PubMed

From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes.

Wei Z, Wang K, Qu HQ, Zhang H, Bradfield J, Kim C, Frackleton E, Hou C, Glessner JT, Chiavacci R, Stanley C, Monos D, Grant SF, Polychronakos C, Hakonarson H.

PLoS Genet. 2009 Oct;5(10):e1000678. Epub 2009 Oct 9.PMID: 19816555 [PubMed - in process]Related articlesFree article

A cis-acting regulatory variant in the IL2RA locus.

Qu HQ, Verlaan DJ, Ge B, Lu Y, Lam KC, Grabs R, Harmsen E, Hudson TJ, Hakonarson H, Pastinen T, Polychronakos C.

J Immunol. 2009 Oct 15;183(8):5158-62. Epub 2009 Sep 30.PMID: 19794070 [PubMed - indexed for MEDLINE]Related articles

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R.

Nat Genet. 2009 Oct;41(10):1110-5. Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156. PMID: 19734900 [PubMed - indexed for MEDLINE]Related articles

Compensatory beliefs about glucose testing are associated with low adherence to treatment and poor metabolic control in adolescents with type 1 diabetes.

Rabiau MA, Knäuper B, Nguyen TK, Sufrategui M, Polychronakos C.

Health Educ Res. 2009 Oct;24(5):890-6. Epub 2009 Jul 17.PMID: 19617303 [PubMed - in process]Related articles

Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells.

Levi D, Polychronakos C.

Diabetologia. 2009 Oct;52(10):2151-8. Epub 2009 Jul 16.PMID: 19609502 [PubMed - in process]Related articles

Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies.

Qu HQ, Grant SF, Bradfield JP, Kim C, Frackelton E, Hakonarson H, Polychronakos C.

J Med Genet. 2009 Aug;46(8):553-4. Epub 2009 May 21.PMID: 19465406 [PubMed - indexed for MEDLINE]Related articles

The effect of the MHC locus on autoantibodies in type 1 diabetes.

Qu HQ, Polychronakos C.

J Med Genet. 2009 Jul;46(7):469-71. Epub 2009 May 7.PMID: 19429597 [PubMed - indexed for MEDLINE]Related articles

Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans.

Bossé Y, Bacot F, Montpetit A, Rung J, Qu HQ, Engert JC, Polychronakos C, Hudson TJ, Froguel P, Sladek R, Desrosiers M.

Hum Genet. 2009 Apr;125(3):305-18. Epub 2009 Jan 29.PMID: 19184112 [PubMed - indexed for MEDLINE]Related articles

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

Meyre D, Delplanque J, Chèvre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proença C, Gaget S, Körner A, Kovacs P, Kiess W, Tichet J, Marre M, Hartikainen AL, Horber F, Potoczna N, Hercberg S, Levy-Marchal C, Pattou F, Heude B, Tauber M, McCarthy MI, Blakemore AI, Montpetit A, Polychronakos C, Weill J, Coin LJ, Asher J, Elliott P, Järvelin MR, Visvikis-Siest S, Balkau B, Sladek R, Balding D, Walley A, Dina C, Froguel P.

Nat Genet. 2009 Feb;41(2):157-9. Epub 2009 Jan 18.PMID: 19151714 [PubMed - indexed for MEDLINE]Related articles

Impedance based DNA chip for direct T(m) measurement.

Marquette CA, Lawrence I, Polychronakos C, Lawrence MF.

Talanta. 2002 Mar 11;56(4):763-8.PMID: 18968553 [PubMed - in process]Related articles

Familial permanent neonatal diabetes with KCNJ11 mutation and the response to glyburide therapy--a three-year follow-up.

Begum-Hasan J, Polychronakos C, Brill H.

J Pediatr Endocrinol Metab. 2008 Sep;21(9):895-903.PMID: 18924582 [PubMed - indexed for MEDLINE]Related articles

Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.

Grant SF, Qu HQ, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Taback SP, Frackelton EC, Eckert AW, Annaiah K, Lawson ML, Otieno FG, Santa E, Shaner JL, Smith RM, Skraban R, Imielinski M, Chiavacci RM, Grundmeier RW, Stanley CA, Kirsch SE, Waggott D, Paterson AD, Monos DS; DCCT/EDIC Research Group, Polychronakos C, Hakonarson H.

Diabetes. 2009 Jan;58(1):290-5. Epub 2008 Oct 7.PMID: 18840781 [PubMed - indexed for MEDLINE]Related articlesFree article

The kisspeptin (KiSS-1)/GPR54 system in cancer biology.

Makri A, Pissimissis N, Lembessis P, Polychronakos C, Koutsilieris M.

Cancer Treat Rev. 2008 Dec;34(8):682-92. Epub 2008 Jun 25. Review.PMID: 18583061 [PubMed - indexed for MEDLINE]Related articles

Common and rare alleles as causes of complex phenotypes.

Polychronakos C.

Curr Atheroscler Rep. 2008 Jun;10(3):194-200. Review.PMID: 18489846 [PubMed - indexed for MEDLINE]Related articles

The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.

