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Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Keymeulen B, Decochez K, Weets I, De Block C, Féry F, Van de Velde U, Vermeulen I, De Pauw P, Mathieu C, Pipeleers DG, Gorus FK; The Belgian Diabetes Registry.

Diabetologia. 2009 Nov 7. [Epub ahead of print]PMID: 19898832 [PubMed - as supplied by publisher]Related articles

Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Gorus FK, Decochez K, Weets I, Keymeulen B, De Block C, Tits J, Pipeleers DG, Mathieu C; Belgian Diabetes Registry.

Diabetes Metab. 2009 Sep;35(4):319-27. Epub 2009 Jul 31.PMID: 19647467 [PubMed - in process]Related articles

Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.

Hilbrands R, Huurman VA, Gillard P, Velthuis JH, De Waele M, Mathieu C, Kaufman L, Pipeleers-Marichal M, Ling Z, Movahedi B, Jacobs-Tulleneers-Thevissen D, Monbaliu D, Ysebaert D, Gorus FK, Roep BO, Pipeleers DG, Keymeulen B.

Diabetes. 2009 Oct;58(10):2267-76. Epub 2009 Jul 14.PMID: 19602536 [PubMed - indexed for MEDLINE]Related articles

Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation.

Roelen DL, Huurman VA, Hilbrands R, Gillard P, Duinkerken G, van der Meer-Prins PW, Versteeg-van der Voort Maarschalk MF, Mathieu C, Keymeulen B, Pipeleers DG, Roep BO, Claas FH.

Clin Exp Immunol. 2009 Apr;156(1):141-8. Epub 2009 Jan 21.PMID: 19161445 [PubMed - indexed for MEDLINE]Related articles

Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation.

Huurman VA, Velthuis JH, Hilbrands R, Tree TI, Gillard P, van der Meer-Prins PM, Duinkerken G, Pinkse GG, Keymeulen B, Roelen DL, Claas FH, Pipeleers DG, Roep BO.

Am J Transplant. 2009 Feb;9(2):382-8. Epub 2008 Nov 27.PMID: 19067657 [PubMed - indexed for MEDLINE]Related articles

Simultaneous measurement of plasma concentrations of proinsulin and C-peptide and their ratio with a trefoil-type time-resolved fluorescence immunoassay.

De Pauw PE, Vermeulen I, Ubani OC, Truyen I, Vekens EM, van Genderen FT, De Grijse JW, Pipeleers DG, Van Schravendijk C, Gorus FK.

Clin Chem. 2008 Dec;54(12):1990-8. Epub 2008 Oct 9.PMID: 18845769 [PubMed - indexed for MEDLINE]Related articles

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.

Huurman VA, Hilbrands R, Pinkse GG, Gillard P, Duinkerken G, van de Linde P, van der Meer-Prins PM, Versteeg-van der Voort Maarschalk MF, Verbeeck K, Alizadeh BZ, Mathieu C, Gorus FK, Roelen DL, Claas FH, Keymeulen B, Pipeleers DG, Roep BO.

PLoS One. 2008 Jun 18;3(6):e2435.PMID: 18560516 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives.

Truyen I, De Grijse J, Van Schravendijk C, De Smet D, Decochez K, Vandemeulebroucke E, Giri M, Keymeulen B, Mathieu C, Van Gaal L, De Pauw P, Weets I, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2007 Oct;50(10):2143-6. Epub 2007 Aug 9.PMID: 17687539 [PubMed - indexed for MEDLINE]Related articles

The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey.

Weets I, Rooman R, Coeckelberghs M, De Block C, Van Gaal L, Kaufman JM, Keymeulen B, Mathieu C, Weber E, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Metab Res Rev. 2007 Nov;23(8):637-43.PMID: 17631647 [PubMed - indexed for MEDLINE]Related articles

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.

