PubMed

Oxidized Low-Density Lipoproteins Upregulate Proline Oxidase to Initiate ROS-dependent Autophagy.

Zabirnyk O, Liu W, Khalil S, Sharma A, Phang JM.

Carcinogenesis. 2009 Nov 25. [Epub ahead of print]PMID: 19942609 [PubMed - as supplied by publisher]Related articlesFree article

Proline oxidase functions as a mitochondrial tumor suppressor in human cancers.

Liu Y, Borchert GL, Donald SP, Diwan BA, Anver M, Phang JM.

Cancer Res. 2009 Aug 15;69(16):6414-22. Epub 2009 Aug 4.PMID: 19654292 [PubMed - indexed for MEDLINE]Related articles

Regulation and function of proline oxidase under nutrient stress.

Pandhare J, Donald SP, Cooper SK, Phang JM.

J Cell Biochem. 2009 Jul 1;107(4):759-68.PMID: 19415679 [PubMed - indexed for MEDLINE]Related articles

Semiconductor nanocrystals in autophagy research: methodology improvement at nanosized scale.

Seleverstov O, Phang JM, Zabirnyk O.

Methods Enzymol. 2009;452:277-96.PMID: 19200889 [PubMed - indexed for MEDLINE]Related articles

Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast.

McCue PP, Phang JM.

J Agric Food Chem. 2008 Nov 26;56(22):11011-7.PMID: 18975972 [PubMed - indexed for MEDLINE]Related articlesFree article

The metabolism of proline as microenvironmental stress substrate.

Phang JM, Pandhare J, Liu Y.

J Nutr. 2008 Oct;138(10):2008S-2015S.PMID: 18806116 [PubMed - indexed for MEDLINE]Related articlesFree article

Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.

Liu Y, Borchert GL, Surazynski A, Phang JM.

Oncogene. 2008 Dec 4;27(53):6729-37. Epub 2008 Sep 15.PMID: 18794809 [PubMed - indexed for MEDLINE]Related articles

PPARgamma and Proline Oxidase in Cancer.

Phang JM, Pandhare J, Zabirnyk O, Liu Y.

PPAR Res. 2008;2008:542694.PMID: 18670615 [PubMed - in process]Related articlesFree article

Proline metabolism in health and disease. Preface.

Hu CA, Phang JM, Valle D.

Amino Acids. 2008 Nov;35(4):651-2. No abstract available. PMID: 18504525 [PubMed - indexed for MEDLINE]Related articlesFree article

Introduction to second proline symposium.

Phang JM.

Amino Acids. 2008 Nov;35(4):653-4. No abstract available. PMID: 18491029 [PubMed - indexed for MEDLINE]Related articlesFree article

The metabolism of proline, a stress substrate, modulates carcinogenic pathways.

Phang JM, Donald SP, Pandhare J, Liu Y.

Amino Acids. 2008 Nov;35(4):681-90. Epub 2008 Apr 10. Review.PMID: 18401543 [PubMed - indexed for MEDLINE]Related articles

Prolidase-dependent regulation of collagen biosynthesis.

Surazynski A, Miltyk W, Palka J, Phang JM.

Amino Acids. 2008 Nov;35(4):731-8. Epub 2008 Mar 5. Review.PMID: 18320291 [PubMed - indexed for MEDLINE]Related articles

A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.

Cooper SK, Pandhare J, Donald SP, Phang JM.

J Biol Chem. 2008 Apr 18;283(16):10485-92. Epub 2008 Feb 19.PMID: 18287100 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular matrix and HIF-1 signaling: the role of prolidase.

Surazynski A, Donald SP, Cooper SK, Whiteside MA, Salnikow K, Liu Y, Phang JM.

Int J Cancer. 2008 Mar 15;122(6):1435-40.PMID: 17999410 [PubMed - indexed for MEDLINE]Related articles

Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.

Nurtjahja-Tjendraputra E, Fu D, Phang JM, Richardson DR.

Blood. 2007 May 1;109(9):4045-54. Epub 2006 Dec 29.PMID: 17197429 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.

Hu CA, Donald SP, Yu J, Lin WW, Liu Z, Steel G, Obie C, Valle D, Phang JM.

