PubMed

Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY).

Cuesta-Muñoz AL, Tuomi T, Cobo-Vuilleumier N, Koskela H, Odili S, Stride A, Buettger C, Otonkoski T, Froguel P, Grimsby J, Garcia-Gimeno M, Matschinsky FM.

Diabetes Care. 2009 Nov 10. [Epub ahead of print]PMID: 19903754 [PubMed - as supplied by publisher]Related articles

The N-glycome of human embryonic stem cells.

Satomaa T, Heiskanen A, Mikkola M, Olsson C, Blomqvist M, Tiittanen M, Jaatinen T, Aitio O, Olonen A, Helin J, Hiltunen J, Natunen J, Tuuri T, Otonkoski T, Saarinen J, Laine J.

BMC Cell Biol. 2009 Jun 2;10:42.PMID: 19490625 [PubMed - indexed for MEDLINE]Related articlesFree article

Laminin isoforms in human embryonic stem cells: Synthesis, receptor usage and growth support.

Vuoristo S, Virtanen I, Takkunen M, Palgi J, Kikkawa Y, Rousselle P, Sekiguchi K, Tuuri T, Otonkoski T.

J Cell Mol Med. 2008 Dec 29. [Epub ahead of print]PMID: 19397785 [PubMed - as supplied by publisher]Related articles

A simple two-step protocol for the purification of human pancreatic beta cells.

Banerjee M, Otonkoski T.

Diabetologia. 2009 Apr;52(4):621-5. Epub 2009 Jan 24.PMID: 19169662 [PubMed - indexed for MEDLINE]Related articles

Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD).

Kelberman D, Turton JP, Woods KS, Mehta A, Al-Khawari M, Greening J, Swift PG, Otonkoski T, Rhodes SJ, Dattani MT.

Clin Endocrinol (Oxf). 2009 Jan;70(1):96-103. Epub 2008 Jun 25.PMID: 19128366 [PubMed - indexed for MEDLINE]Related articles

Bacteriophage Mu integration in yeast and mammalian genomes.

Paatero AO, Turakainen H, Happonen LJ, Olsson C, Palomäki T, Pajunen MI, Meng X, Otonkoski T, Tuuri T, Berry C, Malani N, Frilander MJ, Bushman FD, Savilahti H.

Nucleic Acids Res. 2008 Dec;36(22):e148. Epub 2008 Oct 25.PMID: 18953026 [PubMed - indexed for MEDLINE]Related articlesFree article

Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation.

Otonkoski T, Banerjee M, Korsgren O, Thornell LE, Virtanen I.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:119-27.PMID: 18834439 [PubMed - indexed for MEDLINE]Related articles

Isolation of human embryonic stem cell-derived teratomas for the assessment of pluripotency.

Gertow K, Przyborski S, Loring JF, Auerbach JM, Epifano O, Otonkoski T, Damjanov I, Ahrlund-Richter L.

Curr Protoc Stem Cell Biol. 2007 Oct;Chapter 1:Unit1B.4.PMID: 18785162 [PubMed - indexed for MEDLINE]Related articles

Molecular analysis of novel PROP1 mutations associated with Combined Pituitary Hormone Deficiency.

Kelberman D, Turton J, Woods K, Mehta A, Al-Khawari M, Greening J, Swift P, Otonkoski T, Rhodes S, Dattani M.

Clin Endocrinol (Oxf). 2008 Jun 25. [Epub ahead of print]PMID: 18616709 [PubMed - as supplied by publisher]Related articles

[18F]-DOPA positron emission tomography for preoperative localization in congenital hyperinsulinism.

Mohnike K, Blankenstein O, Minn H, Mohnike W, Fuchtner F, Otonkoski T.

Horm Res. 2008;70(2):65-72. Epub 2008 Jun 12. Review.PMID: 18547951 [PubMed - indexed for MEDLINE]Related articles

Dedifferentiation for replication of human beta-cells: a division between mice and men?

Billestrup N, Otonkoski T.

