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Current status of stroke risk stratification in patients with atrial fibrillation.

Hart RG, Pearce LA.

Stroke. 2009 Jul;40(7):2607-10. Epub 2009 May 21. Review. No abstract available. PMID: 19461020 [PubMed - indexed for MEDLINE]Related articles

Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events.

Apple FS, Pearce LA, Smith SW, Kaczmarek JM, Murakami MM.

Clin Chem. 2009 May;55(5):930-7. Epub 2009 Mar 19.PMID: 19299542 [PubMed - indexed for MEDLINE]Related articles

Neuroprotection trials in Parkinson's disease: systematic review.

Hart RG, Pearce LA, Ravina BM, Yaltho TC, Marler JR.

Mov Disord. 2009 Apr 15;24(5):647-54. Review.PMID: 19117366 [PubMed - indexed for MEDLINE]Related articles

Kinetic screening of antibody-Im7 conjugates by capture on a colicin E7 DNase domain using optical biosensors.

Hosse RJ, Tay L, Hattarki MK, Pontes-Braz L, Pearce LA, Nuttall SD, Dolezal O.

Anal Biochem. 2009 Feb 15;385(2):346-57. Epub 2008 Nov 27.PMID: 19073134 [PubMed - indexed for MEDLINE]Related articles

Assessment of the multiple-biomarker approach for diagnosis of myocardial infarction in patients presenting with symptoms suggestive of acute coronary syndrome.

Apple FS, Smith SW, Pearce LA, Murakami MM.

Clin Chem. 2009 Jan;55(1):93-100. Epub 2008 Nov 21.PMID: 19028826 [PubMed - indexed for MEDLINE]Related articles

Use of the Centaur TnI-Ultra assay for detection of myocardial infarction and adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.

Apple FS, Smith SW, Pearce LA, Ler R, Murakami MM.

Clin Chem. 2008 Apr;54(4):723-8. Epub 2008 Jan 31.PMID: 18238833 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of the bioMérieux VIDAS troponin I ultra assay for the diagnosis of myocardial infarction and detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.

Apple FS, Smith SW, Pearce LA, Ler R, Murakami MM, Benoit MO, Levy C, Dumas C, Paul JL.

Clin Chim Acta. 2008 Apr;390(1-2):72-5. Epub 2008 Jan 11.PMID: 18230357 [PubMed - indexed for MEDLINE]Related articles

Adjusted-dose warfarin versus aspirin for preventing stroke in patients with atrial fibrillation.

Hart RG, Pearce LA, Aguilar MI.

Ann Intern Med. 2007 Oct 16;147(8):590-2. No abstract available. PMID: 17938402 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks.

Aguilar MI, Hart R, Pearce LA.

Cochrane Database Syst Rev. 2007 Jul 18;(3):CD006186. Review.PMID: 17636831 [PubMed - indexed for MEDLINE]Related articles

Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.

Hart RG, Pearce LA, Aguilar MI.

Ann Intern Med. 2007 Jun 19;146(12):857-67.PMID: 17577005 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.

Apple FS, Pearce LA, Chung A, Ler R, Murakami MM.

Clin Chem. 2007 May;53(5):874-81. Epub 2007 Mar 23.PMID: 17384009 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac troponin risk stratification based on 99th percentile reference cutoffs in patients with ischemic symptoms suggestive of acute coronary syndrome: influence of estimated glomerular filtration rates.

Apple FS, Pearce LA, Doyle PJ, Otto AP, Murakami MM.

Am J Clin Pathol. 2007 Apr;127(4):598-603.PMID: 17369136 [PubMed - indexed for MEDLINE]Related articlesFree article

Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas.

Hart RG, Tonarelli SB, Pearce LA.

Stroke. 2005 Jul;36(7):1588-93. Epub 2005 Jun 9. Review.PMID: 15947271 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of congestive heart failure on plasma von Willebrand factor and soluble P-selectin concentrations in patients with non-valvar atrial fibrillation.

Lip GY, Pearce LA, Chin BS, Conway DS, Hart RG.

Heart. 2005 Jun;91(6):759-63.PMID: 15894770 [PubMed - indexed for MEDLINE]Related articlesFree article

Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death.

Apple FS, Murakami MM, Pearce LA, Herzog CA.

