PubMed

Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes.

Pal A, Farmer AJ, Dudley C, Selwood MP, Barrow BA, Klyne R, Grew JP, McCarthy MI, Gloyn AL, Owen KR.

Diabetes Care. 2009 Nov 23. [Epub ahead of print]PMID: 19933992 [PubMed - as supplied by publisher]Related articles

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M; MAGIC, Zeggini E, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM.

Hum Mol Genet. 2009 Dec 2. [Epub ahead of print]PMID: 19933169 [PubMed - as supplied by publisher]Related articlesFree article

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.

Jafar-Mohammadi B, Groves CJ, Owen KR, Frayling TM, Hattersley AT, McCarthy MI, Gloyn AL.

PLoS One. 2009 Aug 12;4(8):e6615.PMID: 19672314 [PubMed - in process]Related articlesFree article

Type 1 and type 2 diabetes-chalk and cheese?

Owen KR, McCarthy MI.

Diabetologia. 2009 Oct;52(10):1983-6. Epub 2009 Aug 1. No abstract available. PMID: 19649612 [PubMed - in process]Related articles

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.PMID: 18454148 [PubMed - indexed for MEDLINE]Related articlesFree article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.

Nat Genet. 2008 May;40(5):638-45. Epub 2008 Mar 30.PMID: 18372903 [PubMed - indexed for MEDLINE]Related articlesFree article

Retrospective study of palmar/plantar annular ligament injury in 71 horses: 2001-2006.

Owen KR, Dyson SJ, Parkin TD, Singer ER, Kristoffersen M, Mair TS.

Equine Vet J. 2008 May;40(3):237-44. Erratum in: Equine Vet J. 2008 Sep;40(6):527. PMID: 18171639 [PubMed - indexed for MEDLINE]Related articles

Genetics of type 2 diabetes.

Owen KR, McCarthy MI.

Curr Opin Genet Dev. 2007 Jun;17(3):239-44. Epub 2007 Apr 26. Review.PMID: 17466512 [PubMed - indexed for MEDLINE]Related articles

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT.

Science. 2007 Jun 1;316(5829):1336-41. Epub 2007 Apr 26. Erratum in: Science. 2007 Aug 24;317(5841):1035-6. PMID: 17463249 [PubMed - indexed for MEDLINE]Related articlesFree article

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI.

Science. 2007 May 11;316(5826):889-94. Epub 2007 Apr 12.PMID: 17434869 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, McCarthy MI.

Diabetes. 2007 Mar;56(3):879-83.PMID: 17327460 [PubMed - indexed for MEDLINE]Related articlesFree article

An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Walker M, Gillespie KM, Bingley PJ, Hitman GA, Holman RR, McCarthy MI, Clark A.

Diabetologia. 2007 Jan;50(1):68-73. Epub 2006 Dec 2.PMID: 17143607 [PubMed - indexed for MEDLINE]Related articles

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E, Rayner NW, Shields B, Owen KR, Hattersley AT, Frayling TM.

PLoS Med. 2006 Oct;3(10):e374.PMID: 17020404 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.

Gloyn AL, Mackay DJ, Weedon MN, McCarthy MI, Walker M, Hitman G, Knight BA, Owen KR, Hattersley AT, Frayling TM.

Diabetes. 2006 Aug;55(8):2272-6.PMID: 16873690 [PubMed - indexed for MEDLINE]Related articlesFree article

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Hitman GA, Walker M, Holman RR, McCarthy MI, Clark A.

Diabetes. 2006 Jun;55(6):1890-4.PMID: 16731859 [PubMed - indexed for MEDLINE]Related articlesFree article

Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome.

Minton JA, Owen KR, Ricketts CJ, Crabtree N, Shaikh G, Ehtisham S, Porter JR, Carey C, Hodge D, Paisey R, Walker M, Barrett TG.

J Clin Endocrinol Metab. 2006 Aug;91(8):3110-6. Epub 2006 May 23.PMID: 16720663 [PubMed - indexed for MEDLINE]Related articlesFree article

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.

Zeggini E, Parkinson JR, Halford S, Owen KR, Walker M, Hitman GA, Levy JC, Sampson MJ, Frayling TM, Hattersley AT, McCarthy MI.

Diabet Med. 2005 Dec;22(12):1696-700.PMID: 16401314 [PubMed - indexed for MEDLINE]Related articles

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.

Zeggini E, Groves CJ, Parkinson JR, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI.

Diabetologia. 2005 Oct;48(10):2013-7. Epub 2005 Aug 18.PMID: 16132956 [PubMed - indexed for MEDLINE]Related articles

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2005 Aug;54(8):2487-91.PMID: 16046319 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR, Walker M, Hitman GA, Levy JC, O'rahilly S, Hattersley AT, Johnston DG, McCarthy MI.

