PubMed

Lack of TXNIP protects against mitochondria-mediated apoptosis, but not against fatty acid-induced, ER-stress-mediated beta cell death.

Chen J, Fontes G, Saxena G, Poitout V, Shalev A.

Diabetes. 2009 Oct 29. [Epub ahead of print]PMID: 19875615 [PubMed - as supplied by publisher]Related articles

Lipid receptors and islet function: therapeutic implications?

Kebede MA, Alquier T, Latour MG, Poitout V.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:10-20.PMID: 19817784 [PubMed - in process]Related articles

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. Epub 2009 Aug 31.PMID: 19720802 [PubMed - in process]Related articles

Glucolipotoxicity of the pancreatic beta cell.

Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontés G.

Biochim Biophys Acta. 2009 Aug 26. [Epub ahead of print]PMID: 19715772 [PubMed - as supplied by publisher]Related articles

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.

Diabetes. 2009 Sep;58(9):2048-58. Epub 2009 Jun 5.PMID: 19502418 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M.

Endocrinology. 2009 Aug;150(8):3465-74. Epub 2009 Apr 30.PMID: 19406947 [PubMed - indexed for MEDLINE]Related articles

GPR40: good cop, bad cop?

Alquier T, Poitout V.

Diabetes. 2009 May;58(5):1035-6. No abstract available. PMID: 19401432 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.

Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M.

J Biol Chem. 2009 Jun 19;284(25):16848-59. Epub 2009 Apr 22.PMID: 19389712 [PubMed - indexed for MEDLINE]Related articles

The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation.

Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R.

J Biol Chem. 2009 Jan 9;284(2):759-65. Epub 2008 Nov 12.PMID: 19004825 [PubMed - indexed for MEDLINE]Related articles

Glucolipotoxicity of the pancreatic beta-cell: myth or reality?

Poitout V.

Biochem Soc Trans. 2008 Oct;36(Pt 5):901-4. Review.PMID: 18793158 [PubMed - indexed for MEDLINE]Related articles

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.

Diabetes. 2008 Sep;57(9):2432-7. Epub 2008 Jun 16. Erratum in: Diabetes. 2008 Nov;57(11):3166. PMID: 18559658 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

Poitout V, Robertson RP.

Endocr Rev. 2008 May;29(3):351-66. Epub 2007 Nov 29. Review.PMID: 18048763 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube.

Poitout V.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E214-6. Epub 2007 Oct 9. No abstract available. PMID: 17925452 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-coupled receptors and insulin secretion: 119 and counting.

Madiraju SR, Poitout V.

Endocrinology. 2007 Jun;148(6):2598-600. No abstract available. PMID: 17507578 [PubMed - indexed for MEDLINE]Related articlesFree article

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

Diabetes. 2007 Apr;56(4):1087-94.PMID: 17395749 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS.

Metz TO, Jacobs JM, Gritsenko MA, Fontès G, Qian WJ, Camp DG 2nd, Poitout V, Smith RD.

J Proteome Res. 2006 Dec;5(12):3345-54.PMID: 17137336 [PubMed - indexed for MEDLINE]Related articles

[2006 Apollinaire Bouchardat Award. Fatty acids and pancreatic beta cell function]

Poitout V.

Journ Annu Diabetol Hotel Dieu. 2006:37-46. Review. French. No abstract available. PMID: 17051848 [PubMed - indexed for MEDLINE]Related articles

Regulation of the insulin gene by glucose and fatty acids.

Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS.

J Nutr. 2006 Apr;136(4):873-6. Review.PMID: 16549443 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

Hagman DK, Hays LB, Parazzoli SD, Poitout V.

J Biol Chem. 2005 Sep 16;280(37):32413-8. Epub 2005 Jun 8.PMID: 15944145 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).

Bihan H, Rouault C, Reach G, Poitout V, Staels B, Guerre-Millo M.

FEBS Lett. 2005 Apr 25;579(11):2284-8.PMID: 15848159 [PubMed - indexed for MEDLINE]Related articles

The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.

Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R.

J Biol Chem. 2005 Mar 25;280(12):11887-94. Epub 2005 Jan 20.PMID: 15665000 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element.

Pino MF, Ye DZ, Linning KD, Green CD, Wicksteed B, Poitout V, Olson LK.

Mol Endocrinol. 2005 May;19(5):1343-60. Epub 2005 Jan 13.PMID: 15650027 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion.

Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V.

Diabetes. 2004 Oct;53(10):2610-6.PMID: 15448091 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell lipotoxicity: burning fat into heat?

Poitout V.

Endocrinology. 2004 Aug;145(8):3563-5. No abstract available. PMID: 15265823 [PubMed - indexed for MEDLINE]Related articlesFree article

Gluco-lipotoxicity of the pancreatic beta cell.

Poitout V, Briaud I, Kelpe C, Hagman D.

