PubMed

A Proposal of Combined Evaluation of Waist Circumference and BMI for the Diagnosis of Metabolic Syndrome.

Takahashi M, Shimomura K, Proks P, Craig TJ, Negishi M, Akuzawa M, Hayashi R, Shimomura Y, Kobayashi I.

Endocr J. 2009 Sep 5. [Epub ahead of print]PMID: 19734693 [PubMed - as supplied by publisher]Related articlesFree article

Sepsis and gas-forming splenic abscess by Clostridium septicum in a patient with type 2 diabetes.

Imamura M, Shimomura K, Watanabe A, Negishi M, Akuzawa M, Takahashi M, Proks P, Shimomura Y.

J Diabetes Complications. 2009 Mar 12. [Epub ahead of print]PMID: 19285435 [PubMed - as supplied by publisher]Related articles

Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes.

Negishi M, Shimomura K, Proks P, Mori M, Shimomura Y.

Diabet Med. 2009 Jan;26(1):76-8.PMID: 19125764 [PubMed - indexed for MEDLINE]Related articles

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM.

J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.PMID: 19065048 [PubMed - indexed for MEDLINE]Related articlesFree article

Xenopus oocytes as a heterologous expression system for studying ion channels with the patch-clamp technique.

Tammaro P, Shimomura K, Proks P.

Methods Mol Biol. 2008;491:127-39.PMID: 18998089 [PubMed - indexed for MEDLINE]Related articles

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):257-67. Review.PMID: 18990670 [PubMed - indexed for MEDLINE]Related articles

Modeling K(ATP) channel gating and its regulation.

Proks P, Ashcroft FM.

Prog Biophys Mol Biol. 2009 Jan;99(1):7-19. Epub 2008 Oct 17. Review.PMID: 18983870 [PubMed - indexed for MEDLINE]Related articles

How ATP inhibits the open K(ATP) channel.

Craig TJ, Ashcroft FM, Proks P.

J Gen Physiol. 2008 Jul;132(1):131-44.PMID: 18591420 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients.

Negishi M, Shimomura K, Proks P, Shimomura Y, Mori M.

Br J Clin Pharmacol. 2008 Aug;66(2):318-9. Epub 2008 Apr 30. No abstract available. PMID: 18507653 [PubMed - indexed for MEDLINE]Related articlesFree article

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.

de Wet H, Proks P, Lafond M, Aittoniemi J, Sansom MS, Flanagan SE, Pearson ER, Hattersley AT, Ashcroft FM.

EMBO Rep. 2008 Jul;9(7):648-54. Epub 2008 May 23.PMID: 18497752 [PubMed - indexed for MEDLINE]Related articlesFree article

Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy.

Shield JP, Flanagan SE, Mackay DJ, Harries LW, Proks P, Girard C, Ashcroft FM, Temple IK, Ellard S.

Diabetes. 2008 Jan;57(1):255-8. Epub 2007 Oct 17.PMID: 17942821 [PubMed - indexed for MEDLINE]Related articlesFree article

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.

Ellard S, Flanagan SE, Girard CA, Patch AM, Harries LW, Parrish A, Edghill EL, Mackay DJ, Proks P, Shimomura K, Haberland H, Carson DJ, Shield JP, Hattersley AT, Ashcroft FM.

Am J Hum Genet. 2007 Aug;81(2):375-82. Epub 2007 Jun 29.PMID: 17668386 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

Proks P, Shimomura K, Craig TJ, Girard CA, Ashcroft FM.

Hum Mol Genet. 2007 Aug 15;16(16):2011-9. Epub 2007 Jun 21.PMID: 17584766 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of 3D geometry modeling of osteochondrosis-like iatrogenic lesions as a template for press-and-fit scaffold seeded with mesenchymal stem cells.

Krupa P, Krsek P, Javorník M, Dostál O, Srnec R, Usvald D, Proks P, Kecová H, Amler E, Jancár J, Gál P, Plánka L, Necas A.

