PubMed

Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. Epub 2009 Jul 14.PMID: 19602585 [PubMed - indexed for MEDLINE]Related articles

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.

Piteau S, Olver A, Kim SJ, Winter K, Pospisilik JA, Lynn F, Manhart S, Demuth HU, Speck M, Pederson RA, McIntosh CH.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):1007-12. Epub 2007 Aug 29.PMID: 17803965 [PubMed - indexed for MEDLINE]Related articles

Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM).

Hinke SA, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2006;575:119-33. Review. No abstract available. PMID: 16700515 [PubMed - indexed for MEDLINE]Related articles

Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus.

McIntosh CH, Demuth HU, Kim SJ, Pospisilik JA, Pederson RA.

Int J Biochem Cell Biol. 2006;38(5-6):860-72. Epub 2006 Jan 11. Review.PMID: 16442340 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors.

Demuth HU, McIntosh CH, Pederson RA.

Biochim Biophys Acta. 2005 Aug 1;1751(1):33-44. Review.PMID: 15978877 [PubMed - indexed for MEDLINE]Related articles

In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide.

Hinke SA, Manhart S, Speck M, Pederson RA, Demuth HU, McIntosh CH.

Life Sci. 2004 Aug 27;75(15):1857-70.PMID: 15302229 [PubMed - indexed for MEDLINE]Related articles

[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.

Hinke SA, Manhart S, Kühn-Wache K, Nian C, Demuth HU, Pederson RA, McIntosh CH.

J Biol Chem. 2004 Feb 6;279(6):3998-4006. Epub 2003 Nov 10.PMID: 14610075 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

Ehses JA, Casilla VR, Doty T, Pospisilik JA, Winter KD, Demuth HU, Pederson RA, McIntosh CH.

Endocrinology. 2003 Oct;144(10):4433-45. Epub 2003 Jun 19.PMID: 12960055 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Gelling R, Manhart S, Lynn F, Pederson RA, Kühn-Wache K, Rosche F, Demuth HU, Coy D, McIntosh CH.

Biol Chem. 2003 Mar;384(3):403-7.PMID: 12715891 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.

Hinke SA, Lynn F, Ehses J, Pamir N, Manhart S, Kühn-Wache K, Rosche F, Demuth HU, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2003;524:293-301. No abstract available. PMID: 12675251 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV inhibition in animal models of diabetes.

Pospisilik JA, Ehses JA, Doty T, McIntosh CH, Demuth HU, Pederson RA.

Adv Exp Med Biol. 2003;524:281-91. No abstract available. PMID: 12675250 [PubMed - indexed for MEDLINE]Related articles

Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.

Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU.

Biochemistry. 2003 Mar 18;42(10):3081-8.PMID: 12627975 [PubMed - indexed for MEDLINE]Related articles

Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Ehlers MR, Egan JM, Elahi D.

Diabetes Care. 2003 Mar;26(3):837-42.PMID: 12610046 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.PMID: 12606516 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.PMID: 12540373 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of phytostanol phosphoryl ascorbate (FM-VP4) on insulin resistance, hyperglycemia, plasma lipid levels, and gastrointestinal absorption of exogenous cholesterol in Zucker (fa/fa) fatty and lean rats.

Wasan KM, Zamfir C, Pritchard PH, Pederson RA.

J Pharm Sci. 2003 Feb;92(2):281-8.PMID: 12532378 [PubMed - indexed for MEDLINE]Related articles

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.PMID: 12475913 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.

Pospisilik JA, Stafford SG, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2002 Sep;51(9):2677-83.PMID: 12196458 [PubMed - indexed for MEDLINE]Related articlesFree article

Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective".

Demuth HU, Hinke SA, Pederson RA, McIntosh CH.

Biochem Biophys Res Commun. 2002 Aug 16;296(2):229-32. No abstract available. PMID: 12163006 [PubMed - indexed for MEDLINE]Related articles

On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.

Hinke SA, McIntosh CH, Hoffmann T, Kühn-Wache K, Wagner L, Bär J, Manhart S, Wermann M, Pederson RA, Demuth HU.

Diabetes Care. 2002 Aug;25(8):1490-1; author reply 1491-2. No abstract available. PMID: 12145269 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.

Ehses JA, Pelech SL, Pederson RA, McIntosh CH.

J Biol Chem. 2002 Oct 4;277(40):37088-97. Epub 2002 Jul 22.PMID: 12138104 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.

Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, McIntosh CH, Pederson RA.

Diabetes. 2002 Apr;51(4):943-50.PMID: 11916911 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

Hinke SA, Kühn-Wache K, Hoffmann T, Pederson RA, McIntosh CH, Demuth HU.

Biochem Biophys Res Commun. 2002 Mar 15;291(5):1302-8.PMID: 11883961 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats.

Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Demuth HU, McIntosh CH.

Diabetes. 2002 Mar;51(3):652-61.PMID: 11872663 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D.

J Gerontol A Biol Sci Med Sci. 2001 Nov;56(11):M681-5.PMID: 11682575 [PubMed - indexed for MEDLINE]Related articles

Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Finegood DT, Elahi D.

Diabetes Care. 2001 Nov;24(11):1951-6.PMID: 11679463 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of aging and diabetes on the enteroinsular axis.

Korosi J, McIntosh CH, Pederson RA, Demuth HU, Habener JF, Gingerich R, Egan JM, Elahi D, Meneilly GS.

J Gerontol A Biol Sci Med Sci. 2001 Sep;56(9):M575-9.PMID: 11524451 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D.

Diabetes Care. 2001 May;24(5):964-5. No abstract available. PMID: 11347771 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Manhart S, Pamir N, Demuth H, W Gelling R, Pederson RA, McIntosh CH.

