PubMed

Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart.

Quiles JL, Pamplona R, Ramirez-Tortosa MC, Naudí A, Portero-Otin M, Araujo-Nepomuceno E, López-Frías M, Battino M, Ochoa JJ.

Mech Ageing Dev. 2009 Nov 27. [Epub ahead of print]PMID: 19948181 [PubMed - as supplied by publisher]Related articles

Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids.

Muntané G, Janué A, Fernandez N, Odena MA, Oliveira E, Boluda S, Portero-Otin M, Naudí A, Boada J, Pamplona R, Ferrer I.

Neurochem Int. 2009 Nov 12. [Epub ahead of print]PMID: 19913586 [PubMed - as supplied by publisher]Related articles

Cell Death and Learning Impairment in Mice Caused by in Vitro Modified Pro-NGF Can Be Related to Its Increased Oxidative Modifications in Alzheimer Disease.

Kichev A, Ilieva EV, Piñol-Ripoll G, Podlesniy P, Ferrer I, Portero-Otín M, Pamplona R, Espinet C.

Am J Pathol. 2009 Nov 5. [Epub ahead of print]PMID: 19893045 [PubMed - as supplied by publisher]Related articles

Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates.

Martínez A, Portero-Otin M, Pamplona R, Ferrer I.

Brain Pathol. 2009 Aug 6. [Epub ahead of print]PMID: 19725834 [PubMed - as supplied by publisher]Related articles

Dietary antioxidants interfere with Amplex Red-coupled-fluorescence assays.

Serrano J, Jové M, Boada J, Bellmunt MJ, Pamplona R, Portero-Otín M.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):443-9. Epub 2009 Aug 11.PMID: 19679104 [PubMed - indexed for MEDLINE]Related articles

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

Gomez J, Caro P, Sanchez I, Naudi A, Jove M, Portero-Otin M, Lopez-Torres M, Pamplona R, Barja G.

J Bioenerg Biomembr. 2009 Jun;41(3):309-21. Epub 2009 Jul 25.PMID: 19633937 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia and glycation in diabetic complications.

Negre-Salvayre A, Salvayre R, Augé N, Pamplona R, Portero-Otín M.

Antioxid Redox Signal. 2009 Dec;11(12):3071-109.PMID: 19489690 [PubMed - in process]Related articles

Mitochondrial ATP-Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology.

Terni B, Boada J, Portero-Otin M, Pamplona R, Ferrer I.

Brain Pathol. 2009 Feb 27. [Epub ahead of print]PMID: 19298596 [PubMed - as supplied by publisher]Related articles

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

Caro P, Gomez J, Sanchez I, Garcia R, López-Torres M, Naudí A, Portero-Otin M, Pamplona R, Barja G.

Biogerontology. 2009 Oct;10(5):579-92. Epub 2008 Nov 28.PMID: 19039676 [PubMed - indexed for MEDLINE]Related articles

Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage.

Martínez A, Carmona M, Portero-Otin M, Naudí A, Pamplona R, Ferrer I.

J Neuropathol Exp Neurol. 2008 Dec;67(12):1122-36. Erratum in: J Neuropathol Exp Neurol. 2009 Jan;68(1):112. PMID: 19018247 [PubMed - indexed for MEDLINE]Related articles

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.

Pamplona R, Naudí A, Gavín R, Pastrana MA, Sajnani G, Ilieva EV, Del Río JA, Portero-Otín M, Ferrer I, Requena JR.

Free Radic Biol Med. 2008 Oct 15;45(8):1159-66. Epub 2008 Jul 23.PMID: 18703134 [PubMed - indexed for MEDLINE]Related articles

Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver.

Caro P, Gómez J, López-Torres M, Sánchez I, Naudi A, Portero-Otín M, Pamplona R, Barja G.

Rejuvenation Res. 2008 Jun;11(3):621-9.PMID: 18593280 [PubMed - indexed for MEDLINE]Related articles

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.

Fourcade S, López-Erauskin J, Galino J, Duval C, Naudi A, Jove M, Kemp S, Villarroya F, Ferrer I, Pamplona R, Portero-Otin M, Pujol A.

Hum Mol Genet. 2008 Jun 15;17(12):1762-73. Epub 2008 Mar 14.PMID: 18344354 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats.

Portero-Otín M, Pamplona R, Boada J, Jové M, Gonzalo H, Buleon M, Linz W, Schäfer S, Tack I, Girolami JP.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):528-35. Epub 2008 Feb 1.PMID: 18243127 [PubMed - indexed for MEDLINE]Related articles

Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes.

Pamplona R, Ilieva E, Ayala V, Bellmunt MJ, Cacabelos D, Dalfo E, Ferrer I, Portero-Otin M.

