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1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice.

Luongo L, Palazzo E, Tambaro S, Giordano C, Gatta L, Scafuro MA, Rossi FS, Lazzari P, Pani L, de Novellis V, Malcangio M, Maione S.

Neurobiol Dis. 2009 Oct 3. [Epub ahead of print]PMID: 19804829 [PubMed - as supplied by publisher]Related articles

Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats.

Marchese G, Casu G, Casti P, Spada GP, Pani L.

Eur J Pharmacol. 2009 Oct 12;620(1-3):36-41. Epub 2009 Aug 5.PMID: 19664616 [PubMed - in process]Related articles

A comparison of continuous subcutaneous paliperidone infusion and repeated subcutaneous injection of risperidone free-base in rats.

Marchese G, Pittau B, Casu G, Peddio G, Spada GP, Pira M, Deriu A, Portesani F, Pisu C, Lazzari P, Pani L.

Eur Psychiatry. 2009 Jul 27. [Epub ahead of print]PMID: 19640686 [PubMed - as supplied by publisher]Related articles

Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.

Olimpieri F, Tambaro S, Fustero S, Lazzari P, Sanchez-Roselló M, Pani L, Volonterio A, Zanda M.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4715-9. Epub 2009 Jun 21.PMID: 19596577 [PubMed - indexed for MEDLINE]Related articles

Synthesis and in vitro Evaluation of Trifluoroethylamine Analogues of Enkephalins.

Sinisi R, Ghilardi A, Ruiu S, Lazzari P, Malpezzi L, Sani M, Pani L, Zanda M.

ChemMedChem. 2009 Sep;4(9):1416-20. No abstract available. PMID: 19533725 [PubMed - in process]Related articles

Expected clinical benefits of paliperidone extended-release formulation when compared with risperidone immediate-release.

Pani L, Marchese G.

Expert Opin Drug Deliv. 2009 Mar;6(3):319-31. Review.PMID: 19317589 [PubMed - indexed for MEDLINE]Related articles

Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration.

Marchese G, Sanna A, Casu G, Casti P, Spada GP, Ruiu S, Pani L.

Eur J Pharmacol. 2008 Nov 19;598(1-3):16-20. Epub 2008 Aug 30.PMID: 18789920 [PubMed - indexed for MEDLINE]Related articles

Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004.

Pani LN, Korenda L, Meigs JB, Driver C, Chamany S, Fox CS, Sullivan L, D'Agostino RB, Nathan DM.

Diabetes Care. 2008 Oct;31(10):1991-6. Epub 2008 Jul 15.PMID: 18628569 [PubMed - indexed for MEDLINE]Related articlesFree article

Practical issues with amisulpride in the management of patients with schizophrenia.

Pani L, Villagrán JM, Kontaxakis VP, Alptekin K.

Clin Drug Investig. 2008;28(8):465-77. Review.PMID: 18598092 [PubMed - indexed for MEDLINE]Related articles

Building a virtual archive using brain architecture and Web 3D to deliver neuropsychopharmacology content over the Internet.

Mongeau R, Casu MA, Pani L, Pillolla G, Lianas L, Giachetti A.

Comput Methods Programs Biomed. 2008 May;90(2):124-36. Epub 2008 Feb 11.PMID: 18262677 [PubMed - indexed for MEDLINE]Related articles

Clinical predictors of disease progression and medication initiation in untreated patients with type 2 diabetes and A1C less than 7%.

Pani LN, Nathan DM, Grant RW.

Diabetes Care. 2008 Mar;31(3):386-90. Epub 2007 Dec 14.PMID: 18083790 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting effects of diazepam and repeated restraint stress on latent inhibition in mice.

Mongeau R, Marcello S, Andersen JS, Pani L.

Behav Brain Res. 2007 Nov 2;183(2):147-55. Epub 2007 Jun 12.PMID: 17629580 [PubMed - indexed for MEDLINE]Related articles

Antipsychotic efficacy: relationship to optimal D2-receptor occupancy.

Pani L, Pira L, Marchese G.

Eur Psychiatry. 2007 Jul;22(5):267-75. Epub 2007 Apr 6. Review.PMID: 17419008 [PubMed - indexed for MEDLINE]Related articles

3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]heptanes as novel potent dopamine uptake inhibitors.

Loriga G, Ruiu S, Manca I, Murineddu G, Dessi C, Pani L, Pinna GA.

Bioorg Med Chem. 2007 Jun 1;15(11):3748-55. Epub 2007 Mar 16.PMID: 17399987 [PubMed - indexed for MEDLINE]Related articles

Effects of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbens.

Casu MA, Sanna A, Spada GP, Falzoi M, Mongeau R, Pani L.

Brain Res. 2007 Apr 13;1141:15-24. Epub 2007 Jan 8.PMID: 17270156 [PubMed - indexed for MEDLINE]Related articles

Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide.

