PubMed

Loss-of-Function CYP2C9 Variants Improve Therapeutic Response to Sulfonylureas in Type 2 Diabetes: A Go-DARTS Study.

Zhou K, Donnelly L, Burch L, Tavendale R, Doney AS, Leese G, Hattersley AT, McCarthy MI, Morris AD, Lang CC, Palmer CN, Pearson ER.

Clin Pharmacol Ther. 2009 Sep 30. [Epub ahead of print]PMID: 19794412 [PubMed - as supplied by publisher]Related articles

Translating TCF7L2: from gene to function.

Pearson ER.

Diabetologia. 2009 Jul;52(7):1227-30. Epub 2009 Apr 22. No abstract available. PMID: 19387612 [PubMed - indexed for MEDLINE]Related articles

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

Zhou K, Donnelly LA, Kimber CH, Donnan PT, Doney AS, Leese G, Hattersley AT, McCarthy MI, Morris AD, Palmer CN, Pearson ER.

Diabetes. 2009 Jun;58(6):1434-9. Epub 2009 Mar 31.PMID: 19336679 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenetics in diabetes.

Pearson ER.

Curr Diab Rep. 2009 Apr;9(2):172-81. Review.PMID: 19323963 [PubMed - indexed for MEDLINE]Related articles

Pharmacogenetics and future strategies in treating hyperglycaemia in diabetes.

Pearson ER.

Front Biosci. 2009 Jan 1;14:4348-62. Review.PMID: 19273354 [PubMed - indexed for MEDLINE]Related articles

Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study.

Donnelly LA, Morris AD, Pearson ER.

Diabetes Obes Metab. 2009 Apr;11(4):338-42.PMID: 19267712 [PubMed - in process]Related articles

Glibenclamide unresponsiveness in a Brazilian child with permanent neonatal diabetes mellitus and DEND syndrome due to a C166Y mutation in KCNJ11 (Kir6.2) gene.

Della Manna T, Battistim C, Radonsky V, Savoldelli RD, Damiani D, Kok F, Pearson ER, Ellard S, Hattersley AT, Reis AF.

Arq Bras Endocrinol Metabol. 2008 Nov;52(8):1350-5.PMID: 19169493 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in the genetics of diabetes.

Pearson ER.

Prim Care Diabetes. 2008 Jun;2(2):67-72. Epub 2008 Feb 12. Review.PMID: 18684425 [PubMed - indexed for MEDLINE]Related articles

Transition from insulin to sulfonylurea in a child with diabetes due to a mutation in KCNJ11 encoding Kir6.2--initial and long-term response to sulfonylurea therapy.

Wagner VM, Kremke B, Hiort O, Flanagan SE, Pearson ER.

Eur J Pediatr. 2009 Mar;168(3):359-61. Epub 2008 Jun 12.PMID: 18548275 [PubMed - indexed for MEDLINE]Related articles

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.

de Wet H, Proks P, Lafond M, Aittoniemi J, Sansom MS, Flanagan SE, Pearson ER, Hattersley AT, Ashcroft FM.

EMBO Rep. 2008 Jul;9(7):648-54. Epub 2008 May 23.PMID: 18497752 [PubMed - indexed for MEDLINE]Related articlesFree article

No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis.

Evans JM, Ogston SA, Reimann F, Gribble FM, Morris AD, Pearson ER.

Diabetes Obes Metab. 2008 Apr;10(4):350-2. Epub 2007 Dec 17.PMID: 18093208 [PubMed - indexed for MEDLINE]Related articles

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.

Pearson ER, Donnelly LA, Kimber C, Whitley A, Doney AS, McCarthy MI, Hattersley AT, Morris AD, Palmer CN.

Diabetes. 2007 Aug;56(8):2178-82. Epub 2007 May 22.PMID: 17519421 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.

Kimber CH, Doney AS, Pearson ER, McCarthy MI, Hattersley AT, Leese GP, Morris AD, Palmer CN.

Diabetologia. 2007 Jun;50(6):1186-91. Epub 2007 Apr 11.PMID: 17429603 [PubMed - indexed for MEDLINE]Related articles

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.

Pearson ER, Boj SF, Steele AM, Barrett T, Stals K, Shield JP, Ellard S, Ferrer J, Hattersley AT.

PLoS Med. 2007 Apr;4(4):e118.PMID: 17407387 [PubMed - indexed for MEDLINE]Related articlesFree article

The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations.

Singh R, Pearson ER, Clark PM, Hattersley AT.

Diabetologia. 2007 Mar;50(3):620-4. Epub 2007 Jan 10.PMID: 17216282 [PubMed - indexed for MEDLINE]Related articles

GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes.