Ann Endocrinol (Paris). 2004 Feb;65(1):37-41. Review. No abstract available. PMID: 15122090 [PubMed - indexed for MEDLINE]Related articles

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M.

Diabetes. 2004 Apr;53(4):1007-19.PMID: 15047616 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.

Robertson RP, Harmon J, Tran PO, Poitout V.

Diabetes. 2004 Feb;53 Suppl 1:S119-24. Review.PMID: 14749276 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate.

Parker SM, Moore PC, Johnson LM, Poitout V.

Metabolism. 2003 Oct;52(10):1367-71.PMID: 14564691 [PubMed - indexed for MEDLINE]Related articles

The ins and outs of fatty acids on the pancreatic beta cell.

Poitout V.

Trends Endocrinol Metab. 2003 Jul;14(5):201-3. Review. No abstract available. PMID: 12826323 [PubMed - indexed for MEDLINE]Related articles

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.

Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V.

J Biol Chem. 2003 Aug 8;278(32):30015-21. Epub 2003 May 27.PMID: 12771145 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory deficiency and glucose intolerance in Rab3A null mice.

Yaekura K, Julyan R, Wicksteed BL, Hays LB, Alarcon C, Sommers S, Poitout V, Baskin DG, Wang Y, Philipson LH, Rhodes CJ.

J Biol Chem. 2003 Mar 14;278(11):9715-21. Epub 2003 Jan 1.PMID: 12510060 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin processing in the diabetic Goto-Kakizaki rat.

Guest PC, Abdel-Halim SM, Gross DJ, Clark A, Poitout V, Amaria R, Ostenson CG, Hutton JC.

J Endocrinol. 2002 Dec;175(3):637-47.PMID: 12475375 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol.

Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong DM, Robertson RP, Reems JA.

Transplantation. 2002 Nov 27;74(10):1414-9.PMID: 12451242 [PubMed - indexed for MEDLINE]Related articles

Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase.

Kelpe CL, Johnson LM, Poitout V.

Endocrinology. 2002 Sep;143(9):3326-32.PMID: 12193544 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V.

Diabetes. 2002 Mar;51(3):662-8.PMID: 11872664 [PubMed - indexed for MEDLINE]Related articlesFree article

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity.

Poitout V, Robertson RP.

Endocrinology. 2002 Feb;143(2):339-42. Review.PMID: 11796484 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance.

Guerre-Millo M, Rouault C, Poulain P, André J, Poitout V, Peters JM, Gonzalez FJ, Fruchart JC, Reach G, Staels B.

Diabetes. 2001 Dec;50(12):2809-14.PMID: 11723064 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats.

Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP.

Diabetes. 2001 Nov;50(11):2481-6.PMID: 11679425 [PubMed - indexed for MEDLINE]Related articlesFree article

[Oxidative stress, insulin secretion, and insulin resistance]

Poitout V, Tanaka Y, Reach G, Robertson RP.

Journ Annu Diabetol Hotel Dieu. 2001:75-86. Review. French. No abstract available. PMID: 11565471 [PubMed - indexed for MEDLINE]Related articles

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.

Briaud I, Rouault C, Bailbé D, Portha B, Reach G, Poitout V.

Horm Metab Res. 2000 Mar;32(3):103-6.PMID: 10786928 [PubMed - indexed for MEDLINE]Related articles

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration.

Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V.

Metabolism. 2000 Apr;49(4):532-6.PMID: 10778881 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.

Briaud I, Rouault C, Bailbé D, Portha B, Reach G, Poitout V.

Horm Metab Res. 2000 Feb;32(2):53-6.PMID: 10741685 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta.

Tran PO, Gleason CE, Poitout V, Robertson RP.

J Biol Chem. 1999 Oct 29;274(44):31245-8.PMID: 10531320 [PubMed - indexed for MEDLINE]Related articlesFree article

Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.

Benes C, Poitout V, Marie JC, Martin-Perez J, Roisin MP, Fagard R.

Biochem J. 1999 May 15;340 ( Pt 1):219-25.PMID: 10229678 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels.

Briaud I, Rouault C, Reach G, Poitout V.

Metabolism. 1999 Mar;48(3):319-23.PMID: 10094107 [PubMed - indexed for MEDLINE]Related articles

Does leptin regulate insulin secretion?

Poitout V, Rouault C, Guerre-Millo M, Reach G.

Diabetes Metab. 1998 Sep;24(4):321-6. Review.PMID: 9805642 [PubMed - indexed for MEDLINE]Related articlesFree article

[Use of islet cells in cell therapy]

Reach G, Darquy S, Poitout V.

Transfus Clin Biol. 1998 Feb;5(1):88-96. Review. French. PMID: 9577883 [PubMed - indexed for MEDLINE]Related articles

Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans.

Poitout V, Rouault C, Guerre-Millo M, Briaud I, Reach G.

Endocrinology. 1998 Mar;139(3):822-6.PMID: 9492008 [PubMed - indexed for MEDLINE]Related articlesFree article