PubMed

Tumor necrosis factor-alpha and lymphotoxin-alpha increase macrophage ABCA1 by gene expression and protein stabilization via different receptors.

Edgel KA, Leboeuf RC, Oram JF.

Atherosclerosis. 2009 Oct 22. [Epub ahead of print]PMID: 19913791 [PubMed - as supplied by publisher]Related articles

The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.

Tang C, Liu Y, Kessler PS, Vaughan AM, Oram JF.

J Biol Chem. 2009 Nov 20;284(47):32336-43. Epub 2009 Sep 25.PMID: 19783654 [PubMed - in process]Related articles

The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes.

Tang C, Oram JF.

Biochim Biophys Acta. 2009 Jul;1791(7):563-72. Epub 2009 Apr 1. Review.PMID: 19344785 [PubMed - indexed for MEDLINE]Related articles

Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux.

Sankaranarayanan S, Oram JF, Asztalos BF, Vaughan AM, Lund-Katz S, Adorni MP, Phillips MC, Rothblat GH.

J Lipid Res. 2009 Feb;50(2):275-84. Epub 2008 Sep 30.PMID: 18827283 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.

Vaughan AM, Tang C, Oram JF.

J Lipid Res. 2009 Feb;50(2):285-92. Epub 2008 Sep 5.PMID: 18776170 [PubMed - indexed for MEDLINE]Related articles

When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein.

Oram JF, Heinecke JW.

Curr Diab Rep. 2008 Jun;8(3):165-7. No abstract available. PMID: 18625111 [PubMed - indexed for MEDLINE]Related articles

When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein.

Oram JF, Heinecke JW.

Curr Atheroscler Rep. 2007 Dec;9(6):425-7. No abstract available. PMID: 18377780 [PubMed - indexed for MEDLINE]Related articles

The ins and outs of ABCA.

Oram JF.

J Lipid Res. 2008 Jun;49(6):1150-1. Epub 2008 Mar 28. No abstract available. PMID: 18375914 [PubMed - indexed for MEDLINE]Related articlesFree article

An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.

Oram JF, Wolfbauer G, Tang C, Davidson WS, Albers JJ.

J Biol Chem. 2008 Apr 25;283(17):11541-9. Epub 2008 Feb 19.PMID: 18287097 [PubMed - indexed for MEDLINE]Related articlesFree article

Myeloperoxidase and inflammatory proteins: pathways for generating dysfunctional high-density lipoprotein in humans.

Vaisar T, Shao B, Green PS, Oda MN, Oram JF, Heinecke JW.

Curr Atheroscler Rep. 2007 Nov;9(5):417-24.PMID: 18001626 [PubMed - indexed for MEDLINE]Related articles

Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes.

Guizzetti M, Chen J, Oram JF, Tsuji R, Dao K, Möller T, Costa LG.

J Biol Chem. 2007 Jun 29;282(26):18740-9. Epub 2007 May 3.PMID: 17478430 [PubMed - indexed for MEDLINE]Related articlesFree article

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.

Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, Zhao XQ, Elkon K, Marcovina S, Ridker P, Oram JF, Heinecke JW.

J Clin Invest. 2007 Mar;117(3):746-56.PMID: 17332893 [PubMed - indexed for MEDLINE]Related articlesFree article

Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway.

Wang Y, Oram JF.

J Lipid Res. 2007 May;48(5):1062-8. Epub 2007 Feb 26.PMID: 17325386 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-Binding cassette cholesterol transporters and cardiovascular disease.

Oram JF, Vaughan AM.

Circ Res. 2006 Nov 10;99(10):1031-43. Review.PMID: 17095732 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.

Vaughan AM, Oram JF.

J Lipid Res. 2006 Nov;47(11):2433-43. Epub 2006 Aug 10.PMID: 16902247 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathways for oxidation of high-density lipoprotein in human cardiovascular disease.

Shao B, Oda MN, Vaisar T, Oram JF, Heinecke JW.

