PubMed

Inhalation by Design: Novel Ultra-Long-Acting beta(2)-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfonamide Agonist Headgroup.

Glossop PA, Lane CA, Price DA, Bunnage ME, Lewthwaite RA, James K, Brown AD, Yeadon M, Perros-Huguet C, Trevethick MA, Clarke NP, Webster R, Jones RM, Burrows JL, Feeder N, Taylor SC, Spence FJ.

J Med Chem. 2010 Aug 30. [Epub ahead of print]PMID: 20804199 [PubMed - as supplied by publisher]Related citations

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells.

Humphreys IR, Lee SW, Jones M, Loewendorf A, Gostick E, Price DA, Benedict CA, Ware CF, Croft M.

Eur J Immunol. 2010 Jul 28. [Epub ahead of print]PMID: 20722077 [PubMed - as supplied by publisher]Related citations

OMIP-002: Phenotypic analysis of specific human CD8+ T-cells using peptide-MHC class I multimers for any of four epitopes.

Chattopadhyay PK, Roederer M, Price DA.

Cytometry A. 2010 Sep;77(9):821-2. No abstract available. PMID: 20722006 [PubMed - in process]Related citations

IL-10 Restricts Memory T Cell Inflation during Cytomegalovirus Infection.

Jones M, Ladell K, Wynn KK, Stacey MA, Quigley MF, Gostick E, Price DA, Humphreys IR.

J Immunol. 2010 Sep 15;185(6):3583-92. Epub 2010 Aug 16.PMID: 20713884 [PubMed - in process]Related citations

Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.

Melenhorst JJ, Leen AM, Bollard CM, Quigley MF, Price DA, Rooney CM, Brenner MK, Barrett AJ, Heslop HE.

Blood. 2010 Aug 13. [Epub ahead of print]PMID: 20709906 [PubMed - as supplied by publisher]Related citations

Mechanisms underlying {gamma}{delta} T cell subset perturbations in SIV-infected Asian rhesus macaques.

Harris LD, Klatt NR, Vinton C, Briant JA, Tabb B, Ladell K, Lifson J, Estes JD, Price DA, Hirsch VM, Brenchley JM.

Blood. 2010 Jul 26. [Epub ahead of print]PMID: 20660793 [PubMed - as supplied by publisher]Related citations

Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies.

Greene N, Aleo MD, Louise-May S, Price DA, Will Y.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5308-12. Epub 2010 Jul 1.PMID: 20655216 [PubMed - in process]Related citations

Enhanced Induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic Cell-targeted Delivery of SOCS-1 siRNA.

Subramanya S, Armant M, Salkowitz JR, Nyakeriga AM, Haridas V, Hasan M, Bansal A, Goepfert PA, Wynn KK, Ladell K, Price DA, N M, Kan-Mitchell J, Shankar P.

Mol Ther. 2010 Jul 20. [Epub ahead of print]PMID: 20648001 [PubMed - as supplied by publisher]Related citations

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.

Cole DK, Edwards ES, Wynn KK, Clement M, Miles JJ, Ladell K, Ekeruche J, Gostick E, Adams KJ, Skowera A, Peakman M, Wooldridge L, Price DA, Sewell AK.

J Immunol. 2010 Aug 15;185(4):2600-10. Epub 2010 Jul 16.PMID: 20639478 [PubMed - in process]Related citations

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination.

Van Tendeloo VF, Van de Velde A, Van Driessche A, Cools N, Anguille S, Ladell K, Gostick E, Vermeulen K, Pieters K, Nijs G, Stein B, Smits EL, Schroyens WA, Gadisseur AP, Vrelust I, Jorens PG, Goossens H, de Vries IJ, Price DA, Oji Y, Oka Y, Sugiyama H, Berneman ZN.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13824-9. Epub 2010 Jul 14.PMID: 20631300 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Rate and risk factors for cataract formation and extraction after Descemet stripping endothelial keratoplasty.

Price MO, Price DA, Fairchild KM, Price FW Jr.

Br J Ophthalmol. 2010 Jul 23. [Epub ahead of print]PMID: 20508038 [PubMed - as supplied by publisher]Free ArticleRelated citations

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

Rosario M, Bridgeman A, Quakkelaar ED, Quigley MF, Hill BJ, Knudsen ML, Ammendola V, Ljungberg K, Borthwick N, Im EJ, McMichael AJ, Drijfhout JW, Greenaway HY, Venturi V, Douek DC, Colloca S, Liljeström P, Nicosia A, Price DA, Melief CJ, Hanke T.