Diabetologia. 2004 Dec;47(12):2168-75. Epub 2004 Dec 15.PMID: 15662557 [PubMed - indexed for MEDLINE]Related articles

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.

Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJ, Hattersley AT, McCarthy MI.

Diabetes. 2004 Dec;53(12):3319-22.PMID: 15561966 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM.

Diabetes. 2004 Nov;53(11):3002-6.PMID: 15504983 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.

Owen KR, Evans JC, Frayling TM, Hattersley AT, McCarthy MI, Walker M, Hitman GA.

Diabetologia. 2004 May;47(5):957-8. Epub 2004 May 7. No abstract available. PMID: 15170499 [PubMed - indexed for MEDLINE]Related articles

Mesangiocapillary glomerulonephritis type 2 associated with familial partial lipodystrophy (Dunnigan-Kobberling syndrome).

Owen KR, Donohoe M, Ellard S, Clarke TJ, Nicholls AJ, Hattersley AT, Bingham C.

Nephron Clin Pract. 2004;96(2):c35-8.PMID: 14988595 [PubMed - indexed for MEDLINE]Related articles

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.

Weedon MN, Schwarz PE, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T, Schulze J, Owen KR, Evans J, Del Bosque-Plata L, Hitman G, Walker M, Levy JC, Sampson M, Bell GI, McCarthy MI, Hattersley AT, Frayling TM.

Am J Hum Genet. 2003 Nov;73(5):1208-12. No abstract available. PMID: 14574648 [PubMed - indexed for MEDLINE]Related articlesFree article

Response to treatment with rosiglitazone in familial partial lipodystrophy due to a mutation in the LMNA gene.

Owen KR, Donohoe M, Ellard S, Hattersley AT.

Diabet Med. 2003 Oct;20(10):823-7.PMID: 14510863 [PubMed - indexed for MEDLINE]Related articles

Etiological investigation of diabetes in young adults presenting with apparent type 2 diabetes.

Owen KR, Stride A, Ellard S, Hattersley AT.

Diabetes Care. 2003 Jul;26(7):2088-93.PMID: 12832318 [PubMed - indexed for MEDLINE]Related articlesFree article

Adolescent onset Type 2 diabetes in a non-obese Caucasian patient with an unbalanced translocation.

Owen KR, Roland J, Smith K, Hattersley AT.

Diabet Med. 2003 Jun;20(6):483-5.PMID: 12786684 [PubMed - indexed for MEDLINE]Related articles

Treating hypertension in diabetic nephropathy.

Tomlinson JW, Owen KR, Close CF.

Diabetes Care. 2003 Jun;26(6):1802-5.PMID: 12766113 [PubMed - indexed for MEDLINE]Related articlesFree article

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI.

Diabetes. 2003 May;52(5):1300-5.PMID: 12716770 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.

Mitchell SM, Weedon MN, Owen KR, Shields B, Wilkins-Wall B, Walker M, McCarthy MI, Frayling TM, Hattersley AT.

Diabetes. 2003 May;52(5):1276-9.PMID: 12716764 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation.

Bingham C, Ellard S, van't Hoff WG, Simmonds HA, Marinaki AM, Badman MK, Winocour PH, Stride A, Lockwood CR, Nicholls AJ, Owen KR, Spyer G, Pearson ER, Hattersley AT.

Kidney Int. 2003 May;63(5):1645-51.PMID: 12675839 [PubMed - indexed for MEDLINE]Related articles

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.

Mitchell SM, Vaxillaire M, Thomas H, Parrizas M, Benmezroua Y, Costa A, Hansen T, Owen KR, Tuomi T, Pirie F, Ryffel GU, Ferrer J, Froguel P, Hattersley AT, Frayling TM.

Diabetologia. 2002 Sep;45(9):1344-8. Epub 2002 Jul 19.PMID: 12242469 [PubMed - indexed for MEDLINE]Related articles

Heterogeneity in young adult onset diabetes: aetiology alters clinical characteristics.

Owen KR, Shepherd M, Stride A, Ellard S, Hattersley AT.

Diabet Med. 2002 Sep;19(9):758-61.PMID: 12207813 [PubMed - indexed for MEDLINE]Related articles

The role of the HNF4alpha enhancer in type 2 diabetes.

Mitchell SM, Gloyn AL, Owen KR, Hattersley AT, Frayling TM.

Mol Genet Metab. 2002 Jun;76(2):148-51.PMID: 12083813 [PubMed - indexed for MEDLINE]Related articles

Neurobiology of tryptophan depletion in depression: effects of m-chlorophenylpiperazine (mCPP).

Price LH, Malison RT, McDougle CJ, McCance-Katz EF, Owen KR, Heninger GR.

Neuropsychopharmacology. 1997 Nov;17(5):342-50.PMID: 9348549 [PubMed - indexed for MEDLINE]Related articlesFree article