PubMed

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

Knowles MA, Platt FM, Ross RL, Hurst CD.

Cancer Metastasis Rev. . [Epub ahead of print]PMID: 20013032 [PubMed - as supplied by publisher]Related articles

AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.

Askham JM, Platt F, Chambers PA, Snowden H, Taylor CF, Knowles MA.

Oncogene. 2009 Oct 5. [Epub ahead of print]PMID: 19802009 [PubMed - as supplied by publisher]Related articles

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.

Platt FM, Hurst CD, Taylor CF, Gregory WM, Harnden P, Knowles MA.

Clin Cancer Res. 2009 Oct 1;15(19):6008-17. Epub 2009 Sep 29.PMID: 19789314 [PubMed - in process]Related articles

Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1.

Smith D, Wallom KL, Williams IM, Jeyakumar M, Platt FM.

Neurobiol Dis. 2009 Nov;36(2):242-51. Epub 2009 Jul 24.PMID: 19632328 [PubMed - in process]Related articles

Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease.

Jeyakumar M, Lee JP, Sibson NR, Lowe JP, Stuckey DJ, Tester K, Fu G, Newlin R, Smith DA, Snyder EY, Platt FM.

Stem Cells. 2009 Sep;27(9):2362-70.PMID: 19591217 [PubMed - indexed for MEDLINE]Related articles

Critical role of iron in the pathogenesis of the murine gangliosidoses.

Jeyakumar M, Williams I, Smith D, Cox TM, Platt FM.

Neurobiol Dis. 2009 Jun;34(3):406-16.PMID: 19449457 [PubMed - indexed for MEDLINE]Related articles

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).

Chapman EJ, Williams SV, Platt FM, Hurst CD, Chambers P, Roberts P, Knowles MA.

Genes Chromosomes Cancer. 2009 Aug;48(8):694-710.PMID: 19405089 [PubMed - indexed for MEDLINE]Related articles

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.

Bentley J, L'Hôte C, Platt F, Hurst CD, Lowery J, Taylor C, Sak SC, Harnden P, Knowles MA, Kiltie AE.

Genes Chromosomes Cancer. 2009 Apr;48(4):310-21.PMID: 19105236 [PubMed - indexed for MEDLINE]Related articles

A new surrogate marker for CNS pathology in Niemann-Pick disease type C?

Platt FM, Lachmann RH.

Mol Genet Metab. 2009 Feb;96(2):53-4. Epub 2008 Dec 10. No abstract available. PMID: 19083252 [PubMed - indexed for MEDLINE]Related articles

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.

De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V.

J Clin Invest. 2008 Dec;118(12):4036-48. doi: 10.1172/JCI36264. Epub 2008 Nov 13.PMID: 19033672 [PubMed - indexed for MEDLINE]Related articlesFree article

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.

De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V.

J Clin Invest. 2008 Nov 13. [Epub ahead of print]PMID: 19008964 [PubMed - as supplied by publisher]Related articlesFree article

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM.

Nat Med. 2008 Nov;14(11):1247-55. Epub 2008 Oct 26.PMID: 18953351 [PubMed - indexed for MEDLINE]Related articles

Treating lysosomal storage disorders: current practice and future prospects.

Platt FM, Lachmann RH.

Biochim Biophys Acta. 2009 Apr;1793(4):737-45. Epub 2008 Sep 5. Review.PMID: 18824038 [PubMed - indexed for MEDLINE]Related articles

[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function]

Porubsky S, Luckow B, Bonrouhi M, Speak A, Cerundolo V, Platt F, Gröne HJ.

Pathologe. 2008 Nov;29 Suppl 2:297-302. German. PMID: 18810447 [PubMed - indexed for MEDLINE]Related articles

Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Townson KH, Speak AO, Greenshields KN, Goodyear CS, Willison HJ, Platt FM.

J Neuroimmunol. 2008 Oct 15;203(1):33-8.PMID: 18684516 [PubMed - indexed for MEDLINE]Related articles

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.

Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA.

J Neurosci. 2008 Jul 2;28(27):6926-37.PMID: 18596167 [PubMed - indexed for MEDLINE]Related articlesFree article

CD1d presentation of glycolipids.

Speak AO, Cerundolo V, Platt FM.

Immunol Cell Biol. 2008 Oct;86(7):588-97. Epub 2008 Jun 10. Review.PMID: 18542099 [PubMed - indexed for MEDLINE]Related articles

Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.

van der Spoel AC, Mott R, Platt FM.

Pharmacogenomics. 2008 Jun;9(6):717-31. Review.PMID: 18518850 [PubMed - indexed for MEDLINE]Related articlesFree article

Substrate reduction therapy.

