PubMed

Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking.

Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19491-19496. Epub 2009 Nov 4.PMID: 19889975 [PubMed - as supplied by publisher]Related articles

The chemokine CCL2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast recruitment.

Mizutani K, Sud S, McGregor NA, Martinovski G, Rice BT, Craig MJ, Varsos ZS, Roca H, Pienta KJ.

Neoplasia. 2009 Nov;11(11):1235-42.PMID: 19881959 [PubMed - in process]Related articlesFree article

CCL2 and IL-6 promote survival of human CD11b+- peripheral blood mononuclear cells and induce M2-type macrophage polarization.

Roca H, Varsos ZS, Sud S, Craig MJ, Ying C, Pienta KJ.

J Biol Chem. 2009 Oct 15. [Epub ahead of print]PMID: 19833726 [PubMed - as supplied by publisher]Related articlesFree article

Possible mechanism of CCL2-induced Akt activation in prostate cancer cells.

Mizutani K, Roca H, Varsos Z, Pienta KJ.

Anticancer Res. 2009 Aug;29(8):3109-13.PMID: 19661323 [PubMed - indexed for MEDLINE]Related articles

Critical appraisal of prostate-specific antigen in prostate cancer screening: 20 years later.

Pienta KJ.

Urology. 2009 May;73(5 Suppl):S11-20. Review.PMID: 19375622 [PubMed - indexed for MEDLINE]Related articles

Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy.

Steinkamp MP, O'Mahony OA, Brogley M, Rehman H, Lapensee EW, Dhanasekaran S, Hofer MD, Kuefer R, Chinnaiyan A, Rubin MA, Pienta KJ, Robins DM.

Cancer Res. 2009 May 15;69(10):4434-42. Epub 2009 Apr 14.PMID: 19366804 [PubMed - indexed for MEDLINE]Related articles

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids.

Hsiao AY, Torisawa YS, Tung YC, Sud S, Taichman RS, Pienta KJ, Takayama S.

Biomaterials. 2009 Jun;30(16):3020-7. Epub 2009 Mar 21.PMID: 19304321 [PubMed - indexed for MEDLINE]Related articles

Regulation of prostate cancer progression by galectin-3.

Wang Y, Nangia-Makker P, Tait L, Balan V, Hogan V, Pienta KJ, Raz A.

Am J Pathol. 2009 Apr;174(4):1515-23. Epub 2009 Mar 12.PMID: 19286570 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model.

Rozel S, Galbán CJ, Nicolay K, Lee KC, Sud S, Neeley C, Snyder LA, Chenevert TL, Rehemtulla A, Ross BD, Pienta KJ.

J Cell Biochem. 2009 May 1;107(1):58-64.PMID: 19259948 [PubMed - indexed for MEDLINE]Related articles

Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data.

Scher HI, Jia X, de Bono JS, Fleisher M, Pienta KJ, Raghavan D, Heller G.

Lancet Oncol. 2009 Mar;10(3):233-9. Epub 2009 Feb 11.PMID: 19213602 [PubMed - indexed for MEDLINE]Related articles

A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone.

Li X, Loberg R, Liao J, Ying C, Snyder LA, Pienta KJ, McCauley LK.

Cancer Res. 2009 Feb 15;69(4):1685-92. Epub 2009 Jan 27.PMID: 19176388 [PubMed - indexed for MEDLINE]Related articles

Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts.

Mizutani K, Sud S, Pienta KJ.

J Cell Biochem. 2009 Mar 1;106(4):563-9.PMID: 19170075 [PubMed - indexed for MEDLINE]Related articlesFree article

Ecological therapy for cancer: defining tumors using an ecosystem paradigm suggests new opportunities for novel cancer treatments.

Pienta KJ, McGregor N, Axelrod R, Axelrod DE.

Transl Oncol. 2008 Dec;1(4):158-64.PMID: 19043526 [PubMed - in process]Related articlesFree article

Phase III multi-institutional trial of adjuvant chemotherapy with paclitaxel, estramustine, and oral etoposide combined with long-term androgen suppression therapy and radiotherapy versus long-term androgen suppression plus radiotherapy alone for high-risk prostate cancer: preliminary toxicity analysis of RTOG 99-02.

