PubMed

CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes.

Mukhopadhyay P, Rajesh M, Bátkai S, Patel V, Kashiwaya Y, Liaudet L, Evgenov OV, Mackie K, Haskó G, Pacher P.

Cardiovasc Res. 2009 Nov 26. [Epub ahead of print]PMID: 19942623 [PubMed - as supplied by publisher]Related articles

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells.

Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, Zhang C, Pacher P, Csiszar A.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1876-81. Epub 2009 Sep 11.PMID: 19749157 [PubMed - indexed for MEDLINE]Related articles

CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis.

Csóka B, Németh ZH, Mukhopadhyay P, Spolarics Z, Rajesh M, Federici S, Deitch EA, Bátkai S, Pacher P, Haskó G.

PLoS One. 2009 Jul 29;4(7):e6409.PMID: 19641602 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of matrix metalloproteinase-2 by PARP inhibitors.

Nicolescu AC, Holt A, Kandasamy AD, Pacher P, Schulz R.

Biochem Biophys Res Commun. 2009 Oct 2;387(4):646-50. Epub 2009 Jul 18.PMID: 19619515 [PubMed - indexed for MEDLINE]Related articlesFree article

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

Bíró T, Tóth BI, Haskó G, Paus R, Pacher P.

Trends Pharmacol Sci. 2009 Aug;30(8):411-20. Epub 2009 Jul 14. Review.PMID: 19608284 [PubMed - indexed for MEDLINE]Related articlesFree article

Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor.

Sovershaev MA, Egorina EM, Hansen JB, Østerud B, Pacher P, Stasch JP, Evgenov OV.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1578-86. Epub 2009 Jul 10.PMID: 19592462 [PubMed - indexed for MEDLINE]Related articles

Endocannabinoids and cardiac contractile function: pathophysiological implications.

Bátkai S, Pacher P.

Pharmacol Res. 2009 Aug;60(2):99-106. Review.PMID: 19569260 [PubMed - indexed for MEDLINE]Related articles

PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase.

Helyar SG, Patel B, Headington K, El Assal M, Chatterjee PK, Pacher P, Mabley JG.

Biochem Pharmacol. 2009 Oct 15;78(8):959-65. Epub 2009 Jun 21.PMID: 19549508 [PubMed - indexed for MEDLINE]Related articlesFree article

Resveratrol induces mitochondrial biogenesis in endothelial cells.

Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, Pacher P, Zhang C, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20. Epub 2009 May 8.PMID: 19429820 [PubMed - indexed for MEDLINE]Related articles

A(2B) adenosine receptors in immunity and inflammation.

Haskó G, Csóka B, Németh ZH, Vizi ES, Pacher P.

Trends Immunol. 2009 Jun;30(6):263-70. Epub 2009 May 7. Review.PMID: 19427267 [PubMed - indexed for MEDLINE]Related articlesFree article

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency.

Ungvari Z, Krasnikov BF, Csiszar A, Labinskyy N, Mukhopadhyay P, Pacher P, Cooper AJ, Podlutskaya N, Austad SN, Podlutsky A.

Age (Dordr). 2008 Sep;30(2-3):121-33. Epub 2008 Jun 14.PMID: 19424862 [PubMed - in process]Related articlesFree article

Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.

Vareniuk I, Pacher P, Pavlov IA, Drel VR, Obrosova IG.

Int J Mol Med. 2009 May;23(5):571-80.PMID: 19360314 [PubMed - indexed for MEDLINE]Related articlesFree article

The emerging role of the endocannabinoid system in cardiovascular disease.

Pacher P, Steffens S.

Semin Immunopathol. 2009 Jun;31(1):63-77. Epub 2009 Apr 9. Review.PMID: 19357846 [PubMed - indexed for MEDLINE]Related articles

Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.

Madesh M, Zong WX, Hawkins BJ, Ramasamy S, Venkatachalam T, Mukhopadhyay P, Doonan PJ, Irrinki KM, Rajesh M, Pacher P, Thompson CB.

Mol Cell Biol. 2009 Jun;29(11):3099-112. Epub 2009 Mar 30.PMID: 19332555 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro.

Mukhopadhyay P, Rajesh M, Bátkai S, Kashiwaya Y, Haskó G, Liaudet L, Szabó C, Pacher P.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83. Epub 2009 Mar 13.PMID: 19286953 [PubMed - indexed for MEDLINE]Related articles

Role of peroxynitrite in the redox regulation of cell signal transduction pathways.

Liaudet L, Vassalli G, Pacher P.