Murineddu G, Lazzari P, Ruiu S, Sanna A, Loriga G, Manca I, Falzoi M, Dessì C, Curzu MM, Chelucci G, Pani L, Pinna GA.

J Med Chem. 2006 Dec 14;49(25):7502-12.PMID: 17149879 [PubMed - indexed for MEDLINE]Related articles

Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide.

Murineddu G, Ruiu S, Loriga G, Manca I, Lazzari P, Reali R, Pani L, Toma L, Pinna GA.

J Med Chem. 2005 Nov 17;48(23):7351-62.PMID: 16279795 [PubMed - indexed for MEDLINE]Related articles

Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors.

Tambaro S, Mongeau R, Dessi C, Pani L, Ruiu S.

Eur J Pharmacol. 2005 Nov 21;525(1-3):150-3. Epub 2005 Nov 3.PMID: 16271359 [PubMed - indexed for MEDLINE]Related articles

Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats.

Saba L, Porcella A, Sanna A, Congeddu E, Marziliano N, Mongeau R, Grayson D, Pani L.

Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):252-7. Epub 2005 Apr 18.PMID: 15950783 [PubMed - indexed for MEDLINE]Related articles

Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system.

Caboi F, Lazzari P, Pani L, Monduzzi M.

Chem Phys Lipids. 2005 Jun;135(2):147-56. Epub 2005 Mar 19.PMID: 15921975 [PubMed - indexed for MEDLINE]Related articles

Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study.

Casu MA, Pisu C, Sanna A, Tambaro S, Spada GP, Mongeau R, Pani L.

Brain Res. 2005 Jun 28;1048(1-2):41-7.PMID: 15913574 [PubMed - indexed for MEDLINE]Related articles

Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors.

Murineddu G, Ruiu S, Mussinu JM, Loriga G, Grella GE, Carai MA, Lazzari P, Pani L, Pinna GA.

Bioorg Med Chem. 2005 May 2;13(9):3309-20.PMID: 15809166 [PubMed - indexed for MEDLINE]Related articles

The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex.

Pira L, Mongeau R, Pani L.

Eur J Pharmacol. 2004 Nov 3;504(1-2):61-4.PMID: 15507222 [PubMed - indexed for MEDLINE]Related articles

Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: relevance to ejaculation delays.

Tambaro S, Ruiu S, Dessi C, Mongeau R, Marchese G, Pani L.

J Pharmacol Exp Ther. 2005 Feb;312(2):710-7. Epub 2004 Oct 6.PMID: 15470085 [PubMed - indexed for MEDLINE]Related articlesFree article

Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia.

Keith SJ, Pani L, Nick B, Emsley R, San L, Turner M, Conley R, Scully P, Chue PS, Lachaux B.

Psychiatr Serv. 2004 Sep;55(9):997-1005. Review.PMID: 15345759 [PubMed - indexed for MEDLINE]Related articlesFree article

Consensus on the use of substituted benzamides in psychiatric patients.

Racagni G, Canonico PL, Ravizza L, Pani L, Amore M.

Neuropsychobiology. 2004;50(2):134-43. Review.PMID: 15292667 [PubMed - indexed for MEDLINE]Related articles

Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice.

Casti P, Marchese G, Casu G, Ruiu S, Pani L.

Neuropharmacology. 2004 Jul;47(1):128-35.PMID: 15165840 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.

Ferrarini PL, Calderone V, Cavallini T, Manera C, Saccomanni G, Pani L, Ruiu S, Gessa GL.

Bioorg Med Chem. 2004 Apr 15;12(8):1921-33.PMID: 15051060 [PubMed - indexed for MEDLINE]Related articles

Hymenoptera sting anaphylactic reactions in the Mediterranean population of Albania.

Mingomataj E, Ohri D, Dhimitri V, Priftanji A, Qirko E, Pani L, Fischer TC, Dinh QT, Peiser C, Fischer A, Groneberg DA.

J Investig Allergol Clin Immunol. 2003;13(4):272-7.PMID: 14989117 [PubMed - indexed for MEDLINE]Related articles

The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100Q) sNP rats.

Sanna A, Congeddu E, Saba L, Porcella A, Marchese G, Ruiu S, Casti P, Saba P, Pani L.

Brain Res. 2004 Feb 20;998(2):148-54.PMID: 14751585 [PubMed - indexed for MEDLINE]Related articles

Haloperidol versus risperidone on rat "early onset" vacuous chewing.

Marchese G, Bartholini F, Casu MA, Ruiu S, Casti P, Congeddu E, Tambaro S, Pani L.

Behav Brain Res. 2004 Feb 4;149(1):9-16.PMID: 14739005 [PubMed - indexed for MEDLINE]Related articles

Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol.

Marchese G, Bartholini F, Ruiu S, Casti P, Casu GL, Pani L.

Eur J Pharmacol. 2004 Jan 1;483(1):65-9.PMID: 14709327 [PubMed - indexed for MEDLINE]Related articles

Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats.

Casu MA, Pisu C, Lobina C, Pani L.

