PubMed

Inhibition of enzymatic degradation of adhesive-dentin interfaces.

De Munck J, Van den Steen PE, Mine A, Van Landuyt KL, Poitevin A, Opdenakker G, Van Meerbeek B.

J Dent Res. 2009 Dec;88(12):1101-6. Epub 2009 Oct 27.PMID: 19861692 [PubMed - in process]Related articles

Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.

Kolaczkowska E, Koziol A, Plytycz B, Arnold B, Opdenakker G.

Immunol Lett. 2009 Sep 22;126(1-2):73-82. Epub 2009 Aug 12.PMID: 19682497 [PubMed - in process]Related articles

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes.

Qiu Z, Dillen C, Hu J, Verbeke H, Struyf S, Van Damme J, Opdenakker G.

Immunobiology. 2009;214(9-10):835-42. Epub 2009 Jul 22.PMID: 19628296 [PubMed - in process]Related articles

"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products.

Piccard H, Hu J, Fiten P, Proost P, Martens E, Van den Steen PE, Van Damme J, Opdenakker G.

Electrophoresis. 2009 Jul;30(13):2366-77.PMID: 19621364 [PubMed - indexed for MEDLINE]Related articles

Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.

Ardi VC, Van den Steen PE, Opdenakker G, Schweighofer B, Deryugina EI, Quigley JP.

J Biol Chem. 2009 Sep 18;284(38):25854-66. Epub 2009 Jul 16.PMID: 19608737 [PubMed - indexed for MEDLINE]Related articles

Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation.

Loos T, Opdenakker G, Van Damme J, Proost P.

Haematologica. 2009 Oct;94(10):1346-53. Epub 2009 Jul 16.PMID: 19608678 [PubMed - in process]Related articlesFree article

Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats.

Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH.

Stroke. 2009 Aug;40(8):2836-42. Epub 2009 Jun 25.PMID: 19556529 [PubMed - indexed for MEDLINE]Related articles

CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8.

Gouwy M, Struyf S, Verbeke H, Put W, Proost P, Opdenakker G, Van Damme J.

J Leukoc Biol. 2009 Sep;86(3):671-80. Epub 2009 May 18.PMID: 19451399 [PubMed - indexed for MEDLINE]Related articles

Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects.

Struyf S, Proost P, Vandercappellen J, Dempe S, Noyens B, Nelissen S, Gouwy M, Locati M, Opdenakker G, Dinsart C, Van Damme J.

Eur J Immunol. 2009 Mar;39(3):843-57.PMID: 19224633 [PubMed - indexed for MEDLINE]Related articles

Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.

Kolaczkowska E, Plytycz B, Arnold B, Piccard H, Opdenakker G.

Immunology. 2009 Sep;128(1 Suppl):e262-74. Epub 2008 Oct 29.PMID: 19175797 [PubMed - in process]Related articles

Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis.

De Palma AM, Thibaut HJ, Li S, Van Aelst I, Dillen C, Swinnen M, Verbeken E, Neyts J, Opdenakker G.

J Pathol. 2009 Apr;217(5):633-41.PMID: 19142976 [PubMed - indexed for MEDLINE]Related articles

The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.

Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M.

J Mol Biol. 2009 Feb 20;386(2):419-34. Epub 2008 Dec 14.PMID: 19109975 [PubMed - indexed for MEDLINE]Related articles

Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis.

Kolaczkowska E, Grzybek W, van Rooijen N, Piccard H, Plytycz B, Arnold B, Opdenakker G.

J Leukoc Biol. 2009 Mar;85(3):374-81. Epub 2008 Dec 16.PMID: 19088179 [PubMed - indexed for MEDLINE]Related articles

Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.

De Palma AM, Verbeken E, Van Aelst I, Van den Steen PE, Opdenakker G, Neyts J.

Virology. 2008 Dec 5;382(1):20-7. Epub 2008 Oct 16.PMID: 18929380 [PubMed - indexed for MEDLINE]Related articles

Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs.

Gammon DB, Snoeck R, Fiten P, Krecmerová M, Holý A, De Clercq E, Opdenakker G, Evans DH, Andrei G.

J Virol. 2008 Dec;82(24):12520-34. Epub 2008 Oct 8.PMID: 18842735 [PubMed - indexed for MEDLINE]Related articlesFree article

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.

Proost P, Loos T, Mortier A, Schutyser E, Gouwy M, Noppen S, Dillen C, Ronsse I, Conings R, Struyf S, Opdenakker G, Maudgal PC, Van Damme J.

J Exp Med. 2008 Sep 1;205(9):2085-97. Epub 2008 Aug 18.PMID: 18710930 [PubMed - indexed for MEDLINE]Related articlesFree article

Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C).

Li S, Martens E, Dillen C, Van den Steen PE, Opdenakker G.

Biochem Pharmacol. 2008 Oct 1;76(7):831-40. Epub 2008 Jul 25.PMID: 18703022 [PubMed - indexed for MEDLINE]Related articles

Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9.

Cauwe B, Martens E, Van den Steen PE, Proost P, Van Aelst I, Blockmans D, Opdenakker G.

Exp Cell Res. 2008 Sep 10;314(15):2739-49. Epub 2008 Jul 16.PMID: 18671965 [PubMed - indexed for MEDLINE]Related articles

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines.

