PubMed

From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum.

Orci L, Ravazzola M, Le Coadic M, Shen WW, Demaurex N, Cosson P.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19358-62. Epub 2009 Nov 11.PMID: 19906989 [PubMed - in process]Related articlesFree article

Diabetes and apoptosis: lipotoxicity.

Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE.

Apoptosis. 2009 Dec;14(12):1484-95.PMID: 19421860 [PubMed - in process]Related articles

Coordination of COPII vesicle trafficking by Sec23.

Fromme JC, Orci L, Schekman R.

Trends Cell Biol. 2008 Jul;18(7):330-6. Epub 2008 Jun 3. Review.PMID: 18534853 [PubMed - indexed for MEDLINE]Related articles

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.

Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6139-44. Epub 2008 Apr 14.PMID: 18413598 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetic basis of a craniofacial disease provides insight into COPII coat assembly.

Fromme JC, Ravazzola M, Hamamoto S, Al-Balwi M, Eyaid W, Boyadjiev SA, Cosson P, Schekman R, Orci L.

Dev Cell. 2007 Nov;13(5):623-34.PMID: 17981132 [PubMed - indexed for MEDLINE]Related articlesFree article

Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America.

Szczepaniak LS, Victor RG, Orci L, Unger RH.

Circ Res. 2007 Oct 12;101(8):759-67. Review.PMID: 17932333 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.

Lee Y, Ravazzola M, Park BH, Bashmakov YK, Orci L, Unger RH.

Diabetes. 2007 Sep;56(9):2295-301. Epub 2007 Jun 11.PMID: 17563069 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment.

Park BH, Wang MY, Lee Y, Yu X, Ravazzola M, Orci L, Unger RH.

J Biol Chem. 2006 Dec 29;281(52):40283-91. Epub 2006 Oct 12.PMID: 17038325 [PubMed - indexed for MEDLINE]Related articlesFree article

Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast.

Wang CW, Hamamoto S, Orci L, Schekman R.

J Cell Biol. 2006 Sep 25;174(7):973-83.PMID: 17000877 [PubMed - indexed for MEDLINE]Related articlesFree article

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.

Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ, Zhang G, Hamamoto S, Schekman R, Ravazzola M, Orci L, Eyaid W.

Nat Genet. 2006 Oct;38(10):1192-7. Epub 2006 Sep 17.PMID: 16980979 [PubMed - indexed for MEDLINE]Related articles

Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity.

Wang MY, Orci L, Ravazzola M, Unger RH.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18011-6. Epub 2005 Dec 2.PMID: 16326804 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic transport of SNARE proteins in the Golgi apparatus.

Cosson P, Ravazzola M, Varlamov O, Söllner TH, Di Liberto M, Volchuk A, Rothman JE, Orci L.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14647-52. Epub 2005 Sep 30.PMID: 16199514 [PubMed - indexed for MEDLINE]Related articlesFree article

Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.

Lee MC, Orci L, Hamamoto S, Futai E, Ravazzola M, Schekman R.

Cell. 2005 Aug 26;122(4):605-17.PMID: 16122427 [PubMed - indexed for MEDLINE]Related articles

Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins.

Carrozzino F, Soulié P, Huber D, Mensi N, Orci L, Cano A, Féraille E, Montesano R.

Am J Physiol Cell Physiol. 2005 Oct;289(4):C1002-14. Epub 2005 Jun 1.PMID: 15930145 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles.

Kim J, Hamamoto S, Ravazzola M, Orci L, Schekman R.

J Biol Chem. 2005 Mar 4;280(9):7758-68. Epub 2004 Dec 28.PMID: 15623526 [PubMed - indexed for MEDLINE]Related articlesFree article

Bi-directional protein transport between the ER and Golgi.

Lee MC, Miller EA, Goldberg J, Orci L, Schekman R.

Annu Rev Cell Dev Biol. 2004;20:87-123. Review.PMID: 15473836 [PubMed - indexed for MEDLINE]Related articles

GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes.

Futai E, Hamamoto S, Orci L, Schekman R.

EMBO J. 2004 Oct 27;23(21):4146-55. Epub 2004 Sep 30.PMID: 15457212 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span.

