PubMed

A brief perspective on insulin production.

Steiner DF, Park SY, Støy J, Philipson LH, Bell GI.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:189-96.PMID: 19817801 [PubMed - in process]Related articles

The granular chloride channel ClC-3 is permissive for insulin secretion.

Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ.

Cell Metab. 2009 Oct;10(4):316-23.PMID: 19808024 [PubMed - in process]Related articles

A Nanoporous, Transparent Microcontainer for Encapsulated Islet Therapy.

Gimi B, Kwon J, Kuznetsov A, Vachha B, Magin RL, Philipson LH, Lee JB.

J Diabetes Sci Technol. 2009 Mar 1;3(2):297-303.PMID: 19746206 [PubMed]Related articlesFree article

Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect.

Kumaraguru J, Flanagan SE, Greeley SA, Nuboer R, Støy J, Philipson LH, Hattersley AT, Rubio-Cabezas O.

Diabetes Care. 2009 Aug;32(8):1428-30. Epub 2009 May 12.PMID: 19435956 [PubMed - indexed for MEDLINE]Related articlesFree article

A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.

Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH.

Biophys J. 2009 Apr 22;96(8):3126-39.PMID: 19383458 [PubMed - indexed for MEDLINE]Related articles

Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.

Chen WS, Peng XD, Wang Y, Xu PZ, Chen ML, Luo Y, Jeon SM, Coleman K, Haschek WM, Bass J, Philipson LH, Hay N.

Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.PMID: 19289493 [PubMed - indexed for MEDLINE]Related articles

The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing.

Jacobson DA, Wicksteed BL, Philipson LH.

Diabetes. 2009 Feb;58(2):304-6. No abstract available. PMID: 19171747 [PubMed - indexed for MEDLINE]Related articlesFree article

The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution.

Chen D, Du W, Liu Y, Liu W, Kuznetsov A, Mendez FE, Philipson LH, Ismagilov RF.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16843-8. Epub 2008 Oct 30.PMID: 18974218 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis and treatment of neonatal diabetes: a United States experience.

Støy J, Greeley SA, Paz VP, Ye H, Pastore AN, Skowron KB, Lipton RB, Cogen FR, Bell GI, Philipson LH; United States Neonatal Diabetes Working Group.

Pediatr Diabetes. 2008 Oct;9(5):450-9. Epub 2008 Jul 25.PMID: 18662362 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells.

Tamarina NA, Kuznetsov A, Philipson LH.

Cell Calcium. 2008 Dec;44(6):533-44. Epub 2008 May 2.PMID: 18452988 [PubMed - indexed for MEDLINE]Related articles

When BAD is good for beta cells.

Philipson LH, Roe MW.

Cell Metab. 2008 Apr;7(4):280-1.PMID: 18396130 [PubMed - indexed for MEDLINE]Related articles

Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis.

Fridlyand LE, Philipson LH.

Curr Diabetes Rev. 2006 May;2(2):241-59. Review.PMID: 18220630 [PubMed - indexed for MEDLINE]Related articles

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O; Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR.

Diabetes. 2008 Apr;57(4):1131-5. Epub 2008 Jan 11.PMID: 18192540 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.

Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S.

Diabetes. 2008 Apr;57(4):1034-42. Epub 2007 Dec 27.PMID: 18162506 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.

Fridlyand LE, Harbeck MC, Roe MW, Philipson LH.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1924-33. Epub 2007 Oct 10.PMID: 17928534 [PubMed - indexed for MEDLINE]Related articlesFree article

Action potentials and insulin secretion: new insights into the role of Kv channels.

Jacobson DA, Philipson LH.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:89-98.PMID: 17919183 [PubMed - indexed for MEDLINE]Related articles

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin gene mutations as a cause of permanent neonatal diabetes.

Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.PMID: 17855560 [PubMed - indexed for MEDLINE]Related articlesFree article

Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH.

Cell Metab. 2007 Sep;6(3):229-35.PMID: 17767909 [PubMed - indexed for MEDLINE]Related articlesFree article

Ethics of hematopoietic stem cell transplantation in type 1 diabetes mellitus.

Ross LF, Philipson LH.

JAMA. 2007 Jul 18;298(3):285; author reply 285-6. No abstract available. PMID: 17635886 [PubMed - indexed for MEDLINE]Related articles

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.

Kitiphongspattana K, Khan TA, Ishii-Schrade K, Roe MW, Philipson LH, Gaskins HR.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1543-54. Epub 2007 Jan 30.PMID: 17264231 [PubMed - indexed for MEDLINE]Related articlesFree article

TRP channels of the pancreatic beta cell.

Jacobson DA, Philipson LH.

Handb Exp Pharmacol. 2007;(179):409-24. Review.PMID: 17217070 [PubMed - indexed for MEDLINE]Related articles

Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.

Jacobson DA, Weber CR, Bao S, Turk J, Philipson LH.

J Biol Chem. 2007 Mar 9;282(10):7442-9. Epub 2006 Dec 29.PMID: 17197450 [PubMed - indexed for MEDLINE]Related articlesFree article

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

Yin D, Tao J, Lee DD, Shen J, Hara M, Lopez J, Kuznetsov A, Philipson LH, Chong AS.

Diabetes. 2006 Dec;55(12):3256-63.PMID: 17130468 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier.

Avila JG, Wang Y, Barbaro B, Gangemi A, Qi M, Kuechle J, Doubleday N, Doubleday M, Churchill T, Salehi P, Shapiro J, Philipson LH, Benedetti E, Lakey JR, Oberholzer J.

