PubMed

Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.

Scherpenzeel MV, van den Berg RJ, Donker-Koopman WE, Liskamp RM, Aerts JM, Overkleeft HS, Pieters RJ.

Bioorg Med Chem. 2009 Oct 31. [Epub ahead of print]PMID: 19931460 [PubMed - as supplied by publisher]Related articles

Synthesis and Pharmacological Evaluation of Dimeric Follicle-Stimulating Hormone Receptor Antagonists.

Bonger KM, Hoogendoorn S, van Koppen CJ, Timmers CM, Overkleeft HS, van der Marel GA.

ChemMedChem. 2009 Nov 9;4(12):2098-2102. [Epub ahead of print]PMID: 19902448 [PubMed - as supplied by publisher]Related articles

Ring-Extended Derivatives of Gramicidin S with Furanoid Sugar Amino Acids in the Turn Region Have Enhanced Antimicrobial Activity.

Knijnenburg AD, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Grotenbreg GM, van der Marel GA, Overkleeft HS, Overhand M.

ChemMedChem. 2009 Oct 27;4(12):1976-1979. [Epub ahead of print] No abstract available. PMID: 19862783 [PubMed - as supplied by publisher]Related articles

Glycosphingolipids--nature, function, and pharmacological modulation.

Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM.

Angew Chem Int Ed Engl. 2009;48(47):8848-69.PMID: 19862781 [PubMed - in process]Related articles

Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, Overkleeft HS.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. Epub 2009 Oct 8.PMID: 19853441 [PubMed - in process]Related articles

Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines.

Clerc J, Florea BI, Kraus M, Groll M, Huber R, Bachmann AS, Dudler R, Driessen C, Overkleeft HS, Kaiser M.

Chembiochem. 2009 Nov 2;10(16):2638-43.PMID: 19746508 [PubMed - in process]Related articles

Structural and biological evaluation of some loloatin C analogues.

Tuin AW, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, van der Marel GA, Noort D, Overkleeft HS, Overhand M.

Bioorg Med Chem. 2009 Sep 1;17(17):6233-40. Epub 2009 Jul 25.PMID: 19679485 [PubMed - in process]Related articles

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.

van der Knaap M, Engels E, Busscher HJ, Otero JM, Llamas-Saiz AL, van Raaij MJ, Mars-Groenendijk RH, Noort D, van der Marel GA, Overkleeft HS, Overhand M.

Bioorg Med Chem. 2009 Sep 1;17(17):6318-28. Epub 2009 Jul 25.PMID: 19674904 [PubMed - in process]Related articles

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.

Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Díaz-Hernández M, Brundin P, Overkleeft HS, Li JY, Lucas JJ, Dantuma NP.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13986-91. Epub 2009 Jul 30.PMID: 19666572 [PubMed - indexed for MEDLINE]Related articles

Equatorial anomeric triflates from mannuronic acid esters.

Walvoort MT, Lodder G, Mazurek J, Overkleeft HS, Codée JD, van der Marel GA.

J Am Chem Soc. 2009 Sep 2;131(34):12080-1.PMID: 19663422 [PubMed - in process]Related articles

O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes.

Witte MD, Florea BI, Verdoes M, Adeyanju O, Van der Marel GA, Overkleeft HS.

J Am Chem Soc. 2009 Sep 2;131(34):12064-5.PMID: 19658393 [PubMed - in process]Related articles

Stereodirecting effect of the pyranosyl C-5 substituent in glycosylation reactions.

Dinkelaar J, de Jong AR, van Meer R, Somers M, Lodder G, Overkleeft HS, Codée JD, van der Marel GA.

J Org Chem. 2009 Jul 17;74(14):4982-91.PMID: 19489535 [PubMed - indexed for MEDLINE]Related articles

Discovery of selective luteinizing hormone receptor agonists using the bivalent ligand method.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, van Koppen CJ, Timmers CM, Overkleeft HS, van der Marel GA.

ChemMedChem. 2009 Jul;4(7):1189-95.PMID: 19475639 [PubMed - indexed for MEDLINE]Related articles

Synthesis of hyaluronic acid oligomers using chemoselective and one-pot strategies.

