PubMed

Neonatal growth and regeneration of {beta} cells are regulated by the Wnt/{beta}-catenin signaling in normal and diabetic rats.

Figeac F, Uzan B, Faro M, Chelali N, Portha B, Movassat J.

Am J Physiol Endocrinol Metab. 2009 Nov 17. [Epub ahead of print]PMID: 19920216 [PubMed - as supplied by publisher]Related articles

Undernutrition of the GK rat during gestation improves pancreatic IGF-2 and beta-cell mass in the fetuses.

Fernández-Millán E, Gangnerau MN, De Miguel-Santos L, Calderari S, Serradas P, Escrivá F, Portha B, Alvarez C.

Growth Factors. 2009 Dec;27(6):409-18.PMID: 19919529 [PubMed - in process]Related articles

Diabetic GK/Par rat {beta}-cells are spontaneously protected against H2O2-induced apoptosis. A cAMP-dependent adaptive response.

Lacraz G, Figeac F, Movassat J, Kassis N, Portha B.

Am J Physiol Endocrinol Metab. 2009 Oct 20. [Epub ahead of print]PMID: 19843875 [PubMed - as supplied by publisher]Related articles

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, Irminger JC, Kergoat M, Portha B, Donath MY, Ehses JA, Homo-Delarche F.

PLoS One. 2009 Sep 9;4(9):e6963.PMID: 19742300 [PubMed - in process]Related articlesFree article

Undernutrition of the GK rat during gestation improves pancreatic IGF-2 and beta-cell mass in the fetuses.

Fernandez-Millan E, Gangnerau MN, De Miguel-Santos L, Calderari S, Serradas P, Escriva F, Portha B, Alvarez C.

Growth Factors. 2009 Aug 21:1. [Epub ahead of print]PMID: 19701837 [PubMed - as supplied by publisher]Related articles

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.

Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N, Irminger JC, Kergoat M, Portha B, Homo-Delarche F, Donath MY.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13998-4003. Epub 2009 Jul 30.PMID: 19666548 [PubMed - indexed for MEDLINE]Related articles

Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses.

Lacraz G, Figeac F, Movassat J, Kassis N, Coulaud J, Galinier A, Leloup C, Bailbé D, Homo-Delarche F, Portha B.

PLoS One. 2009 Aug 5;4(8):e6500.PMID: 19654863 [PubMed - in process]Related articlesFree article

Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.

Uzan B, Figeac F, Portha B, Movassat J.

PLoS One. 2009;4(3):e4734. Epub 2009 Mar 6.PMID: 19266047 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

Diabetes. 2009 May;58(5):1105-15. Epub 2009 Feb 17.PMID: 19223597 [PubMed - indexed for MEDLINE]Related articlesFree article

The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?

Portha B, Lacraz G, Kergoat M, Homo-Delarche F, Giroix MH, Bailbé D, Gangnerau MN, Dolz M, Tourrel-Cuzin C, Movassat J.

Mol Cell Endocrinol. 2009 Jan 15;297(1-2):73-85. Epub 2008 Jul 1. Review.PMID: 18640239 [PubMed - indexed for MEDLINE]Related articles

Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion.

Movassat J, Bailbé D, Lubrano-Berthelier C, Picarel-Blanchot F, Bertin E, Mourot J, Portha B.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E168-75. Epub 2007 Nov 6.PMID: 17986628 [PubMed - indexed for MEDLINE]Related articlesFree article

Early administration of keratinocyte growth factor improves {beta}-cell regeneration in rat with streptozotocin-induced diabetes.

Movassat J, Portha B.

J Endocrinol. 2007 Nov;195(2):333-40.PMID: 17951544 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes - a matter of failing beta-cell neogenesis? Clues from the GK rat model.

Movassat J, Calderari S, Fernández E, Martín MA, Escrivá F, Plachot C, Gangnerau MN, Serradas P, Alvarez C, Portha B.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:187-95. Review.PMID: 17919193 [PubMed - indexed for MEDLINE]Related articles

Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.

Calderari S, Gangnerau MN, Thibault M, Meile MJ, Kassis N, Alvarez C, Portha B, Serradas P.

Diabetologia. 2007 Jul;50(7):1463-71. Epub 2007 May 3.PMID: 17476475 [PubMed - indexed for MEDLINE]Related articles

Is defective pancreatic beta-cell mass environmentally programmed in Goto-Kakizaki rat model of type 2 diabetes?: insights from crossbreeding studies during suckling period.

Calderari S, Gangnerau MN, Meile MJ, Portha B, Serradas P.

Pancreas. 2006 Nov;33(4):412-7.PMID: 17079948 [PubMed - indexed for MEDLINE]Related articles

Undernutrition does not alter the activation of beta-cell neogenesis and replication in adult rats after partial pancreatectomy.