Rosenthal SA, Bae K, Pienta KJ, Sobczak ML, Asbell SO, Rajan R, Kerlin KJ, Michalski JM, Sandler HM; Radiation Therapy Oncology Group Trial 9902.

Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):672-8. Epub 2008 Nov 5.PMID: 18990504 [PubMed - indexed for MEDLINE]Related articles

FYN is overexpressed in human prostate cancer.

Posadas EM, Al-Ahmadie H, Robinson VL, Jagadeeswaran R, Otto K, Kasza KE, Tretiakov M, Siddiqui J, Pienta KJ, Stadler WM, Rinker-Schaeffer C, Salgia R.

BJU Int. 2009 Jan;103(2):171-7. Epub 2008 Oct 16.PMID: 18990162 [PubMed - indexed for MEDLINE]Related articles

-(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro.

Macoska JA, Adsule S, Tantivejkul K, Wang S, Pienta KJ, Lee CT.

Pharmacol Res. 2008 Nov-Dec;58(5-6):323-31. Epub 2008 Sep 16.PMID: 18840529 [PubMed - indexed for MEDLINE]Related articles

Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer.

de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, Doyle GV, Terstappen LW, Pienta KJ, Raghavan D.

Clin Cancer Res. 2008 Oct 1;14(19):6302-9. Erratum in: Clin Cancer Res. 2009 Feb 15;15(4):1506. PMID: 18829513 [PubMed - indexed for MEDLINE]Related articlesFree article

Re: RANKL inhibition is an effective adjuvant for docetaxel in a prostate cancer bone metastasis model.

Mizutani K, Pienta KJ.

Eur Urol. 2008 Sep;54(3):688. No abstract available. PMID: 18792431 [PubMed]Related articles

CCL2, survivin and autophagy: new links with implications in human cancer.

Roca H, Varsos ZS, Mizutani K, Pienta KJ.

Autophagy. 2008 Oct 1;4(7):969-71. Epub 2008 Oct 20.PMID: 18758234 [PubMed - indexed for MEDLINE]Related articles

Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions.

Liao J, Li X, Koh AJ, Berry JE, Thudi N, Rosol TJ, Pienta KJ, McCauley LK.

Int J Cancer. 2008 Nov 15;123(10):2267-78.PMID: 18729185 [PubMed - indexed for MEDLINE]Related articles

CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac.

van Golen KL, Ying C, Sequeira L, Dubyk CW, Reisenberger T, Chinnaiyan AM, Pienta KJ, Loberg RD.

J Cell Biochem. 2008 Aug 1;104(5):1587-97.PMID: 18646053 [PubMed - indexed for MEDLINE]Related articles

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer.

Shiozawa Y, Havens AM, Jung Y, Ziegler AM, Pedersen EA, Wang J, Wang J, Lu G, Roodman GD, Loberg RD, Pienta KJ, Taichman RS.

J Cell Biochem. 2008 Oct 1;105(2):370-80.PMID: 18636554 [PubMed - indexed for MEDLINE]Related articles

CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation.

Roca H, Varsos Z, Pienta KJ.

J Biol Chem. 2008 Sep 5;283(36):25057-73. Epub 2008 Jul 8.PMID: 18611860 [PubMed - indexed for MEDLINE]Related articlesFree article

CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12.

Sun YX, Pedersen EA, Shiozawa Y, Havens AM, Jung Y, Wang J, Pienta KJ, Taichman RS.

Clin Exp Metastasis. 2008;25(7):765-76. Epub 2008 Jun 18.PMID: 18563594 [PubMed - indexed for MEDLINE]Related articles

Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-alpha.

Cooper CR, Graves B, Pruitt F, Chaib H, Lynch JE, Cox AK, Sequeria L, van Golen KL, Evans A, Czymmek K, Bullard RS, Donald CD, Sol-Church K, Gendernalik JD, Weksler B, Farach-Carson MC, Macoska JA, Sikes RA, Pienta KJ.

J Cell Biochem. 2008 Aug 15;104(6):2298-309.PMID: 18561328 [PubMed - indexed for MEDLINE]Related articles

Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis.

