PubMed

Mathematical models of diabetes progression.

De Gaetano A, Hardy T, Beck B, Abu-Raddad E, Palumbo P, Bue-Valleskey J, Pørksen N.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1462-79. Epub 2008 Sep 9.PMID: 18780774 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks.

Hardy TA, Meyers AL, Yu J, Shankar SS, Steinberg HO, Porksen NK.

Diabetes Care. 2007 Jan;30(1):157-8. No abstract available. PMID: 17192353 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo.

Larsen MO, Rolin B, Sturis J, Wilken M, Carr RD, Pørksen N, Gotfredsen CF.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E670-7. Epub 2005 Nov 8.PMID: 16278249 [PubMed - indexed for MEDLINE]Related articlesFree article

Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes.

Hollingdal M, Sturis J, Gall MA, Damsbo P, Pincus S, Veldhuis JD, Pørksen N, Schmitz O, Juhl CB.

Diabet Med. 2005 Oct;22(10):1408-13.PMID: 16176204 [PubMed - indexed for MEDLINE]Related articles

Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs.

Larsen MO, Juhl CB, Pørksen N, Gotfredsen CF, Carr RD, Ribel U, Wilken M, Rolin B.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E412-21. Epub 2004 Oct 12.PMID: 15479954 [PubMed - indexed for MEDLINE]Related articlesFree article

[Psychiatry--all the goals have not yet been achieved]

Pörksen N.

Pflege Aktuell. 2004 Jun;58:328-31. German. No abstract available. PMID: 15239438 [PubMed - indexed for MEDLINE]Related articles

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

Sloop KW, Cao JX, Siesky AM, Zhang HY, Bodenmiller DM, Cox AL, Jacobs SJ, Moyers JS, Owens RA, Showalter AD, Brenner MB, Raap A, Gromada J, Berridge BR, Monteith DK, Porksen N, McKay RA, Monia BP, Bhanot S, Watts LM, Michael MD.

J Clin Invest. 2004 Jun;113(11):1571-81.PMID: 15173883 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility.

Juhl CB, Hollingdal M, Pørksen N, Prange A, Lönnqvist F, Schmitz O.

J Clin Endocrinol Metab. 2003 Aug;88(8):3794-800.PMID: 12915671 [PubMed - indexed for MEDLINE]Related articlesFree article

High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology.

Schmitz O, Brock B, Hollingdal M, Juhl CB, Pørksen N.

Diabetes Metab. 2002 Dec;28(6 Suppl):4S14-20. Review.PMID: 12703061 [PubMed - indexed for MEDLINE]Related articlesFree article

Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes.

Pørksen N.

Diabetes Nutr Metab. 2002 Dec;15(6 Suppl):9-14. Review.PMID: 12702002 [PubMed - indexed for MEDLINE]Related articles

Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs.

Larsen MO, Gotfredsen CF, Wilken M, Carr RD, Pørksen N, Rolin B.

Diabetologia. 2003 Feb;46(2):195-202. Epub 2003 Jan 11. Erratum in: Diabetologia. 2004 Jan;47(1):155. PMID: 12627318 [PubMed - indexed for MEDLINE]Related articles

[Clozapine and diabetic ketoacidosis]

Kristensen SH, Pørksen NK.

Ugeskr Laeger. 2003 Jan 27;165(5):475-6. Danish. PMID: 12599849 [PubMed - indexed for MEDLINE]Related articles

The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo.

Larsen MO, Elander M, Sturis J, Wilken M, Carr RD, Rolin B, Pørksen N.

Diabetologia. 2002 Oct;45(10):1389-96. Epub 2002 Sep 5.PMID: 12378379 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans.

Hollingdal M, Juhl CB, Dall R, Sturis J, Veldhuis JD, Schmitz O, Pørksen N.

Diabetologia. 2002 Jan;45(1):49-55.PMID: 11845223 [PubMed - indexed for MEDLINE]Related articles

The in vivo regulation of pulsatile insulin secretion.

Pørksen N.

Diabetologia. 2002 Jan;45(1):3-20. Review.PMID: 11845219 [PubMed - indexed for MEDLINE]Related articles

Human insulin release processes measured by intraportal sampling.

Pørksen N, Grøfte T, Greisen J, Mengel A, Juhl C, Veldhuis JD, Schmitz O, Rössle M, Vilstrup H.

Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E695-702.PMID: 11832375 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimizing insulin secretagogue therapy in patients with type 2 diabetes: a randomized double-blind study with repaglinide.

Schmitz O, Lund S, Andersen PH, Jønler M, Pørksen N.

Diabetes Care. 2002 Feb;25(2):342-6.PMID: 11815507 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of fasting on physiologically pulsatile insulin release in healthy humans.

Juhl C, Grøfte T, Butler PC, Veldhuis JD, Schmitz O, Pørksen N.

