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Glucagon Like Peptide-1-Directed Human Embryonic Stem Cells Differentiation Into Insulin-Producing Cells Via Hedgehog, cAMP, and PI3K Pathways.

Hui H, Tang YG, Zhu L, Khoury N, Hui Z, Wang KY, Perfetti R, Go VL.

Pancreas. 2009 Nov 16. [Epub ahead of print]PMID: 19924023 [PubMed - as supplied by publisher]Related articles

Quasi-Lagrangian neural network for convex quadratic optimization.

Costantini G, Perfetti R, Todisco M.

IEEE Trans Neural Netw. 2008 Oct;19(10):1804-9.PMID: 18842483 [PubMed - indexed for MEDLINE]Related articles

Recurrent correlation associative memories: a feature space perspective.

Perfetti R, Ricci E.

IEEE Trans Neural Netw. 2008 Feb;19(2):333-45.PMID: 18269963 [PubMed - indexed for MEDLINE]Related articles

Neural associative memory storing gray-coded gray-scale images.

Costantini G, Casali D, Perfetti R.

IEEE Trans Neural Netw. 2003;14(3):703-7.PMID: 18238051 [PubMed - in process]Related articles

Retinal blood vessel segmentation using line operators and support vector classification.

Ricci E, Perfetti R.

IEEE Trans Med Imaging. 2007 Oct;26(10):1357-65.PMID: 17948726 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress.

Santangelo C, Matarrese P, Masella R, Di Carlo MC, Di Lillo A, Scazzocchio B, Vecci E, Malorni W, Perfetti R, Anastasi E.

J Mol Endocrinol. 2007 Feb;38(1-2):147-58.PMID: 17242177 [PubMed - indexed for MEDLINE]Related articlesFree article

Associative memory design using support vector machines.

Casali D, Costantini G, Perfetti R, Ricci E.

IEEE Trans Neural Netw. 2006 Sep;17(5):1165-74.PMID: 17001978 [PubMed - indexed for MEDLINE]Related articles

Analog neural network for support vector machine learning.

Perfetti R, Ricci E.

IEEE Trans Neural Netw. 2006 Jul;17(4):1085-91.PMID: 16856671 [PubMed - indexed for MEDLINE]Related articles

Associative memory design for 256 gray-level images using a multilayer neural network.

Costantini G, Casali D, Perfetti R.

IEEE Trans Neural Netw. 2006 Mar;17(2):519-22.PMID: 16566478 [PubMed - indexed for MEDLINE]Related articles

Rational drug design and PPAR agonists.

Perfetti R, D'Amico E.

Curr Diab Rep. 2005 Oct;5(5):340-5. Review.PMID: 16188168 [PubMed - indexed for MEDLINE]Related articles

Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes.

Hui H, Zhao X, Perfetti R.

Diabetes Metab Res Rev. 2005 Jul-Aug;21(4):313-31. Review.PMID: 15852457 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cells expressing GLP-1 are resistant to the toxic effects of immunosuppressive drugs.

D'Amico E, Hui H, Khoury N, Di Mario U, Perfetti R.

J Mol Endocrinol. 2005 Apr;34(2):377-90.PMID: 15821104 [PubMed - indexed for MEDLINE]Related articlesFree article

The acquisition of an insulin-secreting phenotype by HGF-treated rat pancreatic ductal cells (ARIP) is associated with the development of susceptibility to cytokine-induced apoptosis.

Anastasi E, Santangelo C, Bulotta A, Dotta F, Argenti B, Mincione C, Gulino A, Maroder M, Perfetti R, Di Mario U.

J Mol Endocrinol. 2005 Apr;34(2):367-76.PMID: 15821103 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion.

Noushmehr H, D'Amico E, Farilla L, Hui H, Wawrowsky KA, Mlynarski W, Doria A, Abumrad NA, Perfetti R.

Diabetes. 2005 Feb;54(2):472-81.PMID: 15677505 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

Hui H, Khoury N, Zhao X, Balkir L, D'Amico E, Bullotta A, Nguyen ED, Gambotto A, Perfetti R.

Diabetes. 2005 Feb;54(2):424-33.PMID: 15677500 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of GLP-1 in the life and death of pancreatic beta cells.

Perfetti R, Hui H.