Truyen I, De Grijse J, Weets I, Kaufman L, Pipeleers L, Nanos N, Decochez K, Hilbrands R, Kaufman JM, Keymeulen B, Mathieu C, Van Gaal L, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Clin Exp Immunol. 2007 Aug;149(2):243-50. Epub 2007 May 22.PMID: 17521324 [PubMed - indexed for MEDLINE]Related articlesFree article

Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.

Rui M, Hampe CS, Wang C, Ling Z, Gorus FK, Lernmark A, Pipeleers DG, De Pauw PE.

J Immunol Methods. 2007 Jan 30;319(1-2):133-43. Epub 2006 Dec 14.PMID: 17210161 [PubMed - indexed for MEDLINE]Related articles

Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.

Weets I, Truyen I, Verschraegen I, Van der Auwera B, De Schepper J, Dorchy H, Lebrethon MC, Van Gaal L, Van Rooy P, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2006 Jun;49(6):1158-62. Epub 2006 Mar 29.PMID: 16570164 [PubMed - indexed for MEDLINE]Related articles

Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.

Truyen I, De Pauw P, Jørgensen PN, Van Schravendijk C, Ubani O, Decochez K, Vandemeulebroucke E, Weets I, Mao R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Nov;48(11):2322-9. Epub 2005 Oct 7.PMID: 16211374 [PubMed - indexed for MEDLINE]Related articles

Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients.

van Kampen CA, van de Linde P, Duinkerken G, van Schip JJ, Roelen DL, Keymeulen B, Pipeleers DG, Claas FH, Roep BO.

Transplantation. 2005 Jul 15;80(1):118-26.PMID: 16003242 [PubMed - indexed for MEDLINE]Related articles

HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors.

Bouwman LH, Ling Z, Duinkerken G, Pipeleers DG, Roep BO.

Hum Immunol. 2005 May;66(5):494-500. Epub 2005 Feb 26.PMID: 15935886 [PubMed - indexed for MEDLINE]Related articles

Heterogeneity in distribution of amyloid-positive islets in type-2 diabetic patients.

Borromeo CM, Pottier X, In't Veld PA, Pipeleers-Marichal MA, Kaufman L, Pipeleers DG, Van Schravendijk CF.

Virchows Arch. 2005 Mar;446(3):232-8. Epub 2005 Jan 27.PMID: 15791482 [PubMed - indexed for MEDLINE]Related articles

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes.

Decochez K, Truyen I, van der Auwera B, Weets I, Vandemeulebroucke E, de Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Apr;48(4):687-94. Epub 2005 Mar 9.PMID: 15756536 [PubMed - indexed for MEDLINE]Related articles

EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.

Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H.

Lab Invest. 2005 Jan;85(1):65-74.PMID: 15543206 [PubMed - indexed for MEDLINE]Related articlesFree article

Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.

Weets I, Kaufman L, Van der Auwera B, Crenier L, Rooman RP, De Block C, Casteels K, Weber E, Coeckelberghs M, Laron Z, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2004 Apr;47(4):614-21.PMID: 15298337 [PubMed - indexed for MEDLINE]Related articles

Epidemiology of type 1 and type 2 diabetes. The added value of diabetes registries for conducting clinical studies: the Belgian paradigm.

Gorus FK, Weets I, Couck P, Pipeleers DG; Belgian Diabetes Registry.

Acta Clin Belg. 2004 Jan-Feb;59(1):1-13. Review.PMID: 15065690 [PubMed - indexed for MEDLINE]Related articles

IA-2 autoantibodies predict impending type I diabetes in siblings of patients.

Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2002 Dec;45(12):1658-66. Epub 2002 Nov 12.PMID: 12488955 [PubMed - indexed for MEDLINE]Related articles

Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.

Löbner K, Steinbrenner H, Roberts GA, Ling Z, Huang GC, Piquer S, Pipeleers DG, Seissler J, Christie MR.

Diabetes. 2002 Oct;51(10):2982-8.PMID: 12351437 [PubMed - indexed for MEDLINE]Related articlesFree article

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.

