PubMed

AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.

Ishigaki S, Fonseca SG, Oslowski CM, Jurczyk A, Shearstone JR, Zhu LJ, Permutt MA, Greiner DL, Bortell R, Urano F.

Cell Death Differ. 2009 Nov 13. [Epub ahead of print]PMID: 19911006 [PubMed - as supplied by publisher]Related articles

LKB1 regulates pancreatic beta cell size, polarity, and function.

Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ Jr, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y.

Cell Metab. 2009 Oct;10(4):296-308.PMID: 19808022 [PubMed - in process]Related articles

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.

Cras-Méneur C, Li L, Kopan R, Permutt MA.

Genes Dev. 2009 Sep 1;23(17):2088-101.PMID: 19723764 [PubMed - indexed for MEDLINE]Related articles

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S, Venkatesh R, Frayling TM, Delgado M, Neuman RJ, Zhao J, Sherva R, Glaser B, Walker M, Hitman G, McCarthy MI, Hattersley AT, Permutt MA, Wareham NJ, Deloukas P.

Diabetes. 2008 Nov;57(11):3161-5. Epub 2008 Aug 26.PMID: 18728231 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation.

Sparsø T, Andersen G, Albrechtsen A, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Wasson J, Permutt MA, Glaser B, Madsbad S, Pedersen O, Hansen T.

Diabetologia. 2008 Sep;51(9):1646-52. Epub 2008 Jun 21.PMID: 18568334 [PubMed - indexed for MEDLINE]Related articles

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

Cauchi S, Meyre D, Durand E, Proença C, Marre M, Hadjadj S, Choquet H, De Graeve F, Gaget S, Allegaert F, Delplanque J, Permutt MA, Wasson J, Blech I, Charpentier G, Balkau B, Vergnaud AC, Czernichow S, Patsch W, Chikri M, Glaser B, Sladek R, Froguel P.

PLoS One. 2008 May 7;3(5):e2031.PMID: 18461161 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.

Love-Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A, Rao DC, Hunt SC, Klein S, Neuman RJ, Permutt MA, Abumrad NA.

Hum Mol Genet. 2008 Jun 1;17(11):1695-704. Epub 2008 Feb 27.PMID: 18305138 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA.

PLoS Biol. 2008 Feb;6(2):e37.PMID: 18288891 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.

Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA.

Diabetologia. 2008 Apr;51(4):623-31. Epub 2008 Jan 25.PMID: 18219478 [PubMed - indexed for MEDLINE]Related articles

Candidate gene studies reveal that the WFS1 gene joins the expanding list of novel type 2 diabetes genes.

Wasson J, Permutt MA.

Diabetologia. 2008 Mar;51(3):391-3. Epub 2008 Jan 15. No abstract available. PMID: 18197395 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2008 Apr;57(4):846-59. Epub 2008 Jan 3.PMID: 18174526 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in WFS1 confer risk of type 2 diabetes.

Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, Blech I, Pharoah PD, Palmer CN, Kimber C, Tavendale R, Morris AD, McCarthy MI, Walker M, Hitman G, Glaser B, Permutt MA, Hattersley AT, Wareham NJ, Barroso I.

Nat Genet. 2007 Aug;39(8):951-3. Epub 2007 Jul 1.PMID: 17603484 [PubMed - indexed for MEDLINE]Related articlesFree article

HNF4A genetic variants: role in diabetes.

Love-Gregory L, Permutt MA.

Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):397-402. Review.PMID: 17563455 [PubMed - indexed for MEDLINE]Related articles

A global approach to identify differentially expressed genes in cDNA (two-color) microarray experiments.

Zhou Y, Cras-Méneur C, Ohsugi M, Stormo GD, Permutt MA.

Bioinformatics. 2007 Aug 15;23(16):2073-9. Epub 2007 Jun 5.PMID: 17550914 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.

Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80. Epub 2006 Dec 8.PMID: 17158802 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.

Martinez SC, Cras-Méneur C, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2006 Jun;55(6):1581-91.PMID: 16731820 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.

Koster JC, Permutt MA, Nichols CG.

Diabetes. 2005 Nov;54(11):3065-72. Review.PMID: 16249427 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.PMID: 16215705 [PubMed - indexed for MEDLINE]Related articles

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.

Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S.

Cell Metab. 2005 Aug;2(2):105-17.PMID: 16098828 [PubMed - indexed for MEDLINE]Related articles

Genetic epidemiology of diabetes.

Permutt MA, Wasson J, Cox N.

J Clin Invest. 2005 Jun;115(6):1431-9. Review.PMID: 15931378 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.

Srinivasan S, Ohsugi M, Liu Z, Fatrai S, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2005 Apr;54(4):968-75.PMID: 15793234 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM.

Diabetes. 2004 Nov;53(11):3002-6.PMID: 15504983 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA.

J Clin Invest. 2004 Oct;114(7):928-36.PMID: 15467831 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.

Ohsugi M, Cras-Méneur C, Zhou Y, Warren W, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2004 Jun;53(6):1496-508.PMID: 15161754 [PubMed - indexed for MEDLINE]Related articlesFree article

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, Suarez BK, Permutt MA.

Diabetes. 2004 Apr;53(4):1134-40.PMID: 15047632 [PubMed - indexed for MEDLINE]Related articlesFree article

An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE).

Cras-Méneur C, Inoue H, Zhou Y, Ohsugi M, Bernal-Mizrachi E, Pape D, Clifton SW, Permutt MA.

Diabetologia. 2004 Feb;47(2):284-99. Epub 2004 Jan 13.PMID: 14722648 [PubMed - indexed for MEDLINE]Related articles

Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.