Platt FM, Jeyakumar M.

Acta Paediatr Suppl. 2008 Apr;97(457):88-93. Review.PMID: 18339196 [PubMed - indexed for MEDLINE]Related articles

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms.

Pymar LS, Platt FM, Askham JM, Morrison EE, Knowles MA.

Hum Mol Genet. 2008 Jul 1;17(13):2006-17. Epub 2008 Apr 7.PMID: 18397877 [PubMed - indexed for MEDLINE]Related articlesFree article

Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.

Elliot-Smith E, Speak AO, Lloyd-Evans E, Smith DA, van der Spoel AC, Jeyakumar M, Butters TD, Dwek RA, d'Azzo A, Platt FM.

Mol Genet Metab. 2008 Jun;94(2):204-11. Epub 2008 Apr 1.PMID: 18387328 [PubMed - indexed for MEDLINE]Related articles

Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.

Rabionet M, van der Spoel AC, Chuang CC, von Tümpling-Radosta B, Litjens M, Bouwmeester D, Hellbusch CC, Körner C, Wiegandt H, Gorgas K, Platt FM, Gröne HJ, Sandhoff R.

J Biol Chem. 2008 May 9;283(19):13357-69. Epub 2008 Feb 27.PMID: 18308723 [PubMed - indexed for MEDLINE]Related articlesFree article

N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice.

Baek RC, Kasperzyk JL, Platt FM, Seyfried TN.

Neurochem Int. 2008 May;52(6):1125-33. Epub 2007 Dec 8.PMID: 18207611 [PubMed - indexed for MEDLINE]Related articles

N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice.

Priestman DA, van der Spoel AC, Butters TD, Dwek RA, Platt FM.

Diabetes Obes Metab. 2008 Feb;10(2):159-66.PMID: 18190430 [PubMed - indexed for MEDLINE]Related articles

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.

Salio M, Speak AO, Shepherd D, Polzella P, Illarionov PA, Veerapen N, Besra GS, Platt FM, Cerundolo V.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20490-5. Epub 2007 Dec 11.PMID: 18077358 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

Hurst CD, Tomlinson DC, Williams SV, Platt FM, Knowles MA.

Oncogene. 2008 Apr 24;27(19):2716-27. Epub 2007 Nov 26.PMID: 18037967 [PubMed - indexed for MEDLINE]Related articlesFree article

The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport.

Wu AT, Sutovsky P, Xu W, van der Spoel AC, Platt FM, Oko R.

Dev Biol. 2007 Dec 15;312(2):471-83. Epub 2007 Sep 7.PMID: 17988661 [PubMed - indexed for MEDLINE]Related articles

Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids.

Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trottein F.

Immunity. 2007 Oct;27(4):597-609. Epub 2007 Oct 18.PMID: 17950005 [PubMed - indexed for MEDLINE]Related articles

Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.

Walden CM, Sandhoff R, Chuang CC, Yildiz Y, Butters TD, Dwek RA, Platt FM, van der Spoel AC.

J Biol Chem. 2007 Nov 9;282(45):32655-64. Epub 2007 Sep 11.PMID: 17848577 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.

D'Angelo G, Polishchuk E, Di Tullio G, Santoro M, Di Campli A, Godi A, West G, Bielawski J, Chuang CC, van der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA.

Nature. 2007 Sep 6;449(7158):62-7. Epub 2007 Aug 8.PMID: 17687330 [PubMed - indexed for MEDLINE]Related articles

Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.

Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA, Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley MA, Cerundolo V, Platt FM.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5971-6. Epub 2007 Mar 19.PMID: 17372214 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.

Porubsky S, Speak AO, Luckow B, Cerundolo V, Platt FM, Gröne HJ.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5977-82. Epub 2007 Mar 19.PMID: 17372206 [PubMed - indexed for MEDLINE]Related articlesFree article

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.

Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, Dwek RA, Schwartz P, Tong G, Wenger D, Lipton SA, Seyfried TN, Platt FM, Snyder EY.

Nat Med. 2007 Apr;13(4):439-47. Epub 2007 Mar 11.PMID: 17351625 [PubMed - indexed for MEDLINE]Related articles

Differences in physician and patient perceptions of uncomplicated UTI symptom severity: understanding the communication gap.

Platt FW, Keating KN.

Int J Clin Pract. 2007 Feb;61(2):303-8. Review.PMID: 17263717 [PubMed - indexed for MEDLINE]Related articles

The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study.

Bone W, Walden CM, Fritsch M, Voigtmann U, Leifke E, Gottwald U, Boomkamp S, Platt FM, van der Spoel AC.