Dinkelaar J, Gold H, Overkleeft HS, Codée JD, van der Marel GA.

J Org Chem. 2009 Jun 5;74(11):4208-16.PMID: 19402694 [PubMed - indexed for MEDLINE]Related articles

Synthesis of modified and hybrid protein derived biopolymers.

Weterings JJ, Khan S, Drijfhout JW, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV.

Adv Exp Med Biol. 2009;611:141-2. No abstract available. PMID: 19400130 [PubMed - indexed for MEDLINE]Related articles

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, Aerts JM.

PLoS One. 2009;4(3):e4723. Epub 2009 Mar 23.PMID: 19305508 [PubMed - indexed for MEDLINE]Related articlesFree article

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

Weterings JJ, Khan S, van der Heden van Noort GJ, Melief CJ, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA, Filippov DV.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2249-51. Epub 2009 Feb 27.PMID: 19299126 [PubMed - indexed for MEDLINE]Related articles

Activity-Based Protein Profiling Reveals Broad Reactivity of the Nerve Agent Sarin.

Tuin AW, Mol MA, van den Berg RM, Fidder A, van der Marel GA, Overkleeft HS, Noort D.

Chem Res Toxicol. 2009 Feb 18. [Epub ahead of print]PMID: 19226147 [PubMed - as supplied by publisher]Related articles

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.

Rückrich T, Kraus M, Gogel J, Beck A, Ovaa H, Verdoes M, Overkleeft HS, Kalbacher H, Driessen C.

Leukemia. 2009 Jun;23(6):1098-105. Epub 2009 Feb 19.PMID: 19225532 [PubMed - indexed for MEDLINE]Related articles

Receptor-mediated targeting of cathepsins in professional antigen presenting cells.

Hillaert U, Verdoes M, Florea BI, Saragliadis A, Habets KL, Kuiper J, Van Calenbergh S, Ossendorp F, van der Marel GA, Driessen C, Overkleeft HS.

Angew Chem Int Ed Engl. 2009;48(9):1629-32. Erratum in: Angew Chem Int Ed Engl. 2009;48(14):2442.. Saragliadis, Anastasios [corrected to Saragliadis, Athanasios]. PMID: 19156780 [PubMed - indexed for MEDLINE]Related articles

Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis.

de Nooijer R, Bot I, von der Thüsen JH, Leeuwenburgh MA, Overkleeft HS, Kraaijeveld AO, Dorland R, van Santbrink PJ, van Heiningen SH, Westra MM, Kovanen PT, Jukema JW, van der Wall EE, van Berkel TJ, Shi GP, Biessen EA.

Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):188-94. Epub 2008 Dec 18.PMID: 19095996 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.

Witte MD, Horst D, Wiertz EJ, van der Marel GA, Overkleeft HS.

J Org Chem. 2009 Jan 16;74(2):605-16.PMID: 19072094 [PubMed - indexed for MEDLINE]Related articles

The stereodirecting effect of the glycosyl C5-carboxylate ester: stereoselective synthesis of beta-mannuronic acid alginates.

Codée JD, van den Bos LJ, de Jong AR, Dinkelaar J, Lodder G, Overkleeft HS, van der Marel GA.

J Org Chem. 2009 Jan 2;74(1):38-47.PMID: 19035740 [PubMed - indexed for MEDLINE]Related articles

Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells.

Khan S, Weterings JJ, Britten CM, de Jong AR, Graafland D, Melief CJ, van der Burg SH, van der Marel G, Overkleeft HS, Filippov DV, Ossendorp F.

Mol Immunol. 2009 Mar;46(6):1084-91. Epub 2008 Nov 22.PMID: 19027958 [PubMed - indexed for MEDLINE]Related articles

Synthesis of Sugar Nucleotides by Application of Phosphoramidites.

Gold H, van Delft P, Meeuwenoord N, Codée JD, Filippov DV, Eggink G, Overkleeft HS, van der Marel GA.

