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Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.

Dastani Z, Pajukanta P, Marcil M, Rudzicz N, Ruel I, Bailey SD, Lee JC, Lemire M, Faith J, Platko J, Rioux J, Hudson TJ, Gaudet D, Engert JC, Genest J.

Eur J Hum Genet. 2009 Oct 21. [Epub ahead of print]PMID: 19844255 [PubMed - as supplied by publisher]Related articles

A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia.

Huertas-Vazquez A, Plaisier CL, Geng R, Haas BE, Lee J, Greevenbroek MM, van der Kallen C, de Bruin TW, Taskinen MR, Alagramam KN, Pajukanta P.

Hum Genet. 2009 Oct 9. [Epub ahead of print]PMID: 19816713 [PubMed - as supplied by publisher]Related articles

A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.

Plaisier CL, Horvath S, Huertas-Vazquez A, Cruz-Bautista I, Herrera MF, Tusie-Luna T, Aguilar-Salinas C, Pajukanta P.

PLoS Genet. 2009 Sep;5(9):e1000642. Epub 2009 Sep 11.PMID: 19750004 [PubMed - in process]Related articlesFree article

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.

Meex SJ, Weissglas-Volkov D, van der Kallen CJ, Thuerauf DJ, van Greevenbroek MM, Schalkwijk CG, Stehouwer CD, Feskens EJ, Heldens L, Ayoubi TA, Hofker MH, Wouters BG, Vlietinck R, Sinsheimer JS, Taskinen MR, Kuusisto J, Laakso M, de Bruin TW, Pajukanta P, Glembotski CC.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1322-7. Epub 2009 Aug 10.PMID: 19667116 [PubMed - indexed for MEDLINE]Related articles

Galanin preproprotein is associated with elevated plasma triglycerides.

Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L, Ramírez-Jiménez S, de Bruin TW, Tusié-Luna T, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):147-52. Epub 2008 Nov 6.PMID: 18988886 [PubMed - indexed for MEDLINE]Related articles

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.

Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P.

Am J Hum Genet. 2008 Aug;83(2):180-92.PMID: 18674750 [PubMed - indexed for MEDLINE]Related articlesFree article

Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis.

Presson AP, Sobel EM, Pajukanta P, Plaisier C, Weeks DE, Aberg K, Papp JC.

BMC Bioinformatics. 2008 Jul 21;9:317.PMID: 18644149 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia.

Mar-Heyming R, Miyazaki M, Weissglas-Volkov D, Kolaitis NA, Sadaat N, Plaisier C, Pajukanta P, Cantor RM, de Bruin TW, Ntambi JM, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1193-9. Epub 2008 Mar 13.PMID: 18340007 [PubMed - indexed for MEDLINE]Related articlesFree article

Estimating ethnic admixture from pedigree data.

Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K.

Am J Hum Genet. 2008 Mar;82(3):748-55.PMID: 18319077 [PubMed - indexed for MEDLINE]Related articlesFree article

A treasure trove for lipoprotein biology.

Lusis AJ, Pajukanta P.

Nat Genet. 2008 Feb;40(2):129-30. No abstract available. PMID: 18227868 [PubMed - indexed for MEDLINE]Related articles

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.

Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH.

Nat Genet. 2007 Dec;39(12):1483-7. Epub 2007 Nov 11.PMID: 17994020 [PubMed - indexed for MEDLINE]Related articles

TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.

Huertas-Vazquez A, Plaisier C, Weissglas-Volkov D, Sinsheimer J, Canizales-Quinteros S, Cruz-Bautista I, Nikkola E, Herrera-Hernandez M, Davila-Cervantes A, Tusie-Luna T, Taskinen MR, Aguilar-Salinas C, Pajukanta P.

Diabetologia. 2008 Jan;51(1):62-9. Epub 2007 Oct 31.PMID: 17972059 [PubMed - indexed for MEDLINE]Related articles

USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.

Lee JC, Weissglas-Volkov D, Kyttälä M, Sinsheimer JS, Jokiaho A, de Bruin TW, Lusis AJ, Brennan ML, van Greevenbroek MM, van der Kallen CJ, Hazen SL, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2222-7. Epub 2007 Aug 2.PMID: 17673701 [PubMed - indexed for MEDLINE]Related articlesFree article

Unraveling the complex genetics of familial combined hyperlipidemia.

