PubMed

Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.

Theoret MR, Cohen CJ, Nahvi AV, Ngo LT, Suri KB, Powell DJ Jr, Dudley ME, Morgan RA, Rosenberg SA.

Hum Gene Ther. 2008 Nov;19(11):1219-32.PMID: 19848582 [PubMed - indexed for MEDLINE]Related articles

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.

Zhao Y, Wang QJ, Yang S, Kochenderfer JN, Zheng Z, Zhong X, Sadelain M, Eshhar Z, Rosenberg SA, Morgan RA.

J Immunol. 2009 Nov 1;183(9):5563-74.PMID: 19843940 [PubMed - in process]Related articles

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, Sanchez-Perez L, Muranski P, Kern SJ, Logun C, Palmer DC, Ji Y, Reger RN, Leonard WJ, Danner RL, Rosenberg SA, Restifo NP.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17469-74. Epub 2009 Sep 24.PMID: 19805141 [PubMed - indexed for MEDLINE]Related articles

Liver Resection for Metastatic Melanoma with Postoperative Tumor-Infiltrating Lymphocyte Therapy.

Ripley RT, Davis JL, Klapper JA, Mathur A, Kammula U, Royal RE, Yang JC, Sherry RM, Hughes MS, Libutti SK, White DE, Steinberg SM, Dudley ME, Rosenberg SA, Avital I.

Ann Surg Oncol. 2009 Sep 24. [Epub ahead of print]PMID: 19777192 [PubMed - as supplied by publisher]Related articles

Impact of a Recombinant Fowlpox Vaccine on the Efficacy of Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes in a Patient With Metastatic Melanoma.

Smith FO, Klapper JA, Wunderlich JR, Rosenberg SA, Dudley ME.

J Immunother. 2009 Sep 11. [Epub ahead of print]PMID: 19752747 [PubMed - as supplied by publisher]Related articles

No Correlation Between Clinical Response to CTLA-4 Blockade and Presence of NY-ESO-1 Antibody in Patients With Metastatic Melanoma.

Goff SL, Robbins PF, El-Gamil M, Rosenberg SA.

J Immunother. 2009 Sep 11. [Epub ahead of print] No abstract available. PMID: 19752745 [PubMed - as supplied by publisher]Related articles

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR, Cronin JC, Cruz P, Rosenberg SA, Samuels Y.

Nat Genet. 2009 Oct;41(10):1127-32. Epub 2009 Aug 30.PMID: 19718025 [PubMed - indexed for MEDLINE]Related articles

Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation.

Burns WR, Zheng Z, Rosenberg SA, Morgan RA.

Blood. 2009 Oct 1;114(14):2888-99. Epub 2009 Jul 9.PMID: 19589923 [PubMed - in process]Related articles

Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor.

Kochenderfer JN, Feldman SA, Zhao Y, Xu H, Black MA, Morgan RA, Wilson WH, Rosenberg SA.

J Immunother. 2009 Sep;32(7):689-702.PMID: 19561539 [PubMed - indexed for MEDLINE]Related articles

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.

Peng PD, Cohen CJ, Yang S, Hsu C, Jones S, Zhao Y, Zheng Z, Rosenberg SA, Morgan RA.

Gene Ther. 2009 Aug;16(8):1042-9. Epub 2009 Jun 4.PMID: 19494842 [PubMed - in process]Related articles

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.

Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CC, Restifo NP, Schwarz SL, Cogdill AP, Bishop RJ, Kim H, Brewer CC, Rudy SF, VanWaes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA.

Blood. 2009 Jul 16;114(3):535-46. Epub 2009 May 18.PMID: 19451549 [PubMed - indexed for MEDLINE]Related articles

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.

Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, Rosenberg SA.

Blood. 2009 Aug 20;114(8):1537-44. Epub 2009 May 7.PMID: 19423728 [PubMed - indexed for MEDLINE]Related articles

Frequent mutations in the MITF pathway in melanoma.

Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian BC, Pavan WJ, Samuels Y.

Pigment Cell Melanoma Res. 2009 Aug;22(4):435-44. Epub 2009 Apr 29.PMID: 19422606 [PubMed - in process]Related articles

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma.

Yeh S, Karne NK, Kerkar SP, Heller CK, Palmer DC, Johnson LA, Li Z, Bishop RJ, Wong WT, Sherry RM, Yang JC, Dudley ME, Restifo NP, Rosenberg SA, Nussenblatt RB.

Ophthalmology. 2009 May;116(5):981-989.e1.PMID: 19410956 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy.

Klapper JA, Thomasian AA, Smith DM, Gorgas GC, Wunderlich JR, Smith FO, Hampson BS, Rosenberg SA, Dudley ME.

J Immunol Methods. 2009 Jun 30;345(1-2):90-9. Epub 2009 Apr 21.PMID: 19389403 [PubMed - indexed for MEDLINE]Related articles

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y.

Nat Genet. 2009 May;41(5):518-20. Epub 2009 Mar 29.PMID: 19330028 [PubMed - indexed for MEDLINE]Related articlesFree article

Adoptive cell therapy for the treatment of patients with metastatic melanoma.

