PubMed

Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation.

Madiraju P, Pande SV, Prentki M, Madiraju SR.

Epigenetics. 2009 Aug;4(6):399-403. Epub 2009 Aug 18.PMID: 19755853 [PubMed - in process]Related articles

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R.

Nat Genet. 2009 Oct;41(10):1110-5. Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156. PMID: 19734900 [PubMed - indexed for MEDLINE]Related articles

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. Epub 2009 Aug 31.PMID: 19720802 [PubMed - in process]Related articles

Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.

Peyot ML, Gray JP, Lamontagne J, Smith PJ, Holz GG, Madiraju SR, Prentki M, Heart E.

PLoS One. 2009 Jul 13;4(7):e6221.PMID: 19593440 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy.

Bendayan M, Londono I, Kemp BE, Hardie GD, Ruderman N, Prentki M.

J Histochem Cytochem. 2009 Oct;57(10):963-71. Epub 2009 Jul 6.PMID: 19581628 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II.

Harbilas D, Martineau LC, Harris CS, Adeyiwola-Spoor DC, Saleem A, Lambert J, Caves D, Johns T, Prentki M, Cuerrier A, Arnason JT, Bennett SA, Haddad PS.

Can J Physiol Pharmacol. 2009 Jun;87(6):479-92.PMID: 19526043 [PubMed - in process]Related articles

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M.

Endocrinology. 2009 Aug;150(8):3465-74. Epub 2009 Apr 30.PMID: 19406947 [PubMed - indexed for MEDLINE]Related articles

Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.

Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M.

J Biol Chem. 2009 Jun 19;284(25):16848-59. Epub 2009 Apr 22.PMID: 19389712 [PubMed - indexed for MEDLINE]Related articles

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. Epub 2009 Mar 18.PMID: 19294363 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.

Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, Prentki M, Madiraju M, Jenkinson CP, Cersosimo E, Musi N, Defronzo RA.

Diabetologia. 2009 Apr;52(4):723-32. Epub 2009 Jan 24.PMID: 19169664 [PubMed - indexed for MEDLINE]Related articles

The islet beta-cell: fuel responsive and vulnerable.

Nolan CJ, Prentki M.

Trends Endocrinol Metab. 2008 Oct;19(8):285-91. Epub 2008 Sep 6. Review.PMID: 18774732 [PubMed - indexed for MEDLINE]Related articles

Glycerolipid metabolism and signaling in health and disease.

Prentki M, Madiraju SR.

Endocr Rev. 2008 Oct;29(6):647-76. Epub 2008 Jul 7. Review.PMID: 18606873 [PubMed - indexed for MEDLINE]Related articlesFree article

Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.

Dallaire P, Bellmann K, Laplante M, Gélinas S, Centeno-Baez C, Penfornis P, Peyot ML, Latour MG, Lamontagne J, Trujillo ME, Scherer PE, Prentki M, Deshaies Y, Marette A.

Diabetes. 2008 Aug;57(8):1999-2011. Epub 2008 May 5.PMID: 18458147 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R.

FASEB J. 2008 Jun;22(6):1905-13. Epub 2008 Feb 8.PMID: 18263705 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion.

Guay C, Madiraju SR, Aumais A, Joly E, Prentki M.

J Biol Chem. 2007 Dec 7;282(49):35657-65. Epub 2007 Oct 10.PMID: 17928289 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells.

Przybytkowski E, Joly E, Nolan CJ, Hardy S, Francoeur AM, Langelier Y, Prentki M.

Biochem Cell Biol. 2007 Jun;85(3):301-10.PMID: 17612624 [PubMed - indexed for MEDLINE]Related articles

Circulating lipids are lowered but pancreatic islet lipid metabolism and insulin secretion are unaltered in exercise-trained female rats.

Lamontagne J, Masiello P, Marcil M, Delghingaro-Augusto V, Burelle Y, Prentki M, Nolan CJ.