Suviolahti E, Lilja HE, Pajukanta P.

Ann Med. 2006;38(5):337-51. Review.PMID: 16938803 [PubMed - indexed for MEDLINE]Related articles

Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome.

Weissglas-Volkov D, Huertas-Vazquez A, Suviolahti E, Lee J, Plaisier C, Canizales-Quinteros S, Tusie-Luna T, Aguilar-Salinas C, Taskinen MR, Pajukanta P.

Diabetes. 2006 Jul;55(7):1970-7.PMID: 16804065 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.

Komulainen K, Alanne M, Auro K, Kilpikari R, Pajukanta P, Saarela J, Ellonen P, Salminen K, Kulathinal S, Kuulasmaa K, Silander K, Salomaa V, Perola M, Peltonen L.

PLoS Genet. 2006 May;2(5):e69. Epub 2006 May 12.PMID: 16699592 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial combined hyperlipidemia: upstream transcription factor 1 and beyond.

Lee JC, Lusis AJ, Pajukanta P.

Curr Opin Lipidol. 2006 Apr;17(2):101-9. Review.PMID: 16531745 [PubMed - indexed for MEDLINE]Related articles

Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism.

Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L.

Hum Mol Genet. 2006 Feb 1;15(3):377-86. Epub 2005 Dec 15.PMID: 16357106 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21.

Dastani Z, Quiogue L, Plaisier C, Engert JC, Marcil M, Genest J, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):392-7. Epub 2005 Dec 1.PMID: 16322534 [PubMed - indexed for MEDLINE]Related articlesFree article

USF1 and dyslipidemias: converging evidence for a functional intronic variant.

Naukkarinen J, Gentile M, Soro-Paavonen A, Saarela J, Koistinen HA, Pajukanta P, Taskinen MR, Peltonen L.

Hum Mol Genet. 2005 Sep 1;14(17):2595-605. Epub 2005 Aug 2.PMID: 16076849 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel nonsense apolipoprotein A-I mutation (apoA-I(E136X)) causes low HDL cholesterol in French Canadians.

Dastani Z, Dangoisse C, Boucher B, Desbiens K, Krimbou L, Dufour R, Hegele RA, Pajukanta P, Engert JC, Genest J, Marcil M.

Atherosclerosis. 2006 Mar;185(1):127-36. Epub 2005 Jul 14.PMID: 16023124 [PubMed - indexed for MEDLINE]Related articles

Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.

Huertas-Vazquez A, Aguilar-Salinas C, Lusis AJ, Cantor RM, Canizales-Quinteros S, Lee JC, Mariana-Nuñez L, Riba-Ramirez RM, Jokiaho A, Tusie-Luna T, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1985-91. Epub 2005 Jun 23.PMID: 15976322 [PubMed - indexed for MEDLINE]Related articlesFree article

A male-specific quantitative trait locus on 1p21 controlling human stature.

Sammalisto S, Hiekkalinna T, Suviolahti E, Sood K, Metzidis A, Pajukanta P, Lilja HE, Soro-Paavonen A, Taskinen MR, Tuomi T, Almgren P, Orho-Melander M, Groop L, Peltonen L, Perola M.

J Med Genet. 2005 Dec;42(12):932-9. Epub 2005 Apr 12.PMID: 15827092 [PubMed - indexed for MEDLINE]Related articlesFree article

Association testing in a linked region using large pedigrees.

Cantor RM, Chen GK, Pajukanta P, Lange K.

Am J Hum Genet. 2005 Mar;76(3):538-42. Epub 2005 Jan 18.PMID: 15657872 [PubMed - indexed for MEDLINE]Related articlesFree article

Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population?

Pajukanta P.

J Clin Invest. 2004 Nov;114(9):1244-7. Review.PMID: 15520856 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics of atherosclerosis.

Lusis AJ, Mar R, Pajukanta P.

Annu Rev Genomics Hum Genet. 2004;5:189-218. Review.PMID: 15485348 [PubMed - indexed for MEDLINE]Related articles

Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.