Ann N Y Acad Sci. 2008 Apr;1126:315-9. Epub 2007 Dec 13.PMID: 18079479 [PubMed - indexed for MEDLINE]Related articles

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis.

Ilieva EV, Ayala V, Jové M, Dalfó E, Cacabelos D, Povedano M, Bellmunt MJ, Ferrer I, Pamplona R, Portero-Otín M.

Brain. 2007 Dec;130(Pt 12):3111-23. Epub 2007 Aug 23.PMID: 17716997 [PubMed - indexed for MEDLINE]Related articlesFree article

Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.

Naudí A, Caro P, Jové M, Gómez J, Boada J, Ayala V, Portero-Otín M, Barja G, Pamplona R.

Rejuvenation Res. 2007 Dec;10(4):473-84.PMID: 17716000 [PubMed - indexed for MEDLINE]Related articles

Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.

Cantero AV, Portero-Otín M, Ayala V, Auge N, Sanson M, Elbaz M, Thiers JC, Pamplona R, Salvayre R, Nègre-Salvayre A.

FASEB J. 2007 Oct;21(12):3096-106. Epub 2007 May 15.PMID: 17504976 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver.

Gómez J, Caro P, Naudí A, Portero-Otin M, Pamplona R, Barja G.

Biogerontology. 2007 Oct;8(5):555-66. Epub 2007 May 8.PMID: 17486421 [PubMed - indexed for MEDLINE]Related articles

Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver.

Ayala V, Naudí A, Sanz A, Caro P, Portero-Otin M, Barja G, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):352-60.PMID: 17452727 [PubMed - indexed for MEDLINE]Related articles

Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration.

Brunet N, Tarabal O, Portero-Otín M, Oppenheim RW, Esquerda JE, Calderó J.

J Comp Neurol. 2007 Apr 10;501(5):669-90.PMID: 17299760 [PubMed - indexed for MEDLINE]Related articles

Stimulation of suicidal erythrocyte death by methylglyoxal.

Nicolay JP, Schneider J, Niemoeller OM, Artunc F, Portero-Otin M, Haik G Jr, Thornalley PJ, Schleicher E, Wieder T, Lang F.

Cell Physiol Biochem. 2006;18(4-5):223-32.PMID: 17167227 [PubMed - indexed for MEDLINE]Related articles

Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria.

Caro P, Gómez J, Sanz A, Portero-Otín M, Pamplona R, Barja G.

Biogerontology. 2007 Feb;8(1):1-11. Epub 2006 Jul 5.PMID: 16823605 [PubMed - indexed for MEDLINE]Related articles

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins.

Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G.

FASEB J. 2006 Jun;20(8):1064-73.PMID: 16770005 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of fasting on oxidative stress in rat liver mitochondria.

Sorensen M, Sanz A, Gómez J, Pamplona R, Portero-Otín M, Gredilla R, Barja G.

Free Radic Res. 2006 Apr;40(4):339-47.PMID: 16517498 [PubMed - indexed for MEDLINE]Related articles

Flight activity, mortality rates, and lipoxidative damage in Drosophila.

Magwere T, Pamplona R, Miwa S, Martinez-Diaz P, Portero-Otin M, Brand MD, Partridge L.

J Gerontol A Biol Sci Med Sci. 2006 Feb;61(2):136-45.PMID: 16510857 [PubMed - indexed for MEDLINE]Related articles

Effect of experimental and cold exposure induced hyperthyroidism on H2O2 production and susceptibility to oxidative stress of rat liver mitochondria.

Venditti P, Pamplona R, Portero-Otin M, De Rosa R, Di Meo S.

Arch Biochem Biophys. 2006 Mar 1;447(1):11-22. Epub 2006 Jan 31.PMID: 16487474 [PubMed - indexed for MEDLINE]Related articles

Evidence of oxidative stress in the neocortex in incidental Lewy body disease.

Dalfó E, Portero-Otín M, Ayala V, Martínez A, Pamplona R, Ferrer I.

J Neuropathol Exp Neurol. 2005 Sep;64(9):816-30.PMID: 16141792 [PubMed - indexed for MEDLINE]Related articles

Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals.

Ruiz MC, Ayala V, Portero-Otín M, Requena JR, Barja G, Pamplona R.

Mech Ageing Dev. 2005 Oct;126(10):1106-14.PMID: 15955547 [PubMed - indexed for MEDLINE]Related articles

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals.

Sanz A, Gredilla R, Pamplona R, Portero-Otín M, Vara E, Tresguerres JA, Barja G.

Biogerontology. 2005;6(1):15-26.PMID: 15834660 [PubMed - indexed for MEDLINE]Related articles

Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.

Pamplona R, Dalfó E, Ayala V, Bellmunt MJ, Prat J, Ferrer I, Portero-Otín M.

