PubMed

C-reactive protein and coronary disease: is there a causal link?

Danesh J, Pepys MB.

Circulation. 2009 Nov 24;120(21):2036-9. Epub 2009 Nov 9. No abstract available. PMID: 19901186 [PubMed - in process]Related articles

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.

Kolstoe SE, Ridha BH, Bellotti V, Wang N, Robinson CV, Crutch SJ, Keir G, Kukkastenvehmas R, Gallimore JR, Hutchinson WL, Hawkins PN, Wood SP, Rossor MN, Pepys MB.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23. Epub 2009 Apr 16.PMID: 19372378 [PubMed - indexed for MEDLINE]Related articlesFree article

A molecular correlate of clinicopathology in transthyretin amyloidosis.

Pepys MB.

J Pathol. 2009 Jan;217(1):1-3. Review.PMID: 19061244 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein and coronary heart disease: a critical review.

Casas JP, Shah T, Hingorani AD, Danesh J, Pepys MB.

J Intern Med. 2008 Oct;264(4):295-314. Review.PMID: 18823504 [PubMed - indexed for MEDLINE]Related articles

Complement factor H binds to denatured rather than to native pentameric C-reactive protein.

Hakobyan S, Harris CL, van den Berg CW, Fernandez-Alonso MC, de Jorge EG, de Cordoba SR, Rivas G, Mangione P, Pepys MB, Morgan BP.

J Biol Chem. 2008 Nov 7;283(45):30451-60. Epub 2008 Sep 11.PMID: 18786923 [PubMed - indexed for MEDLINE]Related articlesFree article

Jack Pepys (May 15, 1914-September 9, 1996): a personal recollection.

Pepys MB.

J Allergy Clin Immunol. 2009 Mar;123(3):718-20. Epub 2008 Jun 27. No abstract available. PMID: 18585767 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein is neither a marker nor a mediator of atherosclerosis.

Pepys MB.

Nat Clin Pract Nephrol. 2008 May;4(5):234-5. Epub 2008 Mar 4. Review. No abstract available. PMID: 18317503 [PubMed - indexed for MEDLINE]Related articles

Science and serendipity.

Pepys MB.

Clin Med. 2007 Dec;7(6):562-78. Review.PMID: 18193704 [PubMed - indexed for MEDLINE]Related articles

Disease-associated prion protein is not detectable in human systemic amyloid deposits.

Tennent GA, Head MW, Bishop M, Hawkins PN, Will RG, Knight R, Peden AH, McCardle LM, Ironside JW, Pepys MB.

J Pathol. 2007 Dec;213(4):376-83.PMID: 17955450 [PubMed - indexed for MEDLINE]Related articles

Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice.

Tennent GA, Hutchinson WL, Kahan MC, Hirschfield GM, Gallimore JR, Lewin J, Sabin CA, Dhillon AP, Pepys MB.

Atherosclerosis. 2008 Jan;196(1):248-55. Epub 2007 Jun 22.PMID: 17588586 [PubMed - indexed for MEDLINE]Related articles

Normal circulating serum amyloid P component concentration in systemic sclerosis.

Tennent GA, Dziadzio M, Triantafillidou E, Davies P, Gallimore JR, Denton CP, Pepys MB.

Arthritis Rheum. 2007 Jun;56(6):2013-7.PMID: 17530641 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-edge interactions in a pentadecameric human antibody V kappa domain.

James LC, Jones PC, McCoy A, Tennent GA, Pepys MB, Famm K, Winter G.

J Mol Biol. 2007 Mar 30;367(3):603-8. Epub 2006 Nov 3.PMID: 17292396 [PubMed - indexed for MEDLINE]Related articles

Is leptin an important physiological regulator of CRP?

Hutchinson WL, Coll AP, Gallimore JR, Tennent GA, Pepys MB.

Nat Med. 2007 Jan;13(1):17-8; author reply 19-21. No abstract available. PMID: 17206123 [PubMed - indexed for MEDLINE]Related articles

Human plasma fibrinogen is synthesized in the liver.

Tennent GA, Brennan SO, Stangou AJ, O'Grady J, Hawkins PN, Pepys MB.

Blood. 2007 Mar 1;109(5):1971-4. Epub 2006 Nov 2.PMID: 17082318 [PubMed - indexed for MEDLINE]Related articlesFree article

Organ transplantation in hereditary apolipoprotein AI amyloidosis.

Gillmore JD, Stangou AJ, Lachmann HJ, Goodman HJ, Wechalekar AD, Acheson J, Tennent GA, Bybee A, Gilbertson J, Rowczenio D, O'Grady J, Heaton ND, Pepys MB, Hawkins PN.

Am J Transplant. 2006 Oct;6(10):2342-7. Epub 2006 Aug 21.PMID: 16925563 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein and cardiovascular disease: weighing the evidence.

