PubMed

Thyroid hormone-related regulation of gene expression in human fatty liver.

Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME.

J Clin Endocrinol Metab. 2009 Sep;94(9):3521-9. Epub 2009 Jun 23.PMID: 19549744 [PubMed - indexed for MEDLINE]Related articles

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.

Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB.

Obesity (Silver Spring). 2009 Sep;17(9):1671-7. Epub 2009 Apr 9.PMID: 19360006 [PubMed - indexed for MEDLINE]Related articles

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus.

Honka MJ, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJ, Takala T, Viljanen AP, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M.

Metabolism. 2009 Apr;58(4):541-6.PMID: 19303976 [PubMed - indexed for MEDLINE]Related articles

The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease.

Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA.

Metabolism. 2009 Mar;58(3):401-7.PMID: 19217458 [PubMed - indexed for MEDLINE]Related articles

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.

Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U.

J Intern Med. 2008 Apr;263(4):440-9.PMID: 18324929 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M; EUGENE2 Consortium.

J Clin Endocrinol Metab. 2008 May;93(5):1924-30. Epub 2008 Feb 19.PMID: 18285412 [PubMed - indexed for MEDLINE]Related articlesFree article

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans.

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M.

Obesity (Silver Spring). 2007 Dec;15(12):2902-7.PMID: 18198296 [PubMed - indexed for MEDLINE]Related articles

Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome.

Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H.

Clin Chim Acta. 2007 Aug;383(1-2):126-32. Epub 2007 May 18.PMID: 17573060 [PubMed - indexed for MEDLINE]Related articles

Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects.

Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M.

Atherosclerosis. 2008 Mar;197(1):271-7. Epub 2007 Jun 8.PMID: 17560580 [PubMed - indexed for MEDLINE]Related articles

Cholesterol synthesis prevails over absorption in metabolic syndrome.

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Agren JJ, Rauramaa R, Laakso M, Miettinen TA.

Transl Res. 2007 Jun;149(6):310-6. Epub 2007 May 23.PMID: 17543849 [PubMed - indexed for MEDLINE]Related articles

Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects.

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M.

J Clin Endocrinol Metab. 2007 Mar;92(3):1112-7. Epub 2006 Dec 27. Erratum in: J Clin Endocrinol Metab. 2008 Apr;93(4):1506. PMID: 17192297 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects.

Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M.

Diabetes Care. 2006 Dec;29(12):2714-20.PMID: 17130210 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease.

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma VM, Naukkarinen A, Laakso M.

Scand J Gastroenterol. 2006 Nov;41(11):1299-304.PMID: 17060123 [PubMed - indexed for MEDLINE]Related articles

Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control.

Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Agren JJ, Laakso M, Miettinen TA.

Atherosclerosis. 2007 Oct;194(2):465-72. Epub 2006 Sep 25.PMID: 16996519 [PubMed - indexed for MEDLINE]Related articles

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.

Koivisto AM, Helisalmi S, Pihlajamaki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala EL, Hanninen T, Kervinen K, Kesaniemi YA, Laakso M, Soininen H.

Dement Geriatr Cogn Disord. 2006;22(5-6):449-53. Epub 2006 Sep 21.PMID: 16988505 [PubMed - indexed for MEDLINE]Related articles

Visceral obesity is associated with high levels of serum squalene.

Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M.

Obesity (Silver Spring). 2006 Jul;14(7):1155-63.PMID: 16899796 [PubMed - indexed for MEDLINE]Related articles

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MC, Cox NJ, Bell GI, Laakso M.

Diabetologia. 2006 Jul;49(7):1560-6. Epub 2006 May 12.PMID: 16752174 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.

Koivisto AM, Helisalmi S, Pihlajamäki J, Moilanen L, Kuusisto J, Laakso M, Hiltunen M, Keijo K, Hänninen T, Helkala EL, Kervinen K, Kesäniemi YA, Soininen H.

J Neurogenet. 2005 Jul-Dec;19(3-4):155-61.PMID: 16540406 [PubMed - indexed for MEDLINE]Related articles

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma VM, Naukkarinen A, Laakso M.

Scand J Gastroenterol. 2006 Feb;41(2):191-9.PMID: 16484124 [PubMed - indexed for MEDLINE]Related articles

Visfatin is an adipokine, but it is not regulated by thiazolidinediones.

Hammarstedt A, Pihlajamäki J, Rotter Sopasakis V, Gogg S, Jansson PA, Laakso M, Smith U.

J Clin Endocrinol Metab. 2006 Mar;91(3):1181-4. Epub 2006 Jan 4.PMID: 16394088 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters.

Hallikainen M, Lyyra-Laitinen T, Laitinen T, Agren JJ, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H.

Atherosclerosis. 2006 Oct;188(2):425-32. Epub 2005 Dec 28.PMID: 16386259 [PubMed - indexed for MEDLINE]Related articles

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake.

Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen AP, Knuuti J, Laakso M.

Diabetes. 2005 Dec;54(12):3587-91.PMID: 16306381 [PubMed - indexed for MEDLINE]Related articlesFree article

High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients.

Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M.

Int J Obes (Lond). 2005 Dec;29(12):1464-70.PMID: 16044174 [PubMed - indexed for MEDLINE]Related articles

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes.

Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M.

