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Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones in Rhesus Macaques during Acute Infection.

Minang JT, Trivett MT, Bolton DL, Trubey CM, Estes JD, Li Y, Smedley J, Pung R, Rosati M, Jalah R, Pavlakis GN, Felber BK, Piatak M Jr, Roederer M, Lifson JD, Ott DE, Ohlen C.

J Immunol. 2009 Nov 30. [Epub ahead of print]PMID: 19949091 [PubMed - as supplied by publisher]Related articles

Refined Methods for Propagating Vesicular Stomatitis Virus Vectors that are Defective for G Protein Expression.

Witko SE, Johnson JE, Kalyan NK, Felber BK, Pavlakis GN, Sidhu MK, Hendry RM, Udem SA, Parks CL.

J Virol Methods. 2009 Nov 23. [Epub ahead of print]PMID: 19941901 [PubMed - as supplied by publisher]Related articles

Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA.

Zolotukhin AS, Uranishi H, Lindtner S, Bear J, Pavlakis GN, Felber BK.

Nucleic Acids Res. 2009 Sep 28. [Epub ahead of print]PMID: 19786495 [PubMed - as supplied by publisher]Related articlesFree article

DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge.

Rosati M, Bergamaschi C, Valentin A, Kulkarni V, Jalah R, Alicea C, Patel V, von Gegerfelt AS, Montefiori DC, Venzon DJ, Khan AS, Draghia-Akli R, Van Rompay KK, Felber BK, Pavlakis GN.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15831-6. Epub 2009 Aug 28.PMID: 19717425 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo.

Bergamaschi C, Jalah R, Kulkarni V, Rosati M, Zhang GM, Alicea C, Zolotukhin AS, Felber BK, Pavlakis GN.

J Immunol. 2009 Sep 1;183(5):3064-72.PMID: 19696432 [PubMed - indexed for MEDLINE]Related articles

The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.

Uranishi H, Zolotukhin AS, Lindtner S, Warming S, Zhang GM, Bear J, Copeland NG, Jenkins NA, Pavlakis GN, Felber BK.

J Biol Chem. 2009 Sep 18;284(38):26106-16. Epub 2009 Jul 8.PMID: 19586903 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.

Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA.

J Immunol. 2009 Jul 15;183(2):1120-32. Epub 2009 Jun 29.PMID: 19564339 [PubMed - indexed for MEDLINE]Related articles

Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes.

Valentin A, Chikhlikar P, Patel V, Rosati M, Maciel M, Chang KH, Silvera P, Felber BK, Pavlakis GN, August JT, Marques ET.

Vaccine. 2009 Jul 30;27(35):4840-9. Epub 2009 Jun 17.PMID: 19539586 [PubMed - indexed for MEDLINE]Related articles

Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.

Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, Khan T, Dai RM, Scheetz L, Lincoln E, Back TC, Powell D, Hurwitz AA, Sayers TJ, Kastelein R, Pavlakis GN, Felber BK, Trinchieri G, Wigginton JM.

J Immunol. 2009 Apr 1;182(7):4328-38.PMID: 19299733 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+ T-cell loss and delayed expression of modulators of immune responses at mucosal sites of vaccinated macaques following SIV(mac251) infection.

Vaccari M, Boasso A, Ma ZM, Cecchinato V, Venzon D, Doster MN, Tsai WP, Shearer GM, Fuchs D, Felber BK, Pavlakis GN, Miller CJ, Franchini G.

Mucosal Immunol. 2008 Nov;1(6):497-507. Epub 2008 Sep 17.PMID: 19079217 [PubMed - indexed for MEDLINE]Related articles

Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines.

Xu R, Megati S, Roopchand V, Luckay A, Masood A, Garcia-Hand D, Rosati M, Weiner DB, Felber BK, Pavlakis GN, Sidhu MK, Eldridge JH, Egan MA.

Vaccine. 2008 Sep 2;26(37):4819-29. Epub 2008 Jul 25.PMID: 18657584 [PubMed - indexed for MEDLINE]Related articles

Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques.

Halwani R, Boyer JD, Yassine-Diab B, Haddad EK, Robinson TM, Kumar S, Parkinson R, Wu L, Sidhu MK, Phillipson-Weiner R, Pavlakis GN, Felber BK, Lewis MG, Shen A, Siliciano RF, Weiner DB, Sekaly RP.