Clin Chem. 2004 Dec;50(12):2279-85. Epub 2004 Sep 13.PMID: 15364888 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient ischemic attacks in patients with atrial fibrillation: implications for secondary prevention: the European Atrial Fibrillation Trial and Stroke Prevention in Atrial Fibrillation III trial.

Hart RG, Pearce LA, Koudstaal PJ.

Stroke. 2004 Apr;35(4):948-51. Epub 2004 Feb 26.PMID: 14988571 [PubMed - indexed for MEDLINE]Related articlesFree article

Prognostic value of the Ortho Vitros cardiac troponin I assay in patients with symptoms of myocardial ischemia. Risk stratification using European Society of Cardiology/American College of Cardiology recommended cutoff values.

Apple FS, Murakami MM, Quist HH, Pearce LA, Wieczorek S, Wu AH.

Am J Clin Pathol. 2003 Jul;120(1):114-20.PMID: 12866381 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum potassium level and dietary potassium intake as risk factors for stroke.

Hart RG, Pearce LA; Stroke Prevention in Atrial Fibrillation Investigators.

Neurology. 2003 Jun 10;60(11):1869-70; author reply 1870. No abstract available. PMID: 12796561 [PubMed - indexed for MEDLINE]Related articles

Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation.

Conway DS, Pearce LA, Chin BS, Hart RG, Lip GY.

Circulation. 2003 Jul 1;107(25):3141-5. Epub 2003 Jun 9.PMID: 12796127 [PubMed - indexed for MEDLINE]Related articlesFree article

Lessons from the Stroke Prevention in Atrial Fibrillation trials.

Hart RG, Halperin JL, Pearce LA, Anderson DC, Kronmal RA, McBride R, Nasco E, Sherman DG, Talbert RL, Marler JR; Stroke Prevention in Atrial Fibrillation Investigators.

Ann Intern Med. 2003 May 20;138(10):831-8. Review.PMID: 12755555 [PubMed - indexed for MEDLINE]Related articlesFree article

Aspirin dosage and thromboxane synthesis in patients with vascular disease.

Hart RG, Leonard AD, Talbert RL, Pearce LA, Cornell E, Bovill E, Feinberg WM.

Pharmacotherapy. 2003 May;23(5):579-84.PMID: 12741431 [PubMed - indexed for MEDLINE]Related articles

Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease.

Apple FS, Murakami MM, Pearce LA, Herzog CA.

Circulation. 2002 Dec 3;106(23):2941-5.PMID: 12460876 [PubMed - indexed for MEDLINE]Related articlesFree article

Atrial fibrillation, stroke, and acute antithrombotic therapy: analysis of randomized clinical trials.

Hart RG, Palacio S, Pearce LA.

Stroke. 2002 Nov;33(11):2722-7. Review.PMID: 12411668 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma von Willebrand factor and soluble p-selectin as indices of endothelial damage and platelet activation in 1321 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors.

Conway DS, Pearce LA, Chin BS, Hart RG, Lip GY.

Circulation. 2002 Oct 8;106(15):1962-7.PMID: 12370220 [PubMed - indexed for MEDLINE]Related articlesFree article

Near-bedside whole-blood cardiac troponin I assay for risk assessment of patients with acute coronary syndromes.

Apple FS, Murakami MM, Jesse RL, Levitt MA, Berger AK, Pearce LA, Collinson P.

Clin Chem. 2002 Oct;48(10):1784-7. No abstract available. PMID: 12324498 [PubMed - indexed for MEDLINE]Related articlesFree article

Occurrence of hemispheric and retinal ischemia in atrial fibrillation compared with carotid stenosis.

Anderson DC, Kappelle LJ, Eliasziw M, Babikian VL, Pearce LA, Barnett HJ.

Stroke. 2002 Aug;33(8):1963-7.PMID: 12154246 [PubMed - indexed for MEDLINE]Related articlesFree article

Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage.

Bailey RD, Hart RG, Benavente O, Pearce LA.

Neurology. 2001 Mar 27;56(6):773-7.PMID: 11274313 [PubMed - indexed for MEDLINE]Related articles

ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in V(L) to V(H) orientation drives the formation of dimers, trimers, tetramers and higher molecular mass multimers.

Dolezal O, Pearce LA, Lawrence LJ, McCoy AJ, Hudson PJ, Kortt AA.

