PubMed

Diagnostic work-up of euthyroid nodules: which nodules should undergo fine-needle aspiration biopsy?

Paschke R.

Dtsch Med Wochenschr. 2009 Dec;134(49):2498-2503. Epub 2009 Nov 25.PMID: 19941231 [PubMed - as supplied by publisher]

Anticancer activity of dinuclear gallium(III) carboxylate complexes.

Kaluđerović MR, Gómez-Ruiz S, Gallego B, Hey-Hawkins E, Paschke R, Kaluđerović GN.

Eur J Med Chem. 2009 Oct 31. [Epub ahead of print]PMID: 19926362 [PubMed - as supplied by publisher]Related articles

The hinge region: an important receptor component for GPHR function.

Mueller S, Jaeschke H, Günther R, Paschke R.

Trends Endocrinol Metab. 2009 Oct 9. [Epub ahead of print]PMID: 19819720 [PubMed - as supplied by publisher]Related articles

Lack of Consistent Association of TSH Receptor Mutations In Vitro Activity with the Clinical Course of Patients with Sporadic Non-autoimmune Hyperthyroidism.

Lueblinghoff J, Mueller S, Sontheimer J, Paschke R.

J Endocrinol Invest. 2009 Jul 28. [Epub ahead of print]PMID: 19636218 [PubMed - as supplied by publisher]Related articles

Increased percentage of microvessels but decreased density of large vessels in papillary carcinomas as compared to hot and cold thyroid nodules.

Sancak S, Hardt A, Ricken A, Lorenz S, Eszlinger M, Sen LS, Güllüoglu BM, Sever Z, Eren FT, Akalin NS, Paschke R.

Exp Clin Endocrinol Diabetes. 2009 Nov;117(10):637-44. Epub 2009 Jul 16.PMID: 19609842 [PubMed - in process]Related articles

Cases of borderline in vitro constitutive thyrotropin receptor activity: how to decide whether a thyrotropin receptor mutation is constitutively active or not?

Mueller S, Gozu HI, Bircan R, Jaeschke H, Eszlinger M, Lueblinghoff J, Krohn K, Paschke R.

Thyroid. 2009 Jul;19(7):765-73.PMID: 19583488 [PubMed - indexed for MEDLINE]Related articles

The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.

Mueller S, Kleinau G, Szkudlinski MW, Jaeschke H, Krause G, Paschke R.

J Biol Chem. 2009 Jun 12;284(24):16317-24. Epub 2009 Apr 22.PMID: 19386596 [PubMed - indexed for MEDLINE]Related articles

Relative quantification of indium-111 pentetreotide and gallium-68 DOTATOC uptake in the thyroid gland and association with thyroid pathologies.

Lincke T, Singer J, Kluge R, Sabri O, Paschke R.

Thyroid. 2009 Apr;19(4):381-9.PMID: 19355828 [PubMed - indexed for MEDLINE]Related articles

Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound.

Willmann M, Wacheck V, Buckley J, Nagy K, Thalhammer J, Paschke R, Triche T, Jansen B, Selzer E.

Eur J Clin Invest. 2009 May;39(5):384-94.PMID: 19309323 [PubMed - indexed for MEDLINE]Related articles

Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes.

Zmejkovski BB, Kaluderović GN, Gómez-Ruiz S, Zizak Z, Steinborn D, Schmidt H, Paschke R, Juranić ZD, Sabo TJ.

Eur J Med Chem. 2009 Sep;44(9):3452-8. Epub 2009 Feb 20.PMID: 19272676 [PubMed - indexed for MEDLINE]Related articles

Etiology of simple goiter.

Hegedüs L, Brix TH, Paschke R.

Thyroid. 2009 Mar;19(3):209-11. No abstract available. PMID: 19265491 [PubMed - indexed for MEDLINE]Related articles

Preferences of transmembrane helices for cooperative amplification of G(alpha)s and G (alpha)q signaling of the thyrotropin receptor.

Jaeschke H, Kleinau G, Sontheimer J, Mueller S, Krause G, Paschke R.

Cell Mol Life Sci. 2008 Dec;65(24):4028-38.PMID: 18989620 [PubMed - indexed for MEDLINE]Related articles

Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.

Kleinau G, Jaeschke H, Mueller S, Worth CL, Paschke R, Krause G.

