PubMed

A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.

Dean EJ, Ward T, Pinilla C, Houghten R, Welsh K, Makin G, Ranson M, Dive C.

Br J Cancer. 2009 Nov 10. [Epub ahead of print]PMID: 19904270 [PubMed - as supplied by publisher]Related articles

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.

Carter BZ, Mak DH, Schober WD, Koller E, Pinilla C, Vassilev LT, Reed JC, Andreeff M.

Blood. 2009 Nov 6. [Epub ahead of print]PMID: 19897582 [PubMed - as supplied by publisher]Related articles

[Mortality by avoidable causes in preschool children]

Lurán A, López E, Pinilla C, Sierra P.

Biomedica. 2009 Mar;29(1):98-107. Spanish. PMID: 19753843 [PubMed - indexed for MEDLINE]Related articles

Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs.

Medina-Franco JL, Martínez-Mayorga K, Bender A, Marín RM, Giulianotti MA, Pinilla C, Houghten RA.

J Chem Inf Model. 2009 Feb;49(2):477-91.PMID: 19434846 [PubMed - indexed for MEDLINE]Related articles

Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.

Singh N, Guha R, Giulianotti MA, Pinilla C, Houghten RA, Medina-Franco JL.

J Chem Inf Model. 2009 Apr;49(4):1010-24.PMID: 19301827 [PubMed - indexed for MEDLINE]Related articles

Characterization of Activity Landscapes Using 2D and 3D Similarity Methods: Consensus Activity Cliffs.

Medina-Franco JL, Martínez-Mayorga K, Bender A, Marín RM, Giulianotti MA, Pinilla C, Houghten RA.

J Chem Inf Model. 2009 Jan 30. [Epub ahead of print]PMID: 19182859 [PubMed - as supplied by publisher]Related articles

Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation.

Hammarlund E, Dasgupta A, Pinilla C, Norori P, Früh K, Slifka MK.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14567-72. Epub 2008 Sep 16.PMID: 18796610 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor.

Voelter V, Rufer N, Reynard S, Greub G, Brookes R, Guillaume P, Grosjean F, Fagerberg T, Michelin O, Rowland-Jones S, Pinilla C, Leyvraz S, Romero P, Appay V.

Int Immunol. 2008 Aug;20(8):1087-96. Epub 2008 Jun 23.PMID: 18573812 [PubMed - indexed for MEDLINE]Related articles

Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands.

Muixí L, Carrascal M, Alvarez I, Daura X, Martí M, Armengol MP, Pinilla C, Abian J, Pujol-Borrell R, Jaraquemada D.

J Immunol. 2008 Jul 1;181(1):795-807.PMID: 18566446 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.

Martínez-Mayorga K, Medina-Franco JL, Giulianotti MA, Pinilla C, Dooley CT, Appel JR, Houghten RA.

Bioorg Med Chem. 2008 Jun 1;16(11):5932-8. Epub 2008 Apr 27.PMID: 18468907 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.

Pinilla C, Appel JR, Houghten RA.

Curr Protoc Immunol. 2001 Nov;Chapter 9:Unit 9.5.PMID: 18432860 [PubMed - indexed for MEDLINE]Related articles

Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis.

Zhang X, Tang Y, Sujkowska D, Wang J, Ramgolam V, Sospedra M, Adams J, Martin R, Pinilla C, Markovic-Plese S.

Eur J Immunol. 2008 May;38(5):1297-309.PMID: 18412170 [PubMed - indexed for MEDLINE]Related articles

Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries.

Sidney J, Assarsson E, Moore C, Ngo S, Pinilla C, Sette A, Peters B.

Immunome Res. 2008 Jan 25;4:2.PMID: 18221540 [PubMed - in process]Related articlesFree article

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, Reed JC, Andreeff M.

Blood. 2008 Apr 1;111(7):3742-50. Epub 2008 Jan 10.PMID: 18187663 [PubMed - indexed for MEDLINE]Related articlesFree article

Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.

Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, Brunner D, Schneider J.

J Comb Chem. 2008 Jan-Feb;10(1):3-19. Epub 2007 Dec 8. No abstract available. PMID: 18067268 [PubMed - indexed for MEDLINE]Related articles

Clusters, liquids, and crystals of dialkyimidazolium salts. A combined perspective from ab initio and classical computer simulations.

Del Pópolo MG, Kohanoff J, Lynden-Bell RM, Pinilla C.

Acc Chem Res. 2007 Nov;40(11):1156-64. Epub 2007 Nov 3. Review.PMID: 17979251 [PubMed - indexed for MEDLINE]Related articles

A similarity-based data-fusion approach to the visual characterization and comparison of compound databases.

Medina-Franco JL, Maggiora GM, Giulianotti MA, Pinilla C, Houghten RA.

Chem Biol Drug Des. 2007 Nov;70(5):393-412. Epub 2007 Oct 10.PMID: 17927720 [PubMed - indexed for MEDLINE]Related articles

Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.