Psychopharmacology (Berl). 2004 Mar;172(3):341-51. Epub 2003 Nov 21.PMID: 14634717 [PubMed - indexed for MEDLINE]Related articles

Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.

Marchese G, Casti P, Ruiu S, Saba P, Sanna A, Casu G, Pani L.

Br J Pharmacol. 2003 Oct;140(3):520-6. Epub 2003 Aug 26.PMID: 12970091 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor.

Ruiu S, Pinna GA, Marchese G, Mussinu JM, Saba P, Tambaro S, Casti P, Vargiu R, Pani L.

J Pharmacol Exp Ther. 2003 Jul;306(1):363-70. Epub 2003 Mar 27.PMID: 12663689 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP).

Sanna A, Congeddu E, Porcella A, Saba L, Pistis M, Peis M, Marchese G, Ruiu S, Lobina C, Grayson DR, Gessa GL, Pani L.

Brain Res. 2003 Mar 28;967(1-2):98-105.PMID: 12650970 [PubMed - indexed for MEDLINE]Related articles

Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic.

Devoto P, Flore G, Vacca G, Pira L, Arca A, Casu MA, Pani L, Gessa GL.

Psychopharmacology (Berl). 2003 Apr;167(1):79-84. Epub 2003 Mar 11.PMID: 12632247 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype.

Congeddu E, Saba L, Porcella A, Sanna A, Marchese G, Lobina C, Gessa GL, Pani L.

Brain Res Mol Brain Res. 2003 Feb 20;110(2):289-97.PMID: 12591165 [PubMed - indexed for MEDLINE]Related articles

In vitro evidence for the presence of [3H]-haloperidol uptake in rat brain.

Ruiu S, Marchese G, Saba PL, Satta R, Gessa G, Vaccari A, Pani L.

Br J Pharmacol. 2003 Jan;138(1):188-92.PMID: 12522089 [PubMed - indexed for MEDLINE]Related articlesFree article

Duration and stability of the rapid-cycling course: a long-term personal follow-up of 109 patients.

Koukopoulos A, Sani G, Koukopoulos AE, Minnai GP, Girardi P, Pani L, Albert MJ, Reginaldi D.

J Affect Disord. 2003 Jan;73(1-2):75-85.PMID: 12507740 [PubMed - indexed for MEDLINE]Related articles

Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.

Casu MA, Porcella A, Ruiu S, Saba P, Marchese G, Carai MA, Reali R, Gessa GL, Pani L.

Eur J Pharmacol. 2003 Jan 10;459(1):97-105.PMID: 12505538 [PubMed - indexed for MEDLINE]Related articles

Clinical implications of dopamine research in schizophrenia.

Pani L.

Curr Med Res Opin. 2002;18 Suppl 3:s3-7. Review.PMID: 12418605 [PubMed - indexed for MEDLINE]Related articles

Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats.

Casu MA, Dinucci D, Colombo G, Gessa GL, Pani L.

Brain Res. 2002 Sep 6;948(1-2):192-202.PMID: 12383975 [PubMed - indexed for MEDLINE]Related articles

Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy.

Pani L, Horal M, Loeken MR.

Diabetes. 2002 Sep;51(9):2871-4.PMID: 12196484 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the amisulpride isomers on rat catalepsy.

Marchese G, Bartholini F, Ruiu S, Casti P, Saba P, Gessa G, Pani L.

Eur J Pharmacol. 2002 May 24;444(1-2):69-74.PMID: 12191584 [PubMed - indexed for MEDLINE]Related articles

Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid.

Porcella A, Marchese G, Casu MA, Rocchitta A, Lai ML, Gessa GL, Pani L.

Eur J Endocrinol. 2002 Aug;147(2):255-61. Erratum in: Eur J Endocrinol 2002 Sep;147(3):434. PMID: 12153749 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the amisulpride isomers on rat prolactinemia.

Marchese G, Ruiu S, Casti P, Saba P, Gessa GL, Pani L.

Eur J Pharmacol. 2002 Jul 19;448(2-3):263-6.PMID: 12144950 [PubMed - indexed for MEDLINE]Related articles

Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect.

Marchese G, Ruiu S, Casti P, Bartholini F, Saba P, Gessa GL, Pani L.

Eur J Pharmacol. 2002 Jun 28;447(1):109-14.PMID: 12106810 [PubMed - indexed for MEDLINE]Related articles

Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing.

Marchese G, Casu MA, Bartholini F, Ruiu S, Saba P, Gessa GL, Pani L.

Eur J Neurosci. 2002 Apr;15(7):1187-96.PMID: 11982629 [PubMed - indexed for MEDLINE]Related articles

The substituted benzamides and their clinical potential on dysthymia and on the negative symptoms of schizophrenia.

Pani L, Gessa GL.

Mol Psychiatry. 2002;7(3):247-53. Review.PMID: 11920152 [PubMed - indexed for MEDLINE]Related articlesFree article