu CH, Oza AM.

J Clin Oncol. 2005 Dec 20;23(36):9120-9. Epub 2005 Nov 21.PMID: 16301595 [PubMed - indexed for MEDLINE]Related articles

A phase I clinical trial of 12- O-tetradecanoylphorbol-13-acetate for patients with relapsed/refractory malignancies.

Schaar D, Goodell L, Aisner J, Cui XX, Han ZT, Chang R, Martin J, Grospe S, Dudek L, Riley J, Manago J, Lin Y, Rubin EH, Conney A, Strair RK.

Cancer Chemother Pharmacol. 2006 Jun;57(6):789-95. Epub 2005 Oct 18.PMID: 16231182 [PubMed - indexed for MEDLINE]Related articles

The complexities of individual financial conflicts of interest.

Rubin EH.

Neuropsychopharmacology. 2005 Jan;30(1):1-6. Review.PMID: 15470374 [PubMed - indexed for MEDLINE]Related articlesFree article

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH.

J Biol Chem. 2004 Aug 27;279(35):36440-4. Epub 2004 Jul 9.PMID: 15247280 [PubMed - indexed for MEDLINE]Related articlesFree article

Epothilones: mechanism of action and biologic activity.

Goodin S, Kane MP, Rubin EH.

J Clin Oncol. 2004 May 15;22(10):2015-25. Review.PMID: 15143095 [PubMed - indexed for MEDLINE]Related articles

The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.

Saleem A, Dutta J, Malegaonkar D, Rasheed F, Rasheed Z, Rajendra R, Marshall H, Luo M, Li H, Rubin EH.

Oncogene. 2004 Jul 8;23(31):5293-300.PMID: 15107820 [PubMed - indexed for MEDLINE]Related articles

Development of a bioanalytical liquid chromatography method for quantitation of 9-nitrocamptothecin in human plasma.

Gounder MK, Sun SL, Sands H, Lin Y, Shih WJ, Gu Z, Charles-Williams S, Roychowdhury M, Rajendra R, Rubin EH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 5;799(1):63-72.PMID: 14659436 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of resistance to topoisomerase I-targeting drugs.

Rasheed ZA, Rubin EH.

Oncogene. 2003 Oct 20;22(47):7296-304. Review.PMID: 14576839 [PubMed - indexed for MEDLINE]Related articles

Sequencing topotecan and etoposide plus cisplatin to overcome topoisomerase I and II resistance: a pharmacodynamically based Phase I trial.

Aisner J, Musanti R, Beers S, Smith S, Locsin S, Rubin EH.

Clin Cancer Res. 2003 Jul;9(7):2504-9.PMID: 12855624 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.

Rajendra R, Gounder MK, Saleem A, Schellens JH, Ross DD, Bates SE, Sinko P, Rubin EH.

Cancer Res. 2003 Jun 15;63(12):3228-33.PMID: 12810652 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvements in quality of life and disease-related symptoms in phase I trials of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors.

LoRusso PM, Herbst RS, Rischin D, Ranson M, Calvert H, Raymond E, Kieback D, Kaye S, Gianni L, Harris A, Bjork T, Maddox AM, Rothenberg ML, Small EJ, Rubin EH, Feyereislova A, Heyes A, Averbuch SD, Ochs J, Baselga J.

Clin Cancer Res. 2003 Jun;9(6):2040-8.PMID: 12796366 [PubMed - indexed for MEDLINE]Related articlesFree article

A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild Alzheimer's disease patients.

Grundman M, Capparelli E, Kim HT, Morris JC, Farlow M, Rubin EH, Heidebrink J, Hake A, Ho G, Schultz AN, Schafer K, Houston W, Thomas R, Thal LJ; Alzheimer's Disease Cooperative Study.

Life Sci. 2003 Jun 20;73(5):539-53.PMID: 12770610 [PubMed - indexed for MEDLINE]Related articles

Phase I evaluation of sequential topoisomerase targeting with irinotecan/cisplatin followed by etoposide in patients with advanced malignancy.

Licitra EJ, Vyas V, Nelson K, Musanti R, Beers S, Thomas C, Poplin E, Smith S, Lin Y, Schaaf LJ, Aisner J, Gounder M, Rajendra R, Saleem A, Toppmeyer D, Rubin EH.

Clin Cancer Res. 2003 May;9(5):1673-9.PMID: 12738720 [PubMed - indexed for MEDLINE]Related articlesFree article

Comorbid medical conditions among depressed elderly patients discharged home after acute psychiatric care.

Proctor EK, Morrow-Howell NL, Doré P, Wentz J, Rubin EH, Thompson S, Li H.

Am J Geriatr Psychiatry. 2003 May-Jun;11(3):329-38.PMID: 12724112 [PubMed - indexed for MEDLINE]Related articles

Psychiatric education in an era of rapidly occurring scientific advances.

Rubin EH, Zorumski CF.

Acad Med. 2003 Apr;78(4):351-4.PMID: 12691960 [PubMed - indexed for MEDLINE]Related articles

Transcription-dependent degradation of topoisomerase I-DNA covalent complexes.