Lilja HE, Suviolahti E, Soro-Paavonen A, Hiekkalinna T, Day A, Lange K, Sobel E, Taskinen MR, Peltonen L, Perola M, Pajukanta P.

J Lipid Res. 2004 Oct;45(10):1876-84. Epub 2004 Jul 16.PMID: 15258200 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.

Mar R, Pajukanta P, Allayee H, Groenendijk M, Dallinga-Thie G, Krauss RM, Sinsheimer JS, Cantor RM, de Bruin TW, Lusis AJ.

Circ Res. 2004 Apr 16;94(7):993-9. Epub 2004 Mar 4.PMID: 15001527 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

Pajukanta P, Lilja HE, Sinsheimer JS, Cantor RM, Lusis AJ, Gentile M, Duan XJ, Soro-Paavonen A, Naukkarinen J, Saarela J, Laakso M, Ehnholm C, Taskinen MR, Peltonen L.

Nat Genet. 2004 Apr;36(4):371-6. Epub 2004 Feb 29.PMID: 14991056 [PubMed - indexed for MEDLINE]Related articles

The SLC6A14 gene shows evidence of association with obesity.

Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P.

J Clin Invest. 2003 Dec;112(11):1762-72.PMID: 14660752 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q.

Pajukanta P, Allayee H, Krass KL, Kuraishy A, Soro A, Lilja HE, Mar R, Taskinen MR, Nuotio I, Laakso M, Rotter JI, de Bruin TW, Cantor RM, Lusis AJ, Peltonen L.

Am J Hum Genet. 2003 Apr;72(4):903-17. Epub 2003 Mar 12.PMID: 12638083 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient discovery of single-nucleotide polymorphisms in coding regions of human genes.

Hu G, Modrek B, Riise Stensland HM, Saarela J, Pajukanta P, Kustanovich V, Peltonen L, Nelson SF, Lee C.

Pharmacogenomics J. 2002;2(4):236-42.PMID: 12196912 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.

Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JS, Peltonen L, Taskinen MR.

Eur J Hum Genet. 2002 Sep;10(9):547-52.PMID: 12173032 [PubMed - indexed for MEDLINE]Related articlesFree article

A candidate gene study in low HDL-cholesterol families provides evidence for the involvement of the APOA2 gene and the APOA1C3A4 gene cluster.

Lilja HE, Soro A, Ylitalo K, Nuotio I, Viikari JS, Salomaa V, Vartiainen E, Taskinen MR, Peltonen L, Pajukanta P.

Atherosclerosis. 2002 Sep;164(1):103-11.PMID: 12119199 [PubMed - indexed for MEDLINE]Related articles

Bipolar disorder susceptibility region on Xq24-q27.1 in Finnish families.

Ekholm JM, Pekkarinen P, Pajukanta P, Kieseppä T, Partonen T, Paunio T, Varilo T, Perola M, Lönnqvist J, Peltonen L.

Mol Psychiatry. 2002;7(5):453-9.PMID: 12082562 [PubMed - indexed for MEDLINE]Related articlesFree article

Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia.

Allayee H, Krass KL, Pajukanta P, Cantor RM, van der Kallen CJ, Mar R, Rotter JI, de Bruin TW, Peltonen L, Lusis AJ.

Circ Res. 2002 May 3;90(8):926-31.PMID: 11988495 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families.

Soro A, Pajukanta P, Lilja HE, Ylitalo K, Hiekkalinna T, Perola M, Cantor RM, Viikari JS, Taskinen MR, Peltonen L.

Am J Hum Genet. 2002 May;70(5):1333-40. Epub 2002 Mar 12.PMID: 11891617 [PubMed - indexed for MEDLINE]Related articlesFree article

[Genetics of hereditary dyslipidemia now becoming clear]

Pajukanta P, Palotie L.

Duodecim. 1998;114(15):1447, 1449. Finnish. No abstract available. PMID: 11552231 [PubMed - indexed for MEDLINE]Related articles

Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups.

