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Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Keymeulen B, Decochez K, Weets I, De Block C, Féry F, Van de Velde U, Vermeulen I, De Pauw P, Mathieu C, Pipeleers DG, Gorus FK; The Belgian Diabetes Registry.

Diabetologia. 2009 Nov 7. [Epub ahead of print]PMID: 19898832 [PubMed - as supplied by publisher]Related articles

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.

Hellemans KH, Hannaert JC, Denys B, Steffensen KR, Raemdonck C, Martens GA, Van Veldhoven PP, Gustafsson JA, Pipeleers D.

PLoS One. 2009 Sep 29;4(9):e7266.PMID: 19787047 [PubMed - in process]Related articlesFree article

Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Gorus FK, Decochez K, Weets I, Keymeulen B, De Block C, Tits J, Pipeleers DG, Mathieu C; Belgian Diabetes Registry.

Diabetes Metab. 2009 Sep;35(4):319-27. Epub 2009 Jul 31.PMID: 19647467 [PubMed - in process]Related articles

Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.

Hilbrands R, Huurman VA, Gillard P, Velthuis JH, De Waele M, Mathieu C, Kaufman L, Pipeleers-Marichal M, Ling Z, Movahedi B, Jacobs-Tulleneers-Thevissen D, Monbaliu D, Ysebaert D, Gorus FK, Roep BO, Pipeleers DG, Keymeulen B.

Diabetes. 2009 Oct;58(10):2267-76. Epub 2009 Jul 14.PMID: 19602536 [PubMed - indexed for MEDLINE]Related articles

Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic Islet cell recipients with pretransplant TPO autoantibodies.

Gillard P, Huurman V, Van der Auwera B, Decallonne B, Poppe K, Roep BO, Gorus F, Mathieu C, Pipeleers D, Keymeulen B.

Diabetes Care. 2009 Oct;32(10):1817-9. Epub 2009 Jun 23.PMID: 19549735 [PubMed - in process]Related articles

Glucose, regulator of survival and phenotype of pancreatic beta cells.

Martens GA, Pipeleers D.

Vitam Horm. 2009;80:507-39. Review.PMID: 19251048 [PubMed - indexed for MEDLINE]Related articles

The beta cell population in type 1 diabetes.

Pipeleers D, In't Veld P, Pipeleers-Marichal M, Gorus F.

Novartis Found Symp. 2008;292:19-24; discussion 24-31, 122-9, 202-3.PMID: 19203090 [PubMed - indexed for MEDLINE]Related articles

Functional beta-cell mass and insulin sensitivity is decreased in insulin-independent pancreas-kidney recipients.

Gillard P, Vandemeulebroucke E, Keymeulen B, Pirenne J, Maes B, De Pauw P, Vanrenterghem Y, Pipeleers D, Mathieu C.

Transplantation. 2009 Feb 15;87(3):402-7.PMID: 19202446 [PubMed - indexed for MEDLINE]Related articles

Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation.

Roelen DL, Huurman VA, Hilbrands R, Gillard P, Duinkerken G, van der Meer-Prins PW, Versteeg-van der Voort Maarschalk MF, Mathieu C, Keymeulen B, Pipeleers DG, Roep BO, Claas FH.

Clin Exp Immunol. 2009 Apr;156(1):141-8. Epub 2009 Jan 21.PMID: 19161445 [PubMed - indexed for MEDLINE]Related articles

Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation.

Huurman VA, Velthuis JH, Hilbrands R, Tree TI, Gillard P, van der Meer-Prins PM, Duinkerken G, Pinkse GG, Keymeulen B, Roelen DL, Claas FH, Pipeleers DG, Roep BO.

Am J Transplant. 2009 Feb;9(2):382-8. Epub 2008 Nov 27.PMID: 19067657 [PubMed - indexed for MEDLINE]Related articles

Restoring a functional beta-cell mass in diabetes.

Pipeleers D, Chintinne M, Denys B, Martens G, Keymeulen B, Gorus F.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:54-62. Review.PMID: 18834433 [PubMed - indexed for MEDLINE]Related articles

Simultaneous measurement of plasma concentrations of proinsulin and C-peptide and their ratio with a trefoil-type time-resolved fluorescence immunoassay.

De Pauw PE, Vermeulen I, Ubani OC, Truyen I, Vekens EM, van Genderen FT, De Grijse JW, Pipeleers DG, Van Schravendijk C, Gorus FK.

Clin Chem. 2008 Dec;54(12):1990-8. Epub 2008 Oct 9.PMID: 18845769 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. Epub 2008 Aug 21.PMID: 18719127 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS.

Pancreas. 2009 Jan;38(1):36-48.PMID: 18665014 [PubMed - indexed for MEDLINE]Related articles

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.

El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D, van Obberghen E.

Diabetes. 2008 Oct;57(10):2708-17. Epub 2008 Jun 30.PMID: 18591395 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.