Rosenberg SA, Dudley ME.

Curr Opin Immunol. 2009 Apr;21(2):233-40. Epub 2009 Mar 21. Review.PMID: 19304471 [PubMed - indexed for MEDLINE]Related articles

Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes.

Jones S, Peng PD, Yang S, Hsu C, Cohen CJ, Zhao Y, Abad J, Zheng Z, Rosenberg SA, Morgan RA.

Hum Gene Ther. 2009 Jun;20(6):630-40.PMID: 19265475 [PubMed - indexed for MEDLINE]Related articles

Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells.

Parkhurst MR, Joo J, Riley JP, Yu Z, Li Y, Robbins PF, Rosenberg SA.

Clin Cancer Res. 2009 Jan 1;15(1):169-80.PMID: 19118044 [PubMed - indexed for MEDLINE]Related articles

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

Solomon DA, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T.

Cancer Res. 2008 Dec 15;68(24):10300-6.PMID: 19074898 [PubMed - indexed for MEDLINE]Related articles

Care beyond curing: hospice, values, and culture in the 21st century.

Rosenberg SA.

Caring. 2008 Nov;27(11):38-41. No abstract available. PMID: 19068875 [PubMed - indexed for MEDLINE]Related articles

Lymphography: a great advance, abandoned.

Rosenberg SA.

J Clin Oncol. 2008 Dec 10;26(35):5662-3. Epub 2008 Nov 10. No abstract available. PMID: 19001339 [PubMed - indexed for MEDLINE]Related articles

Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells.

Yang S, Rosenberg SA, Morgan RA.

J Immunother. 2008 Nov-Dec;31(9):830-9.PMID: 18833004 [PubMed - indexed for MEDLINE]Related articles

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions.

Ahmadzadeh M, Felipe-Silva A, Heemskerk B, Powell DJ Jr, Wunderlich JR, Merino MJ, Rosenberg SA.

Blood. 2008 Dec 15;112(13):4953-60. Epub 2008 Sep 26.PMID: 18820132 [PubMed - indexed for MEDLINE]Related articles

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.

Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, Robbins PF, Huang J, Citrin DE, Leitman SF, Wunderlich J, Restifo NP, Thomasian A, Downey SG, Smith FO, Klapper J, Morton K, Laurencot C, White DE, Rosenberg SA.

J Clin Oncol. 2008 Nov 10;26(32):5233-9. Epub 2008 Sep 22.PMID: 18809613 [PubMed - indexed for MEDLINE]Related articlesFree article

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

Boni A, Muranski P, Cassard L, Wrzesinski C, Paulos CM, Palmer DC, Gattinoni L, Hinrichs CS, Chan CC, Rosenberg SA, Restifo NP.

Blood. 2008 Dec 1;112(12):4746-54. Epub 2008 Sep 17.PMID: 18799724 [PubMed - indexed for MEDLINE]Related articles

Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy.

Tran KQ, Zhou J, Durflinger KH, Langhan MM, Shelton TE, Wunderlich JR, Robbins PF, Rosenberg SA, Dudley ME.

J Immunother. 2008 Oct;31(8):742-51.PMID: 18779745 [PubMed - indexed for MEDLINE]Related articlesFree article

Cancer immunotherapy.

Rosenberg SA, Dudley ME, Restifo NP.

N Engl J Med. 2008 Sep 4;359(10):1072. No abstract available. PMID: 18768956 [PubMed - indexed for MEDLINE]Related articles

Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines.

Smith FO, Downey SG, Klapper JA, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Restifo NP, Levy CL, White DE, Steinberg SM, Rosenberg SA.

Clin Cancer Res. 2008 Sep 1;14(17):5610-8.PMID: 18765555 [PubMed - indexed for MEDLINE]Related articlesFree article

Overcoming obstacles to the effective immunotherapy of human cancer.

Rosenberg SA.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12643-4. Epub 2008 Aug 27. No abstract available. PMID: 18753635 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of p53 Overexpression on Cancers and Recognition by anti-p53 TCR Transduced T cells.

Theoret MR, Cohen CJ, Nahvi AV, Ngo LT, Suri KB, Powell DJ, Dudley ME, Morgan RA, Rosenberg SA.

Hum Gene Ther. 2008 Aug 15. [Epub ahead of print]PMID: 18707199 [PubMed - as supplied by publisher]Related articles

Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression.

Wargo JA, Robbins PF, Li Y, Zhao Y, El-Gamil M, Caragacianu D, Zheng Z, Hong JA, Downey S, Schrump DS, Rosenberg SA, Morgan RA.

Cancer Immunol Immunother. 2009 Mar;58(3):383-94. Epub 2008 Aug 2.PMID: 18677478 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.

Breunis WB, Tarazona-Santos E, Chen R, Kiley M, Rosenberg SA, Chanock SJ.

J Immunother. 2008 Jul-Aug;31(6):586-90.PMID: 18528295 [PubMed - indexed for MEDLINE]Related articles

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.