Appl Physiol Nutr Metab. 2007 Apr;32(2):241-8.PMID: 17486165 [PubMed - indexed for MEDLINE]Related articles

A genome-wide association study identifies novel risk loci for type 2 diabetes.

Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P.

Nature. 2007 Feb 22;445(7130):881-5. Epub 2007 Feb 11.PMID: 17293876 [PubMed - indexed for MEDLINE]Related articles

Fatty acid signaling in the beta-cell and insulin secretion.

Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M.

Diabetes. 2006 Dec;55 Suppl 2:S16-23. Review.PMID: 17130640 [PubMed - indexed for MEDLINE]Related articlesFree article

Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential.

Spoor DC, Martineau LC, Leduc C, Benhaddou-Andaloussi A, Meddah B, Harris C, Burt A, Fraser MH, Coonishish J, Joly E, Cuerrier A, Bennett SA, Johns T, Prentki M, Arnason JT, Haddad PS.

Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):847-58.PMID: 17111029 [PubMed - indexed for MEDLINE]Related articles

Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait.

Martineau LC, Couture A, Spoor D, Benhaddou-Andaloussi A, Harris C, Meddah B, Leduc C, Burt A, Vuong T, Mai Le P, Prentki M, Bennett SA, Arnason JT, Haddad PS.

Phytomedicine. 2006 Nov;13(9-10):612-23. Epub 2006 Sep 18.PMID: 16979328 [PubMed - indexed for MEDLINE]Related articles

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.

Diabetologia. 2006 Sep;49(9):2120-30. Epub 2006 Jul 26.PMID: 16868750 [PubMed - indexed for MEDLINE]Related articles

Islet beta cell failure in type 2 diabetes.

Prentki M, Nolan CJ.

J Clin Invest. 2006 Jul;116(7):1802-12. Review.PMID: 16823478 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance.

Kwan EP, Xie L, Sheu L, Nolan CJ, Prentki M, Betz A, Brose N, Gaisano HY.

Diabetes. 2006 May;55(5):1421-9.PMID: 16644700 [PubMed - indexed for MEDLINE]Related articlesFree article

EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.

Cheyssac C, Dina C, Leprêtre F, Vasseur-Delannoy V, Dechaume A, Lobbens S, Balkau B, Ruiz J, Charpentier G, Pattou F, Joly E, Prentki M, Hansen T, Pedersen O, Vaxillaire M, Froguel P.

Diabetes. 2006 Apr;55(4):1171-6.PMID: 16567544 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes.

Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M.

FEBS Lett. 2005 Dec 5;579(29):6581-6. Epub 2005 Nov 9.PMID: 16298369 [PubMed - indexed for MEDLINE]Related articles

A role for hypothalamic malonyl-CoA in the control of food intake.

Hu Z, Dai Y, Prentki M, Chohnan S, Lane MD.

J Biol Chem. 2005 Dec 2;280(48):39681-3. Epub 2005 Oct 11.PMID: 16219771 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes.

Hu L, Deeney JT, Nolan CJ, Peyot ML, Ao A, Richard AM, Luc E, Faergeman NJ, Knudsen J, Guo W, Sorhede-Winzell M, Prentki M, Corkey BE.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1085-92. Epub 2005 Aug 9.PMID: 16091387 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats.

Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E794-800. Epub 2005 Jun 14.PMID: 15956049 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.

Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clément K, Galan P, Hercberg S, Helbecque N, Charpentier G, Prentki M, Hansen T, Pedersen O, Urrutia R, Melloul D, Froguel P.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4807-12. Epub 2005 Mar 17.PMID: 15774581 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.

Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E30-9. Epub 2005 Feb 8.PMID: 15701680 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.

Hardy S, St-Onge GG, Joly E, Langelier Y, Prentki M.

J Biol Chem. 2005 Apr 8;280(14):13285-91. Epub 2005 Feb 4.PMID: 15695516 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes.