Desai SD, Zhang H, Rodriguez-Bauman A, Yang JM, Wu X, Gounder MK, Rubin EH, Liu LF.

Mol Cell Biol. 2003 Apr;23(7):2341-50.PMID: 12640119 [PubMed - indexed for MEDLINE]Related articlesFree article

Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.

Lobell RB, Liu D, Buser CA, Davide JP, DePuy E, Hamilton K, Koblan KS, Lee Y, Mosser S, Motzel SL, Abbruzzese JL, Fuchs CS, Rowinsky EK, Rubin EH, Sharma S, Deutsch PJ, Mazina KE, Morrison BW, Wildonger L, Yao SL, Kohl NE.

Mol Cancer Ther. 2002 Jul;1(9):747-58.PMID: 12479371 [PubMed - indexed for MEDLINE]Related articlesFree article

A phase I trial of a potent P-glycoprotein inhibitor, Zosuquidar.3HCl trihydrochloride (LY335979), administered orally in combination with doxorubicin in patients with advanced malignancies.

Rubin EH, de Alwis DP, Pouliquen I, Green L, Marder P, Lin Y, Musanti R, Grospe SL, Smith SL, Toppmeyer DL, Much J, Kane M, Chaudhary A, Jordan C, Burgess M, Slapak CA.

Clin Cancer Res. 2002 Dec;8(12):3710-7.PMID: 12473580 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial.

Herbst RS, Maddox AM, Rothenberg ML, Small EJ, Rubin EH, Baselga J, Rojo F, Hong WK, Swaisland H, Averbuch SD, Ochs J, LoRusso PM.

J Clin Oncol. 2002 Sep 15;20(18):3815-25.PMID: 12228201 [PubMed - indexed for MEDLINE]Related articles

Revisiting Alzheimer's Disease from a New Prospective: Can "Risk Factors" Play a Key Role?

Price JL, Rubin EH, Morris JC.

J Alzheimers Dis. 2000 Jun;2(2):113-114. No abstract available. PMID: 12214098 [PubMed - as supplied by publisher]Related articlesFree article

The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies.

Rasheed ZA, Saleem A, Ravee Y, Pandolfi PP, Rubin EH.

Exp Cell Res. 2002 Jul 15;277(2):152-60.PMID: 12083797 [PubMed - indexed for MEDLINE]Related articles

Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.

Desai SD, Li TK, Rodriguez-Bauman A, Rubin EH, Liu LF.

Cancer Res. 2001 Aug 1;61(15):5926-32.PMID: 11479235 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinically significant depressive symptoms and very mild to mild dementia of the Alzheimer type.

Rubin EH, Veiel LL, Kinscherf DA, Morris JC, Storandt M.

Int J Geriatr Psychiatry. 2001 Jul;16(7):694-701.PMID: 11466748 [PubMed - indexed for MEDLINE]Related articles

Mild cognitive impairment represents early-stage Alzheimer disease.

Morris JC, Storandt M, Miller JP, McKeel DW, Price JL, Rubin EH, Berg L.

Arch Neurol. 2001 Mar;58(3):397-405.PMID: 11255443 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of resistance to camptothecins.

Saleem A, Edwards TK, Rasheed Z, Rubin EH.

Ann N Y Acad Sci. 2000;922:46-55. Review.PMID: 11193924 [PubMed - indexed for MEDLINE]Related articles

Absence of cognitive impairment or decline in preclinical Alzheimer's disease.

Goldman WP, Price JL, Storandt M, Grant EA, McKeel DW Jr, Rubin EH, Morris JC.

Neurology. 2001 Feb 13;56(3):361-7.PMID: 11171902 [PubMed - indexed for MEDLINE]Related articles

Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis.

Farber NB, Rubin EH, Newcomer JW, Kinscherf DA, Miller JP, Morris JC, Olney JW, McKeel DW Jr.

Arch Gen Psychiatry. 2000 Dec;57(12):1165-73.PMID: 11115331 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

Edwards TK, Saleem A, Shaman JA, Dennis T, Gerigk C, Oliveros E, Gartenberg MR, Rubin EH.

J Biol Chem. 2000 Nov 17;275(46):36181-8.PMID: 10967121 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA topoisomerase expression in tumors--a novel target for chemotherapy.

Rubin EH.

Hum Pathol. 2000 Jun;31(6):631-2. No abstract available. PMID: 10872653 [PubMed - indexed for MEDLINE]Related articles

Effects of mutations in the F361 to R364 region of topoisomerase I (Topo I), in the presence and absence of 9-aminocamptothecin, on the Topo I-DNA interaction.

Pond CD, Li XG, Rubin EH, Barrows LR.

Anticancer Drugs. 1999 Aug;10(7):647-53.PMID: 10507314 [PubMed - indexed for MEDLINE]Related articles

In vitro activation of irinotecan to SN-38 by human liver and intestine.

Ahmed F, Vyas V, Cornfield A, Goodin S, Ravikumar TS, Rubin EH, Gupta E.

Anticancer Res. 1999 May-Jun;19(3A):2067-71.PMID: 10470149 [PubMed - indexed for MEDLINE]Related articles