Lowe GD, Pepys MB.

Curr Atheroscler Rep. 2006 Sep;8(5):421-8. Review.PMID: 16901413 [PubMed - indexed for MEDLINE]Related articles

Targeting C-reactive protein for the treatment of cardiovascular disease.

Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJ, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D, Wood SP.

Nature. 2006 Apr 27;440(7088):1217-21.PMID: 16642000 [PubMed - indexed for MEDLINE]Related articles

Human serum amyloid P component protects against Escherichia coli O157:H7 Shiga toxin 2 in vivo: therapeutic implications for hemolytic-uremic syndrome.

Armstrong GD, Mulvey GL, Marcato P, Griener TP, Kahan MC, Tennent GA, Sabin CA, Chart H, Pepys MB.

J Infect Dis. 2006 Apr 15;193(8):1120-4. Epub 2006 Mar 13.PMID: 16544252 [PubMed - indexed for MEDLINE]Related articles

Amyloidosis.

Pepys MB.

Annu Rev Med. 2006;57:223-41. Review.PMID: 16409147 [PubMed - indexed for MEDLINE]Related articles

Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself.

Pepys MB, Hawkins PN, Kahan MC, Tennent GA, Gallimore JR, Graham D, Sabin CA, Zychlinsky A, de Diego J.

Circ Res. 2005 Nov 25;97(11):e97-103. Epub 2005 Oct 27.PMID: 16254214 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequential heart and autologous stem cell transplantation for systemic AL amyloidosis.

Gillmore JD, Goodman HJ, Lachmann HJ, Offer M, Wechalekar AD, Joshi J, Pepys MB, Hawkins PN.

Blood. 2006 Feb 1;107(3):1227-9. Epub 2005 Oct 6.PMID: 16210334 [PubMed - indexed for MEDLINE]Related articlesFree article

CRP or not CRP? That is the question.

Pepys MB.

Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1091-4. No abstract available. PMID: 15923540 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice.

Hirschfield GM, Gallimore JR, Kahan MC, Hutchinson WL, Sabin CA, Benson GM, Dhillon AP, Tennent GA, Pepys MB.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8309-14. Epub 2005 May 26.PMID: 15919817 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability.

Clapp BR, Hirschfield GM, Storry C, Gallimore JR, Stidwill RP, Singer M, Deanfield JE, MacAllister RJ, Pepys MB, Vallance P, Hingorani AD.

Circulation. 2005 Mar 29;111(12):1530-6.PMID: 15795363 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of granulocyte colony stimulating factor with other acute phase reactants in man.

Noursadeghi M, Pepys MB, Gallimore R, Cohen J.

Clin Exp Immunol. 2005 Apr;140(1):97-100.PMID: 15762880 [PubMed - indexed for MEDLINE]Related articlesFree article

Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats.

Gill R, Kemp JA, Sabin C, Pepys MB.

J Cereb Blood Flow Metab. 2004 Nov;24(11):1214-8.PMID: 15545914 [PubMed - indexed for MEDLINE]Related articles

Preprocedural inflammatory markers do not predict restenosis after successful coronary stenting.

Gomma AH, Hirschfield GM, Gallimore JR Jr, Lowe GD, Pepys MB, Fox KM.

Am Heart J. 2004 Jun;147(6):1071-7.PMID: 15199358 [PubMed - indexed for MEDLINE]Related articles

Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences.

Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, Gallimore JR, Pepys MB, Campbell LV.

Circulation. 2004 Jun 22;109(24):3022-8. Epub 2004 Jun 7.PMID: 15184288 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?

Gillmore JD, Hutchinson WL, Herbert J, Bybee A, Mitchell DA, Hasserjian RP, Yamamura K, Suzuki M, Sabin CA, Pepys MB.

Immunology. 2004 Jun;112(2):255-64.PMID: 15147569 [PubMed - indexed for MEDLINE]Related articlesFree article

Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice.

Hutchinson WL, Herbert J, Botto M, Pepys MB.

Immunology. 2004 Jun;112(2):250-4.PMID: 15147568 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.

Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, Lowe GD, Pepys MB, Gudnason V.

N Engl J Med. 2004 Apr 1;350(14):1387-97.PMID: 15070788 [PubMed - indexed for MEDLINE]Related articlesFree article

Human C-reactive protein does not protect against acute lipopolysaccharide challenge in mice.

Hirschfield GM, Herbert J, Kahan MC, Pepys MB.

J Immunol. 2003 Dec 1;171(11):6046-51.PMID: 14634117 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic effects on baseline values of C-reactive protein and serum amyloid a protein: a comparison of monozygotic and dizygotic twins.

MacGregor AJ, Gallimore JR, Spector TD, Pepys MB.

Clin Chem. 2004 Jan;50(1):130-4. Epub 2003 Nov 18.PMID: 14633907 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein and cardiovascular disease: new insights from an old molecule.