Palmer DC, Chan CC, Gattinoni L, Wrzesinski C, Paulos CM, Hinrichs CS, Powell DJ Jr, Klebanoff CA, Finkelstein SE, Fariss RN, Yu Z, Nussenblatt RB, Rosenberg SA, Restifo NP.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8061-6. Epub 2008 Jun 3.PMID: 18523011 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of developmental delays and participation in early intervention services for young children.

Rosenberg SA, Zhang D, Robinson CC.

Pediatrics. 2008 Jun;121(6):e1503-9. Epub 2008 May 26.PMID: 18504295 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition.

Yang S, Cohen CJ, Peng PD, Zhao Y, Cassard L, Yu Z, Zheng Z, Jones S, Restifo NP, Rosenberg SA, Morgan RA.

Gene Ther. 2008 Nov;15(21):1411-23. Epub 2008 May 22.PMID: 18496571 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration.

Powell DJ Jr, Attia P, Ghetie V, Schindler J, Vitetta ES, Rosenberg SA.

J Immunother. 2008 Feb-Mar;31(2):189-98.PMID: 18481388 [PubMed - indexed for MEDLINE]Related articles

Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.

Heemskerk B, Liu K, Dudley ME, Johnson LA, Kaiser A, Downey S, Zheng Z, Shelton TE, Matsuda K, Robbins PF, Morgan RA, Rosenberg SA.

Hum Gene Ther. 2008 May;19(5):496-510.PMID: 18444786 [PubMed - indexed for MEDLINE]Related articlesFree article

Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions.

Robbins PF, Li YF, El-Gamil M, Zhao Y, Wargo JA, Zheng Z, Xu H, Morgan RA, Feldman SA, Johnson LA, Bennett AD, Dunn SM, Mahon TM, Jakobsen BK, Rosenberg SA.

J Immunol. 2008 May 1;180(9):6116-31.PMID: 18424733 [PubMed - indexed for MEDLINE]Related articlesFree article

Adoptive cell transfer: a clinical path to effective cancer immunotherapy.

Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME.

Nat Rev Cancer. 2008 Apr;8(4):299-308. Review.PMID: 18354418 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.

Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP.

Blood. 2008 Jun 1;111(11):5326-33. Epub 2008 Feb 14.PMID: 18276844 [PubMed - indexed for MEDLINE]Related articlesFree article

Follicular lymphoma revisited.

Rosenberg SA.

J Clin Oncol. 2008 Feb 1;26(4):515-6. No abstract available. PMID: 18235110 [PubMed - indexed for MEDLINE]Related articles

T-cell receptor gene therapy of established tumors in a murine melanoma model.

Abad JD, Wrzensinski C, Overwijk W, De Witte MA, Jorritsma A, Hsu C, Gattinoni L, Cohen CJ, Paulos CM, Palmer DC, Haanen JB, Schumacher TN, Rosenberg SA, Restifo NP, Morgan RA.

J Immunother. 2008 Jan;31(1):1-6.PMID: 18157006 [PubMed - indexed for MEDLINE]Related articlesFree article

Why perform sentinel-lymph-node biopsy in patients with melanoma?

Rosenberg SA.

Nat Clin Pract Oncol. 2008 Jan;5(1):1. No abstract available. PMID: 18097452 [PubMed - indexed for MEDLINE]Related articles

Adoptive cell transfer therapy.

Dudley ME, Rosenberg SA.

Semin Oncol. 2007 Dec;34(6):524-31. Review.PMID: 18083376 [PubMed - indexed for MEDLINE]Related articlesFree article

Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis.

Yang JC, Hughes M, Kammula U, Royal R, Sherry RM, Topalian SL, Suri KB, Levy C, Allen T, Mavroukakis S, Lowy I, White DE, Rosenberg SA.

J Immunother. 2007 Nov-Dec;30(8):825-30.PMID: 18049334 [PubMed - indexed for MEDLINE]Related articlesFree article

Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade.

Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Allen TE, Levy CL, Yellin M, Nichol G, White DE, Steinberg SM, Rosenberg SA.

Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6681-8. Epub 2007 Nov 2.PMID: 17982122 [PubMed - indexed for MEDLINE]Related articlesFree article

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

Zhao Y, Bennett AD, Zheng Z, Wang QJ, Robbins PF, Yu LY, Li Y, Molloy PE, Dunn SM, Jakobsen BK, Rosenberg SA, Morgan RA.

J Immunol. 2007 Nov 1;179(9):5845-54.PMID: 17947658 [PubMed - indexed for MEDLINE]Related articlesFree article

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.

Powell DJ Jr, Felipe-Silva A, Merino MJ, Ahmadzadeh M, Allen T, Levy C, White DE, Mavroukakis S, Kreitman RJ, Rosenberg SA, Pastan I.

J Immunol. 2007 Oct 1;179(7):4919-28.PMID: 17878392 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptors in tumor immunotherapy.

Paulos CM, Kaiser A, Wrzesinski C, Hinrichs CS, Cassard L, Boni A, Muranski P, Sanchez-Perez L, Palmer DC, Yu Z, Antony PA, Gattinoni L, Rosenberg SA, Restifo NP.

Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5280-9. Review.PMID: 17875756 [PubMed - indexed for MEDLINE]Related articlesFree article