Castleden HA, Shields B, Bingley PJ, Williams AJ, Sampson M, Walker M, Gibson JM, McCarthy MI, Hitman GA, Levy JC, Hattersley AT, Vaidya B, Pearson ER.

Diabet Med. 2006 Aug;23(8):834-8.PMID: 16911619 [PubMed - indexed for MEDLINE]Related articles

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT; Neonatal Diabetes International Collaborative Group.

N Engl J Med. 2006 Aug 3;355(5):467-77.PMID: 16885550 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.

Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, Morgan NG.

J Endocrinol. 2006 Jul;190(1):171-81.PMID: 16837621 [PubMed - indexed for MEDLINE]Related articlesFree article

Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes.

Hattersley AT, Pearson ER.

Endocrinology. 2006 Jun;147(6):2657-63. Epub 2006 Mar 23. Review.PMID: 16556760 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations.

Brackenridge A, Pearson ER, Shojaee-Moradie F, Hattersley AT, Russell-Jones D, Umpleby AM.

Diabetes. 2006 Feb;55(2):405-11.PMID: 16443774 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes.

Donnelly LA, Doney AS, Hattersley AT, Morris AD, Pearson ER.

Diabet Med. 2006 Feb;23(2):128-33.PMID: 16433709 [PubMed - indexed for MEDLINE]Related articles

Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.

Pearson ER, Pruhova S, Tack CJ, Johansen A, Castleden HA, Lumb PJ, Wierzbicki AS, Clark PM, Lebl J, Pedersen O, Ellard S, Hansen T, Hattersley AT.

Diabetologia. 2005 May;48(5):878-85. Epub 2005 Apr 14.PMID: 15830177 [PubMed - indexed for MEDLINE]Related articles

Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

Sagen JV, Pearson ER, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad PR, Hattersley AT, Hansen T.

Diabet Med. 2005 Apr;22(4):406-9.PMID: 15787664 [PubMed - indexed for MEDLINE]Related articles

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT.

Hum Mol Genet. 2005 Apr 1;14(7):925-34. Epub 2005 Feb 17.PMID: 15718250 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene.

Stride A, Pearson ER, Brown A, Gooding K, Castleden HA, Hattersley AT.

Diabet Med. 2004 Aug;21(8):928-30.PMID: 15270800 [PubMed - indexed for MEDLINE]Related articles

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT.

N Engl J Med. 2004 Apr 29;350(18):1838-49. Erratum in: N Engl J Med. 2004 Sep 30;351(14):1470. PMID: 15115830 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT.

Diabetes Care. 2004 May;27(5):1102-7.PMID: 15111528 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

No deterioration in glycemic control in HNF-1alpha maturity-onset diabetes of the young following transfer from long-term insulin to sulphonylureas.

Shepherd M, Pearson ER, Houghton J, Salt G, Ellard S, Hattersley AT.

Diabetes Care. 2003 Nov;26(11):3191-2. No abstract available. PMID: 14578267 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic cause of hyperglycaemia and response to treatment in diabetes.

Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT.

Lancet. 2003 Oct 18;362(9392):1275-81.PMID: 14575972 [PubMed - indexed for MEDLINE]Related articles

Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation.

Bingham C, Ellard S, van't Hoff WG, Simmonds HA, Marinaki AM, Badman MK, Winocour PH, Stride A, Lockwood CR, Nicholls AJ, Owen KR, Spyer G, Pearson ER, Hattersley AT.

Kidney Int. 2003 May;63(5):1645-51.PMID: 12675839 [PubMed - indexed for MEDLINE]Related articles

Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene.

Waller SC, Rees L, Woolf AS, Ellard S, Pearson ER, Hattersley AT, Bingham C.

Am J Kidney Dis. 2002 Dec;40(6):1325-30.PMID: 12460054 [PubMed - indexed for MEDLINE]Related articles

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S101-7.PMID: 11272165 [PubMed - indexed for MEDLINE]Related articles

Unravelling the heterogeneity of non insulin dependent diabetes.

Pearson ER, Hattersley AT.

J R Coll Physicians Lond. 2000 Jul-Aug;34(4):332-5. Review. No abstract available. PMID: 11005066 [PubMed - indexed for MEDLINE]Related articles

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes.

Pearson ER, Liddell WG, Shepherd M, Corrall RJ, Hattersley AT.

Diabet Med. 2000 Jul;17(7):543-5.PMID: 10972586 [PubMed - indexed for MEDLINE]Related articles

Hypertensive encephalopathy and nephrotic syndrome: a possible link?

Pearson ER, D'Souza RJ, Hamilton-Wood C, Nicholls AJ, Beaman M.

Nephrol Dial Transplant. 1999 Jul;14(7):1750-2. No abstract available. PMID: 10435888 [PubMed - indexed for MEDLINE]Related articlesFree article