PubMed

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action.

Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934000 [PubMed - as supplied by publisher]

Pdx1 and other factors that regulate pancreatic beta-cell survival.

Fujimoto K, Polonsky KS.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:30-7.PMID: 19817786 [PubMed - in process]Related articles

Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.

Kawai T, Ng MC, Hayes MG, Yoshiuchi I, Tsuchiya T, Robertson H, Cox NJ, Polonsky KS, Bell GI, Ehrmann DA.

Diabetes Res Clin Pract. 2009 Dec;86(3):186-92. Epub 2009 Sep 25.PMID: 19782423 [PubMed - in process]Related articles

Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.

Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS.

J Biol Chem. 2009 Oct 2;284(40):27664-73. Epub 2009 Aug 4.PMID: 19654319 [PubMed - indexed for MEDLINE]Related articles

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

To nap or not to nap? Residents' work hours revisited.

Blanchard MS, Meltzer D, Polonsky KS.

N Engl J Med. 2009 May 21;360(21):2242-4. No abstract available. PMID: 19458371 [PubMed - indexed for MEDLINE]Related articles

Serum leptin levels in obese males during over- and underfeeding.

Cooper JA, Polonsky KS, Schoeller DA.

Obesity (Silver Spring). 2009 Dec;17(12):2149-54. Epub 2009 May 14.PMID: 19444224 [PubMed - in process]Related articles

Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1.

Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF.

J Lipid Res. 2009 May 12. [Epub ahead of print]PMID: 19436065 [PubMed - as supplied by publisher]Related articlesFree article

Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.

Cell Metab. 2009 Apr;9(4):350-61.PMID: 19356716 [PubMed - indexed for MEDLINE]Related articles

The physician scientist training program in internal medicine at Washington University School of Medicine.

Muslin AJ, Kornfeld S, Polonsky KS.

Acad Med. 2009 Apr;84(4):468-71.PMID: 19318780 [PubMed - indexed for MEDLINE]Related articles

Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells.

Uchizono Y, Baldwin AC, Sakuma H, Pugh W, Polonsky KS, Hara M.

Diabetes Res Clin Pract. 2009 Apr;84(1):19-26. Epub 2009 Jan 31.PMID: 19181415 [PubMed - indexed for MEDLINE]Related articles

Gastric banding to treat obesity: band-aid or breakthrough?

Polonsky KS, Klein S.

Nat Clin Pract Endocrinol Metab. 2008 Aug;4(8):421. No abstract available. PMID: 18648393 [PubMed - indexed for MEDLINE]Related articles

Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.

Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8452-7. Epub 2008 Jun 11.PMID: 18550819 [PubMed - indexed for MEDLINE]Related articlesFree article

Standardization of C-peptide measurements.

Little RR, Rohlfing CL, Tennill AL, Madsen RW, Polonsky KS, Myers GL, Greenbaum CJ, Palmer JP, Rogatsky E, Stein DT.

Clin Chem. 2008 Jun;54(6):1023-6. Epub 2008 Apr 17.PMID: 18420730 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.

Althage MC, Ford EL, Wang S, Tso P, Polonsky KS, Wice BM.

J Biol Chem. 2008 Jun 27;283(26):18365-76. Epub 2008 Apr 17.PMID: 18420580 [PubMed - indexed for MEDLINE]Related articlesFree article

Weight loss therapy improves pancreatic endocrine function in obese older adults.

Villareal DT, Banks MR, Patterson BW, Polonsky KS, Klein S.

Obesity (Silver Spring). 2008 Jun;16(6):1349-54. Epub 2008 Apr 3.PMID: 18388888 [PubMed - indexed for MEDLINE]Related articles

Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.

Hara M, Shen J, Pugh W, Polonsky KS, Le Beau MM, Bell GI.

Exp Clin Endocrinol Diabetes. 2007 Nov;115(10):654-61.PMID: 18058600 [PubMed - indexed for MEDLINE]Related articles

International comparison of C-peptide measurements.