J Immunol. 2008 Jun 15;180(12):7969-79.PMID: 18523260 [PubMed - indexed for MEDLINE]Related articlesFree article

Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses.

Megati S, Garcia-Hand D, Cappello S, Roopchand V, Masood A, Xu R, Luckay A, Chong SY, Rosati M, Sackitey S, Weiner DB, Felber BK, Pavlakis GN, Israel ZR, Smith LR, Eldridge JH, Sidhu MK, Egan MA.

Vaccine. 2008 Sep 19;26(40):5083-94. Epub 2008 Apr 24.PMID: 18485543 [PubMed - indexed for MEDLINE]Related articles

The RNA transport element RTE is essential for IAP LTR-retrotransposon mobility.

Zolotukhin AS, Schneider R, Uranishi H, Bear J, Tretyakova I, Michalowski D, Smulevitch S, O'Keeffe S, Pavlakis GN, Felber BK.

Virology. 2008 Jul 20;377(1):88-99. Epub 2008 May 15.PMID: 18485438 [PubMed - indexed for MEDLINE]Related articles

Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation.

Rosati M, Valentin A, Jalah R, Patel V, von Gegerfelt A, Bergamaschi C, Alicea C, Weiss D, Treece J, Pal R, Markham PD, Marques ET, August JT, Khan A, Draghia-Akli R, Felber BK, Pavlakis GN.

Vaccine. 2008 Sep 19;26(40):5223-9. Epub 2008 Apr 21.PMID: 18468743 [PubMed - indexed for MEDLINE]Related articles

An inducible and reversible mouse genetic rescue system.

Zeng H, Horie K, Madisen L, Pavlova MN, Gragerova G, Rohde AD, Schimpf BA, Liang Y, Ojala E, Kramer F, Roth P, Slobodskaya O, Dolka I, Southon EA, Tessarollo L, Bornfeldt KE, Gragerov A, Pavlakis GN, Gaitanaris GA.

PLoS Genet. 2008 May 9;4(5):e1000069.PMID: 18464897 [PubMed - indexed for MEDLINE]Related articlesFree article

A splenic marginal zone-like peripheral blood CD27+B220- B cell population is preferentially depleted in HIV type 1-infected individuals.

Morrow M, Valentin A, Little R, Yarchoan R, Pavlakis GN.

AIDS Res Hum Retroviruses. 2008 Apr;24(4):621-33.PMID: 18426338 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.

Bergamaschi C, Rosati M, Jalah R, Valentin A, Kulkarni V, Alicea C, Zhang GM, Patel V, Felber BK, Pavlakis GN.

J Biol Chem. 2008 Feb 15;283(7):4189-99. Epub 2007 Nov 30.PMID: 18055460 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.

Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, Waldmann TA, Eldridge J, Weiner DB.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18648-53. Epub 2007 Nov 13.PMID: 18000037 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids.

Jalah R, Rosati M, Kulkarni V, Patel V, Bergamaschi C, Valentin A, Zhang GM, Sidhu MK, Eldridge JH, Weiner DB, Pavlakis GN, Felber BK.

DNA Cell Biol. 2007 Dec;26(12):827-40.PMID: 17979522 [PubMed - indexed for MEDLINE]Related articles

Large-scale, saturating insertional mutagenesis of the mouse genome.

Gragerov A, Horie K, Pavlova M, Madisen L, Zeng H, Gragerova G, Rhode A, Dolka I, Roth P, Ebbert A, Moe S, Navas C, Finn E, Bergmann J, Vassilatis DK, Pavlakis GN, Gaitanaris GA.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14406-11. Epub 2007 Aug 24.PMID: 17720809 [PubMed - indexed for MEDLINE]Related articlesFree article

Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses.

Robinson TM, Sidhu MK, Pavlakis GN, Felber BK, Silvera P, Lewis MG, Eldridge J, Weiner DB, Boyer JD.

J Med Primatol. 2007 Aug;36(4-5):276-84.PMID: 17669216 [PubMed - indexed for MEDLINE]Related articles

Posttranscriptional control of HIV-1 and other retroviruses and its practical applications.

Felber BK, Zolotukhin AS, Pavlakis GN.

Adv Pharmacol. 2007;55:161-97. Review. No abstract available. PMID: 17586315 [PubMed - indexed for MEDLINE]Related articles

Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.

