PubMed

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M; MAGIC, Zeggini E, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM.

Hum Mol Genet. 2009 Dec 2. [Epub ahead of print]PMID: 19933169 [PubMed - as supplied by publisher]Related articlesFree article

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

UK IBD Genetics Consortium; Wellcome Trust Case Control Consortium 2, Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP.

Nat Genet. 2009 Dec;41(12):1330-4. Epub 2009 Nov 15.PMID: 19915572 [PubMed - in process]Related articles

Novel insights into the etiology of diabetes from genome-wide association studies.

Palmer CN.

Diabetes. 2009 Nov;58(11):2444-7. No abstract available. PMID: 19875620 [PubMed - in process]Related articles

Genetic association analysis of LARS2 with type 2 diabetes.

Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol.

Basu K, Palmer CN, Tavendale R, Lipworth BJ, Mukhopadhyay S.

J Allergy Clin Immunol. 2009 Oct 2. [Epub ahead of print]PMID: 19800676 [PubMed - as supplied by publisher]Related articles

Loss-of-Function CYP2C9 Variants Improve Therapeutic Response to Sulfonylureas in Type 2 Diabetes: A Go-DARTS Study.

Zhou K, Donnelly L, Burch L, Tavendale R, Doney AS, Leese G, Hattersley AT, McCarthy MI, Morris AD, Lang CC, Palmer CN, Pearson ER.

Clin Pharmacol Ther. 2009 Sep 30. [Epub ahead of print]PMID: 19794412 [PubMed - as supplied by publisher]Related articles

Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta.

Gustafsson MC, Knight D, Palmer CN.

PLoS One. 2009 Sep 16;4(9):e7046.PMID: 19756148 [PubMed - in process]Related articlesFree article

The Y402H variant of complement factor H is associated with age-related macular degeneration but not with diabetic retinal disease in the Go-DARTS study.

Doney AS, Leese GP, Olson J, Morris AD, Palmer CN.

Diabet Med. 2009 May;26(5):460-5.PMID: 19646183 [PubMed - in process]Related articles

Underlying genetic models of inheritance in established type 2 diabetes associations.

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C, Lyssenko V, McCarthy MI, Morris A, Morris AD, Palmer CN, Payne F, Platou CG, Scott LJ, Voight BF, Wareham NJ, Zeggini E, Ioannidis JP.

Am J Epidemiol. 2009 Sep 1;170(5):537-45. Epub 2009 Jul 14.PMID: 19602701 [PubMed - indexed for MEDLINE]Related articles

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium.

PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26. Erratum in: PLoS Genet. 2009 Jul;5(7). doi: 10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928. PMID: 19557161 [PubMed - indexed for MEDLINE]Related articlesFree article

Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.

Rodriguez S, Hall AJ, Granell R, McLean WH, Irvine AD, Palmer CN, Smith GD, Henderson J, Day IN.

PLoS One. 2009 Jun 3;4(6):e5784.PMID: 19492053 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2009 Jul;58(7):1704-9. Epub 2009 Apr 23.PMID: 19389826 [PubMed - indexed for MEDLINE]Related articlesFree article

A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children.

Burch LR, Zhou K, Donnelly LA, Doney AS, Brady J, Goddard C, Morris AD, Hansen MK, Palmer CN.

J Clin Endocrinol Metab. 2009 Jul;94(7):2587-93. Epub 2009 Apr 21.PMID: 19383774 [PubMed - indexed for MEDLINE]Related articles

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

Zhou K, Donnelly LA, Kimber CH, Donnan PT, Doney AS, Leese G, Hattersley AT, McCarthy MI, Morris AD, Palmer CN, Pearson ER.

Diabetes. 2009 Jun;58(6):1434-9. Epub 2009 Mar 31.PMID: 19336679 [PubMed - indexed for MEDLINE]Related articlesFree article

Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema.

Liedén A, Ekelund E, Kuo IC, Kockum I, Huang CH, Mallbris L, Lee SP, Seng LK, Chin GY, Wahlgren CF, Palmer CN, Björkstén B, Ståhle M, Nordenskjöld M, Bradley M, Chua KY, D'Amato M.

Allergy. 2009 Feb;64(2):304-11. Epub 2008 Dec 24. Erratum in: Allergy. 2009 Apr;64(4):667.. Nordenskold, M [corrected to Nordenskjöld, M]. PMID: 19133922 [PubMed - indexed for MEDLINE]Related articles

An obesity-associated FTO gene variant and increased energy intake in children.

Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN.

N Engl J Med. 2008 Dec 11;359(24):2558-66.PMID: 19073975 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in MTNR1B influence fasting glucose levels.

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR.

Nat Genet. 2009 Jan;41(1):77-81. Epub 2008 Dec 7.PMID: 19060907 [PubMed - indexed for MEDLINE]Related articles

Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP, Rayner NW, Walker M, Hitman GA, Doney AS, Palmer CN, Morris AD, Hattersley AT, Zeggini E, Frayling TM, McCarthy MI.

Diabetes. 2009 Feb;58(2):505-10. Epub 2008 Dec 3.PMID: 19056611 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalent and rare mutations in the gene encoding filaggrin in Japanese patients with ichthyosis vulgaris and atopic dermatitis.

Nomura T, Akiyama M, Sandilands A, Nemoto-Hasebe I, Sakai K, Nagasaki A, Palmer CN, Smith FJ, McLean WH, Shimizu H.

J Invest Dermatol. 2009 May;129(5):1302-5. Epub 2008 Nov 27. No abstract available. PMID: 19037238 [PubMed - indexed for MEDLINE]Related articles

Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.

Bisgaard H, Bønnelykke K, Sleiman PM, Brasholt M, Chawes B, Kreiner-Møller E, Stage M, Kim C, Tavendale R, Baty F, Pipper CB, Palmer CN, Hakonarsson H.

Am J Respir Crit Care Med. 2009 Feb 1;179(3):179-85. Epub 2008 Nov 21.PMID: 19029000 [PubMed - indexed for MEDLINE]Related articles

Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly.

Sergeant A, Campbell LE, Hull PR, Porter M, Palmer CN, Smith FJ, McLean WH, Munro CS.

J Invest Dermatol. 2009 Apr;129(4):1042-5. Epub 2008 Nov 6. No abstract available. PMID: 18987673 [PubMed - indexed for MEDLINE]Related articles

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ; DIAGRAM Consortium, Palmer CN, Morris AD, McCarthy MI, Ferrucci L, Hattersley AT, Zeggini E, Frayling TM.

Diabetologia. 2008 Dec;51(12):2205-13. Epub 2008 Oct 14.PMID: 18853133 [PubMed - indexed for MEDLINE]Related articlesFree article

A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study.

Donnelly LA, Doney AS, Dannfald J, Whitley AL, Lang CC, Morris AD, Donnan PT, Palmer CN.

Pharmacogenet Genomics. 2008 Dec;18(12):1021-6.PMID: 18815589 [PubMed - indexed for MEDLINE]Related articles

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.

Weidinger S, Baurecht H, Wagenpfeil S, Henderson J, Novak N, Sandilands A, Chen H, Rodriguez E, O'Regan GM, Watson R, Liao H, Zhao Y, Barker JN, Allen M, Reynolds N, Meggitt S, Northstone K, Smith GD, Strobl C, Stahl C, Kneib T, Klopp N, Bieber T, Behrendt H, Palmer CN, Wichmann HE, Ring J, Illig T, McLean WH, Irvine AD.

J Allergy Clin Immunol. 2008 Sep;122(3):560-8.e4. Erratum in: J Allergy Clin Immunol. 2008 Nov;122(5):976. PMID: 18774391 [PubMed - indexed for MEDLINE]Related articles

Long-term adherence to statin treatment in diabetes.

Donnelly LA, Doney AS, Morris AD, Palmer CN, Donnan PT.

Diabet Med. 2008 Jul;25(7):850-5.PMID: 18644071 [PubMed - indexed for MEDLINE]Related articles

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN.

Diabetes. 2008 Nov;57(11):3129-35. Epub 2008 Jun 30.PMID: 18591388 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

Bisgaard H, Simpson A, Palmer CN, Bønnelykke K, McLean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A.

PLoS Med. 2008 Jun 24;5(6):e131.PMID: 18578563 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.PMID: 18454148 [PubMed - indexed for MEDLINE]Related articlesFree article

Filaggrin variants confer susceptibility to asthma.

McLean WH, Palmer CN, Henderson J, Kabesch M, Weidinger S, Irvine AD.

J Allergy Clin Immunol. 2008 May;121(5):1294-5; author reply 1295-6. Epub 2008 Apr 8. No abstract available. PMID: 18395783 [PubMed - indexed for MEDLINE]Related articles

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.

Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN.

J Allergy Clin Immunol. 2008 Apr;121(4):860-3.PMID: 18395550 [PubMed - indexed for MEDLINE]Related articles

Genome-wide association analysis identifies 20 loci that influence adult height.