Protein Eng. 2000 Aug;13(8):565-74.PMID: 10964986 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of three schemes for stratifying stroke risk in patients with nonvalvular atrial fibrillation.

Pearce LA, Hart RG, Halperin JL.

Am J Med. 2000 Jul;109(1):45-51.PMID: 10936477 [PubMed - indexed for MEDLINE]Related articles

Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators.

Hart RG, Pearce LA, Rothbart RM, McAnulty JH, Asinger RW, Halperin JL.

J Am Coll Cardiol. 2000 Jan;35(1):183-7.PMID: 10636278 [PubMed - indexed for MEDLINE]Related articles

Cardioembolic vs. noncardioembolic strokes in atrial fibrillation: frequency and effect of antithrombotic agents in the stroke prevention in atrial fibrillation studies.

Hart RG, Pearce LA, Miller VT, Anderson DC, Rothrock JF, Albers GW, Nasco E.

Cerebrovasc Dis. 2000 Jan-Feb;10(1):39-43.PMID: 10629345 [PubMed - indexed for MEDLINE]Related articles

Pathophysiologic correlates of thromboembolism in nonvalvular atrial fibrillation: II. Dense spontaneous echocardiographic contrast (The Stroke Prevention in Atrial Fibrillation [SPAF-III] study).

Asinger RW, Koehler J, Pearce LA, Zabalgoitia M, Blackshear JL, Fenster PE, Strauss R, Hess D, Pennock GD, Rothbart RM, Halperin JL.

J Am Soc Echocardiogr. 1999 Dec;12(12):1088-96.PMID: 10588785 [PubMed - indexed for MEDLINE]Related articles

Pathophysiologic correlates of thromboembolism in nonvalvular atrial fibrillation: I. Reduced flow velocity in the left atrial appendage (The Stroke Prevention in Atrial Fibrillation [SPAF-III] study).

Goldman ME, Pearce LA, Hart RG, Zabalgoitia M, Asinger RW, Safford R, Halperin JL.

J Am Soc Echocardiogr. 1999 Dec;12(12):1080-7.PMID: 10588784 [PubMed - indexed for MEDLINE]Related articles

Markers of thrombin and platelet activity in patients with atrial fibrillation: correlation with stroke among 1531 participants in the stroke prevention in atrial fibrillation III study.

Feinberg WM, Pearce LA, Hart RG, Cushman M, Cornell ES, Lip GY, Bovill EG.

Stroke. 1999 Dec;30(12):2547-53.PMID: 10582976 [PubMed - indexed for MEDLINE]Related articlesFree article

Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis.

Hart RG, Benavente O, McBride R, Pearce LA.

Ann Intern Med. 1999 Oct 5;131(7):492-501.PMID: 10507957 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinically significant differences in the International Normalized Ratio measured with reagents of different sensitivities. SPAF Investigators. Stroke Prevention in Atrial Fibrillation.

Lind SE, Pearce LA, Feinberg WM, Bovill EG.

Blood Coagul Fibrinolysis. 1999 Jul;10(5):215-27.PMID: 10456611 [PubMed - indexed for MEDLINE]Related articles

Plasmin-alpha2-antiplasmin complex in patients with atrial fibrillation. Stroke Prevention in Atrial Fibrillation Investigators.

Feinberg WM, Macy E, Cornell ES, Nightingale SD, Pearce LA, Tracy RP, Bovill EG.

Thromb Haemost. 1999 Jul;82(1):100-3.PMID: 10456461 [PubMed - indexed for MEDLINE]Related articles

Increased risk of intracranial hemorrhage when aspirin is combined with warfarin: A meta-analysis and hypothesis.

Hart RG, Benavente O, Pearce LA.

Cerebrovasc Dis. 1999 Jul-Aug;9(4):215-7.PMID: 10393408 [PubMed - indexed for MEDLINE]Related articles

Factors associated with ischemic stroke during aspirin therapy in atrial fibrillation: analysis of 2012 participants in the SPAF I-III clinical trials. The Stroke Prevention in Atrial Fibrillation (SPAF) Investigators.

Hart RG, Pearce LA, McBride R, Rothbart RM, Asinger RW.

