PubMed

Heparan Sulfation Dependent FGF Signalling Maintains Embryonic Stem Cells Primed for Differentiation in a Heterogeneous State.

Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F.

Stem Cells. 2009 Nov 23. [Epub ahead of print]PMID: 19937756 [PubMed - as supplied by publisher]

Generating specificity and diversity in the transcriptional response to hypoxia.

Lendahl U, Lee KL, Yang H, Poellinger L.

Nat Rev Genet. 2009 Dec;10(12):821-32. Epub 2009 Nov 3.PMID: 19884889 [PubMed - in process]Related articles

Complex regulation of the transactivation function of hypoxia-inducible factor-1alpha by direct interaction with two distinct domains of the creb-binding protein/p300.

Ruas JL, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder RG, Pereira T, Poellinger L.

J Biol Chem. 2009 Nov 6. [Epub ahead of print]PMID: 19880525 [PubMed - as supplied by publisher]Related articlesFree article

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.

Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13481-6. Epub 2009 Jul 27.PMID: 19651607 [PubMed - indexed for MEDLINE]Related articles

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.

Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, Kanopka A, Görlach A, Gasmann M, Harris AL, Maxwell P, Scozzafava A.

J Enzyme Inhib Med Chem. 2009 Apr;24 Suppl 1:1-39. Review.PMID: 19330638 [PubMed - indexed for MEDLINE]Related articles

HIF-1 induction attenuates Nrf2-dependent IL-8 production in human endothelial cells.

Loboda A, Stachurska A, Florczyk U, Rudnicka D, Jazwa A, Wegrzyn J, Kozakowska M, Stalinska K, Poellinger L, Levonen AL, Yla-Herttuala S, Jozkowicz A, Dulak J.

Antioxid Redox Signal. 2009 Mar 2. [Epub ahead of print]PMID: 19254160 [PubMed - as supplied by publisher]Related articles

Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX.

Takacova M, Holotnakova T, Vondracek J, Machala M, Pencikova K, Gradin K, Poellinger L, Pastorek J, Pastorekova S, Kopacek J.

Biochem J. 2009 Apr 15;419(2):419-25.PMID: 19154183 [PubMed - indexed for MEDLINE]Related articles

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.

Botusan IR, Sunkari VG, Savu O, Catrina AI, Grünler J, Lindberg S, Pereira T, Ylä-Herttuala S, Poellinger L, Brismar K, Catrina SB.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19426-31. Epub 2008 Dec 4.PMID: 19057015 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.

Ohradanova A, Gradin K, Barathova M, Zatovicova M, Holotnakova T, Kopacek J, Parkkila S, Poellinger L, Pastorekova S, Pastorek J.

Br J Cancer. 2008 Oct 21;99(8):1348-56. Epub 2008 Sep 23.PMID: 18813310 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms.

Poellinger L, Lendahl U.

Curr Opin Genet Dev. 2008 Oct;18(5):449-54. Epub 2008 Sep 4. Review.PMID: 18722525 [PubMed - indexed for MEDLINE]Related articles

Notch signaling mediates hypoxia-induced tumor cell migration and invasion.

Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6392-7. Epub 2008 Apr 21.PMID: 18427106 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal sensing of oxygen is essential for systemic hypoxic response.

Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS.

Cell. 2008 Apr 18;133(2):223-34.PMID: 18423195 [PubMed - indexed for MEDLINE]Related articles

Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2.

Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E, Nishiyama M.

Oncogene. 2008 Jul 10;27(30):4200-9. Epub 2008 Mar 17.PMID: 18345027 [PubMed - indexed for MEDLINE]Related articles

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368-73. Epub 2008 Feb 25.PMID: 18299578 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.

Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M.

Mol Cell Biol. 2008 Feb;28(4):1285-97. Epub 2007 Dec 10.PMID: 18070924 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of vascular gene expression by hypoxia.

Ruas JL, Lendahl U, Poellinger L.

Curr Opin Lipidol. 2007 Oct;18(5):508-14. Review.PMID: 17885420 [PubMed - indexed for MEDLINE]Related articles

HIF-1alpha in endurance training: suppression of oxidative metabolism.

Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson RS.

Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2059-69. Epub 2007 Sep 12.PMID: 17855495 [PubMed - indexed for MEDLINE]Related articles

Hypoxia inducible factor-2alpha in cancer.

Löfstedt T, Fredlund E, Holmquist-Mengelbier L, Pietras A, Ovenberger M, Poellinger L, Påhlman S.