Chong SY, Egan MA, Kutzler MA, Megati S, Masood A, Roopchard V, Garcia-Hand D, Montefiori DC, Quiroz J, Rosati M, Schadeck EB, Boyer JD, Pavlakis GN, Weiner DB, Sidhu M, Eldridge JH, Israel ZR.

Vaccine. 2007 Jun 21;25(26):4967-82. Epub 2007 Feb 14.PMID: 17335943 [PubMed - indexed for MEDLINE]Related articles

Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques.

Luckay A, Sidhu MK, Kjeken R, Megati S, Chong SY, Roopchand V, Garcia-Hand D, Abdullah R, Braun R, Montefiori DC, Rosati M, Felber BK, Pavlakis GN, Mathiesen I, Israel ZR, Eldridge JH, Egan MA.

J Virol. 2007 May;81(10):5257-69. Epub 2007 Feb 28.PMID: 17329330 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.

von Gegerfelt AS, Rosati M, Alicea C, Valentin A, Roth P, Bear J, Franchini G, Albert PS, Bischofberger N, Boyer JD, Weiner DB, Markham P, Israel ZR, Eldridge JH, Pavlakis GN, Felber BK.

J Virol. 2007 Feb;81(4):1972-9. Epub 2006 Nov 29.PMID: 17135321 [PubMed - indexed for MEDLINE]Related articlesFree article

RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.

Lindtner S, Zolotukhin AS, Uranishi H, Bear J, Kulkarni V, Smulevitch S, Samiotaki M, Panayotou G, Felber BK, Pavlakis GN.

J Biol Chem. 2006 Dec 1;281(48):36915-28. Epub 2006 Sep 25.PMID: 17001072 [PubMed - indexed for MEDLINE]Related articlesFree article

Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.

Watanabe D, Brockman MA, Ndung'u T, Mathews L, Lucas WT, Murphy CG, Felber BK, Pavlakis GN, Deluca NA, Knipe DM.

Virology. 2007 Jan 20;357(2):186-98. Epub 2006 Sep 22.PMID: 16996101 [PubMed - indexed for MEDLINE]Related articles

Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.

Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, Bronson RT, Lifson JD, Rosati M, Pavlakis GN, Felber BK, Knipe DM, Desrosiers RC.

Virology. 2007 Jan 20;357(2):199-214. Epub 2006 Sep 7.PMID: 16962628 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct.

Kumar S, Yan J, Muthumani K, Ramanathan MP, Yoon H, Pavlakis GN, Felber BK, Sidhu M, Boyer JD, Weiner DB.

DNA Cell Biol. 2006 Jul;25(7):383-92.PMID: 16848679 [PubMed - indexed for MEDLINE]Related articles

Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques.

von Gegerfelt AS, Alicea C, Valentin A, Morrow M, van Rompay KK, Ayash-Rashkovsky M, Markham P, Else JG, Marthas ML, Pavlakis GN, Ruprecht RM, Felber BK.

AIDS Res Hum Retroviruses. 2006 Jun;22(6):516-28.PMID: 16796527 [PubMed - indexed for MEDLINE]Related articles

RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs.

Smulevitch S, Bear J, Alicea C, Rosati M, Jalah R, Zolotukhin AS, von Gegerfelt A, Michalowski D, Moroni C, Pavlakis GN, Felber BK.

Retrovirology. 2006 Jan 13;3:6.PMID: 16412225 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genes.

Hel Z, Tsai WP, Tryniszewska E, Nacsa J, Markham PD, Lewis MG, Pavlakis GN, Felber BK, Tartaglia J, Franchini G.

J Immunol. 2006 Jan 1;176(1):85-96.PMID: 16365399 [PubMed - indexed for MEDLINE]Related articlesFree article

A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques.

Schadeck EB, Sidhu M, Egan MA, Chong SY, Piacente P, Masood A, Garcia-Hand D, Cappello S, Roopchand V, Megati S, Quiroz J, Boyer JD, Felber BK, Pavlakis GN, Weiner DB, Eldridge JH, Israel ZR.

Vaccine. 2006 May 22;24(21):4677-87. Epub 2005 Oct 26.PMID: 16288822 [PubMed - indexed for MEDLINE]Related articles

Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virus.

Yuste E, Johnson W, Pavlakis GN, Desrosiers RC.