Hall CL, Daignault SD, Shah RB, Pienta KJ, Keller ET.

Prostate. 2008 Sep 15;68(13):1396-404.PMID: 18561248 [PubMed - indexed for MEDLINE]Related articles

Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.

Mehra R, Tomlins SA, Yu J, Cao X, Wang L, Menon A, Rubin MA, Pienta KJ, Shah RB, Chinnaiyan AM.

Cancer Res. 2008 May 15;68(10):3584-90.PMID: 18483239 [PubMed - indexed for MEDLINE]Related articlesFree article

An in vivo mouse model for human prostate cancer metastasis.

Havens AM, Pedersen EA, Shiozawa Y, Ying C, Jung Y, Sun Y, Neeley C, Wang J, Mehra R, Keller ET, McCauley LK, Loberg RD, Pienta KJ, Taichman RS.

Neoplasia. 2008 Apr;10(4):371-80.PMID: 18392141 [PubMed - indexed for MEDLINE]Related articlesFree article

A sequence-based survey of the complex structural organization of tumor genomes.

Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta KJ, Mills GB, Bajsarowicz K, Kobayashi Y, Sridharan S, Paris PL, Tao Q, Aerni SJ, Brown RP, Bashir A, Gray JW, Cheng JF, de Jong P, Nefedov M, Ried T, Padilla-Nash HM, Collins CC.

Genome Biol. 2008;9(3):R59. Epub 2008 Mar 25.PMID: 18364049 [PubMed - indexed for MEDLINE]Related articlesFree article

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.

Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang S.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8. Epub 2008 Mar 3.PMID: 18316739 [PubMed - indexed for MEDLINE]Related articlesFree article

The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites.

Shiozawa Y, Havens AM, Pienta KJ, Taichman RS.

Leukemia. 2008 May;22(5):941-50. Epub 2008 Feb 28. Review.PMID: 18305549 [PubMed - indexed for MEDLINE]Related articles

The current state of preclinical prostate cancer animal models.

Pienta KJ, Abate-Shen C, Agus DB, Attar RM, Chung LW, Greenberg NM, Hahn WC, Isaacs JT, Navone NM, Peehl DM, Simons JW, Solit DB, Soule HR, VanDyke TA, Weber MJ, Wu L, Vessella RL.

Prostate. 2008 May 1;68(6):629-39.PMID: 18213636 [PubMed - indexed for MEDLINE]Related articles

In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.

Loberg RD, McGregor N, Ying C, Sargent E, Pienta KJ.

Neoplasia. 2007 Dec;9(12):1030-7.PMID: 18084610 [PubMed - indexed for MEDLINE]Related articlesFree article

A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the bone.

Lee KC, Bradley DA, Hussain M, Meyer CR, Chenevert TL, Jacobson JA, Johnson TD, Galban CJ, Rehemtulla A, Pienta KJ, Ross BD.

Neoplasia. 2007 Dec;9(12):1003-11.PMID: 18084607 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer.

Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R, Taichman RS.

J Biol Chem. 2008 Feb 15;283(7):4283-94. Epub 2007 Dec 5.PMID: 18057003 [PubMed - indexed for MEDLINE]Related articlesFree article

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome.

Yu J, Yu J, Rhodes DR, Tomlins SA, Cao X, Chen G, Mehra R, Wang X, Ghosh D, Shah RB, Varambally S, Pienta KJ, Chinnaiyan AM.

Cancer Res. 2007 Nov 15;67(22):10657-63.PMID: 18006806 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized clinical trial of a family intervention for prostate cancer patients and their spouses.

Northouse LL, Mood DW, Schafenacker A, Montie JE, Sandler HM, Forman JD, Hussain M, Pienta KJ, Smith DC, Kershaw T.

Cancer. 2007 Dec 15;110(12):2809-18.PMID: 17999405 [PubMed - indexed for MEDLINE]Related articlesFree article

Eleventh Prouts Neck Meeting on Prostate Cancer: emerging strategies in prostate cancer therapy.

Keller ET, Rowley DR, Tomlins SA, Drake CG, Kantoff PW, Pienta KJ, Montie JE, Carter HB, Hruszkewicz AM, Gomez J, Mohla S, Getzenberg RH.