Eur J Immunol. 2010 Jul;40(7):1973-84.PMID: 20468055 [PubMed - in process]Related citations

Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.

Schaubert KL, Price DA, Salkowitz JR, Sewell AK, Sidney J, Asher TE, Blondelle SE, Adams S, Marincola FM, Joseph A, Sette A, Douek DC, Ayyavoo V, Storkus W, Leung MY, Ng HL, Yang OO, Goldstein H, Wilson DB, Kan-Mitchell J.

Eur J Immunol. 2010 Jul;40(7):1950-62.PMID: 20432235 [PubMed - in process]Related citations

Novel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques.

Rosario M, Hopkins R, Fulkerson J, Borthwick N, Quigley MF, Joseph J, Douek DC, Greenaway HY, Venturi V, Gostick E, Price DA, Both GW, Sadoff JC, Hanke T.

J Virol. 2010 Jun;84(12):5898-908. Epub 2010 Apr 7.PMID: 20375158 [PubMed - indexed for MEDLINE]Related citations

Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia.

Giannopoulos K, Dmoszynska A, Kowal M, Rolinski J, Gostick E, Price DA, Greiner J, Rojewski M, Stilgenbauer S, Döhner H, Schmitt M.

Leukemia. 2010 Apr;24(4):798-805. Epub 2010 Mar 11.PMID: 20220777 [PubMed - indexed for MEDLINE]Related citations

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

Wooldridge L, Clement M, Lissina A, Edwards ES, Ladell K, Ekeruche J, Hewitt RE, Laugel B, Gostick E, Cole DK, Debets R, Berrevoets C, Miles JJ, Burrows SR, Price DA, Sewell AK.

J Immunol. 2010 Apr 1;184(7):3357-66. Epub 2010 Feb 26.PMID: 20190139 [PubMed - indexed for MEDLINE]Related citations

Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.

Greene JM, Lhost JJ, Burwitz BJ, Budde ML, Macnair CE, Weiker MK, Gostick E, Friedrich TC, Broman KW, Price DA, O'Connor SL, O'Connor DH.

J Virol. 2010 Apr;84(7):3362-72. Epub 2010 Jan 20.PMID: 20089651 [PubMed - indexed for MEDLINE]Related citations

A/H1N1 flu pandemic. Life threatening infections labelled swine flu.

Houlihan CF, Patel S, Price DA, Valappil M, Schwab U.

BMJ. 2010 Jan 13;340:c137. doi: 10.1136/bmj.c137. No abstract available. PMID: 20071428 [PubMed - indexed for MEDLINE]Related citations

The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor.

Scheinberg P, Melenhorst JJ, Brenchley JM, Hill BJ, Hensel NF, Chattopadhyay PK, Roederer M, Picker LJ, Price DA, Barrett AJ, Douek DC.

Blood. 2009 Dec 3;114(24):5071-80. Epub 2009 Sep 23.PMID: 19776383 [PubMed - indexed for MEDLINE]Related citations

Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.

Mowbray CE, Burt C, Corbau R, Gayton S, Hawes M, Perros M, Tran I, Price DA, Quinton FJ, Selby MD, Stupple PA, Webster R, Wood A.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. Epub 2009 Aug 27.PMID: 19748778 [PubMed - indexed for MEDLINE]Related citations

Survey of steroid usage patterns during and after low-risk penetrating keratoplasty.

Price FW Jr, Price DA, Ngakeng V, Price MO.

Cornea. 2009 Sep;28(8):865-70.PMID: 19654531 [PubMed - indexed for MEDLINE]Related citations

Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.

Price DA, Sorkin A, Zahniser NR.

Mol Pharmacol. 2009 Oct;76(4):812-23. Epub 2009 Jul 23.PMID: 19628755 [PubMed - indexed for MEDLINE]Related citations

Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity.

Honda M, Wang R, Kong WP, Kanekiyo M, Akahata W, Xu L, Matsuo K, Natarajan K, Robinson H, Asher TE, Price DA, Douek DC, Margulies DH, Nabel GJ.

