PubMed

Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes.

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M; MAGIC, Zeggini E, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM.

Hum Mol Genet. 2009 Nov 18. [Epub ahead of print]PMID: 19933169 [PubMed - as supplied by publisher]

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJ, Wareham NJ, Walker M; RISC Consortium.

Diabetologia. 2009 Aug;52(8):1537-42. Epub 2009 May 20.PMID: 19455304 [PubMed - indexed for MEDLINE]Related articles

TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.

Thiébaut R, Kotti S, Jung C, Merlin F, Colombel JF, Lemann M, Almer S, Tysk C, O'Morain M, Gassull M, Binder V, Finkel Y, Pascoe L, Hugot JP.

Am J Gastroenterol. 2009 Feb;104(2):384-91. Epub 2009 Jan 13.PMID: 19174806 [PubMed - indexed for MEDLINE]Related articles

Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium.

Diabetologia. 2008 Nov;51(11):1989-92. Epub 2008 Aug 22.PMID: 18719881 [PubMed - indexed for MEDLINE]Related articles

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.

Diabetes. 2007 Dec;56(12):3101-4. Epub 2007 Sep 5.PMID: 17804762 [PubMed - indexed for MEDLINE]Related articlesFree article

Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family members.

Pascoe L, Zouali H, Sahbatou M, Hugot JP.

Eur J Hum Genet. 2007 Aug;15(8):864-71. Epub 2007 Apr 25.PMID: 17457368 [PubMed - indexed for MEDLINE]Related articlesFree article

Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?

Ménard J, Pascoe L.

J Hypertens. 2006 Jun;24(6):993-7. Review.PMID: 16685193 [PubMed - indexed for MEDLINE]Related articles

The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life.

Graakjaer J, Pascoe L, Der-Sarkissian H, Thomas G, Kolvraa S, Christensen K, Londoño-Vallejo JA.

Aging Cell. 2004 Jun;3(3):97-102.PMID: 15153177 [PubMed - indexed for MEDLINE]Related articles

Adult onset Still's disease: response to Enbrel.

Asherson RA, Pascoe L.

Ann Rheum Dis. 2002 Sep;61(9):859-60; author reply 860. Review. No abstract available. PMID: 12176823 [PubMed - indexed for MEDLINE]Related articlesFree article

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.

Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI.

Nat Struct Biol. 2002 Aug;9(8):612-20.PMID: 12101406 [PubMed - indexed for MEDLINE]Related articles

The use of botulinum toxin-A in the treatment of patients with fibromyalgia.

Asherson RA, Pascoe L.

J Rheumatol. 2001 Jul;28(7):1740. No abstract available. PMID: 11469493 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.

Portrat S, Mulatero P, Curnow KM, Chaussain JL, Morel Y, Pascoe L.

J Clin Endocrinol Metab. 2001 Jul;86(7):3197-201.PMID: 11443188 [PubMed - indexed for MEDLINE]Related articlesFree article

Assembly of desmosomal cadherins into desmosomes is isoform dependent.

Ishii K, Norvell SM, Bannon LJ, Amargo EV, Pascoe LT, Green KJ.

J Invest Dermatol. 2001 Jul;117(1):26-35.PMID: 11442746 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin-converting enzyme and angiotensinogen gene polymorphisms are non-randomly distributed in oral contraceptive-induced hypertension.

Mulatero P, Rabbia F, di Cella SM, Schiavone D, Plazzotta C, Pascoe L, Veglio F.

J Hypertens. 2001 Apr;19(4):713-9.PMID: 11330874 [PubMed - indexed for MEDLINE]Related articles

The efficiency of genetic analysis of DNA from aged siblings to detect chromosomal regions implicated in longevity.

Nemani M, Sahbatou M, Blanché H, Thomas G, Pascoe L.

Mech Ageing Dev. 2000 Oct 20;119(1-2):25-39.PMID: 11040399 [PubMed - indexed for MEDLINE]Related articles

Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain.

Nikkila H, McMillan DR, Nunez BS, Pascoe L, Curnow KM, White PC.