Cell Mol Life Sci. 2008 Nov;65(22):3664-76.PMID: 18850313 [PubMed - indexed for MEDLINE]Related articles

Thyroid nodules: a review of current guidelines, practices, and prospects.

Gharib H, Papini E, Paschke R.

Eur J Endocrinol. 2008 Nov;159(5):493-505. Epub 2008 Aug 26. Review.PMID: 18728120 [PubMed - indexed for MEDLINE]Related articlesFree article

2-(4-(Tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II): a novel platinum compound that overcomes cisplatin resistance and induces apoptosis by mechanisms different from that of cisplatin.

Dietrich A, Mueller T, Paschke R, Kalinowski B, Behlendorf T, Reipsch F, Fruehauf A, Schmoll HJ, Kloft C, Voigt W.

J Med Chem. 2008 Sep 11;51(17):5413-22. Epub 2008 Aug 13.PMID: 18698754 [PubMed - indexed for MEDLINE]Related articles

Large genomic deletions in AIP in pituitary adenoma predisposition.

Georgitsi M, Heliövaara E, Paschke R, Kumar AV, Tischkowitz M, Vierimaa O, Salmela P, Sane T, De Menis E, Cannavò S, Gündogdu S, Lucassen A, Izatt L, Aylwin S, Bano G, Hodgson S, Koch CA, Karhu A, Aaltonen LA.

J Clin Endocrinol Metab. 2008 Oct;93(10):4146-51. Epub 2008 Jul 15.PMID: 18628514 [PubMed - indexed for MEDLINE]Related articlesFree article

Perspectives for improved and more accurate classification of thyroid epithelial tumors.

Eszlinger M, Krohn K, Hauptmann S, Dralle H, Giordano TJ, Paschke R.

J Clin Endocrinol Metab. 2008 Sep;93(9):3286-94. Epub 2008 Jul 1. Review.PMID: 18593772 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple relapses of hyperthyroidism after thyroid surgeries in a patient with long term follow-up of sporadic non-autoimmune hyperthyroidism.

Bircan R, Miehle K, Mladenova G, Ivanova R, Ivanova R, Sarafova A, Borissova AM, Lüblinghoff J, Paschke R.

Exp Clin Endocrinol Diabetes. 2008 Jun;116(6):341-6.PMID: 18528812 [PubMed - indexed for MEDLINE]Related articles

A new silent germline mutation of the TSH receptor: coexpression in a hyperthyroid family member with a second activating somatic mutation.

Gozu HI, Mueller S, Bircan R, Krohn K, Ekinci G, Yavuzer D, Sargin H, Sargin M, Ones T, Gezen C, Orbay E, Cirakoglu B, Paschke R.

Thyroid. 2008 May;18(5):499-508.PMID: 18466076 [PubMed - indexed for MEDLINE]Related articles

Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.

Mueller S, Kleinau G, Jaeschke H, Paschke R, Krause G.

J Biol Chem. 2008 Jun 27;283(26):18048-55. Epub 2008 Apr 25.PMID: 18441013 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas.

Georgitsi M, De Menis E, Cannavò S, Mäkinen MJ, Tuppurainen K, Pauletto P, Curtò L, Weil RJ, Paschke R, Zielinski G, Wasik A, Lubinski J, Vahteristo P, Karhu A, Aaltonen LA.

Clin Endocrinol (Oxf). 2008 Oct;69(4):621-7. Epub 2008 Apr 10.PMID: 18410548 [PubMed - indexed for MEDLINE]Related articles

Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor.

Kleinau G, Jaeschke H, Mueller S, Raaka BM, Neumann S, Paschke R, Krause G.

FASEB J. 2008 Aug;22(8):2798-808. Epub 2008 Apr 1.PMID: 18381815 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypercalcemia as a result of sarcoidosis with normal serum concentrations of vitamin D.

Falk S, Kratzsch J, Paschke R, Koch CA.

Med Sci Monit. 2007 Nov;13(11):CS133-136.PMID: 17968303 [PubMed - indexed for MEDLINE]Related articlesFree article

The TSH receptor is linked with AP1 and NFkappaB signaling in COS7 cells.

Voigt C, Prodinger C, Paschke R.