J Immunol. 2009 Aug 15;183(4):2425-34. Epub 2009 Jul 20.PMID: 19620307 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.

Cole DK, Yuan F, Rizkallah PJ, Miles JJ, Gostick E, Price DA, Gao GF, Jakobsen BK, Sewell AK.

J Biol Chem. 2009 Oct 2;284(40):27281-9. Epub 2009 Jul 15.PMID: 19605354 [PubMed - indexed for MEDLINE]Related citations

Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.

Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA.

J Immunol. 2009 Jul 15;183(2):1120-32. Epub 2009 Jun 29.PMID: 19564339 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response.

Geldmacher C, Metzler IS, Tovanabutra S, Asher TE, Gostick E, Ambrozak DR, Petrovas C, Schuetz A, Ngwenyama N, Kijak G, Maboko L, Hoelscher M, McCutchan F, Price DA, Douek DC, Koup RA.

Blood. 2009 Aug 20;114(8):1553-62. Epub 2009 Jun 19.PMID: 19542300 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Physicochemical drug properties associated with in vivo toxicological outcomes: a review.

Price DA, Blagg J, Jones L, Greene N, Wager T.

Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):921-31. Review.PMID: 19519283 [PubMed - indexed for MEDLINE]Related citations

Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaques.

Bimber BN, Burwitz BJ, O'Connor S, Detmer A, Gostick E, Lank SM, Price DA, Hughes A, O'Connor D.

J Virol. 2009 Aug;83(16):8247-53. Epub 2009 Jun 10.PMID: 19515775 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes.

Greenaway HY, Kurniawan M, Price DA, Douek DC, Davenport MP, Venturi V.

Immunol Cell Biol. 2009 Oct;87(7):546-53. Epub 2009 Jun 9.PMID: 19506572 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Price DA, Martinez AA, Seillier A, Koek W, Acosta Y, Fernandez E, Strong R, Lutz B, Marsicano G, Roberts JL, Giuffrida A.

Eur J Neurosci. 2009 Jun;29(11):2177-86. Epub 2009 May 21.PMID: 19490092 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Apolipoprotein B-associated cholesterol is a determinant of treatment outcome in patients with chronic hepatitis C virus infection receiving anti-viral agents interferon-alpha and ribavirin.

Sheridan DA, Price DA, Schmid ML, Toms GL, Donaldson P, Neely D, Bassendine MF.

Aliment Pharmacol Ther. 2009 Jun 15;29(12):1282-90. Epub 2009 Apr 8.PMID: 19392865 [PubMed - indexed for MEDLINE]Related citations

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity.

Almeida JR, Sauce D, Price DA, Papagno L, Shin SY, Moris A, Larsen M, Pancino G, Douek DC, Autran B, Sáez-Cirión A, Appay V.

Blood. 2009 Jun 18;113(25):6351-60. Epub 2009 Apr 23.PMID: 19389882 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.

Price DA, Asher TE, Wilson NA, Nason MC, Brenchley JM, Metzler IS, Venturi V, Gostick E, Chattopadhyay PK, Roederer M, Davenport MP, Watkins DI, Douek DC.

J Exp Med. 2009 Apr 13;206(4):923-36. Epub 2009 Apr 6.PMID: 19349463 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.

Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM.

PLoS Pathog. 2009 Feb;5(2):e1000313. Epub 2009 Feb 27.PMID: 19247441 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Genetic variation in the popular lab worm Lumbriculus variegatus (Annelida: Clitellata: Lumbriculidae) reveals cryptic speciation.

Gustafsson DR, Price DA, Erséus C.

Mol Phylogenet Evol. 2009 May;51(2):182-9. Epub 2008 Dec 25.PMID: 19141324 [PubMed - indexed for MEDLINE]Related citations

Tricks with tetramers: how to get the most from multimeric peptide-MHC.

Wooldridge L, Lissina A, Cole DK, van den Berg HA, Price DA, Sewell AK.

Immunology. 2009 Feb;126(2):147-64. Review. Erratum in: Immunology. 2009 Mar;126(3):447. PMID: 19125886 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage.

Brenchley JM, Knox KS, Asher AI, Price DA, Kohli LM, Gostick E, Hill BJ, Hage CA, Brahmi Z, Khoruts A, Twigg HL 3rd, Schacker TW, Douek DC.