Huurman VA, Hilbrands R, Pinkse GG, Gillard P, Duinkerken G, van de Linde P, van der Meer-Prins PM, Versteeg-van der Voort Maarschalk MF, Verbeeck K, Alizadeh BZ, Mathieu C, Gorus FK, Roelen DL, Claas FH, Keymeulen B, Pipeleers DG, Roep BO.

PLoS One. 2008 Jun 18;3(6):e2435.PMID: 18560516 [PubMed - indexed for MEDLINE]Related articlesFree article

Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways.

Wang Q, Heimberg H, Pipeleers D, Ling Z.

Diabetologia. 2008 Jul;51(7):1202-12. Epub 2008 May 21.PMID: 18493739 [PubMed - indexed for MEDLINE]Related articles

Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor.

Movahedi B, Gysemans C, Jacobs-Tulleneers-Thevissen D, Mathieu C, Pipeleers D.

Diabetes. 2008 Aug;57(8):2128-36. Epub 2008 May 20.PMID: 18492788 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.

Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M.

Biochem Pharmacol. 2008 May 15;75(10):1981-93. Epub 2008 Feb 26.PMID: 18377870 [PubMed - indexed for MEDLINE]Related articles

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H.

Cell. 2008 Jan 25;132(2):197-207.PMID: 18243096 [PubMed - indexed for MEDLINE]Related articles

Comparison of sirolimus alone with sirolimus plus tacrolimus in type 1 diabetic recipients of cultured islet cell grafts.

Gillard P, Ling Z, Mathieu C, Crenier L, Lannoo M, Maes B, Roep B, Gorus F, Pipeleers D, Keymeulen B.

Transplantation. 2008 Jan 27;85(2):256-63.PMID: 18212631 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.

Hellemans K, Kerckhofs K, Hannaert JC, Martens G, Van Veldhoven P, Pipeleers D.

FEBS J. 2007 Dec;274(23):6094-105. Epub 2007 Oct 26.PMID: 17970749 [PubMed - indexed for MEDLINE]Related articles

Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives.

Truyen I, De Grijse J, Van Schravendijk C, De Smet D, Decochez K, Vandemeulebroucke E, Giri M, Keymeulen B, Mathieu C, Van Gaal L, De Pauw P, Weets I, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2007 Oct;50(10):2143-6. Epub 2007 Aug 9.PMID: 17687539 [PubMed - indexed for MEDLINE]Related articles

The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey.

Weets I, Rooman R, Coeckelberghs M, De Block C, Van Gaal L, Kaufman JM, Keymeulen B, Mathieu C, Weber E, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Metab Res Rev. 2007 Nov;23(8):637-43.PMID: 17631647 [PubMed - indexed for MEDLINE]Related articles

Screening for insulitis in adult autoantibody-positive organ donors.

In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, Gorus F, Pipeleers D.

Diabetes. 2007 Sep;56(9):2400-4. Epub 2007 Jun 11.PMID: 17563060 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.

Truyen I, De Grijse J, Weets I, Kaufman L, Pipeleers L, Nanos N, Decochez K, Hilbrands R, Kaufman JM, Keymeulen B, Mathieu C, Van Gaal L, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Clin Exp Immunol. 2007 Aug;149(2):243-50. Epub 2007 May 22.PMID: 17521324 [PubMed - indexed for MEDLINE]Related articlesFree article

Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release.

Martens GA, Vervoort A, Van de Casteele M, Stangé G, Hellemans K, Van Thi HV, Schuit F, Pipeleers D.

J Biol Chem. 2007 Jul 20;282(29):21134-44. Epub 2007 May 9.PMID: 17491019 [PubMed - indexed for MEDLINE]Related articlesFree article

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.

Br J Pharmacol. 2007 Apr;150(8):1031-43. Epub 2007 Mar 5.PMID: 17339833 [PubMed - indexed for MEDLINE]Related articlesFree article

Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.

Rui M, Hampe CS, Wang C, Ling Z, Gorus FK, Lernmark A, Pipeleers DG, De Pauw PE.

J Immunol Methods. 2007 Jan 30;319(1-2):133-43. Epub 2006 Dec 14.PMID: 17210161 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase.

Wang C, Mao R, Van de Casteele M, Pipeleers D, Ling Z.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1201-6. Epub 2006 Dec 26.PMID: 17190904 [PubMed - indexed for MEDLINE]Related articlesFree article

N-Acetylcysteine derivative inhibits procoagulant activity of human islet cells.

Beuneu C, Vosters O, Ling Z, Pipeleers D, Pradier O, Goldman M, Verhasselt V.

Diabetologia. 2007 Feb;50(2):343-7. Epub 2006 Dec 20.PMID: 17180665 [PubMed - indexed for MEDLINE]Related articles

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M.

Free Radic Biol Med. 2007 Jan 1;42(1):64-78. Epub 2006 Sep 27.PMID: 17157194 [PubMed - indexed for MEDLINE]Related articles

Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations.

Van Lommel L, Janssens K, Quintens R, Tsukamoto K, Vander Mierde D, Lemaire K, Denef C, Jonas JC, Martens G, Pipeleers D, Schuit FC.