Diabetologia. 2005 Jul;48(7):1331-4. Epub 2005 May 24.PMID: 15912394 [PubMed - indexed for MEDLINE]Related articles

Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients.

Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M.

J Clin Endocrinol Metab. 2005 Jul;90(7):4216-23. Epub 2005 Apr 26.PMID: 15855264 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study.

Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen AP, Knuuti J, Laakso M.

J Clin Endocrinol Metab. 2005 Jul;90(7):4249-54. Epub 2005 Apr 26.PMID: 15855261 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns.

Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M.

J Mol Med. 2005 Aug;83(8):638-46. Epub 2005 Mar 17.PMID: 15772804 [PubMed - indexed for MEDLINE]Related articles

Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome.

Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M.

Circulation. 2004 Dec 21;110(25):3842-8. Epub 2004 Dec 13.PMID: 15596567 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group.

J Clin Endocrinol Metab. 2004 Dec;89(12):6286-90.PMID: 15579791 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.

Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma VM, Daly MJ, Lander ES, Laakso M.

Am J Med Genet A. 2004 Nov 1;130A(4):345-50.PMID: 15386476 [PubMed - indexed for MEDLINE]Related articles

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.

Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M.

Obes Res. 2004 Jul;12(7):1060-6.PMID: 15292469 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes.

Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M.

Diabetes Care. 2004 Aug;27(8):2021-6.PMID: 15277434 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity.

Gylling H, Hallikainen M, Pihlajamäki J, Agren J, Laakso M, Rajaratnam RA, Rauramaa R, Miettinen TA.

J Lipid Res. 2004 Sep;45(9):1660-5. Epub 2004 Jun 1.PMID: 15175352 [PubMed - indexed for MEDLINE]Related articlesFree article

Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study.

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group.

Diabetologia. 2004 May;47(5):871-7. Epub 2004 May 1.PMID: 15127203 [PubMed - indexed for MEDLINE]Related articles

The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study.

Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study.

J Clin Endocrinol Metab. 2004 May;89(5):2019-23.PMID: 15126514 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood.

Pihlajamäki J, Vanhala M, Vanhala P, Laakso M.

Obes Res. 2004 Feb;12(2):187-90.PMID: 14981210 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.

Pihlajamäki J, Gylling H, Miettinen TA, Laakso M.

J Lipid Res. 2004 Mar;45(3):507-12. Epub 2003 Dec 1.PMID: 14657199 [PubMed - indexed for MEDLINE]Related articlesFree article

Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland.

Lumiaho A, Ikäheimo R, Pihlajamäki J, Miettinen R, Niemitukia L, Vanninen R, Lampainen E, Laakso M.

Scand J Urol Nephrol. 2003;37(4):352-8.PMID: 12944197 [PubMed - indexed for MEDLINE]Related articles

The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity.

Pihlajamäki J, Ylinen M, Karhapää P, Vauhkonen I, Laakso M.

Obes Res. 2003 Jul;11(7):912-7.PMID: 12855762 [PubMed - indexed for MEDLINE]Related articles

Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.

Kubaszek A, Pihlajamäki J, Komarovski V, Lindi V, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study.

Diabetes. 2003 Jul;52(7):1872-6.PMID: 12829659 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1.

Lumiaho A, Pihlajamäki J, Hartikainen J, Ikäheimo R, Miettinen R, Niemitukia L, Lampainen E, Laakso M.

Am J Kidney Dis. 2003 Jun;41(6):1219-24.PMID: 12776274 [PubMed - indexed for MEDLINE]Related articles

The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism.

Pihlajamäki J, Karhapää P, Vauhkonen I, Kekäläinen P, Kareinen A, Viitanen L, Pesonen U, Kallio J, Uusitupa M, Laakso M.

Metabolism. 2003 May;52(5):643-6.PMID: 12759898 [PubMed - indexed for MEDLINE]Related articles

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.

Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M.

Diabetes Care. 2003 Feb;26(2):464-7.PMID: 12547881 [PubMed - indexed for MEDLINE]Related articlesFree article

The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity.

Kubaszek A, Pihlajamäki J, Punnonen K, Karhapää P, Vauhkonen I, Laakso M.

Diabetes. 2003 Feb;52(2):558-61.PMID: 12540635 [PubMed - indexed for MEDLINE]Related articlesFree article

Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.

Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M.

Diabetes Care. 2003 Jan;26(1):179-82.PMID: 12502677 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.

Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JS, Peltonen L, Taskinen MR.

Eur J Hum Genet. 2002 Sep;10(9):547-52.PMID: 12173032 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland.

Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M.

J Mol Med. 2002 Jul;80(7):412-22. Epub 2002 Apr 11.PMID: 12110947 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease.

Viitanen L, Pihlajamäki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, Kareinen A, Lehto S, Laakso M.

J Mol Med. 2001 Dec;79(12):732-7. Epub 2001 Jul 25.PMID: 11862316 [PubMed - indexed for MEDLINE]Related articles

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia.

Pihlajamäki J, Austin M, Edwards K, Laakso M.

Diabetes. 2001 Oct;50(10):2396-401.PMID: 11574425 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease.

Viitanen L, Pihlajamäki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, Laakso M.

Atherosclerosis. 2001 Jul;157(1):57-64.PMID: 11427204 [PubMed - indexed for MEDLINE]Related articles