Diabetes. 2008 Jun;57(6):1457-8. No abstract available. PMID: 18511447 [PubMed - indexed for MEDLINE]Related articlesFree article

EGF receptor in pancreatic beta-cell mass regulation.

Miettinen P, Ormio P, Hakonen E, Banerjee M, Otonkoski T.

Biochem Soc Trans. 2008 Jun;36(Pt 3):280-5. Review.PMID: 18481942 [PubMed - indexed for MEDLINE]Related articles

Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?

Hanley NA, Hanley KP, Miettinen PJ, Otonkoski T.

Mol Cell Endocrinol. 2008 Jun 25;288(1-2):79-85. Epub 2008 Mar 16. Review.PMID: 18450368 [PubMed - indexed for MEDLINE]Related articles

Blood vessels of human islets of Langerhans are surrounded by a double basement membrane.

Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, Kikkawa Y, Sekiguchi K, Hukkanen M, Konttinen YT, Otonkoski T.

Diabetologia. 2008 Jul;51(7):1181-91. Epub 2008 Apr 26.PMID: 18438639 [PubMed - indexed for MEDLINE]Related articles

Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.

Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipilä I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J.

Am J Hum Genet. 2007 Sep;81(3):467-74. Epub 2007 Jul 26.PMID: 17701893 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.

International Stem Cell Initiative, Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'Brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W.

Nat Biotechnol. 2007 Jul;25(7):803-16. Epub 2007 Jun 17.PMID: 17572666 [PubMed - indexed for MEDLINE]Related articles

Effects of immunosuppressive drugs on in vitro neogenesis of human islets: mycophenolate mofetil inhibits the proliferation of ductal cells.

Gao R, Ustinov J, Korsgren O, Otonkoski T.

Am J Transplant. 2007 Apr;7(4):1021-6.PMID: 17391142 [PubMed - indexed for MEDLINE]Related articles

Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth.

Miettinen PJ, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, Juntti-Berggren L, Berggren PO, Otonkoski T.

Diabetes. 2006 Dec;55(12):3299-308.PMID: 17130473 [PubMed - indexed for MEDLINE]Related articlesFree article

Maturation of in vitro-generated human islets after transplantation in nude mice.

Gao R, Ustinov J, Korsgren O, Mikkola M, Lundin K, Otonkoski T.

Mol Cell Endocrinol. 2007 Jan 29;264(1-2):28-34. Epub 2006 Nov 20.PMID: 17116362 [PubMed - indexed for MEDLINE]Related articles

Rapid genetic analysis in congenital hyperinsulinism.

Christesen HB, Brusgaard K, Alm J, Sjöblad S, Hussain K, Fenger C, Rasmussen L, Hovendal C, Otonkoski T, Jacobsen BB.

Horm Res. 2007;67(4):184-8. Epub 2006 Nov 15.PMID: 17114887 [PubMed - indexed for MEDLINE]Related articles

N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible.

Heiskanen A, Satomaa T, Tiitinen S, Laitinen A, Mannelin S, Impola U, Mikkola M, Olsson C, Miller-Podraza H, Blomqvist M, Olonen A, Salo H, Lehenkari P, Tuuri T, Otonkoski T, Natunen J, Saarinen J, Laine J.

Stem Cells. 2007 Jan;25(1):197-202. Epub 2006 Sep 28.PMID: 17008421 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct differentiation characteristics of individual human embryonic stem cell lines.

Mikkola M, Olsson C, Palgi J, Ustinov J, Palomaki T, Horelli-Kuitunen N, Knuutila S, Lundin K, Otonkoski T, Tuuri T.

BMC Dev Biol. 2006 Aug 8;6:40.PMID: 16895598 [PubMed - indexed for MEDLINE]Related articlesFree article

Proposal for a standardized protocol for 18F-DOPA-PET (PET/CT) in congenital hyperinsulinism.

Mohnike K, Blankenstein O, Christesen HT, De Lonlay J, Hussain K, Koopmans KP, Minn H, Mohnike W, Mutair A, Otonkoski T, Rahier J, Ribeiro M, Schoenle E, Fékété CN.

