PubMed

The utility of stable cell lines to assess species differences in PXR transactivation.

Sinz MW, Pray D, Raucy J.

Drug Metab Lett. 2007 Apr;1(2):147-52.PMID: 19356035 [PubMed - indexed for MEDLINE]Related articles

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.

Trubetskoy O, Marks B, Zielinski T, Yueh MF, Raucy J.

AAPS J. 2005 Mar 4;7(1):E6-13.PMID: 16146350 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

Yueh MF, Kawahara M, Raucy J.

Toxicol In Vitro. 2005 Mar;19(2):275-87.PMID: 15649641 [PubMed - indexed for MEDLINE]Related articles

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line.

Yueh MF, Kawahara M, Raucy J.

Drug Metab Dispos. 2005 Jan;33(1):38-48. Epub 2004 Oct 1.PMID: 15466163 [PubMed - indexed for MEDLINE]Related articlesFree article

Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19.

Hirani VN, Raucy JL, Lasker JM.

Drug Metab Dispos. 2004 Dec;32(12):1462-7. Epub 2004 Sep 24.PMID: 15448116 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.

Krueger SK, Siddens LK, Martin SR, Yu Z, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, Raucy JL, Williams DE.

Drug Metab Dispos. 2004 Dec;32(12):1337-40. Epub 2004 Sep 8.PMID: 15355885 [PubMed - indexed for MEDLINE]Related articlesFree article

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmöller J, Zanger UM, Wojnowski L.

J Biol Chem. 2004 Sep 10;279(37):38379-85. Epub 2004 Jul 12.PMID: 15252010 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes.

Raucy JL, Lasker J, Ozaki K, Zoleta V.

Toxicol Sci. 2004 Jun;79(2):233-41. Epub 2004 Mar 31.PMID: 15056802 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.

Raucy JL.

Drug Metab Dispos. 2003 May;31(5):533-9.PMID: 12695340 [PubMed - indexed for MEDLINE]Related articlesFree article

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.

Raucy J, Warfe L, Yueh MF, Allen SW.

J Pharmacol Exp Ther. 2002 Oct;303(1):412-23.PMID: 12235278 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

Krueger SK, Williams DE, Yueh MF, Martin SR, Hines RN, Raucy JL, Dolphin CT, Shephard EA, Phillips IR.

Drug Metab Rev. 2002 Aug;34(3):523-32. Review.PMID: 12214664 [PubMed - indexed for MEDLINE]Related articles

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes.

Raucy JL, Mueller L, Duan K, Allen SW, Strom S, Lasker JM.

J Pharmacol Exp Ther. 2002 Aug;302(2):475-82.PMID: 12130704 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in P450 research.

Raucy JL, Allen SW.

Pharmacogenomics J. 2001;1(3):178-86. Review.PMID: 11908754 [PubMed - indexed for MEDLINE]Related articles

The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression.

Allen SW, Mueller L, Williams SN, Quattrochi LC, Raucy J.

Drug Metab Dispos. 2001 Aug;29(8):1074-9.PMID: 11454723 [PubMed - indexed for MEDLINE]Related articlesFree article

CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes.

Wester MR, Lasker JM, Johnson EF, Raucy JL.

Drug Metab Dispos. 2000 Mar;28(3):354-9.PMID: 10681382 [PubMed - indexed for MEDLINE]Related articlesFree article

CYP2E1 expression in human lymphocytes from various ethnic populations.

Raucy JL, Schultz ED, Kearins MC, Arora S, Johnston DE, Omdahl JL, Eckmann L, Carpenter SP.

Alcohol Clin Exp Res. 1999 Dec;23(12):1868-74.PMID: 10630604 [PubMed - indexed for MEDLINE]Related articles

Drug metabolizing enzymes in lymphocytes.

Raucy JL, Ingelman-Sundberg M, Carpenter S, Rannug A, Rane A, Franklin M, Romkes M.

J Biochem Mol Toxicol. 1999;13(3-4):223-6. Review. No abstract available. PMID: 10098909 [PubMed - indexed for MEDLINE]Related articles

Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.

Jin R, Koop DR, Raucy JL, Lasker JM.

Arch Biochem Biophys. 1998 Nov 1;359(1):89-98.PMID: 9799565 [PubMed - indexed for MEDLINE]Related articles

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.