Biochim Biophys Acta. 2001 May 5;1547(1):143-55.PMID: 11343800 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion.

Ehses JA, Lee SS, Pederson RA, McIntosh CH.

J Biol Chem. 2001 Jun 29;276(26):23667-73. Epub 2001 Apr 25.PMID: 11323439 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism of glucagon by dipeptidyl peptidase IV (CD26).

Pospisilik JA, Hinke SA, Pederson RA, Hoffmann T, Rosche F, Schlenzig D, Glund K, Heiser U, McIntosh CH, Demuth H.

Regul Pept. 2001 Jan 12;96(3):133-41.PMID: 11111019 [PubMed - indexed for MEDLINE]Related articles

Kinetic analysis of enzymatic and nonenzymatic degradation of peptides by MALDI-TOFMS.

Rosche F, Schmidt J, Hoffmann T, Pauly RP, McIntosh CH, Pederson RA, Demuth HU.

Methods Mol Biol. 2000;146:251-72. Review. No abstract available. PMID: 10948507 [PubMed - indexed for MEDLINE]Related articles

Effect of ageing and diabetes on glucose-dependent insulinotropic polypeptide and dipeptidyl peptidase IV responses to oral glucose.

Meneilly GS, Demuth HU, McIntosh CH, Pederson RA.

Diabet Med. 2000 May;17(5):346-50.PMID: 10872532 [PubMed - indexed for MEDLINE]Related articles

Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance.

Kühn-Wache K, Manhart S, Hoffmann T, Hinke SA, Gelling R, Pederson RA, McIntosh CH, Demuth HU.

Adv Exp Med Biol. 2000;477:187-95. No abstract available. PMID: 10849746 [PubMed - indexed for MEDLINE]Related articles

Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.

Hinke SA, Pauly RP, Ehses J, Kerridge P, Demuth HU, McIntosh CH, Pederson RA.

J Endocrinol. 2000 May;165(2):281-91.PMID: 10810292 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs.

Hinke SA, Pospisilik JA, Demuth HU, Mannhart S, Kühn-Wache K, Hoffmann T, Nishimura E, Pederson RA, McIntosh CH.

J Biol Chem. 2000 Feb 11;275(6):3827-34.PMID: 10660533 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization.

Wheeler MB, Gelling RW, Hinke SA, Tu B, Pederson RA, Lynn F, Ehses J, McIntosh CH.

J Biol Chem. 1999 Aug 27;274(35):24593-601.PMID: 10455124 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide.

Pauly RP, Demuth HU, Rosche F, Schmidt J, White HA, Lynn F, McIntosh CH, Pederson RA.

Metabolism. 1999 Mar;48(3):385-9.PMID: 10094118 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin.

McIntosh CH, Bremsak I, Lynn FC, Gill R, Hinke SA, Gelling R, Nian C, McKnight G, Jaspers S, Pederson RA.

Endocrinology. 1999 Jan;140(1):398-404.PMID: 9886851 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide.

Pederson RA, White HA, Schlenzig D, Pauly RP, McIntosh CH, Demuth HU.

Diabetes. 1998 Aug;47(8):1253-8.PMID: 9703325 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

Pederson RA, Satkunarajah M, McIntosh CH, Scrocchi LA, Flamez D, Schuit F, Drucker DJ, Wheeler MB.

Diabetes. 1998 Jul;47(7):1046-52.PMID: 9648827 [PubMed - indexed for MEDLINE]Related articlesFree article

The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties.

Irwin DM, Satkunarajah M, Wen Y, Brubaker PL, Pederson RA, Wheeler MB.

Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7915-20.PMID: 9223287 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor.

Gelling RW, Wheeler MB, Xue J, Gyomorey S, Nian C, Pederson RA, McIntosh CH.

Endocrinology. 1997 Jun;138(6):2640-3.PMID: 9165060 [PubMed - indexed for MEDLINE]Related articlesFree article

GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro.

Gelling RW, Coy DH, Pederson RA, Wheeler MB, Hinke S, Kwan T, McIntosh CH.

Regul Pept. 1997 Apr 30;69(3):151-4.PMID: 9226399 [PubMed - indexed for MEDLINE]Related articles

The enteroinsular axis in dipeptidyl peptidase IV-negative rats.

Pederson RA, Kieffer TJ, Pauly R, Kofod H, Kwong J, McIntosh CH.

Metabolism. 1996 Nov;45(11):1335-41.PMID: 8931636 [PubMed - indexed for MEDLINE]Related articles

Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach.

Pauly RP, Rosche F, Wermann M, McIntosh CH, Pederson RA, Demuth HU.

J Biol Chem. 1996 Sep 20;271(38):23222-9.PMID: 8798518 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of low and high dose administration of bis(maltolato)oxovanadium(IV) on fa/fa Zucker rats.

Yuen VG, Pederson RA, Dai S, Orvig C, McNeill JH.

Can J Physiol Pharmacol. 1996 Sep;74(9):1001-9.PMID: 8960391 [PubMed - indexed for MEDLINE]Related articles

Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA.

Schieldrop PJ, Gelling RW, Elliot R, Hewitt J, Kieffer TJ, McIntosh CH, Pederson RA.

Biochim Biophys Acta. 1996 Aug 14;1308(2):111-3.PMID: 8764827 [PubMed - indexed for MEDLINE]Related articles

GIP receptors and signal-transduction mechanisms.

McIntosh CH, Wheeler MB, Gelling RW, Brown JC, Pederson RA.

Acta Physiol Scand. 1996 Jul;157(3):361-5. Review. No abstract available. PMID: 8830895 [PubMed - indexed for MEDLINE]Related articles