Cancer Res. 2007 Oct 15;67(20):9613-5. Epub 2007 Oct 10. No abstract available. PMID: 17928375 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo.

Loberg RD, Ying C, Craig M, Day LL, Sargent E, Neeley C, Wojno K, Snyder LA, Yan L, Pienta KJ.

Cancer Res. 2007 Oct 1;67(19):9417-24.PMID: 17909051 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrative analysis of genomic aberrations associated with prostate cancer progression.

Kim JH, Dhanasekaran SM, Mehra R, Tomlins SA, Gu W, Yu J, Kumar-Sinha C, Cao X, Dash A, Wang L, Ghosh D, Shedden K, Montie JE, Rubin MA, Pienta KJ, Shah RB, Chinnaiyan AM.

Cancer Res. 2007 Sep 1;67(17):8229-39.PMID: 17804737 [PubMed - indexed for MEDLINE]Related articlesFree article

The evolving biology and treatment of prostate cancer.

Taichman RS, Loberg RD, Mehra R, Pienta KJ.

J Clin Invest. 2007 Sep;117(9):2351-61.PMID: 17786228 [PubMed - indexed for MEDLINE]Related articlesFree article

Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia.

Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Pienta KJ, Raz A, Glinsky VV.

Neoplasia. 2007 Aug;9(8):662-70.PMID: 17786185 [PubMed - indexed for MEDLINE]Related articlesFree article

CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration.

Loberg RD, Ying C, Craig M, Yan L, Snyder LA, Pienta KJ.

Neoplasia. 2007 Jul;9(7):556-62.PMID: 17710158 [PubMed - indexed for MEDLINE]Related articlesFree article

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.

Wang Q, Li W, Liu XS, Carroll JS, Jänne OA, Keeton EK, Chinnaiyan AM, Pienta KJ, Brown M.

Mol Cell. 2007 Aug 3;27(3):380-92.PMID: 17679089 [PubMed - indexed for MEDLINE]Related articles

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.

Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, Yu J, Wang L, Montie JE, Rubin MA, Pienta KJ, Roulston D, Shah RB, Varambally S, Mehra R, Chinnaiyan AM.

Nature. 2007 Aug 2;448(7153):595-9.PMID: 17671502 [PubMed - indexed for MEDLINE]Related articles

Phase II evaluation of oral estramustine, oral etoposide, and intravenous paclitaxel in patients with hormone-sensitive prostate adenocarcinoma.

Mackler NJ, Pienta KJ, Dunn RL, Cooney KA, Redman BG, Olson KB, Fardig JE, Smith DC.

Clin Genitourin Cancer. 2007 Jun;5(5):318-22.PMID: 17645828 [PubMed - indexed for MEDLINE]Related articles

Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer.

Henry NL, Dunn R, Merjaver S, Pan Q, Pienta KJ, Brewer G, Smith DC.

Oncology. 2006;71(3-4):168-75. Epub 2007 Jul 18.PMID: 17641535 [PubMed - indexed for MEDLINE]Related articles

Living with prostate cancer: patients' and spouses' psychosocial status and quality of life.

Northouse LL, Mood DW, Montie JE, Sandler HM, Forman JD, Hussain M, Pienta KJ, Smith DC, Sanda MG, Kershaw T.

J Clin Oncol. 2007 Sep 20;25(27):4171-7. Epub 2007 Jul 16.PMID: 17635953 [PubMed - indexed for MEDLINE]Related articles

The lethal phenotype of cancer: the molecular basis of death due to malignancy.

Loberg RD, Bradley DA, Tomlins SA, Chinnaiyan AM, Pienta KJ.

CA Cancer J Clin. 2007 Jul-Aug;57(4):225-41. Review. Erratum in: CA Cancer J Clin. 2007 Nov-Dec;57(6):380. PMID: 17626119 [PubMed - indexed for MEDLINE]Related articlesFree article

PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells.

Loberg RD, Tantivejkul K, Craig M, Neeley CK, Pienta KJ.

J Cell Biochem. 2007 Aug 1;101(5):1292-300.PMID: 17492768 [PubMed - indexed for MEDLINE]Related articles