Diabetes. 2006 Dec;55(12):3214-20.PMID: 17130463 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft.

Keymeulen B, Gillard P, Mathieu C, Movahedi B, Maleux G, Delvaux G, Ysebaert D, Roep B, Vandemeulebroucke E, Marichal M, In 't Veld P, Bogdani M, Hendrieckx C, Gorus F, Ling Z, van Rood J, Pipeleers D.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17444-9. Epub 2006 Nov 7.PMID: 17090674 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress.

Yusta B, Baggio LL, Estall JL, Koehler JA, Holland DP, Li H, Pipeleers D, Ling Z, Drucker DJ.

Cell Metab. 2006 Nov;4(5):391-406.PMID: 17084712 [PubMed - indexed for MEDLINE]Related articles

Xenotransplantation of purified pre-natal porcine beta cells in mice normalizes diabetes when a short anti-CD4-CD8 antibody treatment is combined with transient insulin injections.

Veld PI, Pavlovic D, Bogdani M, Pipeleers-Marichal M, Pipeleers D.

Xenotransplantation. 2006 Sep;13(5):415-22.PMID: 16925665 [PubMed - indexed for MEDLINE]Related articles

Metabolic activation of glucose low-responsive beta-cells by glyceraldehyde correlates with their biosynthetic activation in lower glucose concentration range but not at high glucose.

Martens GA, Wang Q, Kerckhofs K, Stangé G, Ling Z, Pipeleers D.

Endocrinology. 2006 Nov;147(11):5196-204. Epub 2006 Aug 17.PMID: 16916947 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.

Weets I, Truyen I, Verschraegen I, Van der Auwera B, De Schepper J, Dorchy H, Lebrethon MC, Van Gaal L, Van Rooy P, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2006 Jun;49(6):1158-62. Epub 2006 Mar 29.PMID: 16570164 [PubMed - indexed for MEDLINE]Related articles

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H.

EMBO J. 2006 Mar 22;25(6):1344-52. Epub 2006 Mar 2.PMID: 16511571 [PubMed - indexed for MEDLINE]Related articlesFree article

Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity.

Ling Z, Wang Q, Stangé G, In't Veld P, Pipeleers D.

Diabetes. 2006 Jan;55(1):78-85.PMID: 16380479 [PubMed - indexed for MEDLINE]Related articlesFree article

Feasibility, safety, and efficacy of percutaneous transhepatic injection of beta-cell grafts.

Maleux G, Gillard P, Keymeulen B, Pipeleers D, Ling Z, Heye S, Thijs M, Mathieu C, Marchal G.

J Vasc Interv Radiol. 2005 Dec;16(12):1693-7.PMID: 16371537 [PubMed - indexed for MEDLINE]Related articles

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.

Pinkse GG, Tysma OH, Bergen CA, Kester MG, Ossendorp F, van Veelen PA, Keymeulen B, Pipeleers D, Drijfhout JW, Roep BO.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18425-30. Epub 2005 Dec 9.PMID: 16339897 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth and functional maturation of beta-cells in implants of endocrine cells purified from prenatal porcine pancreas.

Bogdani M, Suenens K, Bock T, Pipeleers-Marichal M, In't Veld P, Pipeleers D.

Diabetes. 2005 Dec;54(12):3387-94.PMID: 16306353 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose inhibits GABA release by pancreatic beta-cells through an increase in GABA shunt activity.

Wang C, Kerckhofs K, Van de Casteele M, Smolders I, Pipeleers D, Ling Z.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E494-9. Epub 2005 Oct 25.PMID: 16249254 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.

Truyen I, De Pauw P, Jørgensen PN, Van Schravendijk C, Ubani O, Decochez K, Vandemeulebroucke E, Weets I, Mao R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Nov;48(11):2322-9. Epub 2005 Oct 7.PMID: 16211374 [PubMed - indexed for MEDLINE]Related articles

Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.

Huypens P, Quartier E, Pipeleers D, Van de Casteele M.

Eur J Pharmacol. 2005 Aug 22;518(2-3):90-5.PMID: 16039647 [PubMed - indexed for MEDLINE]Related articles

Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients.

van Kampen CA, van de Linde P, Duinkerken G, van Schip JJ, Roelen DL, Keymeulen B, Pipeleers DG, Claas FH, Roep BO.

Transplantation. 2005 Jul 15;80(1):118-26.PMID: 16003242 [PubMed - indexed for MEDLINE]Related articles

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L.

N Engl J Med. 2005 Jun 23;352(25):2598-608.PMID: 15972866 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors.

Bouwman LH, Ling Z, Duinkerken G, Pipeleers DG, Roep BO.

Hum Immunol. 2005 May;66(5):494-500. Epub 2005 Feb 26.PMID: 15935886 [PubMed - indexed for MEDLINE]Related articles

Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.

Huypens P, Moens K, Heimberg H, Ling Z, Pipeleers D, Van de Casteele M.

Life Sci. 2005 Jul 29;77(11):1273-82.PMID: 15893773 [PubMed - indexed for MEDLINE]Related articles