Cnop M, Hannaert JC, Grupping AY, Pipeleers DG.

Endocrinology. 2002 Sep;143(9):3449-53.PMID: 12193557 [PubMed - indexed for MEDLINE]Related articlesFree article

The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.

Weets I, De Leeuw IH, Du Caju MV, Rooman R, Keymeulen B, Mathieu C, Rottiers R, Daubresse JC, Rocour-Brumioul D, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2002 May;25(5):840-6.PMID: 11978678 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.

Cnop M, Hannaert JC, Pipeleers DG.

Biochem Pharmacol. 2002 Apr 1;63(7):1281-5.PMID: 11960604 [PubMed - indexed for MEDLINE]Related articles

To: T.J. Wilkin (2001) The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44: 914-921.

Gorus FK, Weets I, Pipeleers DG.

Diabetologia. 2002 Feb;45(2):288-9; author reply 289. No abstract available. PMID: 11942314 [PubMed - indexed for MEDLINE]Related articles

Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.

Van de Casteele M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG.

Endocrinology. 2002 Jan;143(1):320-6.PMID: 11751624 [PubMed - indexed for MEDLINE]Related articlesFree article

Prospects for predicting and stopping the development of type 1 of diabetes.

Gorus FK, Pipeleers DG; Belgian Diabetes Registry.

Best Pract Res Clin Endocrinol Metab. 2001 Sep;15(3):371-89. Review.PMID: 11554777 [PubMed - indexed for MEDLINE]Related articles

Radioimmunoassay for glutamic acid decarboxylase-65.

Hao W, Daniels T, Pipeleers DG, Smismans A, Reijonen H, Nepom GT, Lernmark A.

Diabetes Technol Ther. 1999 Spring;1(1):13-20.PMID: 11475299 [PubMed - indexed for MEDLINE]Related articles

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG.

Diabetes. 2001 Aug;50(8):1771-7.PMID: 11473037 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice.

Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC.

Virchows Arch. 2001 Apr;438(4):382-7.PMID: 11355173 [PubMed - indexed for MEDLINE]Related articles

Inhibition of human pancreatic islet insulin release by receptor-selective somatostatin analogs directed to somatostatin receptor subtype 5.

Zambre Y, Ling Z, Chen MC, Hou X, Woon CW, Culler M, Taylor JE, Coy DH, Van Schravendijk C, Schuit F, Pipeleers DG, Eizirik DL.

Biochem Pharmacol. 1999 May 15;57(10):1159-64.PMID: 11230804 [PubMed - indexed for MEDLINE]Related articles

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.

Schuit FC, Huypens P, Heimberg H, Pipeleers DG.

Diabetes. 2001 Jan;50(1):1-11. Review.PMID: 11147773 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute onset of type I diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways.

Vreugdenhil GR, Schloot NC, Hoorens A, Rongen C, Pipeleers DG, Melchers WJ, Roep BO, Galama JM.

Clin Infect Dis. 2000 Oct;31(4):1025-31. Epub 2000 Oct 25.PMID: 11049787 [PubMed - indexed for MEDLINE]Related articles

Use of an islet cell antibody assay to identify type 1 diabetic patients with rapid decrease in C-peptide levels after clinical onset. Belgian Diabetes Registry.

Decochez K, Keymeulen B, Somers G, Dorchy H, De Leeuw IH, Mathieu C, Rottiers R, Winnock F, ver Elst K, Weets I, Kaufman L, Pipeleers DG, Rottiers R; Belgian Diabetes Registry.

Diabetes Care. 2000 Aug;23(8):1072-8.PMID: 10937500 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

Ling Z, Van de Casteele M, Eizirik DL, Pipeleers DG.

Diabetes. 2000 Mar;49(3):340-5.PMID: 10868954 [PubMed - indexed for MEDLINE]Related articlesFree article

High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry.