Horm Res. 2006;66(1):40-2. Epub 2006 May 19. No abstract available. PMID: 16710094 [PubMed - indexed for MEDLINE]Related articles

Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography.

Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, Tapanainen P, Eskola O, Parkkola R, Ekström K, Guiot Y, Rahier J, Laakso M, Rintala R, Nuutila P, Minn H.

Diabetes. 2006 Jan;55(1):13-8.PMID: 16380471 [PubMed - indexed for MEDLINE]Related articlesFree article

Massive insulin secretion in response to anaerobic exercise in exercise-induced hyperinsulinism.

Meissner T, Friedmann B, Okun JG, Schwab MA, Otonkoski T, Bauer T, Bärtsch P, Mayatepek E.

Horm Metab Res. 2005 Nov;37(11):690-4.PMID: 16308838 [PubMed - indexed for MEDLINE]Related articles

Stem cells in the treatment of diabetes.

Otonkoski T, Gao R, Lundin K.

Ann Med. 2005;37(7):513-20. Review.PMID: 16278164 [PubMed - indexed for MEDLINE]Related articles

In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells.

Gao R, Ustinov J, Korsgren O, Otonkoski T.

Diabetologia. 2005 Nov;48(11):2296-304. Epub 2005 Sep 29.PMID: 16193291 [PubMed - indexed for MEDLINE]Related articles

Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian populations.

Hermann R, Mantere J, Lipponen K, Veijola R, Soltesz G, Otonkoski T, Simell O, Knip M, Ilonen J.

Diabetes. 2005 Sep;54(9):2816-9.PMID: 16123375 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression signatures of seven individual human embryonic stem cell lines.

Skottman H, Mikkola M, Lundin K, Olsson C, Strömberg AM, Tuuri T, Otonkoski T, Hovatta O, Lahesmaa R.

Stem Cells. 2005 Oct;23(9):1343-56. Epub 2005 Aug 4.PMID: 16081666 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.

Geutskens SB, Otonkoski T, Pulkkinen MA, Drexhage HA, Leenen PJ.

J Leukoc Biol. 2005 Oct;78(4):845-52. Epub 2005 Jul 21.PMID: 16037409 [PubMed - indexed for MEDLINE]Related articlesFree article

[Congenital hyperinsulinism]

Huopio H, Laakso M, Otonkoski T.

Duodecim. 2005;121(11):1166-75. Review. Finnish. No abstract available. PMID: 15999971 [PubMed - indexed for MEDLINE]Related articles

Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets.

Ylipaasto P, Kutlu B, Rasilainen S, Rasschaert J, Salmela K, Teerijoki H, Korsgren O, Lahesmaa R, Hovi T, Eizirik DL, Otonkoski T, Roivainen M.

Diabetologia. 2005 Aug;48(8):1510-22. Epub 2005 Jul 1.PMID: 15991020 [PubMed - indexed for MEDLINE]Related articles

Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism.

Woods KS, Cundall M, Turton J, Rizotti K, Mehta A, Palmer R, Wong J, Chong WK, Al-Zyoud M, El-Ali M, Otonkoski T, Martinez-Barbera JP, Thomas PQ, Robinson IC, Lovell-Badge R, Woodward KJ, Dattani MT.

Am J Hum Genet. 2005 May;76(5):833-49. Epub 2005 Mar 30.PMID: 15800844 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas.

Ketola I, Otonkoski T, Pulkkinen MA, Niemi H, Palgi J, Jacobsen CM, Wilson DB, Heikinheimo M.

Mol Cell Endocrinol. 2004 Oct 29;226(1-2):51-7.PMID: 15489005 [PubMed - indexed for MEDLINE]Related articles

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.

Cuesta-Muñoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, López-Enriquez S, García-Gimeno MA, Sanz P, Soriguer FC, Laakso M.

Diabetes. 2004 Aug;53(8):2164-8.PMID: 15277402 [PubMed - indexed for MEDLINE]Related articlesFree article

[Replacement therapy with beta-cells: the way to treat diabetes in the future?]