Lasker JM, Wester MR, Aramsombatdee E, Raucy JL.

Arch Biochem Biophys. 1998 May 1;353(1):16-28.PMID: 9578596 [PubMed - indexed for MEDLINE]Related articles

Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity.

Raucy JL, Schultz ED, Wester MR, Arora S, Johnston DE, Omdahl JL, Carpenter SP.

Drug Metab Dispos. 1997 Dec;25(12):1429-35.PMID: 9394034 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator activated receptor-alpha expression in human liver.

Palmer CN, Hsu MH, Griffin KJ, Raucy JL, Johnson EF.

Mol Pharmacol. 1998 Jan;53(1):14-22.PMID: 9443928 [PubMed - indexed for MEDLINE]Related articlesFree article

Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion.

Rowell DL, Eckmann L, Dwinell MB, Carpenter SP, Raucy JL, Yang SK, Kagnoff MF.

Am J Physiol. 1997 Aug;273(2 Pt 1):G322-32.PMID: 9277410 [PubMed - indexed for MEDLINE]Related articles

Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver.

Carpenter SP, Savage DD, Schultz ED, Raucy JL.

J Pharmacol Exp Ther. 1997 Aug;282(2):1028-36.PMID: 9262372 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51.

Richardson TH, Griffin KJ, Jung F, Raucy JL, Johnson EF.

Arch Biochem Biophys. 1997 Feb 15;338(2):157-64.PMID: 9028867 [PubMed - indexed for MEDLINE]Related articles

Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases.

Jung F, Richardson TH, Raucy JL, Johnson EF.

Drug Metab Dispos. 1997 Feb;25(2):133-9.PMID: 9029042 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug metabolic enzymes in developmental toxicology.

Miller MS, Juchau MR, Guengerich FP, Nebert DW, Raucy JL.

Fundam Appl Toxicol. 1996 Dec;34(2):165-75. Review.PMID: 8954747 [PubMed - indexed for MEDLINE]Related articles

Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes.

Carpenter SP, Lasker JM, Raucy JL.

Mol Pharmacol. 1996 Feb;49(2):260-8.PMID: 8632758 [PubMed - indexed for MEDLINE]Related articles

Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1.

Raucy JL.

Toxicology. 1995 Dec 28;105(2-3):217-24. Review.PMID: 8571359 [PubMed - indexed for MEDLINE]Related articles

Use of lymphocytes for assessing ethanol-mediated alterations in the expression of hepatic cytochrome P4502E1.

Raucy JL, Curley G, Carpenter SP.

Alcohol Clin Exp Res. 1995 Dec;19(6):1369-75.PMID: 8749797 [PubMed - indexed for MEDLINE]Related articles

A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli.

Richardson TH, Jung F, Griffin KJ, Wester M, Raucy JL, Kemper B, Bornheim LM, Hassett C, Omiecinski CJ, Johnson EF.

Arch Biochem Biophys. 1995 Oct 20;323(1):87-96.PMID: 7487078 [PubMed - indexed for MEDLINE]Related articles

Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.

Daikh BE, Lasker JM, Raucy JL, Koop DR.

J Pharmacol Exp Ther. 1994 Dec;271(3):1427-33.PMID: 7996455 [PubMed - indexed for MEDLINE]Related articles

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.

Goldstein JA, Faletto MB, Romkes-Sparks M, Sullivan T, Kitareewan S, Raucy JL, Lasker JM, Ghanayem BI.

Biochemistry. 1994 Feb 22;33(7):1743-52.PMID: 8110777 [PubMed - indexed for MEDLINE]Related articles

The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues.

Raucy JL, Carpenter SJ.

J Pharmacol Toxicol Methods. 1993 Jun;29(3):121-8. Review. No abstract available. PMID: 8364226 [PubMed - indexed for MEDLINE]Related articles

Induction of P4502E1 by acetone in isolated rabbit hepatocytes. Role of increased protein and mRNA synthesis.

Kraner JC, Lasker JM, Corcoran GB, Ray SD, Raucy JL.

Biochem Pharmacol. 1993 Apr 6;45(7):1483-92.PMID: 8471070 [PubMed - indexed for MEDLINE]Related articles

Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily.

Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA.

