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2002 1
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2017 2
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Page 1
The Efficacy of Pralidoxime in the Treatment of Organophosphate Poisoning in Humans: A Systematic Review and Meta-analysis of Randomized Trials.
Kharel H, Pokhrel NB, Ghimire R, Kharel Z. Kharel H, et al. Cureus. 2020 Mar 4;12(3):e7174. doi: 10.7759/cureus.7174. Cureus. 2020. PMID: 32257715 Free PMC article.
However, the clinical benefit of pralidoxime is still unclear. A recent meta-analysis has found that pralidoxime provides no significant improvement in outcome and rather may cause harm while increasing the economic burden in low-income communities where its use is …
However, the clinical benefit of pralidoxime is still unclear. A recent meta-analysis has found that pralidoxime provides no s …
Intraosseous administration of antidotes - a systematic review.
Elliott A, Dubé PA, Cossette-Côté A, Patakfalvi L, Villeneuve E, Morris M, Gosselin S. Elliott A, et al. Clin Toxicol (Phila). 2017 Dec;55(10):1025-1054. doi: 10.1080/15563650.2017.1337122. Epub 2017 Jun 23. Clin Toxicol (Phila). 2017. PMID: 28644688 Review.
Animal data also suggested an equivalent bio-availability between IO and IV administration for atropine, calcium chloride, dextrose 50%, diazepam, methylene blue, pralidoxime, and sodium bicarbonate. Adverse effect reporting of fat emboli after IO administration of sodium …
Animal data also suggested an equivalent bio-availability between IO and IV administration for atropine, calcium chloride, dextrose 50%, dia …
Oximes for acute organophosphate pesticide poisoning.
Buckley NA, Eddleston M, Li Y, Bevan M, Robertson J. Buckley NA, et al. Cochrane Database Syst Rev. 2011 Feb 16;(2):CD005085. doi: 10.1002/14651858.CD005085.pub2. Cochrane Database Syst Rev. 2011. PMID: 21328273 Review.
We contacted the principal authors of these, but did not obtain further information. MAIN RESULTS: Seven pralidoxime RCTs were found. Three RCTs including 366 patients studied pralidoxime vs placebo and four RCTs including 479 patients compared two or more different …
We contacted the principal authors of these, but did not obtain further information. MAIN RESULTS: Seven pralidoxime RCTs were found. …
Oximes for acute organophosphate pesticide poisoning.
Buckley NA, Eddleston M, Szinicz L. Buckley NA, et al. Cochrane Database Syst Rev. 2005 Jan 25;(1):CD005085. doi: 10.1002/14651858.CD005085. Cochrane Database Syst Rev. 2005. PMID: 15654704 Updated. Review.
MAIN RESULTS: Two RCTs have been published, involving 182 patients treated with pralidoxime. These trials did not find benefit. However, the studies did not take into account a number of issues important for outcome and the methodology is unclear. ...A much larger RCT is r …
MAIN RESULTS: Two RCTs have been published, involving 182 patients treated with pralidoxime. These trials did not find benefit. Howev …
Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials.
Eddleston M, Szinicz L, Eyer P, Buckley N. Eddleston M, et al. QJM. 2002 May;95(5):275-83. doi: 10.1093/qjmed/95.5.275. QJM. 2002. PMID: 11978898 Free PMC article. Review.
RESULTS: We found two randomized controlled trials (RCTs) involving 182 patients treated with pralidoxime. The RCTs found no benefit with pralidoxime, and have been used to argue that pralidoxime should not be used in OP poisoning. ...However, their studies d …
RESULTS: We found two randomized controlled trials (RCTs) involving 182 patients treated with pralidoxime. The RCTs found no benefit …
Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.
Li Y, Tse ML, Gawarammana I, Buckley N, Eddleston M. Li Y, et al. Clin Toxicol (Phila). 2009 Mar;47(3):179-92. doi: 10.1080/15563650701846262. Clin Toxicol (Phila). 2009. PMID: 18988062 Review.
RESULTS: All 56 studies identified were Chinese and reported benefit from the intervention studied, including multiple gastric lavages, use of norepinephrine or pralidoxime in the lavage fluid, concurrent treatment with naloxone or scopolamine, insertion of the gastric tub …
RESULTS: All 56 studies identified were Chinese and reported benefit from the intervention studied, including multiple gastric lavages, use …