Front Biosci. 2009 Jan 1;14:4809-14. Review.PMID: 19273391 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress and accelerated vascular aging: implications for cigarette smoking.

Csiszar A, Podlutsky A, Wolin MS, Losonczy G, Pacher P, Ungvari Z.

Front Biosci. 2009 Jan 1;14:3128-44. Review.PMID: 19273262 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice.

Mabley JG, Pacher P, Szabo C.

Mol Med. 2009 May-Jun;15(5-6):166-72. Epub 2009 Feb 5.PMID: 19209239 [PubMed - indexed for MEDLINE]Related articlesFree article

Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus.

Labinskyy N, Mukhopadhyay P, Toth J, Szalai G, Veres M, Losonczy G, Pinto JT, Pacher P, Ballabh P, Podlutsky A, Austad SN, Csiszar A, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H946-56. Epub 2009 Jan 30.PMID: 19181967 [PubMed - indexed for MEDLINE]Related articles

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy.

Rajesh M, Mukhopadhyay P, Bátkai S, Mukhopadhyay B, Patel V, Haskó G, Szabó C, Mabley JG, Liaudet L, Pacher P.

J Cell Mol Med. 2008 Oct 23. [Epub ahead of print]PMID: 19175688 [PubMed - as supplied by publisher]Related articles

The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury.

Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C.

Shock. 2009 Sep;32(3):258-62.PMID: 19174745 [PubMed - in process]Related articlesFree article

Anaphylatoxin C5a contributes to the pathogenesis of cisplatin-induced nephrotoxicity.

Pan H, Shen Z, Mukhopadhyay P, Wang H, Pacher P, Qin X, Gao B.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F496-504. Epub 2009 Jan 14.PMID: 19144695 [PubMed - indexed for MEDLINE]Related articles

Cannabinoid CB1 receptor antagonists for atherosclerosis and cardiometabolic disorders: new hopes, old concerns?

Pacher P.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):7-9. No abstract available. PMID: 19092136 [PubMed - indexed for MEDLINE]Related articlesFree article

CB1 cannabinoid receptor inhibition: promising approach for heart failure?

Mukhopadhyay P, Mohanraj R, Bátkai S, Pacher P.

Congest Heart Fail. 2008 Nov-Dec;14(6):330-4. Review. No abstract available. PMID: 19076859 [PubMed - indexed for MEDLINE]Related articlesFree article

Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death.

Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P.

J Pharmacol Exp Ther. 2009 Mar;328(3):708-14. Epub 2008 Dec 12.PMID: 19074681 [PubMed - indexed for MEDLINE]Related articles

Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation.

Rajesh M, Mukhopadhyay P, Haskó G, Pacher P.

Biochem Biophys Res Commun. 2008 Dec 26;377(4):1248-52. Epub 2008 Nov 6.PMID: 18996082 [PubMed - indexed for MEDLINE]Related articles

The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.

Godlewski G, Offertáler L, Osei-Hyiaman D, Mo FM, Harvey-White J, Liu J, Davis MI, Zhang L, Razdan RK, Milman G, Pacher P, Mukhopadhyay P, Lovinger DM, Kunos G.

J Pharmacol Exp Ther. 2009 Jan;328(1):351-61. Epub 2008 Oct 15.PMID: 18923087 [PubMed - indexed for MEDLINE]Related articles

Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations.

Pacher P, Mukhopadhyay P, Mohanraj R, Godlewski G, Bátkai S, Kunos G.

Hypertension. 2008 Oct;52(4):601-7. Epub 2008 Sep 8. Review. No abstract available. PMID: 18779440 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion.

Moon KH, Hood BL, Mukhopadhyay P, Rajesh M, Abdelmegeed MA, Kwon YI, Conrads TP, Veenstra TD, Song BJ, Pacher P.

Gastroenterology. 2008 Oct;135(4):1344-57. Epub 2008 Jun 25.PMID: 18778711 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats.

Pacher P, Nagayama T, Mukhopadhyay P, Bátkai S, Kass DA.

Nat Protoc. 2008;3(9):1422-34.PMID: 18772869 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases.

Haskó G, Linden J, Cronstein B, Pacher P.

Nat Rev Drug Discov. 2008 Sep;7(9):759-70. Review.PMID: 18758473 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.

Csiszar A, Labinskyy N, Perez V, Recchia FA, Podlutsky A, Mukhopadhyay P, Losonczy G, Pacher P, Austad SN, Bartke A, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1882-94. Epub 2008 Aug 29.PMID: 18757483 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues.