Decochez K, Tits J, Coolens JL, Van Gaal L, Krzentowski G, Winnock F, Anckaert E, Weets I, Pipeleers DG, Gorus FK.

Diabetes Care. 2000 Jun;23(6):838-44.PMID: 10841006 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-1beta induces ornithine decarboxylase activity in insulin-producing cells.

Smismans A, Eizirik DL, Pipeleers DG.

Cytokine. 2000 Jan;12(1):49-54.PMID: 10623442 [PubMed - indexed for MEDLINE]Related articles

IL-1beta induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic beta-cells. Detection by differential display of messenger RNA.

Chen MC, Schuit F, Pipeleers DG, Eizirik DL.

Cytokine. 1999 Nov;11(11):856-62.PMID: 10547273 [PubMed - indexed for MEDLINE]Related articles

Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.

Hostens K, Pavlovic D, Zambre Y, Ling Z, Van Schravendijk C, Eizirik DL, Pipeleers DG.

J Clin Invest. 1999 Jul;104(1):67-72.PMID: 10393700 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells.

Flodström M, Chen MC, Smismans A, Schuit F, Pipeleers DG, Eizirik DL.

Cytokine. 1999 Jun;11(6):400-7.PMID: 10346979 [PubMed - indexed for MEDLINE]Related articles

Extra-insular beta cells associated with ductules are frequent in adult human pancreas.

Bouwens L, Pipeleers DG.

Diabetologia. 1998 Jun;41(6):629-33.PMID: 9662042 [PubMed - indexed for MEDLINE]Related articles

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft.

Keymeulen B, Ling Z, Gorus FK, Delvaux G, Bouwens L, Grupping A, Hendrieckx C, Pipeleers-Marichal M, Van Schravendijk C, Salmela K, Pipeleers DG.

Diabetologia. 1998 Apr;41(4):452-9.PMID: 9562350 [PubMed - indexed for MEDLINE]Related articles

Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells.

Ling Z, Chen MC, Smismans A, Pavlovic D, Schuit F, Eizirik DL, Pipeleers DG.

Endocrinology. 1998 Apr;139(4):1540-5.PMID: 9528932 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased prevalence of abnormal immunoglobulin M, G, and A concentrations at clinical onset of insulin-dependent diabetes mellitus: a registry-based study. The Belgian Diabetes Registry.

Gorus FK, Vandewalle CL, Winnock F, Lebleu F, Keymeulen B, Van der Auwera B, Falorni A, Dorchy H, Féry F, Pipeleers DG.

Pancreas. 1998 Jan;16(1):50-9.PMID: 9436863 [PubMed - indexed for MEDLINE]Related articles

Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells.

Lefebvre VH, Otonkoski T, Ustinov J, Huotari MA, Pipeleers DG, Bouwens L.

Diabetes. 1998 Jan;47(1):134-7.PMID: 9421388 [PubMed - indexed for MEDLINE]Related articles

Low density lipoprotein binding and uptake by human and rat islet beta cells.

Grupping AY, Cnop M, Van Schravendijk CF, Hannaert JC, Van Berkel TJ, Pipeleers DG.

Endocrinology. 1997 Oct;138(10):4064-8.PMID: 9322913 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry.

Vandewalle CL, Coeckelberghs MI, De Leeuw IH, Du Caju MV, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1556-61.PMID: 9314635 [PubMed - indexed for MEDLINE]Related articles

Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.

Vandewalle CL, Falorni A, Lernmark A, Goubert P, Dorchy H, Coucke W, Semakula C, Van der Auwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1547-52.PMID: 9314633 [PubMed - indexed for MEDLINE]Related articles

Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets.

Sandler S, Andersson A, Eizirik DL, Hellerström C, Espevik T, Kulseng B, Thu B, Pipeleers DG, Skjåk-Braek G.

Transplantation. 1997 Jun 27;63(12):1712-8.PMID: 9210493 [PubMed - indexed for MEDLINE]Related articles