Otonkoski T, Korsgren O, Salmela K.

Duodecim. 2004;120(9):1133-4. Review. Finnish. No abstract available. PMID: 15232855 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinemic hypoglycemia in children.

de Lonlay P, Giurgea I, Robert JJ, Fournet JC, Touati G, Nihoul-Fékété C, Brunelle F, Jaubert F, Rahier J, Sempoux C, Junien C, Saudubray JM, Dunne M, Otonkoski T, Ribeiro M, Bellané-Chantelot C; European Group of Hyperinsulinism.

Ann Endocrinol (Paris). 2004 Feb;65(1):96-8. Review. No abstract available. PMID: 15122102 [PubMed - indexed for MEDLINE]Related articles

Severe transient neonatal hyperinsulinism associated with hyperlactataemia in non-asphyxiated infants.

Hussain K, Thornton PS, Otonkoski T, Aynsley-Green A.

J Pediatr Endocrinol Metab. 2004 Feb;17(2):203-9.PMID: 15055355 [PubMed - indexed for MEDLINE]Related articles

A syndrome with multiple malformations, mental retardation, and ACTH deficiency.

Kajantie E, Otonkoski T, Kivirikko S, Somer M.

Am J Med Genet A. 2004 Apr 30;126A(3):313-8.PMID: 15054849 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of coxsackievirus B5 mediated beta-cell death depend on the multiplicity of infection.

Rasilainen S, Ylipaasto P, Roivainen M, Lapatto R, Hovi T, Otonkoski T.

J Med Virol. 2004 Apr;72(4):586-96.PMID: 14981761 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of beta cell death during restricted and unrestricted enterovirus infection.

Rasilainen S, Ylipaasto P, Roivainen M, Bouwens L, Lapatto R, Hovi T, Otonkoski T.

J Med Virol. 2004 Mar;72(3):451-61.PMID: 14748069 [PubMed - indexed for MEDLINE]Related articles

Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells.

Ylipaasto P, Klingel K, Lindberg AM, Otonkoski T, Kandolf R, Hovi T, Roivainen M.

Diabetologia. 2004 Feb;47(2):225-39. Epub 2004 Jan 15.PMID: 14727023 [PubMed - indexed for MEDLINE]Related articles

Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture.

Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O, Otonkoski T.

Diabetes. 2003 Aug;52(8):2007-15.PMID: 12882917 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.

Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM.

Diabetologia. 2003 Feb;46(2):241-9. Epub 2003 Jan 9. Erratum in: Diabetologia. 2004 Jan;47(1):155. PMID: 12627323 [PubMed - indexed for MEDLINE]Related articles

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M.

Lancet. 2003 Jan 25;361(9354):301-7.PMID: 12559865 [PubMed - indexed for MEDLINE]Related articles

The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells.

Pulkkinen MA, Spencer-Dene B, Dickson C, Otonkoski T.

Mech Dev. 2003 Feb;120(2):167-75.PMID: 12559489 [PubMed - indexed for MEDLINE]Related articles

Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release.

Otonkoski T, Kaminen N, Ustinov J, Lapatto R, Meissner T, Mayatepek E, Kere J, Sipilä I.

Diabetes. 2003 Jan;52(1):199-204.PMID: 12502513 [PubMed - indexed for MEDLINE]Related articlesFree article

ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture.

Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, Yarden Y, Otonkoski T.

Endocrinology. 2002 Nov;143(11):4437-46.PMID: 12399441 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism.

Huopio H, Jääskeläinen J, Komulainen J, Miettinen R, Kärkkäinen P, Laakso M, Tapanainen P, Voutilainen R, Otonkoski T.

J Clin Endocrinol Metab. 2002 Oct;87(10):4502-7.PMID: 12364426 [PubMed - indexed for MEDLINE]Related articlesFree article

[Cell replacement and stem cell therapies are coming]

Sariola H, Otonkoski T.

Duodecim. 2001;117(14):1405-7. Finnish. No abstract available. PMID: 12181949 [PubMed - indexed for MEDLINE]Related articles