PubMed

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. Epub 2009 Mar 18.PMID: 19294363 [PubMed - indexed for MEDLINE]Related articles

In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.

J Biol Chem. 2008 Nov 21;283(47):32462-70. Epub 2008 Aug 21.PMID: 18718916 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. Epub 2008 Jan 29.PMID: 18230696 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL.

Diabetes. 2007 Jan;56(1):88-95.PMID: 17192469 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL.

Diabetes. 2006 Dec;55(12):3289-98.PMID: 17130472 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.

Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA.

Gene Expr Patterns. 2006 Oct;6(8):971-7. Epub 2006 Apr 22.PMID: 16750430 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.PMID: 16046294 [PubMed - indexed for MEDLINE]Related articlesFree article

Manipulation of pancreatic stem cells for cell replacement therapy.

Peshavaria M, Pang K.

Diabetes Technol Ther. 2000 Autumn;2(3):453-60. Review.PMID: 11467348 [PubMed - indexed for MEDLINE]Related articles

The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells.

Peshavaria M, Cissell MA, Henderson E, Petersen HV, Stein R.

Mol Endocrinol. 2000 Dec;14(12):1907-17.PMID: 11117522 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor.

Petersen HV, Peshavaria M, Pedersen AA, Philippe J, Stein R, Madsen OD, Serup P.

FEBS Lett. 1998 Jul 24;431(3):362-6.PMID: 9714543 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene.

Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R.

Mol Cell Biol. 1997 Oct;17(10):6002-13.PMID: 9315659 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional characterization of the transactivation properties of the PDX-1 homeodomain protein.

Peshavaria M, Henderson E, Sharma A, Wright CV, Stein R.

Mol Cell Biol. 1997 Jul;17(7):3987-96.PMID: 9199333 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells.

Carty MD, Lillquist JS, Peshavaria M, Stein R, Soeller WC.

J Biol Chem. 1997 May 2;272(18):11986-93.PMID: 9115263 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.

Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, Stein R.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9127-31. Erratum in: Proc Natl Acad Sci U S A 1995 Nov 21;92(24):11322. PMID: 7568086 [PubMed - indexed for MEDLINE]Related articlesFree article

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CV, Stein R.

Mol Endocrinol. 1994 Jun;8(6):806-16.PMID: 7935494 [PubMed - indexed for MEDLINE]Related articles

Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription.

Robinson GL, Peshavaria M, Henderson E, Shieh SY, Tsai MJ, Teitelman G, Stein R.

J Biol Chem. 1994 Jan 28;269(4):2452-60.PMID: 8300572 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylation patterns in the human muscle-specific enolase gene (ENO3).

Peshavaria M, Day IN.

Biochem J. 1993 Jun 15;292 ( Pt 3):701-4.PMID: 8318001 [PubMed - indexed for MEDLINE]Related articlesFree article

A differential molecular clock in enolase isoprotein evolution.

Day IN, Peshavaria M, Quinn GB.

J Mol Evol. 1993 Jun;36(6):599-601. No abstract available. PMID: 8350354 [PubMed - indexed for MEDLINE]Related articles

Molecular structure of the human muscle-specific enolase gene (ENO3).

Peshavaria M, Day IN.

Biochem J. 1991 Apr 15;275 ( Pt 2):427-33.PMID: 1840492 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular biology of the human enolase gene family: nerve (gamma), muscle (beta) and general (alpha) isoforms.

Peshavaria M, Quinn GB, Reeves I, Hinks LJ, Day IN.

Biochem Soc Trans. 1990 Apr;18(2):254-5. No abstract available. PMID: 2379701 [PubMed - indexed for MEDLINE]Related articles

Structure of human muscle (beta) enolase mRNA and protein deduced from a genomic clone.

Peshavaria M, Hinks LJ, Day IN.

Nucleic Acids Res. 1989 Nov 11;17(21):8862. No abstract available. PMID: 2587223 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunolocalization of betagranin: a chromogranin A-related protein of the pancreatic B-cell.

Hutton JC, Peshavaria M, Johnston CF, Ravazzola M, Orci L.

Endocrinology. 1988 Mar;122(3):1014-20.PMID: 3277836 [PubMed - indexed for MEDLINE]Related articles

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules.

Davidson HW, Peshavaria M, Hutton JC.

Biochem J. 1987 Sep 1;246(2):279-86.PMID: 3318807 [PubMed - indexed for MEDLINE]Related articlesFree article

Biosynthesis of betagranin in pancreatic beta-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin.

Hutton JC, Davidson HW, Grimaldi KA, Peshavaria M.

Biochem J. 1987 Jun 1;244(2):449-56.PMID: 3311030 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10).

Hutton JC, Davidson HW, Peshavaria M.

Biochem J. 1987 Jun 1;244(2):457-64.PMID: 2822006 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanism of chromogranin A processing.

Hutton JC, Davidson HW, Peshavaria M.

Nature. 1987 Feb 26-Mar 4;325(6107):766. No abstract available. PMID: 3821867 [PubMed - indexed for MEDLINE]Related articles

The insulin secretory granule: features and functions in common with other endocrine granules.

Hutton JC, Peshavaria M, Daivdson HW, Grimaldi K, Von Strandmann RP, Siddle K.

Adv Exp Med Biol. 1986;211:385-96. No abstract available. PMID: 3300195 [PubMed - indexed for MEDLINE]Related articles

beta-Granins: 21 kDa co-secreted peptides of the insulin granule closely related to adrenal medullary chromogranin A.

Hutton JC, Hansen F, Peshavaria M.

FEBS Lett. 1985 Sep 2;188(2):336-40.PMID: 3896848 [PubMed - indexed for MEDLINE]Related articles

Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma.

Hutton JC, Peshavaria M, Brocklehurst KW.

Biochem J. 1984 Dec 1;224(2):483-90.PMID: 6097221 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Hydroxytryptamine transport in cells and secretory granules from a transplantable rat insulinoma.

Hutton JC, Peshavaria M, Tooke NE.

Biochem J. 1983 Mar 15;210(3):803-10.PMID: 6307272 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate.

Hutton JC, Penn EJ, Peshavaria M.

Biochem J. 1983 Feb 15;210(2):297-305.PMID: 6344863 [PubMed - indexed for MEDLINE]Related articlesFree article

Nucleotide and bivalent cation specificity of the insulin-granule proton translocase.

Hutton JC, Peshavaria M.

Biochem J. 1983 Jan 15;210(1):235-42.PMID: 6303313 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation and characterisation of insulin secretory granules from a rat islet cell tumour.

Hutton JC, Penn EJ, Peshavaria M.

Diabetologia. 1982 Oct;23(4):365-73.PMID: 6292032 [PubMed - indexed for MEDLINE]Related articles

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules.

Hutton JC, Peshavaria M.

Biochem J. 1982 Apr 15;204(1):161-70.PMID: 6126182 [PubMed - indexed for MEDLINE]Related articlesFree article