PubMed

The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells.

Baan B, van der Zon GC, Maassen JA, Ouwens DM.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):94-100. Epub 2009 Jul 30.PMID: 19647037 [PubMed - in process]Related articles

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography.

van den Brom CE, Huisman MC, Vlasblom R, Boontje NM, Duijst S, Lubberink M, Molthoff CF, Lammertsma AA, van der Velden J, Boer C, Ouwens DM, Diamant M.

Cardiovasc Diabetol. 2009 Jul 22;8:39.PMID: 19624828 [PubMed - indexed for MEDLINE]Related articlesFree article

PRAS40: target or modulator of mTORC1 signalling and insulin action?

Nascimento EB, Ouwens DM.

Arch Physiol Biochem. 2009 Oct;115(4):163-75.PMID: 19480563 [PubMed - in process]Related articles

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.

Verschuren L, Kooistra T, Bernhagen J, Voshol PJ, Ouwens DM, van Erk M, de Vries-van der Weij J, Leng L, van Bockel JH, van Dijk KW, Fingerle-Rowson G, Bucala R, Kleemann R.

Circ Res. 2009 Jul 2;105(1):99-107. Epub 2009 May 28.PMID: 19478200 [PubMed - indexed for MEDLINE]Related articles

Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes.

Luiken JJ, Ouwens DM, Habets DD, van der Zon GC, Coumans WA, Schwenk RW, Bonen A, Glatz JF.

J Endocrinol. 2009 May;201(2):199-209. Epub 2009 Mar 9.PMID: 19273501 [PubMed - indexed for MEDLINE]Related articles

Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?

van Raalte DH, Ouwens DM, Diamant M.

Eur J Clin Invest. 2009 Feb;39(2):81-93. Review.PMID: 19200161 [PubMed - indexed for MEDLINE]Related articles

Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation.

van den Hoek AM, van Heijningen C, Schröder-van der Elst JP, Ouwens DM, Havekes LM, Romijn JA, Kalsbeek A, Pijl H.

Diabetes. 2008 Sep;57(9):2304-10. Epub 2008 Jun 10.PMID: 18544708 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice.

Korsheninnikova E, Voshol PJ, Baan B, van der Zon GC, Havekes LM, Romijn JA, Maassen JA, Ouwens DM.

Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):173-85.PMID: 18158643 [PubMed - indexed for MEDLINE]Related articles

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

Maassen JA, 't Hart LM, Ouwens DM.

Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):693-7. Review.PMID: 18089949 [PubMed - indexed for MEDLINE]Related articles

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients.

Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM, Meinders AE.

Diabetologia. 2008 Feb;51(2):309-19. Epub 2007 Dec 14.PMID: 18080107 [PubMed - indexed for MEDLINE]Related articles

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification.

Ouwens DM, Diamant M, Fodor M, Habets DD, Pelsers MM, El Hasnaoui M, Dang ZC, van den Brom CE, Vlasblom R, Rietdijk A, Boer C, Coort SL, Glatz JF, Luiken JJ.

Diabetologia. 2007 Sep;50(9):1938-48. Epub 2007 Jul 18.PMID: 17639306 [PubMed - indexed for MEDLINE]Related articlesFree article

SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status.

de Preux AS, Goosen K, Zhang W, Sima AA, Shimano H, Ouwens DM, Diamant M, Hillebrands JL, Rozing J, Lemke G, Beckmann JS, Smit AB, Verheijen MH, Chrast R.

Mol Cell Neurosci. 2007 Aug;35(4):525-34. Epub 2007 May 1.PMID: 17632011 [PubMed - indexed for MEDLINE]Related articles

Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy.

Ouwens DM, Diamant M.

Arch Physiol Biochem. 2007 Apr;113(2):76-86. Review.PMID: 17558606 [PubMed - indexed for MEDLINE]Related articles

Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.

Ciapaite J, Bakker SJ, Van Eikenhorst G, Wagner MJ, Teerlink T, Schalkwijk CG, Fodor M, Ouwens DM, Diamant M, Heine RJ, Westerhoff HV, Krab K.

Biochim Biophys Acta. 2007 Mar;1772(3):307-16. Epub 2006 Nov 10.PMID: 17184976 [PubMed - indexed for MEDLINE]Related articles

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.

Nascimento EB, Fodor M, van der Zon GC, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, Diamant M, Ouwens DM.

Diabetes. 2006 Dec;55(12):3221-8.PMID: 17130464 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of sarcolemmal transport of substrates in the healthy and diseased heart.

Glatz JF, Bonen A, Ouwens DM, Luiken JJ.

Cardiovasc Drugs Ther. 2006 Dec;20(6):471-6. Review.PMID: 17119873 [PubMed - indexed for MEDLINE]Related articles

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.

Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA.

Diabetologia. 2006 Dec;49(12):3049-57. Epub 2006 Sep 28.PMID: 17006666 [PubMed - indexed for MEDLINE]Related articles

Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice.

den Boer MA, Voshol PJ, Schröder-van der Elst JP, Korsheninnikova E, Ouwens DM, Kuipers F, Havekes LM, Romijn JA.

Endocrinology. 2006 Oct;147(10):4553-8. Epub 2006 May 18.PMID: 16709607 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

Baan B, van Dam H, van der Zon GC, Maassen JA, Ouwens DM.