Nisato RE, Harrison JA, Buser R, Orci L, Rinsch C, Montesano R, Dupraz P, Pepper MS.

Am J Pathol. 2004 Jul;165(1):11-24.PMID: 15215158 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid transformation of white adipocytes into fat-oxidizing machines.

Orci L, Cook WS, Ravazzola M, Wang MY, Park BH, Montesano R, Unger RH.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2058-63. Epub 2004 Feb 9.PMID: 14769942 [PubMed - indexed for MEDLINE]Related articlesFree article

Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.

Volchuk A, Ravazzola M, Perrelet A, Eng WS, Di Liberto M, Varlamov O, Fukasawa M, Engel T, Söllner TH, Rothman JE, Orci L.

Mol Biol Cell. 2004 Apr;15(4):1506-18. Epub 2004 Jan 23.PMID: 14742712 [PubMed - indexed for MEDLINE]Related articlesFree article

i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion.

Varlamov O, Volchuk A, Rahimian V, Doege CA, Paumet F, Eng WS, Arango N, Parlati F, Ravazzola M, Orci L, Söllner TH, Rothman JE.

J Cell Biol. 2004 Jan 5;164(1):79-88. Epub 2003 Dec 29.PMID: 14699088 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles.

Miller EA, Beilharz TH, Malkus PN, Lee MC, Hamamoto S, Orci L, Schekman R.

Cell. 2003 Aug 22;114(4):497-509.PMID: 12941277 [PubMed - indexed for MEDLINE]Related articles

Self-assembly of minimal COPII cages.

Antonny B, Gounon P, Schekman R, Orci L.

EMBO Rep. 2003 Apr;4(4):419-24.PMID: 12671686 [PubMed - indexed for MEDLINE]Related articlesFree article

Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae.

Orci L, Ravazzola M, Mack GJ, Barlowe C, Otte S.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4586-91. Epub 2003 Mar 27.PMID: 12663859 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoapoptosis: its mechanism and its diseases.

Unger RH, Orci L.

Biochim Biophys Acta. 2002 Dec 30;1585(2-3):202-12. Review.PMID: 12531555 [PubMed - indexed for MEDLINE]Related articles

Sec16p potentiates the action of COPII proteins to bud transport vesicles.

Supek F, Madden DT, Hamamoto S, Orci L, Schekman R.

J Cell Biol. 2002 Sep 16;158(6):1029-38. Epub 2002 Sep 16.PMID: 12235121 [PubMed - indexed for MEDLINE]Related articlesFree article

A resident Golgi protein is excluded from peri-Golgi vesicles in NRK cells.

Cosson P, Amherdt M, Rothman JE, Orci L.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12831-4. Epub 2002 Sep 10.PMID: 12223891 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10299-304. Epub 2002 Jul 22.PMID: 12136131 [PubMed - indexed for MEDLINE]Related articlesFree article

Microscopy: an art?

Orci L, Pepper MS.

Nat Rev Mol Cell Biol. 2002 Feb;3(2):133-7.PMID: 11836515 [PubMed - indexed for MEDLINE]Related articles

Surface structure of the COPII-coated vesicle.

Matsuoka K, Schekman R, Orci L, Heuser JE.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13705-9.PMID: 11717432 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of the COPII coat with GTP and stable analogues.

Antonny B, Madden D, Hamamoto S, Orci L, Schekman R.

Nat Cell Biol. 2001 Jun;3(6):531-7.PMID: 11389436 [PubMed - indexed for MEDLINE]Related articles

Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.

Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF.

J Biol Chem. 2001 Jul 20;276(29):27197-202. Epub 2001 May 16.PMID: 11356850 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.

Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, Banerji S, Huarte J, Montesano R, Jackson DG, Orci L, Alitalo K, Christofori G, Pepper MS.

EMBO J. 2001 Feb 15;20(4):672-82.PMID: 11179212 [PubMed - indexed for MEDLINE]Related articlesFree article

Diseases of liporegulation: new perspective on obesity and related disorders.

Unger RH, Orci L.

FASEB J. 2001 Feb;15(2):312-21. Review.PMID: 11156947 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipotoxic diseases of nonadipose tissues in obesity.