Am J Transplant. 2006 Dec;6(12):2861-70.PMID: 17062000 [PubMed - indexed for MEDLINE]Related articles

Cold climate genes and the prevalence of type 2 diabetes mellitus.

Fridlyand LE, Philipson LH.

Med Hypotheses. 2006;67(5):1034-41. Epub 2006 Jun 23. Review.PMID: 16797871 [PubMed - indexed for MEDLINE]Related articles

Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy.

Roe MW, Fiekers JF, Philipson LH, Bindokas VP.

Methods Mol Biol. 2006;319:37-66.PMID: 16719350 [PubMed - indexed for MEDLINE]Related articles

Functional MR microimaging of pancreatic beta-cell activation.

Gimi B, Leoni L, Oberholzer J, Braun M, Avila J, Wang Y, Desai T, Philipson LH, Magin RL, Roman BB.

Cell Transplant. 2006;15(2):195-203.PMID: 16719054 [PubMed - indexed for MEDLINE]Related articles

Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.

Jacobson DA, Cho J, Landa LR Jr, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E587-95. Epub 2006 Apr 18.PMID: 16621893 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH.

Science. 2006 Mar 24;311(5768):1774-5.PMID: 16556844 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches.

Fridlyand LE, Philipson LH.

Ann N Y Acad Sci. 2005 Dec;1066:136-51. Review.PMID: 16533924 [PubMed - indexed for MEDLINE]Related articles

Reactive species and early manifestation of insulin resistance in type 2 diabetes.

Fridlyand LE, Philipson LH.

Diabetes Obes Metab. 2006 Mar;8(2):136-45. Review.PMID: 16448517 [PubMed - indexed for MEDLINE]Related articles

Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.

Tamarina NA, Kuznetsov A, Rhodes CJ, Bindokas VP, Philipson LH.

Diabetes. 2005 Nov;54(11):3073-81.PMID: 16249428 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling.

Tamarina NA, Kuznetsov A, Fridlyand LE, Philipson LH.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E578-85. Epub 2005 Jul 12.PMID: 16014354 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.

Fridlyand LE, Ma L, Philipson LH.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E839-48. Epub 2005 Jun 28.PMID: 15985450 [PubMed - indexed for MEDLINE]Related articlesFree article

5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.

Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH.

Biochem Biophys Res Commun. 2005 May 20;330(4):1073-9.PMID: 15823553 [PubMed - indexed for MEDLINE]Related articles

Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.

Hays LB, Wicksteed B, Wang Y, McCuaig JF, Philipson LH, Edwardson JM, Rhodes CJ.

J Endocrinol. 2005 Apr;185(1):57-67.PMID: 15817827 [PubMed - indexed for MEDLINE]Related articlesFree article

FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets.

Kuznetsov A, Bindokas VP, Marks JD, Philipson LH.

Am J Physiol Cell Physiol. 2005 Jul;289(1):C224-9. Epub 2005 Mar 9.PMID: 15758044 [PubMed - indexed for MEDLINE]Related articlesFree article

Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?

Fridlyand LE, Philipson LH.

Diabetes. 2004 Aug;53(8):1942-8. Review.PMID: 15277370 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.

Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9266-71. Epub 2004 Jun 14.PMID: 15197259 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.

Tamarina NA, Wang Y, Mariotto L, Kuznetsov A, Bond C, Adelman J, Philipson LH.

Diabetes. 2003 Aug;52(8):2000-6.PMID: 12882916 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores.

Fridlyand LE, Tamarina N, Philipson LH.

Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E138-54. Epub 2003 Mar 18.PMID: 12644446 [PubMed - indexed for MEDLINE]Related articlesFree article

Visualizing superoxide production in normal and diabetic rat islets of Langerhans.

Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH.

J Biol Chem. 2003 Mar 14;278(11):9796-801. Epub 2003 Jan 4.PMID: 12514170 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory deficiency and glucose intolerance in Rab3A null mice.

Yaekura K, Julyan R, Wicksteed BL, Hays LB, Alarcon C, Sommers S, Poitout V, Baskin DG, Wang Y, Philipson LH, Rhodes CJ.

J Biol Chem. 2003 Mar 14;278(11):9715-21. Epub 2003 Jan 1.PMID: 12510060 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-Agonists and metabolism.

Philipson LH.

J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S313-7. Review.PMID: 12464941 [PubMed - indexed for MEDLINE]Related articles

TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells.

Qian F, Huang P, Ma L, Kuznetsov A, Tamarina N, Philipson LH.

Diabetes. 2002 Feb;51 Suppl 1:S183-9.PMID: 11815479 [PubMed - indexed for MEDLINE]Related articlesFree article

Baculovirus-mediated gene transfer into pancreatic islet cells.

Ma L, Tamarina N, Wang Y, Kuznetsov A, Patel N, Kending C, Hering BJ, Philipson LH.

Diabetes. 2000 Dec;49(12):1986-91.PMID: 11117998 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS.

Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51.PMID: 10662719 [PubMed - indexed for MEDLINE]Related articlesFree article

The status of voltage-dependent calcium channels in alpha 1E knock-out mice.

Wilson SM, Toth PT, Oh SB, Gillard SE, Volsen S, Ren D, Philipson LH, Lee EC, Fletcher CF, Tessarollo L, Copeland NG, Jenkins NA, Miller RJ.

J Neurosci. 2000 Dec 1;20(23):8566-71.PMID: 11102459 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell ion channels: keys to endodermal excitability.

Philipson LH.

Horm Metab Res. 1999 Aug;31(8):455-61. Review.PMID: 10494870 [PubMed - indexed for MEDLINE]Related articles