Diabetes. 2002 Feb;51 Suppl 1:S255-7.PMID: 11815488 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulsatile insulin secretion: detection, regulation, and role in diabetes.

Pørksen N, Hollingdal M, Juhl C, Butler P, Veldhuis JD, Schmitz O.

Diabetes. 2002 Feb;51 Suppl 1:S245-54. Review.PMID: 11815487 [PubMed - indexed for MEDLINE]Related articlesFree article

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.

Juhl CB, Hollingdal M, Sturis J, Jakobsen G, Agersø H, Veldhuis J, Pørksen N, Schmitz O.

Diabetes. 2002 Feb;51(2):424-9.PMID: 11812750 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes.

Juhl CB, Pørksen N, Pincus SM, Hansen AP, Veldhuis JD, Schmitz O.

Diabetes. 2001 Aug;50(8):1778-84.PMID: 11473038 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance.

Ritzel R, Schulte M, Pørksen N, Nauck MS, Holst JJ, Juhl C, März W, Schmitz O, Schmiegel WH, Nauck MA.

Diabetes. 2001 Apr;50(4):776-84.PMID: 11289042 [PubMed - indexed for MEDLINE]Related articlesFree article

Irregular circulating insulin concentrations in type 2 diabetes mellitus: an inverse relationship between circulating free fatty acid and the disorderliness of an insulin time series in diabetic and healthy individuals.

Schmitz O, Juhl CB, Hollingdal M, Veldhuis JD, Pørksen N, Pincus SM.

Metabolism. 2001 Jan;50(1):41-6.PMID: 11172473 [PubMed - indexed for MEDLINE]Related articles

HbA1c does not reflect prandial plasma glucose excursions in type 2 diabetes.

Schmitz O, Juhl CB, Lund S, Djurhuus CB, Nyholm B, Pørksen N, Ostergård T.

Diabetes Care. 2000 Dec;23(12):1859-60. No abstract available. PMID: 11128373 [PubMed - indexed for MEDLINE]Related articlesFree article

Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.

Laedtke T, Kjems L, Pørksen N, Schmitz O, Veldhuis J, Kao PC, Butler PC.

Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E520-8.PMID: 10950818 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.

Hollingdal M, Juhl CB, Pincus SM, Sturis J, Veldhuis JD, Polonsky KS, Pørksen N, Schmitz O.

Diabetes. 2000 Aug;49(8):1334-40.PMID: 10923634 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of insulin secretion in relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus: evidence of early beta-cell dysfunction.

Nyholm B, Pørksen N, Juhl CB, Gravholt CH, Butler PC, Weeke J, Veldhuis JD, Pincus S, Schmitz O.

Metabolism. 2000 Jul;49(7):896-905.PMID: 10910002 [PubMed - indexed for MEDLINE]Related articles

Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type II diabetes with no effect on orderliness.

Juhl CB, Schmitz O, Pincus S, Holst JJ, Veldhuis J, Pørksen N.

Diabetologia. 2000 May;43(5):583-8.PMID: 10855533 [PubMed - indexed for MEDLINE]Related articles

Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency.

Juhl CB, Pørksen N, Hollingdal M, Sturis J, Pincus S, Veldhuis JD, Dejgaard A, Schmitz O.

Diabetes Care. 2000 May;23(5):675-81.PMID: 10834429 [PubMed - indexed for MEDLINE]Related articlesFree article

[Early changes in the function of pancreatic beta cells and insulin pulsatility as predictors of type 2 diabetes]

Pørksen N.

Diabetes Metab. 1999 Dec;25 Suppl 7:14-6. French. PMID: 10746005 [PubMed - indexed for MEDLINE]Related articles

High-frequency oscillations in circulating amylin concentrations in healthy humans.

Juhl CB, Pørksen N, Sturis J, Hansen AP, Veldhuis JD, Pincus S, Fineman M, Schmitz O.

Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E484-90.PMID: 10710503 [PubMed - indexed for MEDLINE]Related articlesFree article

Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions.

Pørksen N, Juhl C, Hollingdal M, Pincus SM, Sturis J, Veldhuis JD, Schmitz O.

Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E162-70.PMID: 10644551 [PubMed - indexed for MEDLINE]Related articlesFree article

The pharmacokinetics of free insulin-like growth factor-I in healthy subjects.

Frystyk J, Hussain M, Skjaerbaek C, Pørksen N, Froesch ER, Orskov H.

Growth Horm IGF Res. 1999 Apr;9(2):150-6.PMID: 10373348 [PubMed - indexed for MEDLINE]Related articles

[Substrate metabolism in untreated and treated thyrotoxicosis]

Møller N, Hove KY, Nielsen S, Nyholm B, Pørksen NK, Weeke J.

Ugeskr Laeger. 1998 Mar 2;160(10):1475-9. Danish. PMID: 9520616 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion.

Pørksen N, Grøfte B, Nyholm B, Holst JJ, Pincus SM, Veldhuis JD, Schmitz O, Butler PC.