Physiol Res. 2007;56 Suppl 1:S107-14. Epub 2007 May 31.PMID: 17552888 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of peroxisome proliferator-activated receptor alpha ligand fenofibrate on K(v) channels in the insulin-secreting cell line HIT-T15.

Shimomura K, Ikeda M, Ariyama Y, Proks P, Shimomura Y, Mori M, Matsumoto S.

Gen Physiol Biophys. 2006 Dec;25(4):455-60.PMID: 17356236 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

Girard CA, Shimomura K, Proks P, Absalom N, Castano L, Perez de Nanclares G, Ashcroft FM.

Pflugers Arch. 2006 Dec;453(3):323-32. Epub 2006 Sep 22.PMID: 17021801 [PubMed - indexed for MEDLINE]Related articles

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM.

Diabetes. 2006 Jun;55(6):1731-7.PMID: 16731836 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM.

Diabetes. 2006 Jun;55(6):1705-12. Erratum in: Diabetes. 2007 Mar;56(3):897. Hattersely, Andrew T [corrected to Hattersley, Andrew T]. PMID: 16731833 [PubMed - indexed for MEDLINE]Related articlesFree article

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.

Proks P, Arnold AL, Bruining J, Girard C, Flanagan SE, Larkin B, Colclough K, Hattersley AT, Ashcroft FM, Ellard S.

Hum Mol Genet. 2006 Jun 1;15(11):1793-800. Epub 2006 Apr 13.PMID: 16613899 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane ion channels and diabetes.

Proks P, Lippiat JD.

Curr Pharm Des. 2006;12(4):485-501. Review.PMID: 16472141 [PubMed - indexed for MEDLINE]Related articles

Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.

Tammaro P, Proks P, Ashcroft FM.

J Physiol. 2006 Feb 15;571(Pt 1):3-14. Epub 2005 Dec 8.PMID: 16339180 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

Proks P, Girard C, Ashcroft FM.

Hum Mol Genet. 2005 Sep 15;14(18):2717-26. Epub 2005 Aug 8.PMID: 16087682 [PubMed - indexed for MEDLINE]Related articlesFree article

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.

Haider S, Antcliff JF, Proks P, Sansom MS, Ashcroft FM.

J Mol Cell Cardiol. 2005 Jun;38(6):927-36. Review.PMID: 15910877 [PubMed - indexed for MEDLINE]Related articles

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.

Proks P, Girard C, Haider S, Gloyn AL, Hattersley AT, Sansom MS, Ashcroft FM.

EMBO Rep. 2005 May;6(5):470-5.PMID: 15864298 [PubMed - indexed for MEDLINE]Related articlesFree article

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD.

Diabetologia. 2005 Apr;48(4):675-86. Epub 2005 Feb 24.PMID: 15729571 [PubMed - indexed for MEDLINE]Related articles

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT.

Hum Mol Genet. 2005 Apr 1;14(7):925-34. Epub 2005 Feb 17.PMID: 15718250 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

Antcliff JF, Haider S, Proks P, Sansom MS, Ashcroft FM.

EMBO J. 2005 Jan 26;24(2):229-39. Epub 2005 Jan 13.PMID: 15650751 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.

Proks P, Antcliff JF, Lippiat J, Gloyn AL, Hattersley AT, Ashcroft FM.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17539-44. Epub 2004 Dec 6.PMID: 15583126 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.

Campbell JD, Proks P, Lippiat JD, Sansom MS, Ashcroft FM.

Diabetes. 2004 Dec;53 Suppl 3:S123-7.PMID: 15561899 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of ATP-sensitive potassium channels by haloperidol.

Yang SB, Proks P, Ashcroft FM, Rupnik M.

Br J Pharmacol. 2004 Dec;143(8):960-7. Epub 2004 Nov 8.PMID: 15533888 [PubMed - indexed for MEDLINE]Related articlesFree article

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT.