Horm Metab Res. 2004 Nov-Dec;36(11-12):804-10. Review.PMID: 15655712 [PubMed - indexed for MEDLINE]Related articles

3,5,3'-Triiodo-L-thyronine enhances the differentiation of a human pancreatic duct cell line (hPANC-1) towards a beta-cell-Like phenotype.

Misiti S, Anastasi E, Sciacchitano S, Verga Falzacappa C, Panacchia L, Bucci B, Khouri D, D'Acquarica I, Brunetti E, Di Mario U, Toscano V, Perfetti R.

J Cell Physiol. 2005 Jul;204(1):286-96.PMID: 15648097 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling of cultured human islet preparations.

Hui H, Wang C, Li H, Bulotta A, D'Amico E, Khoury N, Nguyen E, Di Mario U, Chen IY, Perfetti R.

Diabetes Technol Ther. 2004 Aug;6(4):481-92.PMID: 15321003 [PubMed - indexed for MEDLINE]Related articles

The role of GLP-1 in the regulation of islet cell mass.

Bulotta A, Farilla L, Hui H, Perfetti R.

Cell Biochem Biophys. 2004;40(3 Suppl):65-78. Review.PMID: 15289644 [PubMed - indexed for MEDLINE]Related articles

Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death.

Hui H, Dotta F, Di Mario U, Perfetti R.

J Cell Physiol. 2004 Aug;200(2):177-200. Review.PMID: 15174089 [PubMed - indexed for MEDLINE]Related articles

Novel strategies for the pharmacological management of type 2 diabetes.

Nourparvar A, Bulotta A, Di Mario U, Perfetti R.

Trends Pharmacol Sci. 2004 Feb;25(2):86-91. Review.PMID: 15102494 [PubMed - indexed for MEDLINE]Related articles

GLP-1 inhibition of pancreatic islet cell apoptosis.

Urusova IA, Farilla L, Hui H, D'Amico E, Perfetti R.

Trends Endocrinol Metab. 2004 Jan-Feb;15(1):27-33. Review.PMID: 14693423 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.

Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R.

Endocrinology. 2003 Dec;144(12):5149-58. Epub 2003 Aug 28.PMID: 12960095 [PubMed - indexed for MEDLINE]Related articlesFree article

The contribution of gene profile analysis to the design of a molecular approach to treat diabetes in humans.

Perfetti R, D'Amico E.

Diabetes Technol Ther. 2003;5(3):421-3. No abstract available. PMID: 12828826 [PubMed - indexed for MEDLINE]Related articles

GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release.

Bulotta A, Perfetti R, Hui H, Boros LG.

J Lipid Res. 2003 Aug;44(8):1559-65. Epub 2003 Jun 1.PMID: 12777469 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and glucose regulate the expression of the DNA repair enzyme XPD.

Merkel P, Khoury N, Bertolotto C, Perfetti R.

Mol Cell Endocrinol. 2003 Mar 28;201(1-2):75-85.PMID: 12706296 [PubMed - indexed for MEDLINE]Related articles

GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.

Egan JM, Bulotta A, Hui H, Perfetti R.

Diabetes Metab Res Rev. 2003 Mar-Apr;19(2):115-23. Review.PMID: 12673779 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway.

Hui H, Nourparvar A, Zhao X, Perfetti R.

Endocrinology. 2003 Apr;144(4):1444-55.PMID: 12639928 [PubMed - indexed for MEDLINE]Related articlesFree article

Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1.

Bulotta A, Hui H, Anastasi E, Bertolotto C, Boros LG, Di Mario U, Perfetti R.

J Mol Endocrinol. 2002 Dec;29(3):347-60.PMID: 12459036 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U, Perfetti R.

Endocrinology. 2002 Nov;143(11):4397-408.PMID: 12399437 [PubMed - indexed for MEDLINE]Related articlesFree article

Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion.

Hui H, Yu R, Bousquet C, Perfetti R.

Endocrinology. 2002 Sep;143(9):3529-39. Erratum in: Endocrinology 2002 Nov;143(11):4349. PMID: 12193567 [PubMed - indexed for MEDLINE]Related articlesFree article

The short half-life of glucagon-like peptide-1 in plasma does not reflect its long-lasting beneficial effects.

Hui H, Farilla L, Merkel P, Perfetti R.

Eur J Endocrinol. 2002 Jun;146(6):863-9.PMID: 12039708 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.