Diabetes. 1998 Jan;47(1):45-9.PMID: 9421373 [PubMed - indexed for MEDLINE]Related articles

In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts.

Pørksen N, Nyholm B, Veldhuis JD, Butler PC, Schmitz O.

Am J Physiol. 1997 Nov;273(5 Pt 1):E908-14.PMID: 9374676 [PubMed - indexed for MEDLINE]Related articlesFree article

[Homeless patients in the psychiatric clinic. Results of a 12-month study of the living conditions of psychiatric patients in an urban public health clinic]

Wessel T, Pörksen N, Zechert C.

Psychiatr Prax. 1997 Jul;24(4):167-71. German. PMID: 9340654 [PubMed - indexed for MEDLINE]Related articles

IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates.

Pørksen N, Hussain MA, Bianda TL, Nyholm B, Christiansen JS, Butler PC, Veldhuis JD, Froesch ER, Schmitz O.

Am J Physiol. 1997 Mar;272(3 Pt 1):E352-8.PMID: 9124538 [PubMed - indexed for MEDLINE]Related articles

Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM.

Schmitz O, Pørksen N, Nyholm B, Skjaerbaek C, Butler PC, Veldhuis JD, Pincus SM.

Am J Physiol. 1997 Feb;272(2 Pt 1):E218-26.PMID: 9124326 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of sulfonylurea's stimulation of insulin secretion in vivo: selective amplification of insulin secretory burst mass.

Pørksen NK, Munn SR, Steers JL, Schmitz O, Veldhuis JD, Butler PC.

Diabetes. 1996 Dec;45(12):1792-7.PMID: 8922367 [PubMed - indexed for MEDLINE]Related articles

Effects of glucose ingestion versus infusion on pulsatile insulin secretion. The incretin effect is achieved by amplification of insulin secretory burst mass.

Pørksen N, Munn S, Steers J, Veldhuis JD, Butler PC.

Diabetes. 1996 Oct;45(10):1317-23.PMID: 8826965 [PubMed - indexed for MEDLINE]Related articles

Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass.

Pørksen N, Munn SR, Steers JL, Veldhuis JD, Butler PC.

Am J Physiol. 1996 Jun;270(6 Pt 1):E1043-9.PMID: 8764190 [PubMed - indexed for MEDLINE]Related articles

Glucose turnover, fuel oxidation and forearm substrate exchange in patients with thyrotoxicosis before and after medical treatment.

Møller N, Nielsen S, Nyholm B, Pørksen N, Alberti KG, Weeke J.

Clin Endocrinol (Oxf). 1996 Apr;44(4):453-9.PMID: 8706313 [PubMed - indexed for MEDLINE]Related articles

Effects of the somatostatin analog, octreotide, on glucose metabolism and insulin sensitivity in insulin-dependent diabetes mellitus.

Orskov L, Møller N, Bak JF, Pørksen N, Schmitz O.

Metabolism. 1996 Feb;45(2):211-7.PMID: 8596492 [PubMed - indexed for MEDLINE]Related articles

Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis.

Pørksen N, Munn S, Steers J, Veldhuis JD, Butler PC.

Am J Physiol. 1995 Dec;269(6 Pt 1):E1106-14.PMID: 8572204 [PubMed - indexed for MEDLINE]Related articles

Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting.

Pørksen N, Munn S, Steers J, Vore S, Veldhuis J, Butler P.

Am J Physiol. 1995 Sep;269(3 Pt 1):E478-88.PMID: 7573425 [PubMed - indexed for MEDLINE]Related articles

[Community psychiatry. The "incurable"--touchstone for community psychiatry]

Pörksen N.

Pflege Z. 1994 Dec;47(12):674-7. German. No abstract available. PMID: 7850130 [PubMed - indexed for MEDLINE]Related articles

Effect of needle biopsy from the vastus lateralis muscle on insulin-stimulated glucose metabolism in humans.

Holck P, Pørksen N, Nielsen MF, Nyholm B, Bak JF, Andreasen F, Møller N, Schmitz O.

Am J Physiol. 1994 Oct;267(4 Pt 1):E544-8.PMID: 7943303 [PubMed - indexed for MEDLINE]Related articles

Coordinate pulsatile insulin secretion by chronic intraportally transplanted islets in the isolated perfused rat liver.

Pørksen N, Munn S, Ferguson D, O'Brien T, Veldhuis J, Butler P.

J Clin Invest. 1994 Jul;94(1):219-27.PMID: 8040264 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmented effect of short-term pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects.

Schmitz O, Pedersen SB, Mengel A, Pørksen N, Bak J, Møller N, Richelsen B, Alberti KG, Butler PC, Orskov H.

Metabolism. 1994 Jul;43(7):842-6.PMID: 7913205 [PubMed - indexed for MEDLINE]Related articles