J Org Chem. 2008 Nov 8. [Epub ahead of print]PMID: 18991380 [PubMed - as supplied by publisher]Related articles

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

Abello N, Geurink PP, van der Toorn M, van Oosterhout AJ, Lugtenburg J, van der Marel GA, Kerstjens HA, Postma DS, Overkleeft HS, Bischoff R.

Anal Chem. 2008 Dec 1;80(23):9171-80.PMID: 18954088 [PubMed - indexed for MEDLINE]Related articles

A versatile one-pot procedure to phosphate monoesters and pyrophosphates using di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite.

van der Heden van Noort GJ, Verhagen CP, van der Horst MG, Overkleeft HS, van der Marel GA, Filippov DV.

Org Lett. 2008 Oct 16;10(20):4461-4. Epub 2008 Sep 19.PMID: 18800840 [PubMed - indexed for MEDLINE]Related articles

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

Kaschani F, Verhelst SH, van Swieten PF, Verdoes M, Wong CS, Wang Z, Kaiser M, Overkleeft HS, Bogyo M, van der Hoorn RA.

Plant J. 2009 Jan;57(2):373-85. Epub 2008 Oct 25.PMID: 18786180 [PubMed - indexed for MEDLINE]Related articles

Stereoselective synthesis of L-guluronic acid alginates.

Dinkelaar J, van den Bos LJ, Hogendorf WF, Lodder G, Overkleeft HS, Codée JD, van der Marel GA.

Chemistry. 2008;14(30):9400-11.PMID: 18770512 [PubMed - indexed for MEDLINE]Related articles

Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling.

Verdoes M, Florea BI, Hillaert U, Willems LI, van der Linden WA, Sae-Heng M, Filippov DV, Kisselev AF, van der Marel GA, Overkleeft HS.

Chembiochem. 2008 Jul 21;9(11):1735-8. No abstract available. PMID: 18600815 [PubMed - indexed for MEDLINE]Related articles

Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA.

Bioorg Med Chem. 2008 Apr 1;16(7):3744-58. Epub 2008 Feb 2.PMID: 18282756 [PubMed - indexed for MEDLINE]Related articles

Conjugation of nucleosides and oligonucleotides by [3+2] cycloaddition.

Jawalekar AM, Meeuwenoord N, Cremers JS, Overkleeft HS, van der Marel GA, Rutjes FP, van Delft FL.

J Org Chem. 2008 Jan 4;73(1):287-90. Epub 2007 Dec 4.PMID: 18052191 [PubMed - indexed for MEDLINE]Related articles

Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease.

Kapoerchan VV, Wiesner M, Overhand M, van der Marel GA, Koning F, Overkleeft HS.

Bioorg Med Chem. 2008 Feb 15;16(4):2053-62. Epub 2007 Nov 4.PMID: 18037302 [PubMed - indexed for MEDLINE]Related articles

Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity.

Witte MD, Descals CV, de Lavoir SV, Florea BI, van der Marel GA, Overkleeft HS.

Org Biomol Chem. 2007 Nov 21;5(22):3690-7. Epub 2007 Aug 29.PMID: 17971999 [PubMed - indexed for MEDLINE]Related articles

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.

Verdoes M, Hillaert U, Florea BI, Sae-Heng M, Risseeuw MD, Filippov DV, van der Marel GA, Overkleeft HS.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6169-71. Epub 2007 Sep 8.PMID: 17888658 [PubMed - indexed for MEDLINE]Related articles

Synthesis of alkylated sugar amino acids: conformationally restricted L-Xaa-L-Ser/Thr mimics.

Risseeuw MD, Mazurek J, van Langenvelde A, van der Marel GA, Overkleeft HS, Overhand M.

Org Biomol Chem. 2007 Jul 21;5(14):2311-4. Epub 2007 Jun 20.PMID: 17609763 [PubMed - indexed for MEDLINE]Related articles

Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations.

Dinkelaar J, Codée JD, van den Bos LJ, Overkleeft HS, van der Marel GA.

J Org Chem. 2007 Jul 20;72(15):5737-42. Epub 2007 Jun 22.PMID: 17585821 [PubMed - indexed for MEDLINE]Related articles

Synthesis and evaluation of homo-bivalent GnRHR ligands.