J Biol Chem. 2005 Jun 3;280(22):21522-30. Epub 2005 Mar 29.PMID: 15799962 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon.

Portero-Otín M, Requena JR, Bellmunt MJ, Ayala V, Pamplona R.

Exp Gerontol. 2004 Oct;39(10):1527-35.PMID: 15501023 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end products in urine: are some sugar-derived products better than others?

Pamplona R, Portero-Otin M.

J Lab Clin Med. 2004 Aug;144(2):58-9. Review. No abstract available. PMID: 15338576 [PubMed - indexed for MEDLINE]Related articles

Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria.

Lambert AJ, Portero-Otin M, Pamplona R, Merry BJ.

Mech Ageing Dev. 2004 Aug;125(8):529-38.PMID: 15336910 [PubMed - indexed for MEDLINE]Related articles

Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain.

Pamplona R, Portero-Otin M, Sanz A, Requena J, Barja G.

Exp Gerontol. 2004 May;39(5):725-33.PMID: 15130667 [PubMed - indexed for MEDLINE]Related articles

Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants.

Venditti P, De Rosa R, Portero-Otin M, Pamplona R, Di Meo S.

Int J Biochem Cell Biol. 2004 Jul;36(7):1319-31.PMID: 15109575 [PubMed - indexed for MEDLINE]Related articles

Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids.

Portero-Otin M, Bellmunt MJ, Requena JR, Pamplona R.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1403-5. Review.PMID: 14641074 [PubMed - indexed for MEDLINE]Related articles

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otín M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ, Brand MD.

EMBO J. 2003 Aug 15;22(16):4103-10.PMID: 12912909 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids.

Ruiz MC, Portero-Otín M, Pamplona R, Requena JR, Prat J, Lafarga MA, Borràs M, Bellmunt MJ.

Perit Dial Int. 2003 Jan-Feb;23(1):23-32.PMID: 12691503 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

Pamplona R, Portero-Otín M, Requena J, Gredilla R, Barja G.

Mech Ageing Dev. 2002 Sep;123(11):1437-46.PMID: 12425950 [PubMed - indexed for MEDLINE]Related articles

Protein oxidative stress in dialysis patients.

Doñate T, Herreros A, Martinez E, Martinez J, Andrés E, Cabezas A, Ortiz A, de Prado A, Pou JM, Pamplona R, Portero Otin M, Bellmunt MJ.

Adv Perit Dial. 2002;18:15-7.PMID: 12402579 [PubMed - indexed for MEDLINE]Related articles

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.

Brand MD, Pamplona R, Portero-Otín M, Requena JR, Roebuck SJ, Buckingham JA, Clapham JC, Cadenas S.

Biochem J. 2002 Dec 1;368(Pt 2):597-603.PMID: 12193161 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.

Pamplona R, Portero-Otín M, Bellmun MJ, Gredilla R, Barja G.

Free Radic Res. 2002 Jan;36(1):47-54.PMID: 11999702 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end product precursors impair epidermal growth factor receptor signaling.

Portero-Otín M, Pamplona R, Bellmunt MJ, Ruiz MC, Prat J, Salvayre R, Nègre-Salvayre A.

Diabetes. 2002 May;51(5):1535-42.PMID: 11978653 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?

Pamplona R, Barja G, Portero-Otín M.

Ann N Y Acad Sci. 2002 Apr;959:475-90. Review.PMID: 11976221 [PubMed - indexed for MEDLINE]Related articles

Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle.

Gredilla R, López Torres M, Portero-Otín M, Pamplona R, Barja G.

Mol Cell Biochem. 2001 May;221(1-2):41-8.PMID: 11506185 [PubMed - indexed for MEDLINE]Related articles

Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential.

Portero-Otín M, Bellmunt MJ, Ruiz MC, Barja G, Pamplona R.

Lipids. 2001 May;36(5):491-8.PMID: 11432462 [PubMed - indexed for MEDLINE]Related articles

Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage.

Herrero A, Portero-Otín M, Bellmunt MJ, Pamplona R, Barja G.

Mech Ageing Dev. 2001 Apr 15;122(4):427-43.PMID: 11240164 [PubMed - indexed for MEDLINE]Related articles

Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans.

Pamplona R, Portero-Otín M, Riba D, Requena JR, Thorpe SR, López-Torres M, Barja G.

J Gerontol A Biol Sci Med Sci. 2000 Jun;55(6):B286-91.PMID: 10843345 [PubMed - indexed for MEDLINE]Related articles

Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals.

Pamplona R, Portero-Otín M, Ruiz C, Gredilla R, Herrero A, Barja G.

Mech Ageing Dev. 2000 Jan 10;112(3):169-83.PMID: 10687923 [PubMed - indexed for MEDLINE]Related articles