Exp Clin Endocrinol Diabetes. 2007 Oct;115(9):590-3.PMID: 17943693 [PubMed - indexed for MEDLINE]Related articles

Insights from molecular pathways: potential pharmacologic targets of benign thyroid nodules.

Eszlinger M, Jaeschke H, Paschke R.

Curr Opin Endocrinol Diabetes Obes. 2007 Oct;14(5):393-7. Review.PMID: 17940470 [PubMed - indexed for MEDLINE]Related articles

A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping.

Fujarewicz K, Jarzab M, Eszlinger M, Krohn K, Paschke R, Oczko-Wojciechowska M, Wiench M, Kukulska A, Jarzab B, Swierniak A.

Endocr Relat Cancer. 2007 Sep;14(3):809-26.PMID: 17914110 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors.

Krohn K, Maier J, Paschke R.

Nat Clin Pract Endocrinol Metab. 2007 Oct;3(10):713-20. Review.PMID: 17893690 [PubMed - indexed for MEDLINE]Related articles

32(nd) Annual Meeting of the European Thyroid Association in Leipzig, Germany.

Paschke R.

Thyroid. 2007 Jul;17(7):601. No abstract available. PMID: 17696826 [PubMed - indexed for MEDLINE]Related articles

[Thyroid nodules]

Paschke R.

MMW Fortschr Med. 2007 Mar 29;149(13):39-43; quiz 44. German. PMID: 17672397 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormone resistance without mutations in thyroid hormone receptor beta.

Bottcher Y, Paufler T, Stehr T, Bertschat FL, Paschke R, Koch CA.

Med Sci Monit. 2007 Jun;13(6):CS67-70.PMID: 17534237 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of TSHR signaling by posttranslational modifications.

Kursawe R, Paschke R.

Trends Endocrinol Metab. 2007 Jul;18(5):199-207. Epub 2007 May 23. Review.PMID: 17524661 [PubMed - indexed for MEDLINE]Related articles

Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia.

Georgitsi M, Raitila A, Karhu A, van der Luijt RB, Aalfs CM, Sane T, Vierimaa O, Mäkinen MJ, Tuppurainen K, Paschke R, Gimm O, Koch CA, Gündogdu S, Lucassen A, Tischkowitz M, Izatt L, Aylwin S, Bano G, Hodgson S, De Menis E, Launonen V, Vahteristo P, Aaltonen LA.

J Clin Endocrinol Metab. 2007 Aug;92(8):3321-5. Epub 2007 May 22.PMID: 17519308 [PubMed - indexed for MEDLINE]Related articlesFree article

Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice.

Maier J, van Steeg H, van Oostrom C, Paschke R, Weiss RE, Krohn K.

Biochim Biophys Acta. 2007 Jun;1773(6):990-9. Epub 2007 Mar 24.PMID: 17467074 [PubMed - indexed for MEDLINE]Related articles

Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.

Georgitsi M, Raitila A, Karhu A, Tuppurainen K, Mäkinen MJ, Vierimaa O, Paschke R, Saeger W, van der Luijt RB, Sane T, Robledo M, De Menis E, Weil RJ, Wasik A, Zielinski G, Lucewicz O, Lubinski J, Launonen V, Vahteristo P, Aaltonen LA.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4101-5. Epub 2007 Feb 28.PMID: 17360484 [PubMed - indexed for MEDLINE]Related articlesFree article

Perspectives and limitations of microarray-based gene expression profiling of thyroid tumors.

Eszlinger M, Krohn K, Kukulska A, Jarzab B, Paschke R.

Endocr Rev. 2007 May;28(3):322-38. Epub 2007 Mar 12. Review.PMID: 17353294 [PubMed - indexed for MEDLINE]Related articlesFree article

Monoterpenes as drug shuttles: cytotoxic (6-aminomethylnicotinate)dichloridoplatinum(II) complexes with potential to overcome cisplatin resistance.

Schobert R, Biersack B, Dietrich A, Grotemeier A, Müller T, Kalinowski B, Knauer S, Voigt W, Paschke R.

J Med Chem. 2007 Mar 22;50(6):1288-93. Epub 2007 Mar 1.PMID: 17328536 [PubMed - indexed for MEDLINE]Related articles

Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans.