Unger RH, Orci L.

Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S28-32. Review.PMID: 11126236 [PubMed - indexed for MEDLINE]Related articles

Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae.

Shimoni Y, Kurihara T, Ravazzola M, Amherdt M, Orci L, Schekman R.

J Cell Biol. 2000 Nov 27;151(5):973-84.PMID: 11086000 [PubMed - indexed for MEDLINE]Related articlesFree article

Exclusion of golgi residents from transport vesicles budding from Golgi cisternae in intact cells.

Orci L, Amherdt M, Ravazzola M, Perrelet A, Rothman JE.

J Cell Biol. 2000 Sep 18;150(6):1263-70.PMID: 10995433 [PubMed - indexed for MEDLINE]Related articlesFree article

Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack.

Volchuk A, Amherdt M, Ravazzola M, Brügger B, Rivera VM, Clackson T, Perrelet A, Söllner TH, Rothman JE, Orci L.

Cell. 2000 Aug 4;102(3):335-48.PMID: 10975524 [PubMed - indexed for MEDLINE]Related articles

Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles.

Orci L, Ravazzola M, Volchuk A, Engel T, Gmachl M, Amherdt M, Perrelet A, Sollner TH, Rothman JE.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10400-5.PMID: 10962035 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of hepatocyte growth factor/scatter factor and transforming growth factor-beta1 in mammary gland ductal morphogenesis.

Soriano JV, Pepper MS, Orci L, Montesano R.

J Mammary Gland Biol Neoplasia. 1998 Apr;3(2):133-50. Review.PMID: 10819523 [PubMed - indexed for MEDLINE]Related articles

Lipotoxic heart disease in obese rats: implications for human obesity.

Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, Orci L, Unger RH.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1784-9.PMID: 10677535 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum.

Rivera VM, Wang X, Wardwell S, Courage NL, Volchuk A, Keenan T, Holt DA, Gilman M, Orci L, Cerasoli F Jr, Rothman JE, Clackson T.

Science. 2000 Feb 4;287(5454):826-30.PMID: 10657290 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.

Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unger RH.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11513-8.PMID: 10500208 [PubMed - indexed for MEDLINE]Related articlesFree article

Chromogranin A alters ductal morphogenesis and increases deposition of basement membrane components by mammary epithelial cells in vitro.

Soriano JV, Pepper MS, Taupenot L, Bader MF, Orci L, Montesano R.

Biochem Biophys Res Commun. 1999 Jun 16;259(3):563-8.PMID: 10364458 [PubMed - indexed for MEDLINE]Related articles

p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway.

Gommel D, Orci L, Emig EM, Hannah MJ, Ravazzola M, Nickel W, Helms JB, Wieland FT, Sohn K.

FEBS Lett. 1999 Mar 26;447(2-3):179-85.PMID: 10214941 [PubMed - indexed for MEDLINE]Related articles

Sec24 proteins and sorting at the endoplasmic reticulum.

Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP.

J Biol Chem. 1999 Mar 19;274(12):7833-40.PMID: 10075675 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of fatty acid homeostasis in cells: novel role of leptin.

Unger RH, Zhou YT, Orci L.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2327-32.PMID: 10051641 [PubMed - indexed for MEDLINE]Related articlesFree article

Traumatic neuroma with biliary duct obstruction after orthotopic liver transplantation.

Mentha G, Rubbia-Brandt L, Orci L, Becker C, Giostra E, Majno P, Borisch B, Hadengue A, Morel P.

Transplantation. 1999 Jan 15;67(1):177-9.PMID: 9921816 [PubMed - indexed for MEDLINE]Related articles

Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes.

Spang A, Matsuoka K, Hamamoto S, Schekman R, Orci L.

Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11199-204.PMID: 9736713 [PubMed - indexed for MEDLINE]Related articlesFree article

Two transgenic approaches to define the cell lineages in endocrine pancreas development.

Herrera PL, Orci L, Vassalli JD.

Mol Cell Endocrinol. 1998 May 25;140(1-2):45-50.PMID: 9722167 [PubMed - indexed for MEDLINE]Related articles