Stroke. 1999 Jun;30(6):1223-9.PMID: 10356104 [PubMed - indexed for MEDLINE]Related articlesFree article

Aortic plaque in atrial fibrillation: prevalence, predictors, and thromboembolic implications.

Blackshear JL, Pearce LA, Hart RG, Zabalgoitia M, Labovitz A, Asinger RW, Halperin JL.

Stroke. 1999 Apr;30(4):834-40.PMID: 10187888 [PubMed - indexed for MEDLINE]Related articlesFree article

Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation. SPAF TEE Investigators. Stroke Prevention and Atrial Fibrillation. Transesophageal echocardiography.

Blackshear JL, Zabalgoitia M, Pennock G, Fenster P, Strauss R, Halperin J, Asinger R, Pearce LA.

Am J Cardiol. 1999 Feb 1;83(3):453-5, A9.PMID: 10072242 [PubMed - indexed for MEDLINE]Related articles

Left atrial diameter in nonvalvular atrial fibrillation: An echocardiographic study. Stroke Prevention in Atrial Fibrillation Investigators.

Dittrich HC, Pearce LA, Asinger RW, McBride R, Webel R, Zabalgoitia M, Pennock GD, Safford RE, Rothbart RM, Halperin JL, Hart RG.

Am Heart J. 1999 Mar;137(3):494-9.PMID: 10047632 [PubMed - indexed for MEDLINE]Related articles

Transesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. Stroke Prevention in Atrial Fibrillation III Investigators.

Zabalgoitia M, Halperin JL, Pearce LA, Blackshear JL, Asinger RW, Hart RG.

J Am Coll Cardiol. 1998 Jun;31(7):1622-6.PMID: 9626843 [PubMed - indexed for MEDLINE]Related articles

Expression in Escherichia coli of the putative N-acetylneuraminate lyase gene (nanA) from Haemophilus influenzae: overproduction, purification, and crystallization.

Lilley GG, Barbosa JA, Pearce LA.

Protein Expr Purif. 1998 Apr;12(3):295-304.PMID: 9535696 [PubMed - indexed for MEDLINE]Related articles

Linear gene fusions of antibody fragments with streptavidin can be linked to biotin labelled secondary molecules to form bispecific reagents.

Pearce LA, Oddie GW, Coia G, Kortt AA, Hudson PJ, Lilley GG.

Biochem Mol Biol Int. 1997 Sep;42(6):1179-88.PMID: 9305536 [PubMed - indexed for MEDLINE]Related articles

Relationship between prothrombin activation fragment F1.2 and international normalized ratio in patients with atrial fibrillation. Stroke Prevention in Atrial Fibrillation Investigators.

Feinberg WM, Cornell ES, Nightingale SD, Pearce LA, Tracy RP, Hart RG, Bovill EG.

Stroke. 1997 Jun;28(6):1101-6.PMID: 9183333 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer.

Kortt AA, Lah M, Oddie GW, Gruen CL, Burns JE, Pearce LA, Atwell JL, McCoy AJ, Howlett GJ, Metzger DW, Webster RG, Hudson PJ.

Protein Eng. 1997 Apr;10(4):423-33.PMID: 9194168 [PubMed - indexed for MEDLINE]Related articlesFree article

Design and expression of a stable bispecific scFv dimer with affinity for both glycophorin and N9 neuraminidase.

Atwell JL, Pearce LA, Lah M, Gruen LC, Kortt AA, Hudson PJ.

Mol Immunol. 1996 Dec;33(17-18):1301-12.PMID: 9171890 [PubMed - indexed for MEDLINE]Related articles

F-amplitude, left atrial appendage velocity, and thromboembolic risk in nonrheumatic atrial fibrillation. Stroke Prevention in Atrial Fibrillation Investigators.

Blackshear JL, Safford RE, Pearce LA.

Clin Cardiol. 1996 Apr;19(4):309-13.PMID: 8706371 [PubMed - indexed for MEDLINE]Related articles

Differential effect of aspirin versus warfarin on clinical stroke types in patients with atrial fibrillation. Stroke Prevention in Atrial Fibrillation Investigators.

Miller VT, Pearce LA, Feinberg WM, Rothrock JF, Anderson DC, Hart RG.

Neurology. 1996 Jan;46(1):238-40.PMID: 8559383 [PubMed - indexed for MEDLINE]Related articles