Kralisch S, Bluher M, Tonjes A, Lossner U, Paschke R, Stumvoll M, Fasshauer M.

Eur J Endocrinol. 2007 Feb;156(2):257-61.PMID: 17287416 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipokines and adipocyte targets in the future management of obesity and the metabolic syndrome.

Kralisch S, Bluher M, Paschke R, Stumvoll M, Fasshauer M.

Mini Rev Med Chem. 2007 Jan;7(1):39-45. Review.PMID: 17266636 [PubMed - indexed for MEDLINE]Related articles

Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms: role of G protein-coupled receptor kinases, protein kinase C and beta-arrestins.

Lorenz S, Frenzel R, Paschke R, Breitwieser GE, Miedlich SU.

Endocrinology. 2007 May;148(5):2398-404. Epub 2007 Jan 25.PMID: 17255208 [PubMed - indexed for MEDLINE]Related articlesFree article

Platinum(II) complexes with l-methionylglycine and l-methionyl-l-leucine ligands: synthesis, characterization and in vitro antitumoral activity.

Kaluderović GN, Schmidt H, Paschke R, Kalinowski B, Dietrich A, Mueller T, Steinborn D.

J Inorg Biochem. 2007 Mar;101(3):543-9. Epub 2006 Nov 30.PMID: 17223197 [PubMed - indexed for MEDLINE]Related articles

Selenium and goiter prevalence in borderline iodine sufficiency.

Brauer VF, Schweizer U, Köhrle J, Paschke R.

Eur J Endocrinol. 2006 Dec;155(6):807-12.PMID: 17132749 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone induces apelin mRNA expression and secretion in mouse 3T3-L1 adipocytes.

Kralisch S, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M.

Regul Pept. 2007 Mar 1;139(1-3):84-9. Epub 2006 Nov 28.PMID: 17126924 [PubMed - indexed for MEDLINE]Related articles

Toward the application of proteomics to human thyroid tissue.

Krause K, Schierhorn A, Sinz A, Wissmann JD, Beck-Sickinger AG, Paschke R, Fuhrer D.

Thyroid. 2006 Nov;16(11):1131-43.PMID: 17123340 [PubMed - indexed for MEDLINE]Related articles

Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.

Kleinau G, Claus M, Jaeschke H, Mueller S, Neumann S, Paschke R, Krause G.

J Biol Chem. 2007 Jan 5;282(1):518-25. Epub 2006 Nov 1.PMID: 17079233 [PubMed - indexed for MEDLINE]Related articlesFree article

[Increased levels of auto-antibodies in thyroid diagnostics: Hashimoto thyroidities or Graves disease?]

Paschke R.

Internist (Berl). 2006 Nov;47(11):1193-4. German. No abstract available. PMID: 17043781 [PubMed - indexed for MEDLINE]Related articles

Impaired enteral levothyroxine absorption in hypothyroidism refractory to oral therapy after thyroid ablation for papillary thyroid cancer: case report and kinetic studies.

Tönjes A, Karger S, Koch CA, Paschke R, Tannapfel A, Stumvoll M, Fuhrer D.

Thyroid. 2006 Oct;16(10):1047-51.PMID: 17042692 [PubMed - indexed for MEDLINE]Related articles

[Hypercalcemia in dialysis-dependent renal insufficiency]

Paschke R.

Internist (Berl). 2006 Nov;47(11):1192. German. No abstract available. PMID: 17033780 [PubMed - indexed for MEDLINE]Related articles

Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.

Gozu HI, Bircan R, Krohn K, Müller S, Vural S, Gezen C, Sargin H, Yavuzer D, Sargin M, Cirakoglu B, Paschke R.

Eur J Endocrinol. 2006 Oct;155(4):535-45.PMID: 16990652 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor.

Claus M, Neumann S, Kleinau G, Krause G, Paschke R.

J Mol Med. 2006 Nov;84(11):943-54. Epub 2006 Sep 6.PMID: 16955277 [PubMed - indexed for MEDLINE]Related articles

Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.

Mueller S, Kleinau G, Jaeschke H, Neumann S, Krause G, Paschke R.

J Biol Chem. 2006 Oct 20;281(42):31638-46. Epub 2006 Aug 9.PMID: 16899458 [PubMed - indexed for MEDLINE]Related articlesFree article