Ounissi-Benkalha H, Polychronakos C.

Trends Mol Med. 2008 Jun;14(6):268-75. Epub 2008 May 14. Review.PMID: 18482868 [PubMed - indexed for MEDLINE]Related articles

Advances in type I diabetes associated tolerance mechanisms.

Chentoufi AA, Binder NR, Berka N, Abunadi T, Polychronakos C.

Scand J Immunol. 2008 Jul;68(1):1-11. Epub 2008 May 9. Review.PMID: 18482207 [PubMed - indexed for MEDLINE]Related articles

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.

Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, Cavalcanti-Proença C, Marchand M, Hartikainen AL, Sovio U, De Graeve F, Rung J, Vaxillaire M, Tichet J, Marre M, Balkau B, Weill J, Elliott P, Jarvelin MR, Meyre D, Polychronakos C, Dina C, Sladek R, Froguel P.

Science. 2008 May 23;320(5879):1085-8. Epub 2008 May 1.PMID: 18451265 [PubMed - indexed for MEDLINE]Related articlesFree article

Association analysis of type 2 diabetes Loci in type 1 diabetes.

Qu HQ, Grant SF, Bradfield JP, Kim C, Frackelton E, Hakonarson H, Polychronakos C.

Diabetes. 2008 Jul;57(7):1983-6. Epub 2008 Apr 21.PMID: 18426861 [PubMed - indexed for MEDLINE]Related articlesFree article

The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II.

Qu HQ, Marchand L, Szymborski A, Grabs R, Polychronakos C.

Genes Immun. 2008 Apr;9(3):264-6. Epub 2008 Mar 13.PMID: 18340361 [PubMed - indexed for MEDLINE]Related articles

[What is new in the genetics of type 2 diabetes]

Polychronakos C.

Med Sci (Paris). 2008 Mar;24(3):241-2. French. No abstract available. PMID: 18334167 [PubMed - indexed for MEDLINE]Related articles

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.

Hakonarson H, Qu HQ, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Eckert AW, Annaiah K, Lawson ML, Otieno FG, Santa E, Shaner JL, Smith RM, Onyiah CC, Skraban R, Chiavacci RM, Robinson LJ, Stanley CA, Kirsch SE, Devoto M, Monos DS, Grant SF, Polychronakos C.

Diabetes. 2008 Apr;57(4):1143-6. Epub 2008 Jan 15.PMID: 18198356 [PubMed - indexed for MEDLINE]Related articlesFree article

New applications of microarray data analysis: integrating genetics with 'Omics'. Organized by the Cambridge Healthtech Institute, 15-17 August 2007, Washington DC, USA.

Polychronakos C.

Pharmacogenomics. 2008 Jan;9(1):15-7. Review. No abstract available. PMID: 18154445 [PubMed - indexed for MEDLINE]Related articles

The association between the IFIH1 locus and type 1 diabetes.

Qu HQ, Marchand L, Grabs R, Polychronakos C.

Diabetologia. 2008 Mar;51(3):473-5. Epub 2007 Dec 11.PMID: 18071670 [PubMed - indexed for MEDLINE]Related articles

Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes.

Gutierrez-Aguilar R, Benmezroua Y, Balkau B, Marre M, Helbecque N, Charpentier G, Polychronakos C, Sladek R, Froguel P, Neve B.

Diabetes Metab. 2007 Nov;33(5):372-8. Epub 2007 Oct 10.PMID: 17931948 [PubMed - indexed for MEDLINE]Related articlesFree article

The TCF7L2 locus and type 1 diabetes.

Qu HQ, Polychronakos C.

BMC Med Genet. 2007 Aug 3;8:51.PMID: 17683561 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C.

Nature. 2007 Aug 2;448(7153):591-4. Epub 2007 Jul 15.PMID: 17632545 [PubMed - indexed for MEDLINE]Related articles

The IRF5 polymorphism in type 1 diabetes.

Qu HQ, Marchand L, Grabs R, Polychronakos C.

J Med Genet. 2007 Oct;44(10):670-2. Epub 2007 Jun 8.PMID: 17557928 [PubMed - indexed for MEDLINE]Related articles

Toward further mapping of the association between the IL2RA locus and type 1 diabetes.

Qu HQ, Montpetit A, Ge B, Hudson TJ, Polychronakos C.

Diabetes. 2007 Apr;56(4):1174-6.PMID: 17395754 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes.

Marchand L, Polychronakos C.

Diabetes. 2007 Mar;56(3):709-13.PMID: 17327440 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide association study identifies novel risk loci for type 2 diabetes.

Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P.

Nature. 2007 Feb 22;445(7130):881-5. Epub 2007 Feb 11.PMID: 17293876 [PubMed - indexed for MEDLINE]Related articles

Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes.

Qu HQ, Lu Y, Marchand L, Bacot F, Fréchette R, Tessier MC, Montpetit A, Polychronakos C.

Diabetes. 2007 Jan;56(1):270-5.PMID: 17192492 [PubMed - indexed for MEDLINE]Related articlesFree article

No association of type 1 diabetes with a functional polymorphism of the LRAP gene.