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JR, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CN, Morris AD, Ouwehand WH; Cambridge GEM Consortium, Zhao JH, Li S, Loos RJ, Barroso I, Deloukas P, Sandhu MS, Wheeler E, Soranzo N, Inouye M, Wareham NJ, Caulfield M, Munroe PB, Hattersley AT, McCarthy MI, Frayling TM.

Nat Genet. 2008 May;40(5):575-83. Epub 2008 Apr 6.PMID: 18391952 [PubMed - indexed for MEDLINE]Related articlesFree article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.

Nat Genet. 2008 May;40(5):638-45. Epub 2008 Mar 30.PMID: 18372903 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.

Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, Lindgren CM, Lango H, Melzer D, Ferrucci L, Paolisso G, Neville MJ, Karpe F, Palmer CN, Morris AD, Elliott P, Jarvelin MR, Smith GD, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2008 May;57(5):1419-26. Epub 2008 Mar 17.PMID: 18346983 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.

Donnelly LA, Palmer CN, Whitley AL, Lang CC, Doney AS, Morris AD, Donnan PT.

Pharmacogenet Genomics. 2008 Apr;18(4):279-87.PMID: 18334912 [PubMed - indexed for MEDLINE]Related articles

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.

Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN, Knott SA, Kolcic I, Polasek O, Graessler J, Wilson JF, Marinaki A, Riches PL, Shu X, Janicijevic B, Smolej-Narancic N, Gorgoni B, Morgan J, Campbell S, Biloglav Z, Barac-Lauc L, Pericic M, Klaric IM, Zgaga L, Skaric-Juric T, Wild SH, Richardson WA, Hohenstein P, Kimber CH, Tenesa A, Donnelly LA, Fairbanks LD, Aringer M, McKeigue PM, Ralston SH, Morris AD, Rudan P, Hastie ND, Campbell H, Wright AF.

Nat Genet. 2008 Apr;40(4):437-42. Epub 2008 Mar 9.PMID: 18327257 [PubMed - indexed for MEDLINE]Related articles

The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.

Henderson J, Northstone K, Lee SP, Liao H, Zhao Y, Pembrey M, Mukhopadhyay S, Smith GD, Palmer CN, McLean WH, Irvine AD.

J Allergy Clin Immunol. 2008 Apr;121(4):872-7.e9. Epub 2008 Mar 5.PMID: 18325573 [PubMed - indexed for MEDLINE]Related articles

Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults.

Basu K, Palmer CN, Lipworth BJ, Irwin McLean WH, Terron-Kwiatkowski A, Zhao Y, Liao H, Smith FJ, Mitra A, Mukhopadhyay S.

Allergy. 2008 Sep;63(9):1211-7. Epub 2008 Feb 25.PMID: 18307574 [PubMed - indexed for MEDLINE]Related articles

Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan.

Nomura T, Akiyama M, Sandilands A, Nemoto-Hasebe I, Sakai K, Nagasaki A, Ota M, Hata H, Evans AT, Palmer CN, Shimizu H, McLean WH.

J Invest Dermatol. 2008 Jun;128(6):1436-41. Epub 2008 Jan 17.PMID: 18200065 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families.

Ekelund E, Liedén A, Link J, Lee SP, D'Amato M, Palmer CN, Kockum I, Bradley M.

Acta Derm Venereol. 2008;88(1):15-9.PMID: 18176743 [PubMed - indexed for MEDLINE]Related articles

Filaggrin null alleles are not associated with hand eczema or contact allergy.

Lerbaek A, Bisgaard H, Agner T, Ohm Kyvik K, Palmer CN, Menné T.

Br J Dermatol. 2007 Dec;157(6):1199-204. Epub 2007 Oct 26.PMID: 17970802 [PubMed - indexed for MEDLINE]Related articles

A common variant of HMGA2 is associated with adult and childhood height in the general population.

Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM.

Nat Genet. 2007 Oct;39(10):1245-50. Epub 2007 Sep 2.PMID: 17767157 [PubMed - indexed for MEDLINE]Related articles

Variants of the peroxisome proliferator-activated receptor gamma- and beta-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children.

Cecil JE, Palmer CN, Fischer B, Watt P, Wallis DJ, Murrie I, Hetherington MM.

Am J Clin Nutr. 2007 Jul;86(1):167-73.PMID: 17616777 [PubMed - indexed for MEDLINE]Related articlesFree article

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.

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