Curr Opin Mol Ther. 2006 Jun;8(3):198-205. Review.PMID: 16774039 [PubMed - indexed for MEDLINE]Related articles

Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein.

Shao B, Oda MN, Oram JF, Heinecke JW.

Curr Opin Cardiol. 2006 Jul;21(4):322-8. Review.PMID: 16755201 [PubMed - indexed for MEDLINE]Related articles

Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I.

Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, Oram JF, Heinecke JW.

J Biol Chem. 2006 Apr 7;281(14):9001-4. Epub 2006 Feb 22.PMID: 16497665 [PubMed - indexed for MEDLINE]Related articlesFree article

Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1.

Tang C, Vaughan AM, Anantharamaiah GM, Oram JF.

J Lipid Res. 2006 Jan;47(1):107-14. Epub 2005 Oct 6.PMID: 16210729 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease.

Oram JF, Heinecke JW.

Physiol Rev. 2005 Oct;85(4):1343-72. Review.PMID: 16183915 [PubMed - indexed for MEDLINE]Related articlesFree article

Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I.

Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW.

J Biol Chem. 2005 Oct 28;280(43):36386-96. Epub 2005 Aug 25.PMID: 16126721 [PubMed - indexed for MEDLINE]Related articlesFree article

Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway.

Wang Y, Oram JF.

J Biol Chem. 2005 Oct 28;280(43):35896-903. Epub 2005 Aug 23.PMID: 16118212 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride.

Berfield AK, Chait A, Oram JF, Zager RA, Johnson AC, Abrass CK.

Am J Physiol Renal Physiol. 2006 Jan;290(1):F138-47. Epub 2005 Aug 2.PMID: 16077083 [PubMed - indexed for MEDLINE]Related articlesFree article

Acrolein modifies apolipoprotein A-I in the human artery wall.

Shao B, O'brien KD, McDonald TO, Fu X, Oram JF, Uchida K, Heinecke JW.

Ann N Y Acad Sci. 2005 Jun;1043:396-403.PMID: 16037261 [PubMed - indexed for MEDLINE]Related articles

ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins.

Vaughan AM, Oram JF.

J Biol Chem. 2005 Aug 26;280(34):30150-7. Epub 2005 Jun 30.PMID: 15994327 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells.

Passarelli M, Tang C, McDonald TO, O'Brien KD, Gerrity RG, Heinecke JW, Oram JF.

Diabetes. 2005 Jul;54(7):2198-205.PMID: 15983222 [PubMed - indexed for MEDLINE]Related articlesFree article

Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?

Chait A, Han CY, Oram JF, Heinecke JW.

J Lipid Res. 2005 Mar;46(3):389-403. Epub 2005 Feb 1. Review.PMID: 15722558 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.

Shao B, Bergt C, Fu X, Green P, Voss JC, Oda MN, Oram JF, Heinecke JW.

J Biol Chem. 2005 Feb 18;280(7):5983-93. Epub 2004 Nov 30.PMID: 15574409 [PubMed - indexed for MEDLINE]Related articlesFree article

The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.

Bergt C, Pennathur S, Fu X, Byun J, O'Brien K, McDonald TO, Singh P, Anantharamaiah GM, Chait A, Brunzell J, Geary RL, Oram JF, Heinecke JW.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13032-7. Epub 2004 Aug 23.PMID: 15326314 [PubMed - indexed for MEDLINE]Related articlesFree article

Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.

Pennathur S, Bergt C, Shao B, Byun J, Kassim SY, Singh P, Green PS, McDonald TO, Brunzell J, Chait A, Oram JF, O'brien K, Geary RL, Heinecke JW.

J Biol Chem. 2004 Oct 8;279(41):42977-83. Epub 2004 Aug 2.PMID: 15292228 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1.

Natarajan P, Forte TM, Chu B, Phillips MC, Oram JF, Bielicki JK.

J Biol Chem. 2004 Jun 4;279(23):24044-52. Epub 2004 Mar 29.PMID: 15051721 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes.

Oram JF, Bornfeldt KE.