Cillessen SA, Reed JC, Welsh K, Pinilla C, Houghten R, Hooijberg E, Deurhof J, Castricum KC, Kortman P, Hess CJ, Ossenkoppele GJ, Meijer CJ, Oudejans JJ.

Blood. 2008 Jan 1;111(1):369-75. Epub 2007 Oct 4.PMID: 17916749 [PubMed - indexed for MEDLINE]Related articlesFree article

Simulations of ionic liquids, solutions, and surfaces.

Lynden-Bell RM, Del Pópolo MG, Youngs TG, Kohanoff J, Hanke CG, Harper JB, Pinilla CC.

Acc Chem Res. 2007 Nov;40(11):1138-45. Epub 2007 Oct 4. Review.PMID: 17914887 [PubMed - indexed for MEDLINE]Related articles

Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library.

Sidney J, Peters B, Moore C, Pencille TJ, Ngo S, Masterman KA, Asabe S, Pinilla C, Chisari FV, Sette A.

Immunogenetics. 2007 Sep;59(9):745-51. Epub 2007 Aug 16.PMID: 17701407 [PubMed - indexed for MEDLINE]Related articles

Local and semilocal density functional computations for crystals of 1-alkyl-3-methyl-imidazolium salts.

Del Pópolo MG, Pinilla C, Ballone P.

J Chem Phys. 2007 Apr 14;126(14):144705.PMID: 17444730 [PubMed]Related articles

Polyspecificity of T cell and B cell receptor recognition.

Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE.

Semin Immunol. 2007 Aug;19(4):216-24. Epub 2007 Mar 29. Review.PMID: 17398114 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutral and charged 1-butyl-3-methylimidazolium triflate clusters: equilibrium concentration in the vapor phase and thermal properties of nanometric droplets.

Ballone P, Pinilla C, Kohanoff J, Del Pópolo MG.

J Phys Chem B. 2007 May 10;111(18):4938-50. Epub 2007 Feb 27.PMID: 17388428 [PubMed]Related articles

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein.

Karikari CA, Roy I, Tryggestad E, Feldmann G, Pinilla C, Welsh K, Reed JC, Armour EP, Wong J, Herman J, Rakheja D, Maitra A.

Mol Cancer Ther. 2007 Mar;6(3):957-66. Epub 2007 Mar 5.PMID: 17339366 [PubMed - indexed for MEDLINE]Related articlesFree article

Polarization relaxation in an ionic liquid confined between electrified walls.

Pinilla C, Del Pópolo MG, Kohanoff J, Lynden-Bell RM.

J Phys Chem B. 2007 May 10;111(18):4877-84. Epub 2007 Feb 13.PMID: 17295537 [PubMed]Related articles

Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools.

Greenbaum JA, Andersen PH, Blythe M, Bui HH, Cachau RE, Crowe J, Davies M, Kolaskar AS, Lund O, Morrison S, Mumey B, Ofran Y, Pellequer JL, Pinilla C, Ponomarenko JV, Raghava GP, van Regenmortel MH, Roggen EL, Sette A, Schlessinger A, Sollner J, Zand M, Peters B.

J Mol Recognit. 2007 Mar-Apr;20(2):75-82. Review.PMID: 17205610 [PubMed - indexed for MEDLINE]Related articles

Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis.

Lünemann JD, Gelderblom H, Sospedra M, Quandt JA, Pinilla C, Marques A, Martin R.

Infect Immun. 2007 Jan;75(1):243-51. Epub 2006 Oct 23.PMID: 17060473 [PubMed - indexed for MEDLINE]Related articlesFree article

New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases.

Fujimoto DF, Pinilla C, Segall AM.

J Mol Biol. 2006 Nov 10;363(5):891-907. Epub 2006 Aug 24.PMID: 16996084 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis of platinum(II) chiral tetraamine coordination complexes.

Nefzi A, Hoesl CE, Pinilla C, Kauffman GB, Maggiora GM, Pasquale E, Houghten RA.

J Comb Chem. 2006 Sep-Oct;8(5):780-3.PMID: 16961414 [PubMed - indexed for MEDLINE]Related articles

Structure and dynamics of a confined ionic liquid. Topics of relevance to dye-sensitized solar cells.

Pinilla C, Del Pópolo MG, Lynden-Bell RM, Kohanoff J.

J Phys Chem B. 2005 Sep 29;109(38):17922-7.PMID: 16853300 [PubMed]Related articles

Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide.

Appay V, Speiser DE, Rufer N, Reynard S, Barbey C, Cerottini JC, Leyvraz S, Pinilla C, Romero P.

Eur J Immunol. 2006 Jul;36(7):1805-14.PMID: 16761313 [PubMed - indexed for MEDLINE]Related articles

Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.

Sospedra M, Muraro PA, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R.

J Immunol. 2006 Feb 1;176(3):1951-61.PMID: 16424227 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of cross-reactive peptides using combinatorial libraries circumvents tolerance against Her-2/neu-immunodominant epitope.