Hui H, Perfetti R.

Eur J Endocrinol. 2002 Feb;146(2):129-41. Review.PMID: 11834421 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cells expressing the Arg64 variant of the beta(3)-adrenergic receptor exhibit abnormal insulin secretory activity.

Perfetti R, Hui H, Chamie K, Binder S, Seibert M, McLenithan J, Silver K, Walston JD.

J Mol Endocrinol. 2001 Oct;27(2):133-44.PMID: 11564599 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of glucose homeostasis by incretin hormones.

Perfetti R, Brown TA, Velikina R, Busselen S.

Diabetes Technol Ther. 1999 Fall;1(3):297-305. Review.PMID: 11475276 [PubMed - indexed for MEDLINE]Related articles

Enhancing insulin action: from chemical elements to thiazolidinediones.

Perfetti R, Chamie K.

J Endocrinol Invest. 2001 Apr;24(4):274-87. Review.PMID: 11383915 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells.

Hui H, Wright C, Perfetti R.

Diabetes. 2001 Apr;50(4):785-96.PMID: 11289043 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function.

Perfetti R, Merkel P.

Eur J Endocrinol. 2000 Dec;143(6):717-25. Review.PMID: 11124853 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats.

Perfetti R, Zhou J, Doyle ME, Egan JM.

Endocrinology. 2000 Dec;141(12):4600-5.PMID: 11108273 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel sulfonylurea and non-sulfonylurea drugs to promote the secretion of insulin.

Perfetti R, Ahmad A.

Trends Endocrinol Metab. 2000 Aug;11(6):218-23. Review.PMID: 10878751 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats.

Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, Jansen E, Zambre Y, Pipeleers D, Friedman TC.

J Clin Invest. 2000 Apr;105(7):955-65.PMID: 10749575 [PubMed - indexed for MEDLINE]Related articlesFree article

Signalling via receptor tyrosine kinase modulates the expression of the DNA repair enzyme XPD in cultured cells.

Perfetti R, Aggarwal S.

Mol Cell Endocrinol. 1999 Nov 25;157(1-2):171-80.PMID: 10619408 [PubMed - indexed for MEDLINE]Related articles

Novel therapeutic strategies for the treatment of type 2 diabetes.

Perfetti R, Barnett PS, Mathur R, Egan JM.

Diabetes Metab Rev. 1998 Sep;14(3):207-25. Review.PMID: 9816470 [PubMed - indexed for MEDLINE]Related articles

Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions.

Wang Y, Kole HK, Montrose-Rafizadeh C, Perfetti R, Bernier M, Egan JM.

J Mol Endocrinol. 1997 Dec;19(3):241-8.PMID: 9460645 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test.

De Ore K, Greig NH, Holloway HW, Wang Y, Perfetti R, Egan JM.

J Gerontol A Biol Sci Med Sci. 1997 Sep;52(5):B245-9.PMID: 9310073 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

Wang Y, Perfetti R, Greig NH, Holloway HW, DeOre KA, Montrose-Rafizadeh C, Elahi D, Egan JM.

J Clin Invest. 1997 Jun 15;99(12):2883-9.PMID: 9185511 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression and activation of the insulin receptor enhances expression of ERCC-1 messenger ribonucleic acid in cultured cells.

Perfetti R, Lee-Kwon W, Montrose-Rafizadeh C, Bernier M.

Endocrinology. 1997 May;138(5):1829-35.PMID: 9112375 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic reg gene expression is inhibited during cellular differentiation.

Zenilman ME, Magnuson TH, Perfetti R, Chen J, Shuldiner AR.

Ann Surg. 1997 Mar;225(3):327-32.PMID: 9060590 [PubMed - indexed for MEDLINE]Related articlesFree article

Training Spatially Homogeneous Fully Recurrent Neural Networks in Eigenvalue Space.

Massarelli E, Perfetti R.

Neural Netw. 1997 Jan;10(1):125-137.PMID: 12662892 [PubMed - as supplied by publisher]Related articles

Molecular investigation of age-related changes in mouse endocrine pancreas.

Perfetti R, Wang Y, Shuldiner AR, Egan JM.

J Gerontol A Biol Sci Med Sci. 1996 Sep;51(5):B331-6.PMID: 8808981 [PubMed - indexed for MEDLINE]Related articles