Mol Cell Biochem. 2007 Jan;295(1-2):85-92. Epub 2006 Jul 28.PMID: 16874462 [PubMed - indexed for MEDLINE]Related articles

Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.

Liu Y, Borchert GL, Surazynski A, Hu CA, Phang JM.

Oncogene. 2006 Sep 14;25(41):5640-7. Epub 2006 Apr 17.PMID: 16619034 [PubMed - indexed for MEDLINE]Related articles

Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms.

Pandhare J, Cooper SK, Phang JM.

J Biol Chem. 2006 Jan 27;281(4):2044-52. Epub 2005 Nov 21.PMID: 16303758 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide regulates prolidase activity by serine/threonine phosphorylation.

Surazynski A, Liu Y, Miltyk W, Phang JM.

J Cell Biochem. 2005 Dec 1;96(5):1086-94.PMID: 16167338 [PubMed - indexed for MEDLINE]Related articles

A concept of dietary dipeptides: a step to resolve the problem of amino acid availability in the early life of vertebrates.

Dabrowski K, Terjesen BF, Zhang Y, Phang JM, Lee KJ.

J Exp Biol. 2005 Aug;208(Pt 15):2885-94.PMID: 16043593 [PubMed - indexed for MEDLINE]Related articlesFree article

MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.

Liu Y, Borchert GL, Donald SP, Surazynski A, Hu CA, Weydert CJ, Oberley LW, Phang JM.

Carcinogenesis. 2005 Aug;26(8):1335-42. Epub 2005 Apr 7.PMID: 15817612 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells.

Miltyk W, Surazynski A, Kasprzak KS, Fivash MJ Jr, Buzard GS, Phang JM.

J Cell Biochem. 2005 Apr 15;94(6):1210-7.PMID: 15696600 [PubMed - indexed for MEDLINE]Related articles

Diet-gene interactions in p53-deficient mice: insulin-like growth factor-1 as a mechanistic target.

Hursting SD, Lavigne JA, Berrigan D, Donehower LA, Davis BJ, Phang JM, Barrett JC, Perkins SN.

J Nutr. 2004 Sep;134(9):2482S-2486S. Review.PMID: 15333746 [PubMed - indexed for MEDLINE]Related articlesFree article

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.

Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.

J Biol Chem. 2004 Sep 24;279(39):40337-44. Epub 2004 Jul 22.PMID: 15271983 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells.

Liu Y, Borchert GL, Phang JM.

J Biol Chem. 2004 Apr 30;279(18):18694-700. Epub 2004 Feb 19.PMID: 14976201 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex.

Mei JM, Borchert GL, Donald SP, Phang JM.

Carcinogenesis. 2002 Dec;23(12):2119-22.PMID: 12507936 [PubMed - indexed for MEDLINE]Related articlesFree article

Neural inhibition by c-Jun as a synergizing factor in bone morphogenetic protein 4 signaling.

Peng Y, Xu RH, Mei JM, Li XP, Yan D, Kung HF, Phang JM.

Neuroscience. 2002;109(4):657-64.PMID: 11927148 [PubMed - indexed for MEDLINE]Related articles

Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis.

Hursting SD, Shen JC, Sun XY, Wang TT, Phang JM, Perkins SN.

Mol Carcinog. 2002 Jan;33(1):16-24.PMID: 11807954 [PubMed - indexed for MEDLINE]Related articles

Testosterone and prostate specific antigen stimulate generation of reactive oxygen species in prostate cancer cells.

Sun XY, Donald SP, Phang JM.

Carcinogenesis. 2001 Nov;22(11):1775-80.PMID: 11698338 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet and cancer prevention studies in p53-deficient mice.

Hursting SD, Perkins SN, Phang JM, Barrett JC.

J Nutr. 2001 Nov;131(11 Suppl):3092S-4S. Review.PMID: 11694654 [PubMed - indexed for MEDLINE]Related articlesFree article

Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.

Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D, Phang JM.

Cancer Res. 2001 Mar 1;61(5):1810-5.PMID: 11280728 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype.

Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM.

Cancer Res. 2000 Jul 1;60(13):3379-83.PMID: 10910042 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells.

Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM.

FASEB J. 2000 Jun;14(9):1188-201.PMID: 10834941 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc.

Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM.

Carcinogenesis. 1999 Apr;20(4):737-40.PMID: 10223208 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice.