N Engl J Med. 2004 Apr 29;350(18):1838-49. Erratum in: N Engl J Med. 2004 Sep 30;351(14):1470. PMID: 15115830 [PubMed - indexed for MEDLINE]Related articlesFree article

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.

Capener CE, Proks P, Ashcroft FM, Sansom MS.

Biophys J. 2003 Apr;84(4):2345-56.PMID: 12668443 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.

Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM.

Diabetologia. 2003 Feb;46(2):241-9. Epub 2003 Jan 9. Erratum in: Diabetologia. 2004 Jan;47(1):155. PMID: 12627323 [PubMed - indexed for MEDLINE]Related articles

The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.

Proks P, Antcliff JF, Ashcroft FM.

EMBO Rep. 2003 Jan;4(1):70-5.PMID: 12524524 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea stimulation of insulin secretion.

Proks P, Reimann F, Green N, Gribble F, Ashcroft F.

Diabetes. 2002 Dec;51 Suppl 3:S368-76. Review.PMID: 12475777 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382.

Proks P, Treinies I, Mest HJ, Trapp S.

Eur J Pharmacol. 2002 Sep 27;452(1):11-9.PMID: 12323381 [PubMed - indexed for MEDLINE]Related articles

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.

Proks P, Capener CE, Jones P, Ashcroft FM.

J Gen Physiol. 2001 Oct;118(4):341-53.PMID: 11585848 [PubMed - indexed for MEDLINE]Related articlesFree article

Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells.

Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM.

Diabetologia. 2001 Aug;44(8):1019-25.PMID: 11484080 [PubMed - indexed for MEDLINE]Related articles

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.

Reimann F, Proks P, Ashcroft FM.

Br J Pharmacol. 2001 Apr;132(7):1542-8.PMID: 11264248 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of stilbene disulphonates with cloned K(ATP) channels.

Proks P, Jones P, Ashcroft FM.

Br J Pharmacol. 2001 Mar;132(5):973-82.PMID: 11226127 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide.

Tanabe K, Tucker SJ, Ashcroft FM, Proks P, Kioka N, Amachi T, Ueda K.

Biochem Biophys Res Commun. 2000 Jun 7;272(2):316-9.PMID: 10833411 [PubMed - indexed for MEDLINE]Related articles

Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells.

Smith PA, Proks P, Ashcroft FM.

J Physiol. 1999 Dec 15;521 Pt 3:651-64.PMID: 10601496 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of vanadate with the cloned beta cell K(ATP) channel.

Proks P, Ashfield R, Ashcroft FM.

J Biol Chem. 1999 Sep 3;274(36):25393-7.PMID: 10464267 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

Reimann F, Tucker SJ, Proks P, Ashcroft FM.

J Physiol. 1999 Jul 15;518 ( Pt 2):325-36.PMID: 10381582 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct effects of tolbutamide on mitochondrial function, intracellular Ca2+ and exocytosis in pancreatic beta-cells.

Smith PA, Proks P, Moorhouse A.

Pflugers Arch. 1999 Mar;437(4):577-88.PMID: 10089571 [PubMed - indexed for MEDLINE]Related articles

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.

Tanabe K, Tucker SJ, Matsuo M, Proks P, Ashcroft FM, Seino S, Amachi T, Ueda K.

J Biol Chem. 1999 Feb 12;274(7):3931-3.PMID: 9933580 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM.

J Physiol. 1999 Jan 1;514 ( Pt 1):19-25.PMID: 9831713 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.

Gribble FM, Proks P, Corkey BE, Ashcroft FM.

J Biol Chem. 1998 Oct 9;273(41):26383-7.PMID: 9756869 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

Trapp S, Proks P, Tucker SJ, Ashcroft FM.

J Gen Physiol. 1998 Sep;112(3):333-49.PMID: 9725893 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.

Mikhailov MV, Proks P, Ashcroft FM, Ashcroft SJ.

FEBS Lett. 1998 Jun 16;429(3):390-4.PMID: 9662455 [PubMed - indexed for MEDLINE]Related articles