Perola M, Ohman M, Hiekkalinna T, Leppävuori J, Pajukanta P, Wessman M, Koskenvuo M, Palotie A, Lange K, Kaprio J, Peltonen L.

Am J Hum Genet. 2001 Jul;69(1):117-23. Epub 2001 Jun 15.PMID: 11410840 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum C3 but not plasma acylation-stimulating protein is elevated in Finnish patients with familial combined hyperlipidemia.

Ylitalo K, Pajukanta P, Meri S, Cantor RM, Mero-Matikainen N, Vakkilainen J, Nuotio I, Taskinen MR.

Arterioscler Thromb Vasc Biol. 2001 May;21(5):838-43.PMID: 11348883 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.

Pajukanta P, Bodnar JS, Sallinen R, Chu M, Airaksinen T, Xiao Q, Castellani LW, Sheth SS, Wessman M, Palotie A, Sinsheimer JS, Demant P, Lusis AJ, Peltonen L.

Mamm Genome. 2001 Mar;12(3):238-45.PMID: 11252174 [PubMed - indexed for MEDLINE]Related articles

Reduced hormone-sensitive lipase activity is not a major metabolic defect in Finnish FCHL families.

Ylitalo K, Large V, Pajukanta P, Reynisdottir S, Porkka KV, Vakkilainen J, Nuotio I, Taskinen MR, Arner P.

Atherosclerosis. 2000 Dec;153(2):373-81.PMID: 11164426 [PubMed - indexed for MEDLINE]Related articles

Genetics of familial combined hyperlipidemia.

Pajukanta P, Porkka KV.

Curr Atheroscler Rep. 1999 Jul;1(1):79-86. Review.PMID: 11122695 [PubMed - indexed for MEDLINE]Related articles

Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings.

Perola M, Kainulainen K, Pajukanta P, Terwilliger JD, Hiekkalinna T, Ellonen P, Kaprio J, Koskenvuo M, Kontula K, Peltonen L.

J Hypertens. 2000 Nov;18(11):1579-85.PMID: 11081770 [PubMed - indexed for MEDLINE]Related articles

Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.

Pajukanta P, Cargill M, Viitanen L, Nuotio I, Kareinen A, Perola M, Terwilliger JD, Kempas E, Daly M, Lilja H, Rioux JD, Brettin T, Viikari JS, Rönnemaa T, Laakso M, Lander ES, Peltonen L.

Am J Hum Genet. 2000 Dec;67(6):1481-93. Epub 2000 Nov 13.PMID: 11078477 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.

Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen MR, Peltonen L.

Am J Hum Genet. 1999 May;64(5):1453-63.PMID: 10205279 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia.

Tahvanainen E, Pajukanta P, Porkka K, Nieminen S, Ikävalko L, Nuotio I, Taskinen MR, Peltonen L, Ehnholm C.

Arterioscler Thromb Vasc Biol. 1998 Nov;18(11):1810-7.PMID: 9812922 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.

Pajukanta P, Nuotio I, Terwilliger JD, Porkka KV, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen AC, Lehtimäki T, Viikari JS, Laakso M, Taskinen MR, Ehnholm C, Peltonen L.

Nat Genet. 1998 Apr;18(4):369-73.PMID: 9537421 [PubMed - indexed for MEDLINE]Related articles

Glucose intolerance in familial combined hyperlipidaemia. EUFAM study group.

Vakkilainen J, Porkka KV, Nuotio I, Pajukanta P, Suurinkeroinen L, Ylitalo K, Viikari JS, Ehnholm C, Taskinen MR.

Eur J Clin Invest. 1998 Jan;28(1):24-32.PMID: 9502184 [PubMed - indexed for MEDLINE]Related articles

Phenotype expression in familial combined hyperlipidemia.

Porkka KV, Nuotio I, Pajukanta P, Ehnholm C, Suurinkeroinen L, Syvänne M, Lehtimäki T, Lahdenkari AT, Lahdenperä S, Ylitalo K, Antikainen M, Perola M, Raitakari OT, Kovanen P, Viikari JS, Peltonen L, Taskinen MR.

Atherosclerosis. 1997 Sep;133(2):245-53.PMID: 9298685 [PubMed - indexed for MEDLINE]Related articles