Qu HQ, Marchand L, Fréchette R, Bacot F, Lu Y, Polychronakos C.

Mol Immunol. 2007 Mar;44(8):2135-8. Epub 2006 Nov 28.PMID: 17129607 [PubMed - indexed for MEDLINE]Related articles

Genetic testing in clinical endocrinology.

Polychronakos C.

Hormones (Athens). 2003 Oct-Dec;2(4):201-10. No abstract available. PMID: 17003024 [PubMed]Related articlesFree article

Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones.

Palumbo MO, Levi D, Chentoufi AA, Polychronakos C.

Diabetes. 2006 Sep;55(9):2595-601.PMID: 16936209 [PubMed - indexed for MEDLINE]Related articlesFree article

Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms.

Qu HQ, Lawrence SG, Guo F, Majewski J, Polychronakos C.

BMC Genomics. 2006 Aug 17;7:213.PMID: 16916449 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional evaluation of the autoimmunity-associated CTLA4 gene: the effect of the (AT) repeat in the 3'untranslated region (UTR).

Anjos SM, Polychronakos C.

J Autoimmun. 2006 Sep;27(2):105-9. Epub 2006 Aug 7.PMID: 16891094 [PubMed - indexed for MEDLINE]Related articles

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

Durinovic-Belló I, Rosinger S, Olson JA, Congia M, Ahmad RC, Rickert M, Hampl J, Kalbacher H, Drijfhout JW, Mellins ED, Al Dahouk S, Kamradt T, Maeurer MJ, Nhan C, Roep BO, Boehm BO, Polychronakos C, Nepom GT, Karges W, McDevitt HO, Sønderstrup G.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11683-8. Epub 2006 Jul 25.PMID: 16868084 [PubMed - indexed for MEDLINE]Related articlesFree article

Annual incidence of type 1 diabetes in Québec between 1989-2000 in children.

Legault L, Polychronakos C.

Clin Invest Med. 2006 Feb;29(1):10-3.PMID: 16553358 [PubMed - indexed for MEDLINE]Related articles

Lack of association of type 1 diabetes with the IL4R gene.

Qu HQ, Tessier MC, Fréchette R, Bacot F, Polychronakos C.

Diabetologia. 2006 May;49(5):958-61. Epub 2006 Mar 15.PMID: 16538488 [PubMed - indexed for MEDLINE]Related articles

Genetic variation and health; towards individualized medicine.

Polychronakos C.

Pediatr Endocrinol Rev. 2004 Aug;1 Suppl 3:540-4. Review.PMID: 16444190 [PubMed - indexed for MEDLINE]Related articles

Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.

Durinovic-Belló I, Jelinek E, Schlosser M, Eiermann T, Boehm BO, Karges W, Marchand L, Polychronakos C.

Diabetes. 2005 Dec;54 Suppl 2:S18-24.PMID: 16306335 [PubMed - indexed for MEDLINE]Related articlesFree article

Monogenic and other unusual causes of diabetes mellitus.

Nakhla M, Polychronakos C.

Pediatr Clin North Am. 2005 Dec;52(6):1637-50.PMID: 16301086 [PubMed - indexed for MEDLINE]Related articles

Immunogenetics of type 1 diabetes.

Kim MS, Polychronakos C.

Horm Res. 2005;64(4):180-8. Epub 2005 Oct 24. Review.PMID: 16254432 [PubMed - indexed for MEDLINE]Related articles

Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?

Tessier MC, Qu HQ, Fréchette R, Bacot F, Grabs R, Taback SP, Lawson ML, Kirsch SE, Hudson TJ, Polychronakos C.

J Med Genet. 2006 Feb;43(2):129-32. Epub 2005 Jul 13.PMID: 16014697 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3' +6230G>A polymorphism.

Anjos SM, Shao W, Marchand L, Polychronakos C.

Genes Immun. 2005 Jun;6(4):305-11.PMID: 15858600 [PubMed - indexed for MEDLINE]Related articles

Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study.

Qu H, Tessier MC, Hudson TJ, Polychronakos C.

J Med Genet. 2005 Mar;42(3):266-70. No abstract available. PMID: 15744042 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

Qu H, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD, Hudson TJ, Polychronakos C.

Nat Genet. 2005 Feb;37(2):111-2; author reply 112-3. No abstract available. PMID: 15678135 [PubMed - indexed for MEDLINE]Related articles

Early onset diabetes mellitus. Tip or iceberg?

Polychronakos C.

Pediatr Diabetes. 2004 Dec;5(4):171-3. No abstract available. PMID: 15601358 [PubMed - indexed for MEDLINE]Related articles

Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome.

Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C.

Diabetologia. 2004 Dec;47(12):2160-7. Epub 2004 Dec 8.PMID: 15592663 [PubMed - indexed for MEDLINE]Related articles

Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block.

Anjos SM, Tessier MC, Polychronakos C.

J Clin Endocrinol Metab. 2004 Dec;89(12):6257-65.PMID: 15579786 [PubMed - indexed for MEDLINE]Related articlesFree article