Fernández E, Martín MA, Fajardo S, Bailbé D, Gangnerau MN, Portha B, Escrivá F, Serradas P, Alvarez C.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E913-21. Epub 2006 Jun 6.PMID: 16757552 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat.

Homo-Delarche F, Calderari S, Irminger JC, Gangnerau MN, Coulaud J, Rickenbach K, Dolz M, Halban P, Portha B, Serradas P.

Diabetes. 2006 Jun;55(6):1625-33. Erratum in: Diabetes. 2006 Sep;55(9):2665. PMID: 16731824 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1 based therapy for type 2 diabetes.

Arulmozhi DK, Portha B.

Eur J Pharm Sci. 2006 May;28(1-2):96-108. Epub 2006 Feb 20. Review.PMID: 16488579 [PubMed - indexed for MEDLINE]Related articles

Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production.

Dolz M, Bailbé D, Giroix MH, Calderari S, Gangnerau MN, Serradas P, Rickenbach K, Irminger JC, Portha B.

Diabetes. 2005 Nov;54(11):3229-37.PMID: 16249449 [PubMed - indexed for MEDLINE]Related articlesFree article

Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.

Portha B.

Diabetes Metab Res Rev. 2005 Nov-Dec;21(6):495-504. Review.PMID: 15926190 [PubMed - indexed for MEDLINE]Related articles

Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging.

Iltis I, Kober F, Desrois M, Dalmasso C, Lan C, Portha B, Cozzone PJ, Bernard M.

Invest Radiol. 2005 Jan;40(1):19-26.PMID: 15597016 [PubMed - indexed for MEDLINE]Related articles

Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat.

Martín MA, Serradas P, Ramos S, Fernández E, Goya L, Gangnerau MN, Lacorne M, Pascual-Leone AM, Escrivá F, Portha B, Alvarez C.

Endocrinology. 2005 Mar;146(3):1364-71. Epub 2004 Dec 2.PMID: 15576465 [PubMed - indexed for MEDLINE]Related articlesFree article

[Transmitted beta-cell dysfunction as a cause for type 2-diabetes]

Portha B.

Med Sci (Paris). 2003 Aug-Sep;19(8-9):847-53. Review. French. PMID: 14593616 [PubMed - indexed for MEDLINE]Related articlesFree article

Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells.

Movassat J, Beattie GM, Lopez AD, Portha B, Hayek A.

Diabetologia. 2003 Jun;46(6):822-9. Epub 2003 Jun 11.PMID: 12802496 [PubMed - indexed for MEDLINE]Related articles

Comparison between D-[3-3H]- and D-[5-3H]glucose and fructose utilization in pancreatic islets from control and hereditarily diabetic rats.

Giroix MH, Scruel O, Courtois P, Sener A, Portha B, Malaisse WJ.

Arch Biochem Biophys. 2002 Dec 1;408(1):111-23.PMID: 12485609 [PubMed - indexed for MEDLINE]Related articles

Energy restriction with protein restriction increases basal metabolism and meal-induced thermogenesis in rats.

Even PC, Bertin E, Gangnerau MN, Roseau S, Tome D, Portha B.

Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R751-9. Epub 2002 Nov 27.PMID: 12456383 [PubMed - indexed for MEDLINE]Related articles

Development of beta-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy.

Bertin E, Gangnerau MN, Bellon G, Bailbé D, Arbelot De Vacqueur A, Portha B.

Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R623-30.PMID: 12184996 [PubMed - indexed for MEDLINE]Related articles

Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.

Tourrel C, Bailbe D, Lacorne M, Meile MJ, Kergoat M, Portha B.

Diabetes. 2002 May;51(5):1443-52.PMID: 11978641 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism of D-[3-3H]glucose, D-[5-3H]glucose, D-[U-14C]glucose, D-[1-14C]glucose and D-[6-14C]glucose in pancreatic islets in an animal model of type-2 diabetes.

Giroix MH, Nadi AB, Sener A, Portha B, Malaisse WJ.

Int J Mol Med. 2002 Apr;9(4):381-4.PMID: 11891532 [PubMed - indexed for MEDLINE]Related articles

Fetal insulin-like growth factor-2 production is impaired in the GK rat model of type 2 diabetes.

Serradas P, Goya L, Lacorne M, Gangnerau MN, Ramos S, Alvarez C, Pascual-Leone AM, Portha B.

Diabetes. 2002 Feb;51(2):392-7.PMID: 11812746 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired beta-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes.

Plachot C, Movassat J, Portha B.

Histochem Cell Biol. 2001 Aug;116(2):131-9.PMID: 11685541 [PubMed - indexed for MEDLINE]Related articles

Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitus.

Plachot C, Portha B.