Biochemistry. 1993 Feb 9;32(5):1390. No abstract available. PMID: 8095407 [PubMed - indexed for MEDLINE]Related articles

Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.

Raucy JL, Kraner JC, Lasker JM.

Crit Rev Toxicol. 1993;23(1):1-20. Review.PMID: 8471158 [PubMed - indexed for MEDLINE]Related articles

Expression of cytochrome P450 3A in amphibian, rat, and human kidney.

Schuetz EG, Schuetz JD, Grogan WM, Naray-Fejes-Toth A, Fejes-Toth G, Raucy J, Guzelian P, Gionela K, Watlington CO.

Arch Biochem Biophys. 1992 Apr;294(1):206-14.PMID: 1550347 [PubMed - indexed for MEDLINE]Related articles

Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.

Bornheim LM, Lasker JM, Raucy JL.

Drug Metab Dispos. 1992 Mar-Apr;20(2):241-6.PMID: 1352216 [PubMed - indexed for MEDLINE]Related articles

Identification of lanosterol 14 alpha-methyl demethylase in human tissues.

Raucy JL, Carpenter SJ, Trzaskos JM.

Biochem Biophys Res Commun. 1991 May 31;177(1):497-503.PMID: 2043135 [PubMed - indexed for MEDLINE]Related articles

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA.

Biochemistry. 1991 Apr 2;30(13):3247-55. Erratum in: Biochemistry. 1993 Feb 9;32(5):1390. PMID: 2009263 [PubMed - indexed for MEDLINE]Related articles

Induction of cytochrome P450IIE1 in the obese overfed rat.

Raucy JL, Lasker JM, Kraner JC, Salazar DE, Lieber CS, Corcoran GB.

Mol Pharmacol. 1991 Mar;39(3):275-80.PMID: 2005876 [PubMed - indexed for MEDLINE]Related articles

Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo early after hepatotoxic acetaminophen overdose in mice.

Ray SD, Sorge CL, Tavacoli A, Raucy JL, Corcoran GB.

Adv Exp Med Biol. 1991;283:699-705.PMID: 2069042 [PubMed - indexed for MEDLINE]Related articles

Isolation of P450 enzymes from human liver.

Raucy JL, Lasker JM.

Methods Enzymol. 1991;206:577-87. No abstract available. PMID: 1664480 [PubMed - indexed for MEDLINE]Related articles

Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.

Ray SD, Sorge CL, Raucy JL, Corcoran GB.

Toxicol Appl Pharmacol. 1990 Nov;106(2):346-51.PMID: 2256122 [PubMed - indexed for MEDLINE]Related articles

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

Wrighton SA, Brian WR, Sari MA, Iwasaki M, Guengerich FP, Raucy JL, Molowa DT, Vandenbranden M.

Mol Pharmacol. 1990 Aug;38(2):207-13.PMID: 2385232 [PubMed - indexed for MEDLINE]Related articles

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2.

Raucy JL, Lasker JM, Lieber CS, Black M.

Arch Biochem Biophys. 1989 Jun;271(2):270-83.PMID: 2729995 [PubMed - indexed for MEDLINE]Related articles

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8.

Leo MA, Lasker JM, Raucy JL, Kim CI, Black M, Lieber CS.

Arch Biochem Biophys. 1989 Feb 15;269(1):305-12.PMID: 2916844 [PubMed - indexed for MEDLINE]Related articles

Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone.

Schwab GE, Raucy JL, Johnson EF.

Mol Pharmacol. 1988 May;33(5):493-9.PMID: 3367901 [PubMed - indexed for MEDLINE]Related articles

Purification and characterization of human liver cytochrome P-450-ALC.

Lasker JM, Raucy J, Kubota S, Bloswick BP, Black M, Lieber CS.

Biochem Biophys Res Commun. 1987 Oct 14;148(1):232-8.PMID: 3675576 [PubMed - indexed for MEDLINE]Related articles

Identification of a human liver cytochrome P-450 exhibiting catalytic and immunochemical similarities to cytochrome P-450 3a of rabbit liver.

Raucy J, Fernandes P, Black M, Yang SL, Koop DR.

Biochem Pharmacol. 1987 Sep 15;36(18):2921-6.PMID: 3632717 [PubMed - indexed for MEDLINE]Related articles