Wiedmeyer HM, Polonsky KS, Myers GL, Little RR, Greenbaum CJ, Goldstein DE, Palmer JP.

Clin Chem. 2007 Apr;53(4):784-7. Epub 2007 Mar 1.PMID: 17332147 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.

Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80. Epub 2006 Dec 8.PMID: 17158802 [PubMed - indexed for MEDLINE]Related articlesFree article

International trial of the Edmonton protocol for islet transplantation.

Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR.

N Engl J Med. 2006 Sep 28;355(13):1318-30.PMID: 17005949 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressed insulin signaling and increased apoptosis in CD38-null islets.

Johnson JD, Ford EL, Bernal-Mizrachi E, Kusser KL, Luciani DS, Han Z, Tran H, Randall TD, Lund FE, Polonsky KS.

Diabetes. 2006 Oct;55(10):2737-46.PMID: 17003338 [PubMed - indexed for MEDLINE]Related articlesFree article

A significant role for histocompatibility in human islet transplantation.

Mohanakumar T, Narayanan K, Desai N, Ramachandran S, Shenoy S, Jendrisak M, Susskind BM, Olack B, Benshoff N, Phelan DL, Brennan DC, Fernandez LA, Odorico JS, Polonsky KS.

Transplantation. 2006 Jul 27;82(2):180-7.PMID: 16858280 [PubMed - indexed for MEDLINE]Related articles

Retinol-binding protein 4, insulin resistance, and type 2 diabetes.

Polonsky KS.

N Engl J Med. 2006 Jun 15;354(24):2596-8. No abstract available. PMID: 16775241 [PubMed - indexed for MEDLINE]Related articles

Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle.

Otani K, Polonsky KS, Holloszy JO, Han DH.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E544-8. Epub 2006 May 16.PMID: 16705056 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets.

Luciani DS, Misler S, Polonsky KS.

J Physiol. 2006 Apr 15;572(Pt 2):379-92. Epub 2006 Feb 2.PMID: 16455690 [PubMed - indexed for MEDLINE]Related articlesFree article

Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals.

Dalla Man C, Campioni M, Polonsky KS, Basu R, Rizza RA, Toffolo G, Cobelli C.

Diabetes. 2005 Nov;54(11):3265-73.PMID: 16249454 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic pancreatic beta cells ARNT all they should be.

Levisetti MG, Polonsky KS.

Cell Metab. 2005 Aug;2(2):78-80.PMID: 16098823 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals.

Kim SH, Abbasi F, Chu JW, McLaughlin TL, Lamendola C, Polonsky KS, Reaven GM.

Diabetes. 2005 Aug;54(8):2447-52.PMID: 16046313 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity by oral glucose minimal models: validation against clamp.

Dalla Man C, Yarasheski KE, Caumo A, Robertson H, Toffolo G, Polonsky KS, Cobelli C.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E954-9. Epub 2005 Jul 12.PMID: 16014353 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA.

J Clin Invest. 2004 Oct;114(7):928-36.PMID: 15467831 [PubMed - indexed for MEDLINE]Related articlesFree article

Portal vein thrombosis complicating islet transplantation in a recipient with the Factor V Leiden mutation.

Brennan DC, Shannon MB, Koch MJ, Polonsky KS, Desai N, Shapiro J.

Transplantation. 2004 Jul 15;78(1):172-3. No abstract available. PMID: 15257060 [PubMed - indexed for MEDLINE]Related articles

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.

Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS.

J Biol Chem. 2004 Jun 4;279(23):24794-802. Epub 2004 Mar 25.PMID: 15044459 [PubMed - indexed for MEDLINE]Related articlesFree article

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

Johnson JD, Kuang S, Misler S, Polonsky KS.

FASEB J. 2004 May;18(7):878-80. Epub 2004 Mar 19.PMID: 15033925 [PubMed - indexed for MEDLINE]Related articlesFree article

Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.

Otani K, Han DH, Ford EL, Garcia-Roves PM, Ye H, Horikawa Y, Bell GI, Holloszy JO, Polonsky KS.