Hursting SD, Slaga TJ, Fischer SM, DiGiovanni J, Phang JM.

J Natl Cancer Inst. 1999 Feb 3;91(3):215-25. Review.PMID: 10037099 [PubMed - indexed for MEDLINE]Related articlesFree article

p53-independent inhibition of nitric oxide generation by cancer preventive interventions in ex vivo mouse peritoneal macrophages.

Mei JJ, Hursting SD, Perkins SN, Phang JM.

Cancer Lett. 1998 Jul 17;129(2):191-7.PMID: 9719461 [PubMed - indexed for MEDLINE]Related articles

Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice.

Perkins SN, Hursting SD, Phang JM, Haines DC.

J Invest Dermatol. 1998 Aug;111(2):292-6.PMID: 9699732 [PubMed - indexed for MEDLINE]Related articles

Differential expression and activity of phosphatases and protein kinases in adriamycin sensitive and resistant human breast cancer MCF-7 cells.

Ratnasinghe D, Phang JM, Yeh GC.

Int J Oncol. 1998 Jul;13(1):79-84.PMID: 9625806 [PubMed - indexed for MEDLINE]Related articles

Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells.

Sun XY, Plouzek CA, Henry JP, Wang TT, Phang JM.

Cancer Res. 1998 Jun 1;58(11):2379-84.PMID: 9622078 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolidase in human breast cancer MCF-7 cells.

Palka JA, Phang JM.

Cancer Lett. 1998 May 15;127(1-2):63-70.PMID: 9619859 [PubMed - indexed for MEDLINE]Related articles

Prolidase activity in fibroblasts is regulated by interaction of extracellular matrix with cell surface integrin receptors.

Palka JA, Phang JM.

J Cell Biochem. 1997 Nov 1;67(2):166-75.PMID: 9328822 [PubMed - indexed for MEDLINE]Related articles

Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice.

Hursting SD, Perkins SN, Brown CC, Haines DC, Phang JM.

Cancer Res. 1997 Jul 15;57(14):2843-6.PMID: 9230186 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice.

Wang TT, Hursting SD, Perkins SN, Phang JM.

Cancer Lett. 1997 Jun 3;116(1):61-9.PMID: 9177459 [PubMed - indexed for MEDLINE]Related articles

Chemoprevention of spontaneous tumorigenesis in nullizygous p53-deficient mice by dehydroepiandrosterone and its analog 16alpha-fluoro-5-androsten-17-one.

Perkins SN, Hursting SD, Haines DC, James SJ, Miller BJ, Phang JM.

Carcinogenesis. 1997 May;18(5):989-94.PMID: 9163685 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of N-(4-hydroxyphenyl)retinamide on apoptosis in human breast cancer cells.

Wang TT, Phang JM.

Cancer Lett. 1996 Oct 1;107(1):65-71.PMID: 8913268 [PubMed - indexed for MEDLINE]Related articles

Effects of chronic administration of N-(4-hydroxyphenyl)retinamide (4-HPR) in rats on vitamin A metabolism in the eye.

Lewis KC, Zech LA, Phang JM.

Eur J Cancer. 1996 Sep;32A(10):1803-8.PMID: 8983293 [PubMed - indexed for MEDLINE]Related articles

Molecular effects of genistein on estrogen receptor mediated pathways.

Wang TT, Sathyamoorthy N, Phang JM.

Carcinogenesis. 1996 Feb;17(2):271-5.PMID: 8625449 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemoprevention of spontaneous tumorigenesis in p53-knockout mice.

Hursting SD, Perkins SN, Haines DC, Ward JM, Phang JM.

Cancer Res. 1995 Sep 15;55(18):3949-53.PMID: 7664260 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7.

Wang TT, Phang JM.

Cancer Res. 1995 Jun 15;55(12):2487-9.PMID: 7780952 [PubMed - indexed for MEDLINE]Related articlesFree article

Accumulation of fatty alcohol in MCF-7 breast cancer cells.

Welsh CJ, Robinson M, Warne TR, Pierce JH, Yeh GC, Phang JM.

Arch Biochem Biophys. 1994 Nov 15;315(1):41-7.PMID: 7979403 [PubMed - indexed for MEDLINE]Related articles