Front Biosci. 2004 May 1;9:1240-53. Review.PMID: 14977541 [PubMed - indexed for MEDLINE]Related articles

LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.

Wang Y, Kurdi-Haidar B, Oram JF.

J Lipid Res. 2004 May;45(5):972-80. Epub 2004 Feb 16.PMID: 14967823 [PubMed - indexed for MEDLINE]Related articlesFree article

Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.

Tang C, Vaughan AM, Oram JF.

J Biol Chem. 2004 Feb 27;279(9):7622-8. Epub 2003 Dec 9.PMID: 14668333 [PubMed - indexed for MEDLINE]Related articlesFree article

Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells.

Oram JF, Wolfbauer G, Vaughan AM, Tang C, Albers JJ.

J Biol Chem. 2003 Dec 26;278(52):52379-85. Epub 2003 Oct 14.PMID: 14559902 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidized HDL: the paradox-idation of lipoproteins.

Bergt C, Oram JF, Heinecke JW.

Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1488-90. Review. No abstract available. PMID: 12972461 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoprotein lipase and hepatic lipase: their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II).

Cheung MC, Sibley SD, Palmer JP, Oram JF, Brunzell JD.

J Lipid Res. 2003 Aug;44(8):1552-8. Epub 2003 Jun 1.PMID: 12777470 [PubMed - indexed for MEDLINE]Related articlesFree article

Cultured gallbladder epithelial cells synthesize apolipoproteins A-I and E.

Lee J, Tauscher A, Seo DW, Oram JF, Kuver R.

Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G630-41. Epub 2003 May 28.PMID: 12773300 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions.

Vaughan AM, Oram JF.

J Lipid Res. 2003 Jul;44(7):1373-80. Epub 2003 Apr 16.PMID: 12700343 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1 as a New Therapeutic Target for Treating Cardiovascular Disease.

Oram JF.

Drug News Perspect. 2002 Jan;15(1):24-28.PMID: 12677241 [PubMed - as supplied by publisher]Related articles

HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol.

Oram JF.

Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):720-7. Epub 2003 Jan 9. Review.PMID: 12615680 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-binding cassette transporter A1 and cholesterol trafficking.

Oram JF.

Curr Opin Lipidol. 2002 Aug;13(4):373-81. Review.PMID: 12151852 [PubMed - indexed for MEDLINE]Related articles

The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular disease.

Oram JF.

Trends Cardiovasc Med. 2002 May;12(4):170-5. Review.PMID: 12069757 [PubMed - indexed for MEDLINE]Related articles

Polarized cholesterol and phospholipid efflux in cultured gall-bladder epithelial cells: evidence for an ABCA1-mediated pathway.

Lee J, Shirk A, Oram JF, Lee SP, Kuver R.

Biochem J. 2002 Jun 1;364(Pt 2):475-84.PMID: 12023891 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1.

Oram JF.

Trends Mol Med. 2002 Apr;8(4):168-73. Review.PMID: 11927274 [PubMed - indexed for MEDLINE]Related articles

Sterol efflux mediated by endogenous macrophage ApoE expression is independent of ABCA1.

Huang ZH, Lin CY, Oram JF, Mazzone T.

Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2019-25.PMID: 11742879 [PubMed - indexed for MEDLINE]Related articlesFree article

Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1.

Wang Y, Oram JF.

J Biol Chem. 2002 Feb 15;277(7):5692-7. Epub 2001 Dec 12.PMID: 11741998 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol.

Oram JF, Vaughan AM, Stocker R.

J Biol Chem. 2001 Oct 26;276(43):39898-902. Epub 2001 Aug 23.PMID: 11546785 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1. The gatekeeper for eliminating excess tissue cholesterol.

Oram JF, Lawn RM.

J Lipid Res. 2001 Aug;42(8):1173-9. Review.PMID: 11483617 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel approaches to treating cardiovascular disease: lessons from Tangier disease.

Oram JF.

Expert Opin Investig Drugs. 2001 Mar;10(3):427-38. Review.PMID: 11227043 [PubMed - indexed for MEDLINE]Related articles