Fegley DB, Holmes A, Riordan T, Faber CA, Weiss JR, Ma S, Batkai S, Pacher P, Dobolyi A, Murphy A, Sleeman MW, Usdin TB.

Genes Brain Behav. 2008 Nov;7(8):933-42. Epub 2008 Sep 17.PMID: 18700839 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta.

Pacher P, Sharma K, Csordás G, Zhu Y, Hajnóczky G.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1303-12. Epub 2008 Jul 23.PMID: 18653477 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.

Csóka B, Himer L, Selmeczy Z, Vizi ES, Pacher P, Ledent C, Deitch EA, Spolarics Z, Németh ZH, Haskó G.

FASEB J. 2008 Oct;22(10):3491-9. Epub 2008 Jul 14.PMID: 18625677 [PubMed - indexed for MEDLINE]Related articlesFree article

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.

Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C.

J Endocrinol. 2008 Sep;198(3):581-9. Epub 2008 Jun 18.PMID: 18562629 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease.

Pacher P, Szabo C.

Am J Pathol. 2008 Jul;173(1):2-13. Epub 2008 Jun 5. Review.PMID: 18535182 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

Drel VR, Pacher P, Ali TK, Shin J, Julius U, El-Remessy AB, Obrosova IG.

Int J Mol Med. 2008 Jun;21(6):667-76.PMID: 18506358 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.

Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35. Epub 2008 Apr 18.PMID: 18424637 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage function.

Csóka B, Németh ZH, Selmeczy Z, Koscsó B, Pacher P, Vizi ES, Deitch EA, Haskó G.

Purinergic Signal. 2007 Sep;3(4):447-52. Epub 2007 Sep 5.PMID: 18404457 [PubMed - in process]Related articlesFree article

Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.

Horiguchi N, Wang L, Mukhopadhyay P, Park O, Jeong WI, Lafdil F, Osei-Hyiaman D, Moh A, Fu XY, Pacher P, Kunos G, Gao B.

Gastroenterology. 2008 Apr;134(4):1148-58. Epub 2008 Jan 11.PMID: 18395093 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral endocannabinoid system activity in patients treated with sibutramine.

Engeli S, Heusser K, Janke J, Gorzelniak K, Bátkai S, Pacher P, Harvey-White J, Luft FC, Jordan J.

Obesity (Silver Spring). 2008 May;16(5):1135-7. Epub 2008 Mar 6.PMID: 18356837 [PubMed - indexed for MEDLINE]Related articlesFree article

Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells.

Michalski CW, Maier M, Erkan M, Sauliunaite D, Bergmann F, Pacher P, Batkai S, Giese NA, Giese T, Friess H, Kleeff J.

PLoS One. 2008 Feb 27;3(2):e1701.PMID: 18301776 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseases.

Pacher P, Gao B.

Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G850-4. Epub 2008 Jan 31. Review.PMID: 18239059 [PubMed - indexed for MEDLINE]Related articlesFree article

Pleiotropic effects of the CB2 cannabinoid receptor activation on human monocyte migration: implications for atherosclerosis and inflammatory diseases.

Pacher P, Ungvári Z.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1133-4. Epub 2008 Jan 18. No abstract available. PMID: 18203843 [PubMed - indexed for MEDLINE]Related articlesFree article

Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy".

Pacher P.

Free Radic Biol Med. 2008 Mar 15;44(6):969-71. Epub 2008 Jan 14. No abstract available. PMID: 18194675 [PubMed - indexed for MEDLINE]Related articlesFree article

A2A receptors in inflammation and injury: lessons learned from transgenic animals.

Haskó G, Pacher P.

J Leukoc Biol. 2008 Mar;83(3):447-55. Epub 2007 Dec 26. Review.PMID: 18160539 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál [corrected] Pacher. Interviewed by Helene F. Rosenberg.

Pacher PA.

J Leukoc Biol. 2007 Dec;82(6):1390-2. No abstract available. Erratum in: J Leukoc Biol. 2008 Feb;83(2):438. PMID: 18040082 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning.

Pacher P, Haskó G.

Br J Pharmacol. 2008 Jan;153(2):252-62. Epub 2007 Nov 19. Review.PMID: 18026124 [PubMed - indexed for MEDLINE]Related articlesFree article

CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.

Rajesh M, Mukhopadhyay P, Haskó G, Huffman JW, Mackie K, Pacher P.

Br J Pharmacol. 2008 Jan;153(2):347-57. Epub 2007 Nov 12.PMID: 17994109 [PubMed - indexed for MEDLINE]Related articlesFree article