Histochem J. 2001 Mar;33(3):141-7.PMID: 11508337 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

Tourrel C, Bailbé D, Meile MJ, Kergoat M, Portha B.

Diabetes. 2001 Jul;50(7):1562-70.PMID: 11423477 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony.

Portha B, Giroix MH, Serradas P, Gangnerau MN, Movassat J, Rajas F, Bailbe D, Plachot C, Mithieux G, Marie JC.

Diabetes. 2001 Feb;50 Suppl 1:S89-93.PMID: 11272210 [PubMed - indexed for MEDLINE]Related articles

Early development of beta-cells is impaired in the GK rat model of type 2 diabetes.

Miralles F, Portha B.

Diabetes. 2001 Feb;50 Suppl 1:S84-8.PMID: 11272209 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetes.

Marie JC, Bailbé D, Gylfe E, Portha B.

J Endocrinol. 2001 Apr;169(1):169-76.PMID: 11250658 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM.

Alvarez C, Bailbe D, Picarel-Blanchot F, Bertin E, Pascual-Leone AM, Portha B.

Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1097-103.PMID: 10827013 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.

Briaud I, Rouault C, Bailbé D, Portha B, Reach G, Poitout V.

Horm Metab Res. 2000 Mar;32(3):103-6.PMID: 10786928 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.

Briaud I, Rouault C, Bailbé D, Portha B, Reach G, Poitout V.

Horm Metab Res. 2000 Feb;32(2):53-6.PMID: 10741685 [PubMed - indexed for MEDLINE]Related articles

[Growth and regeneration potential abnormalities of pancreatic beta-cells in GK rats, NIDDM mellitus model]

Portha B, Movassat J, Plachot C, Saulnier C.

Journ Annu Diabetol Hotel Dieu. 1999:25-38. French. No abstract available. PMID: 10732402 [PubMed - indexed for MEDLINE]Related articles

Metabolic and secretory interactions between D-glucose and D-fructose in islets from GK rats.

Giroix MH, Scruel O, Ladriere L, Sener A, Portha B, Malaisse WJ.

Endocrinology. 1999 Dec;140(12):5556-65.PMID: 10579319 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data.

Giroix MH, Saulnier C, Portha B.

Diabetologia. 1999 Aug;42(8):965-77.PMID: 10491757 [PubMed - indexed for MEDLINE]Related articles

Metabolic and secretory response to D-fructose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period.

Scruel O, Giroix MH, Sener A, Portha B, Malaisse WJ.

Mol Genet Metab. 1999 Sep;68(1):86-90.PMID: 10479486 [PubMed - indexed for MEDLINE]Related articles

Beta-cell growth in the neonatal Goto-Kakisaki rat and regeneration after treatment with streptozotocin at birth.

Movassat J, Portha B.

Diabetologia. 1999 Sep;42(9):1098-106.PMID: 10447522 [PubMed - indexed for MEDLINE]Related articles

Glucose metabolism and beta-cell mass in adult offspring of rats protein and/or energy restricted during the last week of pregnancy.

Bertin E, Gangnerau MN, Bailbé D, Portha B.

Am J Physiol. 1999 Jul;277(1 Pt 1):E11-7.PMID: 10409122 [PubMed - indexed for MEDLINE]Related articlesFree article

Galphaolf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetes.

Frayon S, Pessah M, Giroix MH, Mercan D, Boissard C, Malaisse WJ, Portha B, Garel JM.

Biochem Biophys Res Commun. 1999 Jan 8;254(1):269-72.PMID: 9920769 [PubMed - indexed for MEDLINE]Related articles

Effect of gliclazide treatment on insulin secretion and beta-cell mass in non-insulin dependent diabetic Goto-Kakisaki rats.

Dachicourt N, Bailbé D, Gangnerau MN, Serradas P, Ravel D, Portha B.

Eur J Pharmacol. 1998 Nov 20;361(2-3):243-51.PMID: 9865514 [PubMed - indexed for MEDLINE]Related articles

Evaluation of dual-energy X-Ray absorptiometry for body-composition assessment in rats.

Bertin E, Ruiz JC, Mourot J, Peiniau P, Portha B.

J Nutr. 1998 Sep;128(9):1550-4.PMID: 9732318 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered activity of the autonomous nervous system as a determinant of the impaired beta-cell secretory response after protein-energy restriction in the rat.

Leon-Quinto T, Magnan C, Portha B.

Endocrinology. 1998 Aug;139(8):3382-9.PMID: 9681486 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

Bernard C, Thibault C, Berthault MF, Magnan C, Saulnier C, Portha B, Pralong WF, Pénicaud L, Ktorza A.

Diabetes. 1998 Jul;47(7):1058-65.PMID: 9648829 [PubMed - indexed for MEDLINE]Related articlesFree article