Osman AA, Saito M, Makepeace C, Permutt MA, Schlesinger P, Mueckler M.

J Biol Chem. 2003 Dec 26;278(52):52755-62. Epub 2003 Oct 3.PMID: 14527944 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional program of the endocrine pancreas in mice and humans.

Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ Jr, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Méneur C, Permutt MA.

Diabetes. 2003 Jul;52(7):1604-10.PMID: 12829622 [PubMed - indexed for MEDLINE]Related articlesFree article

E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, Permutt MA.

Diabetologia. 2003 Jan;46(1):136-7. No abstract available. PMID: 12643262 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling in islet biology and diabetes research.

Bernal-Mizrachi E, Cras-Méneur C, Ohsugi M, Permutt MA.

Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):32-42. Review.PMID: 12592642 [PubMed - indexed for MEDLINE]Related articles

Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells.

Bernal-Mizrachi E, Wen W, Shornick M, Permutt MA.

Diabetes. 2002 Dec;51 Suppl 3:S484-8.PMID: 12475794 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for type 2 diabetes genes on chromosome 20.

Permutt MA, Wasson J, Love-Gregory L, Ma J, Skolnick G, Suarez B, Lin J, Glaser B.

Diabetes. 2002 Dec;51 Suppl 3:S308-15.PMID: 12475768 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway.

Srinivasan S, Bernal-Mizrachi E, Ohsugi M, Permutt MA.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E784-93.PMID: 12217896 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.

Scearce LM, Brestelli JE, McWeeney SK, Lee CS, Mazzarelli J, Pinney DF, Pizarro A, Stoeckert CJ Jr, Clifton SW, Permutt MA, Brown J, Melton DA, Kaestner KH.

Diabetes. 2002 Jul;51(7):1997-2004.PMID: 12086925 [PubMed - indexed for MEDLINE]Related articlesFree article

A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference.

Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sørensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Gropp E, Allison DB.

Int J Obes Relat Metab Disord. 2002 May;26(5):640-6.PMID: 12032747 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessing allele frequencies of single nucleotide polymorphisms in DNA pools by pyrosequencing technology.

Wasson J, Skolnick G, Love-Gregory L, Permutt MA.

Biotechniques. 2002 May;32(5):1144-6, 1148, 1150 passim.PMID: 12019788 [PubMed - indexed for MEDLINE]Related articles

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.

Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA.

J Clin Invest. 2001 Dec;108(11):1631-8.PMID: 11733558 [PubMed - indexed for MEDLINE]Related articlesFree article

Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.

Heo M, Leibel RL, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sørensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Allison DB.

Genetics. 2001 Nov;159(3):1163-78.PMID: 11729160 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells.

Bernal-Mizrachi E, Wen W, Srinivasan S, Klenk A, Cohen D, Permutt MA.

Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1286-99.PMID: 11701445 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.

Matsubara A, Wasson JC, Donelan SS, Welling CM, Glaser B, Permutt MA.

Diabetologia. 2001 Jul;44(7):910-3.PMID: 11508278 [PubMed - indexed for MEDLINE]Related articles

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

Chen H, Jawahar S, Qian Y, Duong Q, Chan G, Parker A, Meyer JM, Moore KJ, Chayen S, Gross DJ, Glaser B, Permutt MA, Fricker LD.

Hum Mutat. 2001 Aug;18(2):120-31.PMID: 11462236 [PubMed - indexed for MEDLINE]Related articles

Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells.

Wice BM, Bernal-Mizrachi E, Permutt MA.

Diabetologia. 2001 Apr;44(4):453-63.PMID: 11357476 [PubMed - indexed for MEDLINE]Related articles

Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.

Grimberg A, Ferry RJ Jr, Kelly A, Koo-McCoy S, Polonsky K, Glaser B, Permutt MA, Aguilar-Bryan L, Stafford D, Thornton PS, Baker L, Stanley CA.

Diabetes. 2001 Feb;50(2):322-8.PMID: 11272143 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population.

Permutt MA, Wasson JC, Suarez BK, Lin J, Thomas J, Meyer J, Lewitzky S, Rennich JS, Parker A, DuPrat L, Maruti S, Chayen S, Glaser B.

Diabetes. 2001 Mar;50(3):681-5.PMID: 11246891 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for type 2 diabetes genes in the post-genome era.

Permutt MA, Hattersley AT.

Trends Endocrinol Metab. 2000 Nov;11(9):383-93. Review.PMID: 11042470 [PubMed - indexed for MEDLINE]Related articles

Calpain 10: the first positional cloning of a gene for type 2 diabetes?

Permutt MA, Bernal-Mizrachi E, Inoue H.

J Clin Invest. 2000 Oct;106(7):819-21. No abstract available. PMID: 11018067 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells.

Bernal-Mizrachi E, Wice B, Inoue H, Permutt MA.

J Biol Chem. 2000 Aug 18;275(33):25681-9.PMID: 10829028 [PubMed - indexed for MEDLINE]Related articlesFree article

Intragenic single nucleotide polymorphism haplotype analysis of SUR1 mutations in familial hyperinsulinism.

Glaser B, Furth J, Stanley CA, Baker L, Thornton PS, Landau H, Permutt MA.

Hum Mutat. 1999;14(1):23-9.PMID: 10447255 [PubMed - indexed for MEDLINE]Related articles

Neonatal Hyperinsulinism.

Glaser B, Landau H, Permutt MA.

Trends Endocrinol Metab. 1999 Mar;10(2):55-61.PMID: 10322395 [PubMed - as supplied by publisher]Related articles