Hirschfield GM, Pepys MB.

QJM. 2003 Nov;96(11):793-807. Review.PMID: 14566035 [PubMed - indexed for MEDLINE]Related articlesFree article

Determination of C-reactive protein: comparison of three high-sensitivity immunoassays.

Khuseyinova N, Imhof A, Trischler G, Rothenbacher D, Hutchinson WL, Pepys MB, Koenig W.

Clin Chem. 2003 Oct;49(10):1691-5. No abstract available. PMID: 14500603 [PubMed - indexed for MEDLINE]Related articlesFree article

Markers of inflammation in women on different hormone replacement therapies.

Fröhlich M, Mühlberger N, Hanke H, Imhof A, Döring A, Pepys MB, Koenig W.

Ann Med. 2003;35(5):353-61.PMID: 12952022 [PubMed - indexed for MEDLINE]Related articles

Refinement of the association of serum C-reactive protein concentration and coronary heart disease risk by correction for within-subject variation over time: the MONICA Augsburg studies, 1984 and 1987.

Koenig W, Sund M, Fröhlich M, Löwel H, Hutchinson WL, Pepys MB.

Am J Epidemiol. 2003 Aug 15;158(4):357-64.PMID: 12915501 [PubMed - indexed for MEDLINE]Related articlesFree article

Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy.

Lachmann HJ, Gallimore R, Gillmore JD, Carr-Smith HD, Bradwell AR, Pepys MB, Hawkins PN.

Br J Haematol. 2003 Jul;122(1):78-84.PMID: 12823348 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein: a critical update.

Pepys MB, Hirschfield GM.

J Clin Invest. 2003 Jun;111(12):1805-12. Review. No abstract available. Erratum in: J Clin Invest. 2003 Jul;112(2):299. PMID: 12813013 [PubMed - indexed for MEDLINE]Related articlesFree article

MHC typing in variant Creutzfeldt-Jakob disease.

Pepys MB, Bybee A, Booth DR, Bishop MT, Will RG, Little AM, Prokupek B, Madrigal JA.

Lancet. 2003 Feb 8;361(9356):487-9.PMID: 12583949 [PubMed - indexed for MEDLINE]Related articles

The structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose.

Thompson D, Pepys MB, Tickle I, Wood S.

J Mol Biol. 2002 Jul 26;320(5):1081-6.PMID: 12126626 [PubMed - indexed for MEDLINE]Related articles

Production of granulocyte colony-stimulating factor in the nonspecific acute phase response enhances host resistance to bacterial infection.

Noursadeghi M, Bickerstaff MC, Herbert J, Moyes D, Cohen J, Pepys MB.

J Immunol. 2002 Jul 15;169(2):913-9.PMID: 12097396 [PubMed - indexed for MEDLINE]Related articlesFree article

Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis.

Lachmann HJ, Booth DR, Booth SE, Bybee A, Gilbertson JA, Gillmore JD, Pepys MB, Hawkins PN.

N Engl J Med. 2002 Jun 6;346(23):1786-91.PMID: 12050338 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.

Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN.

Nature. 2002 May 16;417(6886):254-9.PMID: 12015594 [PubMed - indexed for MEDLINE]Related articles

Influenza virus infection is not affected by serum amyloid P component.

Herbert J, Hutchinson WL, Carr J, Ives J, Jakob-Roetne R, Yamamura K, Suzuki M, Pepys MB.

Mol Med. 2002 Jan;8(1):9-15.PMID: 11984001 [PubMed - indexed for MEDLINE]Related articlesFree article

Unicentric Castleman's disease complicated by systemic AA amyloidosis: a curable disease.

Lachmann HJ, Gilbertson JA, Gillmore JD, Hawkins PN, Pepys MB.

QJM. 2002 Apr;95(4):211-8. Review.PMID: 11937647 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein risk prediction: low specificity, high sensitivity.

Koenig W, Pepys MB.

Ann Intern Med. 2002 Apr 2;136(7):550-2. No abstract available. PMID: 11926792 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of seasonal variation in C-reactive protein.

Fröhlich M, Sund M, Thorand B, Hutchinson WL, Pepys MB, Koenig W.

Clin Chem. 2002 Mar;48(3):575-7. No abstract available. PMID: 11861455 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein and its role in the pathogenesis of myocardial infarction.

Pepys MB, Hirschfield GM.

Ital Heart J. 2001 Nov;2(11):804-6.PMID: 11770862 [PubMed - indexed for MEDLINE]Related articles

Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein.

Gillmore JD, Lovat LB, Persey MR, Pepys MB, Hawkins PN.

Lancet. 2001 Jul 7;358(9275):24-9.PMID: 11454373 [PubMed - indexed for MEDLINE]Related articles