Lustgarten J, Dominguez AL, Pinilla C.

J Immunol. 2006 Feb 1;176(3):1796-805.PMID: 16424210 [PubMed - indexed for MEDLINE]Related articlesFree article

Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity.

Sospedra M, Zhao Y, zur Hausen H, Muraro PA, Hamashin C, de Villiers EM, Pinilla C, Martin R.

PLoS Pathog. 2005 Dec;1(4):e41. Epub 2005 Dec 16.PMID: 16362076 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone.

Venturini S, Allicotti G, Zhao Y, Simon R, Burton DR, Pinilla C, Poignard P.

Eur J Immunol. 2006 Jan;36(1):27-36.PMID: 16323241 [PubMed - indexed for MEDLINE]Related articles

High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: implications for the initiation of autoimmune response in multiple sclerosis.

Markovic-Plese S, Hemmer B, Zhao Y, Simon R, Pinilla C, Martin R.

J Neuroimmunol. 2005 Dec;169(1-2):31-8. Epub 2005 Sep 15.PMID: 16150497 [PubMed - indexed for MEDLINE]Related articles

How the T cell repertoire becomes peptide and MHC specific.

Huseby ES, White J, Crawford F, Vass T, Becker D, Pinilla C, Marrack P, Kappler JW.

Cell. 2005 Jul 29;122(2):247-60.PMID: 16051149 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.

Kater AP, Dicker F, Mangiola M, Welsh K, Houghten R, Ostresh J, Nefzi A, Reed JC, Pinilla C, Kipps TJ.

Blood. 2005 Sep 1;106(5):1742-8. Epub 2005 May 24.PMID: 15914559 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV-1 CTL epitope Gag77-85.

Boggiano C, Moya R, Pinilla C, Bihl F, Brander C, Sidney J, Sette A, Blondelle SE.

Eur J Immunol. 2005 May;35(5):1428-37.PMID: 15789356 [PubMed - indexed for MEDLINE]Related articles

Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

Berezovskaya O, Schimmer AD, Glinskii AB, Pinilla C, Hoffman RM, Reed JC, Glinsky GV.

Cancer Res. 2005 Mar 15;65(6):2378-86.PMID: 15781653 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.

Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, Wells RA, Messner H, Chun K, Reed JC, Schimmer AD.

Blood. 2005 May 15;105(10):4043-50. Epub 2005 Feb 1.PMID: 15687241 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes.

Judkowski V, Rodriguez E, Pinilla C, Masteller E, Bluestone JA, Sarvetnick N, Wilson DB.

Clin Immunol. 2004 Oct;113(1):29-37.PMID: 15380527 [PubMed - indexed for MEDLINE]Related articles

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.

Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC.

J Biol Chem. 2004 Nov 12;279(46):48168-76. Epub 2004 Aug 27.PMID: 15337764 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptides from common viral and bacterial pathogens can efficiently activate diabetogenic T-cells.

Judkowski VA, Allicotti GM, Sarvetnick N, Pinilla C.

Diabetes. 2004 Sep;53(9):2301-9.PMID: 15331539 [PubMed - indexed for MEDLINE]Related articlesFree article

The initiation of the autoimmune response in multiple sclerosis.

Markovic-Plese S, Pinilla C, Martin R.

Clin Neurol Neurosurg. 2004 Jun;106(3):218-22. Review.PMID: 15177771 [PubMed - indexed for MEDLINE]Related articles

Strong attraction may be dangerous: parameters for the development of long term commitment.

Judkowski V, Pinilla C, Alicotti G, Flödstrom M, Sanna P, Sarvetnick N.

Mol Immunol. 2004 Feb;40(14-15):1109-12. Review. No abstract available. PMID: 15036916 [PubMed - indexed for MEDLINE]Related articles

Peptidic complex mixtures as therapeutic agents in CNS autoimmunity.

Shukaliak Quandt J, Borras E, Prat E, Gelderblom H, Houghten RA, Kashani A, Pinilla C, Stuerzebecher CS, Martin R.

Mol Immunol. 2004 Feb;40(14-15):1075-87.PMID: 15036912 [PubMed - indexed for MEDLINE]Related articles

A powerful combination: the use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes.

Nino-Vasquez JJ, Allicotti G, Borras E, Wilson DB, Valmori D, Simon R, Martin R, Pinilla C.

Mol Immunol. 2004 Feb;40(14-15):1063-74.PMID: 15036911 [PubMed - indexed for MEDLINE]Related articles

Specificity and degeneracy of T cells.

Wilson DB, Wilson DH, Schroder K, Pinilla C, Blondelle S, Houghten RA, Garcia KC.

Mol Immunol. 2004 Feb;40(14-15):1047-55. Review.PMID: 15036909 [PubMed - indexed for MEDLINE]Related articles

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC.

Cancer Cell. 2004 Jan;5(1):25-35.PMID: 14749124 [PubMed - indexed for MEDLINE]Related articles