Cell Cycle. 2007 Apr 15;6(8):919-26. Epub 2007 Apr 13. Review.PMID: 17404509 [PubMed - indexed for MEDLINE]Related articles

Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.

Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.

J Biol Chem. 2007 May 11;282(19):14073-82. Epub 2007 Mar 12.PMID: 17355974 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia inducible factor regulates the cardiac expression and secretion of apelin.

Ronkainen VP, Ronkainen JJ, Hänninen SL, Leskinen H, Ruas JL, Pereira T, Poellinger L, Vuolteenaho O, Tavi P.

FASEB J. 2007 Jun;21(8):1821-30. Epub 2007 Mar 6.PMID: 17341685 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation of the hypoxia-inducible factor 1alpha: where does it happen?

Pereira T, Zheng X, Poellinger L.

Cell Cycle. 2006 Dec;5(23):2720-2. Epub 2006 Dec 1.PMID: 17172857 [PubMed - indexed for MEDLINE]Related articles

HIF1alpha delays premature senescence through the activation of MIF.

Welford SM, Bedogni B, Gradin K, Poellinger L, Broome Powell M, Giaccia AJ.

Genes Dev. 2006 Dec 15;20(24):3366-71. Epub 2006 Dec 1.PMID: 17142669 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.

Holmquist-Mengelbier L, Fredlund E, Löfstedt T, Noguera R, Navarro S, Nilsson H, Pietras A, Vallon-Christersson J, Borg A, Gradin K, Poellinger L, Påhlman S.

Cancer Cell. 2006 Nov;10(5):413-23.PMID: 17097563 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.

Catrina SB, Botusan IR, Rantanen A, Catrina AI, Pyakurel P, Savu O, Axelson M, Biberfeld P, Poellinger L, Brismar K.

Clin Cancer Res. 2006 Aug 1;12(15):4506-14.PMID: 16899596 [PubMed - indexed for MEDLINE]Related articlesFree article

The constitutively active Ah receptor (CA-Ahr) mouse as a potential model for dioxin exposure--effects in vital organs.

Brunnberg S, Andersson P, Lindstam M, Paulson I, Poellinger L, Hanberg A.

Toxicology. 2006 Jul 25;224(3):191-201.PMID: 16766111 [PubMed - indexed for MEDLINE]Related articles

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.

Zheng X, Ruas JL, Cao R, Salomons FA, Cao Y, Poellinger L, Pereira T.

Mol Cell Biol. 2006 Jun;26(12):4628-41.PMID: 16738327 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway.

Peters AK, Nijmeijer S, Gradin K, Backlund M, Bergman A, Poellinger L, Denison MS, Van den Berg M.

Toxicol Sci. 2006 Jul;92(1):133-42. Epub 2006 Apr 6.PMID: 16601081 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein.

Kashuba EV, Gradin K, Isaguliants M, Szekely L, Poellinger L, Klein G, Kazlauskas A.

J Biol Chem. 2006 Jan 13;281(2):1215-23. Epub 2005 Oct 28.PMID: 16257957 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M.

Dev Cell. 2005 Nov;9(5):617-28.PMID: 16256737 [PubMed - indexed for MEDLINE]Related articles

Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.

Gerbal-Chaloin S, Pichard-Garcia L, Fabre JM, Sa-Cunha A, Poellinger L, Maurel P, Daujat-Chavanieu M.

Cell Signal. 2006 May;18(5):740-50. Epub 2005 Aug 16.PMID: 16109480 [PubMed - indexed for MEDLINE]Related articles

Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.

Pajusola K, Künnapuu J, Vuorikoski S, Soronen J, André H, Pereira T, Korpisalo P, Ylä-Herttuala S, Poellinger L, Alitalo K.

FASEB J. 2005 Aug;19(10):1365-7. Epub 2005 Jun 15.PMID: 15958522 [PubMed - indexed for MEDLINE]Related articlesFree article

TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells.

Nakamura H, Makino Y, Okamoto K, Poellinger L, Ohnuma K, Morimoto C, Tanaka H.

J Immunol. 2005 Jun 15;174(12):7592-9.PMID: 15944259 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia-dependent activation of HIF into a transcriptional regulator.

Ruas JL, Poellinger L.

Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):514-22. Review.PMID: 15908239 [PubMed - indexed for MEDLINE]Related articles

Gastric hamartomatous tumours in a transgenic mouse model expressing an activated dioxin/Ah receptor.

Andersson P, Rubio C, Poellinger L, Hanberg A.