Mol Endocrinol. 2000 Sep;14(9):1351-64.PMID: 10976914 [PubMed - indexed for MEDLINE]Related articlesFree article

CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.

Mulatero P, Schiavone D, Fallo F, Rabbia F, Pilon C, Chiandussi L, Pascoe L, Veglio F.

Hypertension. 2000 Mar;35(3):694-8.PMID: 10720580 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic, biochemical, and clinical studies of patients with A328V or R213C mutations in 11betaHSD2 causing apparent mineralocorticoid excess.

Morineau G, Marc JM, Boudi A, Galons H, Gourmelen M, Corvol P, Pascoe L, Fiet J.

Hypertension. 1999 Sep;34(3):435-41.PMID: 10489390 [PubMed - indexed for MEDLINE]Related articlesFree article

Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.

Cerame BI, Newfield RS, Pascoe L, Curnow KM, Nimkarn S, Roe TF, New MI, Wilson RC.

J Clin Endocrinol Metab. 1999 Sep;84(9):3129-34.PMID: 10487675 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural analysis and evaluation of the 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) gene in human essential hypertension.

Brand E, Kato N, Chatelain N, Krozowski ZS, Jeunemaitre X, Corvol P, Plouin PF, Cambien F, Pascoe L, Soubrier F.

J Hypertens. 1998 Nov;16(11):1627-33.PMID: 9856363 [PubMed - indexed for MEDLINE]Related articles

Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene.

Portrat-Doyen S, Tourniaire J, Richard O, Mulatero P, Aupetit-Faisant B, Curnow KM, Pascoe L, Morel Y.

J Clin Endocrinol Metab. 1998 Nov;83(11):4156-61.PMID: 9814506 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol.

Mulatero P, Curnow KM, Aupetit-Faisant B, Foekling M, Gomez-Sanchez C, Veglio F, Jeunemaitre X, Corvol P, Pascoe L.

J Clin Endocrinol Metab. 1998 Nov;83(11):3996-4001.PMID: 9814482 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural analysis and evaluation of the aldosterone synthase gene in hypertension.

Brand E, Chatelain N, Mulatero P, Féry I, Curnow K, Jeunemaitre X, Corvol P, Pascoe L, Soubrier F.

Hypertension. 1998 Aug;32(2):198-204.PMID: 9719043 [PubMed - indexed for MEDLINE]Related articlesFree article

[A case of apparent mineralocorticoid excess caused by type 2 11 beta- hydroxysteroid dehydrogenase deficiency]

Morineau G, Pascoe L, Marc JM, Caillette A, Krozowski Z, Corvol P, Fiet J.

Arch Mal Coeur Vaiss. 1997 Aug;90(8):1111-5. French. PMID: 9404418 [PubMed - indexed for MEDLINE]Related articles

The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme.

Curnow KM, Mulatero P, Emeric-Blanchouin N, Aupetit-Faisant B, Corvol P, Pascoe L.

Nat Struct Biol. 1997 Jan;4(1):32-5.PMID: 8989319 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree.

Pascoe L, Jeunemaitre X, Lebrethon MC, Curnow KM, Gomez-Sanchez CE, Gasc JM, Saez JM, Corvol P.

J Clin Invest. 1995 Nov;96(5):2236-46.PMID: 7593610 [PubMed - indexed for MEDLINE]Related articlesFree article

[Hyperaldosteronism sensitive to dexamethasone with adrenal adenoma. Clinical, biological and genetic study]

Jeunemaitre X, Charru A, Pascoe L, Guyene TT, Aupetit-Faisant B, Shackleton CH, Schambelan M, Plouin PF, Corvol P.

Presse Med. 1995 Sep 23;24(27):1243-8. French. PMID: 7501605 [PubMed - indexed for MEDLINE]Related articles

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.

Curnow KM, Pascoe L, Davies E, White PC, Corvol P, Clauser E.

Mol Endocrinol. 1995 Sep;9(9):1250-62.PMID: 7491117 [PubMed - indexed for MEDLINE]Related articles

The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone.

Pascoe L.