J Virol. 2005 Oct;79(19):12455-63.PMID: 16160173 [PubMed - indexed for MEDLINE]Related articlesFree article

Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice.

Egan MA, Megati S, Roopchand V, Garcia-Hand D, Luckay A, Chong SY, Rosati M, Sackitey S, Weiner DB, Felber BK, Pavlakis GN, Israel ZR, Eldridge JH, Sidhu MK.

Vaccine. 2006 May 22;24(21):4510-23. Epub 2005 Aug 19.PMID: 16140439 [PubMed - indexed for MEDLINE]Related articles

Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus.

Egan MA, Chong SY, Megati S, Montefiori DC, Rose NF, Boyer JD, Sidhu MK, Quiroz J, Rosati M, Schadeck EB, Pavlakis GN, Weiner DB, Rose JK, Israel ZR, Udem SA, Eldridge JH.

AIDS Res Hum Retroviruses. 2005 Jul;21(7):629-43.PMID: 16060834 [PubMed - indexed for MEDLINE]Related articles

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.

Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB.

J Immunol. 2005 Jul 1;175(1):112-23.PMID: 15972637 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.

Rosati M, von Gegerfelt A, Roth P, Alicea C, Valentin A, Robert-Guroff M, Venzon D, Montefiori DC, Markham P, Felber BK, Pavlakis GN.

J Virol. 2005 Jul;79(13):8480-92.PMID: 15956591 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors.

Daelemans D, Pannecouque C, Pavlakis GN, Tabarrini O, De Clercq E.

Mol Pharmacol. 2005 May;67(5):1574-80. Epub 2005 Feb 23.PMID: 15728798 [PubMed - indexed for MEDLINE]Related articlesFree article

Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.

Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Erwin-Cohen R, Chrousos GP, Pavlakis GN.

J Virol. 2005 Mar;79(5):2780-7.PMID: 15708996 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and functional analysis of the RNA transport element, a member of an extensive family present in the mouse genome.

Smulevitch S, Michalowski D, Zolotukhin AS, Schneider R, Bear J, Roth P, Pavlakis GN, Felber BK.

J Virol. 2005 Feb;79(4):2356-65.PMID: 15681436 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo.

Daelemans D, Costes SV, Lockett S, Pavlakis GN.

Mol Cell Biol. 2005 Jan;25(2):728-39.PMID: 15632073 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer.

Daelemans D, Costes SV, Cho EH, Erwin-Cohen RA, Lockett S, Pavlakis GN.

J Biol Chem. 2004 Nov 26;279(48):50167-75. Epub 2004 Aug 3.PMID: 15294891 [PubMed - indexed for MEDLINE]Related articlesFree article

Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.

Kino T, Pavlakis GN.

DNA Cell Biol. 2004 Apr;23(4):193-205. Review.PMID: 15142377 [PubMed - indexed for MEDLINE]Related articles

A potent anti-HIV immunotoxin blocks spreading infection by primary HIV type 1 isolates in multiple cell types.

Lueders KK, De Rosa SC, Valentin A, Pavlakis GN, Roederer M, Hamer DH.

AIDS Res Hum Retroviruses. 2004 Feb;20(2):145-50.PMID: 15018701 [PubMed - indexed for MEDLINE]Related articles

Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques.

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J Immunol Methods. 2003 Aug;279(1-2):55-67. Erratum in: J Immunol Methods. 2009 May 31;344(2):138. Hermanstayne, Keith [corrected to Hermanstyne, Keith]. PMID: 12969547 [PubMed - indexed for MEDLINE]Related articles

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Zhao J, Lou Y, Pinczewski J, Malkevitch N, Aldrich K, Kalyanaraman VS, Venzon D, Peng B, Patterson LJ, Edghill-Smith Y, Woodward R, Pavlakis GN, Robert-Guroff M.

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Natural killer cells are persistently infected and resistant to direct killing by HIV-1.

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Anticancer Res. 2003 May-Jun;23(3A):2071-5.PMID: 12894580 [PubMed - indexed for MEDLINE]Related articles

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Patterson LJ, Malkevitch N, Pinczewski J, Venzon D, Lou Y, Peng B, Munch C, Leonard M, Richardson E, Aldrich K, Kalyanaraman VS, Pavlakis GN, Robert-Guroff M.

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