Bonger KM, van den Berg RJ, Heitman LH, IJzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA.

Bioorg Med Chem. 2007 Jul 15;15(14):4841-56. Epub 2007 May 6.PMID: 17517510 [PubMed - indexed for MEDLINE]Related articles

Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors.

Verdoes M, Florea BI, van der Linden WA, Renou D, van den Nieuwendijk AM, van der Marel GA, Overkleeft HS.

Org Biomol Chem. 2007 May 7;5(9):1416-26. Epub 2007 Mar 23.PMID: 17464411 [PubMed - indexed for MEDLINE]Related articles

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.

Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJ, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH, Ossendorp F.

J Biol Chem. 2007 Jul 20;282(29):21145-59. Epub 2007 Apr 26.PMID: 17462991 [PubMed - indexed for MEDLINE]Related articlesFree article

A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.

van Swieten PF, Samuel E, Hernández RO, van den Nieuwendijk AM, Leeuwenburgh MA, van der Marel GA, Kessler BM, Overkleeft HS, Kisselev AF.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3402-5. Epub 2007 Apr 2.PMID: 17442566 [PubMed - indexed for MEDLINE]Related articles

N-azidoacetylmannosamine-mediated chemical tagging of gangliosides.

Bussink AP, van Swieten PF, Ghauharali K, Scheij S, van Eijk M, Wennekes T, van der Marel GA, Boot RG, Aerts JM, Overkleeft HS.

J Lipid Res. 2007 Jun;48(6):1417-21. Epub 2007 Mar 27.PMID: 17392268 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.

Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O'Rahilly S, Overkleeft HS.

Diabetes. 2007 May;56(5):1341-9. Epub 2007 Feb 7.PMID: 17287460 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins.

Reich M, van Swieten PF, Sommandas V, Kraus M, Fischer R, Weber E, Kalbacher H, Overkleeft HS, Driessen C.

J Leukoc Biol. 2007 Apr;81(4):990-1001. Epub 2007 Jan 29.PMID: 17261546 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, Overkleeft HS.

J Org Chem. 2007 Feb 16;72(4):1088-97. Epub 2007 Jan 23.PMID: 17243712 [PubMed - indexed for MEDLINE]Related articles

Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides.

Agrawal PR, Hofmann MW, Meeuwenoord NJ, Filippov DV, Stalz H, Hulsbergen F, Langosch D, Overkleeft HS, De Groot H.

J Pept Sci. 2007 Feb;13(2):75-80.PMID: 17121421 [PubMed - indexed for MEDLINE]Related articles

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.

Verdoes M, Florea BI, Menendez-Benito V, Maynard CJ, Witte MD, van der Linden WA, van den Nieuwendijk AM, Hofmann T, Berkers CR, van Leeuwen FW, Groothuis TA, Leeuwenburgh MA, Ovaa H, Neefjes JJ, Filippov DV, van der Marel GA, Dantuma NP, Overkleeft HS.

Chem Biol. 2006 Nov;13(11):1217-26.PMID: 17114003 [PubMed - indexed for MEDLINE]Related articles

Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.

Boot RG, Verhoek M, Donker-Koopman W, Strijland A, van Marle J, Overkleeft HS, Wennekes T, Aerts JM.

J Biol Chem. 2007 Jan 12;282(2):1305-12. Epub 2006 Nov 14.PMID: 17105727 [PubMed - indexed for MEDLINE]Related articlesFree article

Stereocontrolled synthesis of beta-D-mannuronic acid esters: synthesis of an alginate trisaccharide.

van den Bos LJ, Dinkelaar J, Overkleeft HS, van der Marel GA.

J Am Chem Soc. 2006 Oct 11;128(40):13066-7.PMID: 17017782 [PubMed]Related articles

The use of cyclic bifunctional protecting groups in oligosaccharide synthesis--an overview.

Litjens RE, van den Bos LJ, Codée JD, Overkleeft HS, van der Marel GA.

Carbohydr Res. 2007 Feb 26;342(3-4):419-29. Epub 2006 Sep 27. Review.PMID: 17007825 [PubMed - indexed for MEDLINE]Related articles