J Endocrinol Invest. 1995 Jul-Aug;18(7):571-5. No abstract available. PMID: 9221276 [PubMed - indexed for MEDLINE]Related articles

Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.

Pascoe L, Curnow KM.

Steroids. 1995 Jan;60(1):22-7. Review.PMID: 7792811 [PubMed - indexed for MEDLINE]Related articles

Reduced genetic load revealed by slow inbreeding in Drosophila melanogaster.

Latter BD, Mulley JC, Reid D, Pascoe L.

Genetics. 1995 Jan;139(1):287-97.PMID: 7705630 [PubMed - indexed for MEDLINE]Related articlesFree article

Disorders of steroid 11 beta-hydroxylase isozymes.

White PC, Curnow KM, Pascoe L.

Endocr Rev. 1994 Aug;15(4):421-38. Review.PMID: 7988480 [PubMed - indexed for MEDLINE]Related articles

Enamel hypoplasia and dental caries in Australian aboriginal children: prevalence and correlation between the two diseases.

Pascoe L, Seow WK.

Pediatr Dent. 1994 May-Jun;16(3):193-9.PMID: 8058543 [PubMed - indexed for MEDLINE]Related articles

Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.

Curnow KM, Slutsker L, Vitek J, Cole T, Speiser PW, New MI, White PC, Pascoe L.

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4552-6.PMID: 8506298 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

Pascoe L, Curnow KM, Slutsker L, Connell JM, Speiser PW, New MI, White PC.

Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8327-31.PMID: 1518866 [PubMed - indexed for MEDLINE]Related articlesFree article

Disorders of steroid 11beta-hydroxylase isozymes.

White PC, Pascoe L.

Trends Endocrinol Metab. 1992 Aug;3(6):229-34.PMID: 18407105 [PubMed - in process]Related articles

Genetic analysis of the human type-1 angiotensin II receptor.

Curnow KM, Pascoe L, White PC.

Mol Endocrinol. 1992 Jul;6(7):1113-8.PMID: 1508224 [PubMed - indexed for MEDLINE]Related articles

Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency.

Pascoe L, Curnow KM, Slutsker L, Rösler A, White PC.

Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4996-5000.PMID: 1594605 [PubMed - indexed for MEDLINE]Related articlesFree article

The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.

Curnow KM, Tusie-Luna MT, Pascoe L, Natarajan R, Gu JL, Nadler JL, White PC.

Mol Endocrinol. 1991 Oct;5(10):1513-22.PMID: 1775135 [PubMed - indexed for MEDLINE]Related articles

The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.

Küster W, Pascoe L, Purrmann J, Funk S, Majewski F.

Am J Med Genet. 1989 Jan;32(1):105-8.PMID: 2705471 [PubMed - indexed for MEDLINE]Related articles

Combined segregation and linkage analysis for IDDM and HLA-DR under several ascertainment assumptions.

Pascoe L, Sherman S, Wu D, Becker M, Falk C.

Genet Epidemiol. 1989;6(1):131-6.PMID: 2499499 [PubMed - indexed for MEDLINE]Related articles

Occurrence of desmoids in patients with familial adenomatous polyposis of the colon.

Klemmer S, Pascoe L, DeCosse J.

Am J Med Genet. 1987 Oct;28(2):385-92.PMID: 2827474 [PubMed - indexed for MEDLINE]Related articles

The inheritance of cutaneous malignant melanoma (CMM) and dysplastic nevus syndrome (DNS).

Pascoe L.

Am J Hum Genet. 1987 May;40(5):464-5. No abstract available. PMID: 3578283 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of map functions in multipoint mapping.

Pascoe L, Morton NE.

Am J Hum Genet. 1987 Feb;40(2):174-83.PMID: 3565379 [PubMed - indexed for MEDLINE]Related articlesFree article

Formation and distribution of vitamin C in the radical and cotyledon of the broad bean (Vicia faba).

SHAW AC, PASCOE LC.

Nature. 1949 Oct 8;164(4171):624. No abstract available. PMID: 18142473 [PubMed - OLDMEDLINE]Related articles