J Biol Chem. 2004 May 14;279(20):20915-20. Epub 2004 Mar 9.PMID: 15014085 [PubMed - indexed for MEDLINE]Related articlesFree article

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

Palmer JP, Fleming GA, Greenbaum CJ, Herold KC, Jansa LD, Kolb H, Lachin JM, Polonsky KS, Pozzilli P, Skyler JS, Steffes MW.

Diabetes. 2004 Jan;53(1):250-64. Erratum in: Diabetes. 2004 Jul;53(7):1934. PMID: 14693724 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.

Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA.

Diabetes. 2004 Jan;53(1):91-8.PMID: 14693702 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome.

Ehrmann DA, Breda E, Corcoran MC, Cavaghan MK, Imperial J, Toffolo G, Cobelli C, Polonsky KS.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E241-6. Epub 2003 Dec 9.PMID: 14665448 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.

Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ, Holst JJ, Brubaker PL, Corvol P, Polonsky KS, Ostrega D, Becker KL, Bertagna X, Hutton JC, White A, Dattani MT, Hussain K, Middleton SJ, Nicole TM, Milla PJ, Lindley KJ, O'Rahilly S.

J Clin Invest. 2003 Nov;112(10):1550-60.PMID: 14617756 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.

Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS.

Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E41-9. Epub 2003 Sep 30.PMID: 14519599 [PubMed - indexed for MEDLINE]Related articlesFree article

A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.

Zhou YP, Sreenan S, Pan CY, Currie KP, Bindokas VP, Horikawa Y, Lee JP, Ostrega D, Ahmed N, Baldwin AC, Cox NJ, Fox AP, Miller RJ, Bell GI, Polonsky KS.

Metabolism. 2003 May;52(5):528-34.PMID: 12759879 [PubMed - indexed for MEDLINE]Related articles

Organ alchemy: producing insulin in the liver.

Polonsky KS, Bell GI.

Nat Med. 2003 May;9(5):504-5. No abstract available. PMID: 12724755 [PubMed - indexed for MEDLINE]Related articles

Increased islet apoptosis in Pdx1+/- mice.

Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS.

J Clin Invest. 2003 Apr;111(8):1147-60.PMID: 12697734 [PubMed - indexed for MEDLINE]Related articlesFree article

Visualizing superoxide production in normal and diabetic rat islets of Langerhans.

Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH.

J Biol Chem. 2003 Mar 14;278(11):9796-801. Epub 2003 Jan 4.PMID: 12514170 [PubMed - indexed for MEDLINE]Related articlesFree article

Ginseng berry reduces blood glucose and body weight in db/db mice.

Xie JT, Zhou YP, Dey L, Attele AS, Wu JA, Gu M, Polonsky KS, Yuan CS.

Phytomedicine. 2002 Apr;9(3):254-8.PMID: 12046868 [PubMed - indexed for MEDLINE]Related articles

Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance.

Ehrmann DA, Breda E, Cavaghan MK, Bajramovic S, Imperial J, Toffolo G, Cobelli C, Polonsky KS.

Diabetologia. 2002 Apr;45(4):509-17.PMID: 12032626 [PubMed - indexed for MEDLINE]Related articles

Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.

Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS.

Diabetes. 2002 Jun;51(6):1851-8.PMID: 12031973 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis of acromegaly in a patient with type 1 diabetes mellitus.

Hofmann EA, Polonsky KS, Weiss RE.

Endocr Pract. 2002 Mar-Apr;8(2):113-8.PMID: 11942776 [PubMed - indexed for MEDLINE]Related articles

Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.

Breda E, Toffolo G, Polonsky KS, Cobelli C.

Diabetes. 2002 Feb;51 Suppl 1:S227-33.PMID: 11815484 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes mellitus and genetically programmed defects in beta-cell function.

Bell GI, Polonsky KS.

Nature. 2001 Dec 13;414(6865):788-91. Review.PMID: 11742410 [PubMed - indexed for MEDLINE]Related articles