Reprod Biol Endocrinol. 2007 Jan 22;5:1.PMID: 17241468 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment.

Heare T, Alp NJ, Priestman DA, Kulkarni AB, Qasba P, Butters TD, Dwek RA, Clarke K, Channon KM, Platt FM.

J Inherit Metab Dis. 2007 Feb;30(1):79-87. Epub 2006 Dec 25.PMID: 17189993 [PubMed - indexed for MEDLINE]Related articles

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.

Gadola SD, Silk JD, Jeans A, Illarionov PA, Salio M, Besra GS, Dwek R, Butters TD, Platt FM, Cerundolo V.

J Exp Med. 2006 Oct 2;203(10):2293-303. Epub 2006 Sep 18.PMID: 16982810 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycolipid receptor depletion as an approach to specific antimicrobial therapy.

Svensson M, Platt FM, Svanborg C.

FEMS Microbiol Lett. 2006 May;258(1):1-8. Review.PMID: 16630247 [PubMed - indexed for MEDLINE]Related articles

Disclosing errors and adverse events in the intensive care unit.

Boyle D, O'Connell D, Platt FW, Albert RK.

Crit Care Med. 2006 May;34(5):1532-7. Review.PMID: 16540948 [PubMed - indexed for MEDLINE]Related articles

Activation of invariant NKT cells by the helminth parasite schistosoma mansoni.

Mallevaey T, Zanetta JP, Faveeuw C, Fontaine J, Maes E, Platt F, Capron M, de-Moraes ML, Trottein F.

J Immunol. 2006 Feb 15;176(4):2476-85.PMID: 16456008 [PubMed - indexed for MEDLINE]Related articlesFree article

New developments in treating glycosphingolipid storage diseases.

Platt FM, Jeyakumar M, Andersson U, Dwek RA, Butters TD.

Adv Exp Med Biol. 2005;564:117-26. Review. No abstract available. PMID: 16400817 [PubMed - indexed for MEDLINE]Related articles

Glycosylation: disease targets and therapy.

Zitzmann N, Block T, Methta A, Rudd P, Burton D, Wilson I, Platt F, Butters T, Dwek RA.

Adv Exp Med Biol. 2005;564:1-2. No abstract available. PMID: 16400797 [PubMed - indexed for MEDLINE]Related articles

Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin.

Walden CM, Butters TD, Dwek RA, Platt FM, van der Spoel AC.

Hum Reprod. 2006 May;21(5):1309-15. Epub 2006 Jan 5.PMID: 16396932 [PubMed - indexed for MEDLINE]Related articlesFree article

The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.

Smith DC, Sillence DJ, Falguières T, Jarvis RM, Johannes L, Lord JM, Platt FM, Roberts LM.

Mol Biol Cell. 2006 Mar;17(3):1375-87. Epub 2005 Dec 28.PMID: 16381816 [PubMed - indexed for MEDLINE]Related articlesFree article

"What else?" Setting the agenda for the clinical interview.

Baker LH, O'connell D, Platt FW.

Ann Intern Med. 2005 Nov 15;143(10):766-70. No abstract available. PMID: 16287811 [PubMed - indexed for MEDLINE]Related articlesFree article

MRS reveals additional hexose N-acetyl resonances in the brain of a mouse model for Sandhoff disease.

Lowe JP, Stuckey DJ, Awan FR, Jeyakumar M, Neville DC, Platt FM, Griffin JL, Styles P, Blamire AM, Sibson NR.

NMR Biomed. 2005 Dec;18(8):517-26.PMID: 16206131 [PubMed - indexed for MEDLINE]Related articles

Discussing health care costs with patients: an opportunity for empathic communication.

Hardee JT, Platt FW, Kasper IK.

J Gen Intern Med. 2005 Jul;20(7):666-9.PMID: 16050867 [PubMed - indexed for MEDLINE]Related articlesFree article

Storage solutions: treating lysosomal disorders of the brain.

Jeyakumar M, Dwek RA, Butters TD, Platt FM.

Nat Rev Neurosci. 2005 Sep;6(9):713-25. Review.PMID: 16049428 [PubMed - indexed for MEDLINE]Related articles

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.

Butters TD, Dwek RA, Platt FM.

Glycobiology. 2005 Oct;15(10):43R-52R. Epub 2005 May 18. Review.PMID: 15901676 [PubMed - indexed for MEDLINE]Related articlesFree article

Talking about the unthinkable: perinatal/neonatal communication issues and procedures.

Fox S, Platt FW, White MK, Hulac P.

Clin Perinatol. 2005 Mar;32(1):157-70, vii-viii. Review.PMID: 15777827 [PubMed - indexed for MEDLINE]Related articles