Mol Endocrinol. 2006 Aug;20(8):1786-95. Epub 2006 Apr 6.PMID: 16601071 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a 2-day very low-energy diet on skeletal muscle insulin sensitivity in obese type 2 diabetic patients on insulin therapy.

Jazet IM, Ouwens DM, Schaart G, Pijl H, Keizer H, Maassen JA, Meinders AE.

Metabolism. 2005 Dec;54(12):1669-78.PMID: 16311102 [PubMed - indexed for MEDLINE]Related articles

Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats.

Ouwens DM, Boer C, Fodor M, de Galan P, Heine RJ, Maassen JA, Diamant M.

Diabetologia. 2005 Jun;48(6):1229-37. Epub 2005 Apr 30.PMID: 15864533 [PubMed - indexed for MEDLINE]Related articles

Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production.

Grefhorst A, Hoekstra J, Derks TG, Ouwens DM, Baller JF, Havinga R, Havekes LM, Romijn JA, Kuipers F.

Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G592-8. Epub 2005 Apr 7.PMID: 15817811 [PubMed - indexed for MEDLINE]Related articlesFree article

Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.

Bazuine M, Ouwens DM, Gomes de Mesquita DS, Maassen JA.

Eur J Biochem. 2003 Oct;270(19):3891-903.PMID: 14511371 [PubMed - indexed for MEDLINE]Related articlesFree article

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice.

Goudriaan JR, Dahlmans VE, Teusink B, Ouwens DM, Febbraio M, Maassen JA, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16.PMID: 12923231 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice.

Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA.

Endocrinology. 2003 Aug;144(8):3456-62.PMID: 12865325 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.

Ouwens DM, de Ruiter ND, van der Zon GC, Carter AP, Schouten J, van der Burgt C, Kooistra K, Bos JL, Maassen JA, van Dam H.

EMBO J. 2002 Jul 15;21(14):3782-93.PMID: 12110590 [PubMed - indexed for MEDLINE]Related articlesFree article

Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF-I and secrete more IGFBP-3.

Kamp GA, Ouwens DM, Hoogerbrugge CM, Zwinderman AH, Maassen JA, Wit JM.

Clin Endocrinol (Oxf). 2002 Apr;56(4):439-47.PMID: 11966736 [PubMed - indexed for MEDLINE]Related articles

Hyperosmotic stress activates the insulin receptor in CHO cells.

Ouwens DM, Gomes de Mesquita DS, Dekker J, Maassen JA.

Biochim Biophys Acta. 2001 Aug 22;1540(2):97-106.PMID: 11513972 [PubMed - indexed for MEDLINE]Related articles

Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2.

Ouwens DM, van der Zon GC, Maassen JA.

Mol Cell Endocrinol. 2001 Apr 25;175(1-2):131-40.PMID: 11325523 [PubMed - indexed for MEDLINE]Related articles

Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.

Kessler A, Uphues I, Ouwens DM, Till M, Eckel J.

Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E65-74.PMID: 11120660 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanisms of contraction-regulated cardiac glucose transport.

Till M, Ouwens DM, Kessler A, Eckel J.

Biochem J. 2000 Mar 15;346 Pt 3:841-7.PMID: 10698715 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

Withers DJ, Ouwens DM, Nave BT, van der Zon GC, Alarcon CM, Cardenas ME, Heitman J, Maassen JA, Shepherd PR.

Biochem Biophys Res Commun. 1997 Dec 29;241(3):704-9.PMID: 9434772 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D.

Ouwens DM, Mikkers HM, van der Zon GC, Stein-Gerlach M, Ullrich A, Maassen JA.

Biochem J. 1996 Sep 1;318 ( Pt 2):609-14.PMID: 8809054 [PubMed - indexed for MEDLINE]Related articlesFree article

Replacement of the conserved tyrosine 1210 by phenylalanine in the insulin receptor affects insulin-induced dephosphorylation of focal adhesion kinase but leaves other responses intact.

Van der Zon GC, Ouwens DM, Dorrestijn J, Maassen JA.

Biochemistry. 1996 Aug 13;35(32):10377-82.PMID: 8756693 [PubMed - indexed for MEDLINE]Related articles

Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin.

Dorrestijn J, Ouwens DM, Van den Berghe N, Bos JL, Maassen JA.

Diabetologia. 1996 May;39(5):558-63.PMID: 8739915 [PubMed - indexed for MEDLINE]Related articles

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.

Ouwens DM, van der Zon GC, Pronk GJ, Bos JL, Möller W, Cheatham B, Kahn CR, Maassen JA.

J Biol Chem. 1994 Dec 30;269(52):33116-22.PMID: 7806540 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of overexpressed receptors for insulin and epidermal growth factor interferes in mitogenic signaling without affecting the activation of p21ras.

Osterop AP, Medema RH, Ouwens DM, Van der Zon GC, Möller W, Maassen JA.

Biochemistry. 1994 Jun 14;33(23):7453-9.PMID: 8003510 [PubMed - indexed for MEDLINE]Related articles

Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes.

van den Berghe N, Ouwens DM, Maassen JA, van Mackelenbergh MG, Sips HC, Krans HM.

Mol Cell Biol. 1994 Apr;14(4):2372-7.PMID: 7511205 [PubMed - indexed for MEDLINE]Related articlesFree article