Pelletier A, Joly E, Prentki M, Coderre L.

Endocrinology. 2005 May;146(5):2285-94. Epub 2005 Jan 27.PMID: 15677757 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Herrero L, Rubí B, Sebastián D, Serra D, Asins G, Maechler P, Prentki M, Hegardt FG.

Diabetes. 2005 Feb;54(2):462-71.PMID: 15677504 [PubMed - indexed for MEDLINE]Related articlesFree article

A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice.

Rosenberg L, Lipsett M, Yoon JW, Prentki M, Wang R, Jun HS, Pittenger GL, Taylor-Fishwick D, Vinik AI.

Ann Surg. 2004 Nov;240(5):875-84.PMID: 15492571 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.

Gremlich S, Nolan C, Roduit R, Burcelin R, Peyot ML, Delghingaro-Augusto V, Desvergne B, Michalik L, Prentki M, Wahli W.

Endocrinology. 2005 Jan;146(1):375-82. Epub 2004 Sep 30.PMID: 15459119 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.

Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M.

Diabetes. 2004 Jul;53(7):1733-42.PMID: 15220197 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for activating transcription factor 3 in stress-induced beta-cell apoptosis.

Hartman MG, Lu D, Kim ML, Kociba GJ, Shukri T, Buteau J, Wang X, Frankel WL, Guttridge D, Prentki M, Grey ST, Ron D, Hai T.

Mol Cell Biol. 2004 Jul;24(13):5721-32.PMID: 15199129 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.

Buteau J, El-Assaad W, Rhodes CJ, Rosenberg L, Joly E, Prentki M.

Diabetologia. 2004 May;47(5):806-15. Epub 2004 Apr 17.PMID: 15095038 [PubMed - indexed for MEDLINE]Related articles

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome.

Ruderman N, Prentki M.

Nat Rev Drug Discov. 2004 Apr;3(4):340-51. Review. No abstract available. PMID: 15060529 [PubMed - indexed for MEDLINE]Related articles

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M.

Diabetes. 2004 Apr;53(4):1007-19.PMID: 15047616 [PubMed - indexed for MEDLINE]Related articlesFree article

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M.

Endocrinology. 2003 Sep;144(9):4154-63.PMID: 12933690 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.

Ruderman NB, Park H, Kaushik VK, Dean D, Constant S, Prentki M, Saha AK.

Acta Physiol Scand. 2003 Aug;178(4):435-42. Review.PMID: 12864749 [PubMed - indexed for MEDLINE]Related articles

Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin.

Hardy S, El-Assaad W, Przybytkowski E, Joly E, Prentki M, Langelier Y.

J Biol Chem. 2003 Aug 22;278(34):31861-70. Epub 2003 Jun 12.PMID: 12805375 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor.

Buteau J, Foisy S, Joly E, Prentki M.

Diabetes. 2003 Jan;52(1):124-32.PMID: 12502502 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

Maestre I, Jordán J, Calvo S, Reig JA, Ceña V, Soria B, Prentki M, Roche E.

Endocrinology. 2003 Jan;144(1):335-45.PMID: 12488362 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes.

Prentki M, Joly E, El-Assaad W, Roduit R.

Diabetes. 2002 Dec;51 Suppl 3:S405-13. Review.PMID: 12475783 [PubMed - indexed for MEDLINE]Related articlesFree article

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.

Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ.

Diabetes. 2002 Aug;51(8):2496-504.PMID: 12145163 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.

Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK.

J Biol Chem. 2002 Sep 6;277(36):32571-7. Epub 2002 Jun 13.PMID: 12065578 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats.

Mason TM, Chan B, El-Bahrani B, Goh T, Gupta N, Gamble J, Qing Shi Z, Prentki M, Steiner G, Giacca A.

Atherosclerosis. 2002 Apr;161(2):345-52.PMID: 11888517 [PubMed - indexed for MEDLINE]Related articles