Anticancer Res. 2005 Mar-Apr;25(2A):903-11.PMID: 15868926 [PubMed - indexed for MEDLINE]Related articles

Physiological activation of hypoxia inducible factor-1 in human skeletal muscle.

Ameln H, Gustafsson T, Sundberg CJ, Okamoto K, Jansson E, Poellinger L, Makino Y.

FASEB J. 2005 Jun;19(8):1009-11. Epub 2005 Apr 5.PMID: 15811877 [PubMed - indexed for MEDLINE]Related articlesFree article

The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis.

Kuznetsov NV, Andersson P, Gradin K, Stein P, Dieckmann A, Pettersson S, Hanberg A, Poellinger L.

Oncogene. 2005 Apr 28;24(19):3216-22.PMID: 15735673 [PubMed - indexed for MEDLINE]Related articles

HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia.

Nilsson H, Jögi A, Beckman S, Harris AL, Poellinger L, Påhlman S.

Exp Cell Res. 2005 Feb 15;303(2):447-56.PMID: 15652356 [PubMed - indexed for MEDLINE]Related articles

Role of CBP in regulating HIF-1-mediated activation of transcription.

Ruas JL, Poellinger L, Pereira T.

J Cell Sci. 2005 Jan 15;118(Pt 2):301-11. Epub 2004 Dec 22.PMID: 15615775 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function.

Catrina SB, Okamoto K, Pereira T, Brismar K, Poellinger L.

Diabetes. 2004 Dec;53(12):3226-32.PMID: 15561954 [PubMed - indexed for MEDLINE]Related articlesFree article

A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice.

Moennikes O, Loeppen S, Buchmann A, Andersson P, Ittrich C, Poellinger L, Schwarz M.

Cancer Res. 2004 Jul 15;64(14):4707-10.PMID: 15256435 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells.

Löfstedt T, Jögi A, Sigvardsson M, Gradin K, Poellinger L, Påhlman S, Axelson H.

J Biol Chem. 2004 Sep 17;279(38):39223-31. Epub 2004 Jul 13.PMID: 15252039 [PubMed - indexed for MEDLINE]Related articlesFree article

HIF-1 and hypoxic response: the plot thickens.

Poellinger L, Johnson RS.

Curr Opin Genet Dev. 2004 Feb;14(1):81-5. Review.PMID: 15108809 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells.

Makino Y, Nakamura H, Ikeda E, Ohnuma K, Yamauchi K, Yabe Y, Poellinger L, Okada Y, Morimoto C, Tanaka H.

J Immunol. 2003 Dec 15;171(12):6534-40.PMID: 14662854 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance.

Tanimoto K, Yoshiga K, Eguchi H, Kaneyasu M, Ukon K, Kumazaki T, Oue N, Yasui W, Imai K, Nakachi K, Poellinger L, Nishiyama M.

Carcinogenesis. 2003 Nov;24(11):1779-83. Epub 2003 Aug 14.PMID: 12919954 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia-induced dedifferentiation in neuroblastoma cells.

Jögi A, Øra I, Nilsson H, Poellinger L, Axelson H, Påhlman S.

Cancer Lett. 2003 Jul 18;197(1-2):145-50. Review.PMID: 12880974 [PubMed - indexed for MEDLINE]Related articles

Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.

Liu MY, Poellinger L, Walker CL.

Cancer Res. 2003 May 15;63(10):2675-80.PMID: 12750296 [PubMed - indexed for MEDLINE]Related articlesFree article

A constitutively active aryl hydrocarbon receptor causes loss of peritoneal B1 cells.

Andersson P, Ridderstad A, McGuire J, Pettersson S, Poellinger L, Hanberg A.

Biochem Biophys Res Commun. 2003 Mar 7;302(2):336-41.PMID: 12604351 [PubMed - indexed for MEDLINE]Related articles

Development and validation of an average mammalian estrogen receptor-based QSAR model.

Mekenya O, Kamenska V, Serafimova R, Poellinger L, Brouwer A, Walker J.

SAR QSAR Environ Res. 2002 Oct;13(6):579-95.PMID: 12479373 [PubMed - indexed for MEDLINE]Related articles

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.

Pereira T, Zheng X, Ruas JL, Tanimoto K, Poellinger L.

J Biol Chem. 2003 Feb 28;278(9):6816-23. Epub 2002 Dec 4.PMID: 12468553 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein.

Ruas JL, Poellinger L, Pereira T.

J Biol Chem. 2002 Oct 11;277(41):38723-30. Epub 2002 Jul 19.PMID: 12133832 [PubMed - indexed for MEDLINE]Related articlesFree article