Mucosal Immunol. 2008 Jan;1(1):49-58.PMID: 19079160 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV.

Venturi V, Chin HY, Asher TE, Ladell K, Scheinberg P, Bornstein E, van Bockel D, Kelleher AD, Douek DC, Price DA, Davenport MP.

J Immunol. 2008 Dec 1;181(11):7853-62.PMID: 19017975 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow.

Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Gostick E, Ladell K, Roederer M, Hensel NF, Douek DC, Barrett AJ, Price DA.

Blood. 2009 Mar 5;113(10):2238-44. Epub 2008 Nov 7.PMID: 18997173 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers.

Lissina A, Ladell K, Skowera A, Clement M, Edwards E, Seggewiss R, van den Berg HA, Gostick E, Gallagher K, Jones E, Melenhorst JJ, Godkin AJ, Peakman M, Price DA, Sewell AK, Wooldridge L.

J Immunol Methods. 2009 Jan 1;340(1):11-24. Epub 2008 Oct 16.PMID: 18929568 [PubMed - indexed for MEDLINE]Related citations

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.

Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Weinfurter JT, Kaizu M, Soma T, León EJ, MacNair C, Leaman DP, Zwick MB, Gostick E, Musani SK, Price DA, Friedrich TC, Rakasz EG, Wilson NA, McDermott AB, Boyle R, Allison DB, Burton DR, Koff WC, Watkins DI.

J Exp Med. 2008 Oct 27;205(11):2537-50. Epub 2008 Oct 6.PMID: 18838548 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers.

Chattopadhyay PK, Melenhorst JJ, Ladell K, Gostick E, Scheinberg P, Barrett AJ, Wooldridge L, Roederer M, Sewell AK, Price DA.

Cytometry A. 2008 Nov;73(11):1001-9. Review.PMID: 18836993 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update.

Seggewiss R, Price DA, Purbhoo MA.

Cytotherapy. 2008;10(6):633-41. Review.PMID: 18836918 [PubMed - indexed for MEDLINE]Related citations

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.

Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, De Rosa SC.

J Leukoc Biol. 2009 Jan;85(1):88-97. Epub 2008 Oct 10.PMID: 18820174 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV.

Price DA, Armour D, de Groot M, Leishman D, Napier C, Perros M, Stammen BL, Wood A.

Curr Top Med Chem. 2008;8(13):1140-51.PMID: 18782009 [PubMed - indexed for MEDLINE]Related citations

Physiochemical drug properties associated with in vivo toxicological outcomes.

Hughes JD, Blagg J, Price DA, Bailey S, Decrescenzo GA, Devraj RV, Ellsworth E, Fobian YM, Gibbs ME, Gilles RW, Greene N, Huang E, Krieger-Burke T, Loesel J, Wager T, Whiteley L, Zhang Y.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4872-5. Epub 2008 Jul 24.PMID: 18691886 [PubMed - indexed for MEDLINE]Related citations

The role of production frequency in the sharing of simian immunodeficiency virus-specific CD8+ TCRs between macaques.

Venturi V, Chin HY, Price DA, Douek DC, Davenport MP.

J Immunol. 2008 Aug 15;181(4):2597-609.PMID: 18684950 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.

Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Lissina A, Gostick E, Cole DK, Wooldridge L, van den Berg HA, Bornstein E, Hensel NF, Douek DC, Roederer M, Sewell AK, Barrett AJ, Price DA.

J Immunol Methods. 2008 Sep 30;338(1-2):31-9. Epub 2008 Jul 31.PMID: 18675271 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.

Brenchley JM, Paiardini M, Knox KS, Asher AI, Cervasi B, Asher TE, Scheinberg P, Price DA, Hage CA, Kholi LM, Khoruts A, Frank I, Else J, Schacker T, Silvestri G, Douek DC.

Blood. 2008 Oct 1;112(7):2826-35. Epub 2008 Jul 29.PMID: 18664624 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Multiple sclerosis: glatiramer acetate induces anti-inflammatory T cells in the cerebrospinal fluid.

Hestvik AL, Skorstad G, Price DA, Vartdal F, Holmoy T.

Mult Scler. 2008 Jul;14(6):749-58.PMID: 18611988 [PubMed - indexed for MEDLINE]Related citations