Van den Steen PE, Deroost K, Van Aelst I, Geurts N, Martens E, Struyf S, Nie CQ, Hansen DS, Matthys P, Van Damme J, Opdenakker G.

Eur J Immunol. 2008 Apr;38(4):1082-95.PMID: 18383042 [PubMed - indexed for MEDLINE]Related articles

Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells.

Redondo-Muñoz J, Ugarte-Berzal E, García-Marco JA, del Cerro MH, Van den Steen PE, Opdenakker G, Terol MJ, García-Pardo A.

Blood. 2008 Jul 1;112(1):169-78. Epub 2008 Mar 7.PMID: 18326820 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinase-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis.

Muroski ME, Roycik MD, Newcomer RG, Van den Steen PE, Opdenakker G, Monroe HR, Sahab ZJ, Sang QX.

Curr Pharm Biotechnol. 2008 Feb;9(1):34-46. Review.PMID: 18289055 [PubMed - indexed for MEDLINE]Related articles

Interphotoreceptor retinoid-binding protein as biomarker in systemic autoimmunity with eye inflictions.

Descamps FJ, Kangave D, Cauwe B, Martens E, Geboes K, Abu El-Asrar A, Opdenakker G.

J Cell Mol Med. 2008 Dec;12(6A):2449-56. Epub 2008 Feb 4.PMID: 18266969 [PubMed - indexed for MEDLINE]Related articles

Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils.

Kolaczkowska E, Arnold B, Opdenakker G.

Immunobiology. 2008;213(2):109-24. Epub 2007 Sep 10.PMID: 18241695 [PubMed - indexed for MEDLINE]Related articles

Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3.

Geurts N, Martens E, Van Aelst I, Proost P, Opdenakker G, Van den Steen PE.

Biochemistry. 2008 Feb 26;47(8):2689-99. Epub 2008 Feb 1.PMID: 18237197 [PubMed - indexed for MEDLINE]Related articles

Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis.

Bergin PJ, Raghavan S, Svensson H, Starckx S, Van Aelst I, Gjertsson I, Opdenakker G, Quiding-Järbrink M.

FEMS Immunol Med Microbiol. 2008 Jan;52(1):88-98. Epub 2007 Nov 11.PMID: 17995959 [PubMed - indexed for MEDLINE]Related articles

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.

Rosenblum G, Van den Steen PE, Cohen SR, Grossmann JG, Frenkel J, Sertchook R, Slack N, Strange RW, Opdenakker G, Sagi I.

Structure. 2007 Oct;15(10):1227-36.PMID: 17937912 [PubMed - indexed for MEDLINE]Related articles

Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells.

Vandercappellen J, Noppen S, Verbeke H, Put W, Conings R, Gouwy M, Schutyser E, Proost P, Sciot R, Geboes K, Opdenakker G, Van Damme J, Struyf S.

J Leukoc Biol. 2007 Dec;82(6):1519-30. Epub 2007 Sep 7.PMID: 17827342 [PubMed - indexed for MEDLINE]Related articlesFree article

Triggering of T-cell leukemia and dissemination of T-cell lymphoma in MMP-9-deficient mice.

Roy JS, Van Themsche C, Demers M, Opdenakker G, Arnold B, St-Pierre Y.

Leukemia. 2007 Dec;21(12):2506-11. Epub 2007 Sep 6.PMID: 17805326 [PubMed - indexed for MEDLINE]Related articles

DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.

Andrei G, Fiten P, Froeyen M, De Clercq E, Opdenakker G, Snoeck R.

Antivir Ther. 2007;12(5):719-32.PMID: 17713155 [PubMed - indexed for MEDLINE]Related articles

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

Cauwe B, Van den Steen PE, Opdenakker G.

Crit Rev Biochem Mol Biol. 2007 May-Jun;42(3):113-85. Review.PMID: 17562450 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.

Hu J, Van den Steen PE, Sang QX, Opdenakker G.

Nat Rev Drug Discov. 2007 Jun;6(6):480-98. Review.PMID: 17541420 [PubMed - indexed for MEDLINE]Related articles

Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient.

Andrei G, Fiten P, Goubau P, van Landuyt H, Gordts B, Selleslag D, De Clercq E, Opdenakker G, Snoeck R.

Transpl Infect Dis. 2007 Jun;9(2):126-31.PMID: 17461998 [PubMed - indexed for MEDLINE]Related articles

The role of chemokines and their receptors in uveitis.

Abu El-Asrar AM, Struyf S, Opdenakker G, Geboes K, Van Damme J.

Int Ophthalmol. 2007 Oct;27(5):321-7. Epub 2007 Mar 13. Review.PMID: 17431548 [PubMed - indexed for MEDLINE]Related articles

Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders.

Abu El-Asrar AM, Van den Steen PE, Al-Amro SA, Missotten L, Opdenakker G, Geboes K.

Int Ophthalmol. 2007 Feb;27(1):11-22. Epub 2007 Mar 21.PMID: 17375263 [PubMed - indexed for MEDLINE]Related articles

Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.

Fan X, Patera AC, Pong-Kennedy A, Deno G, Gonsiorek W, Manfra DJ, Vassileva G, Zeng M, Jackson C, Sullivan L, Sharif-Rodriguez W, Opdenakker G, Van Damme J, Hedrick JA, Lundell D, Lira SA, Hipkin RW.

J Biol Chem. 2007 Apr 20;282(16):11658-66. Epub 2006 Dec 29.PMID: 17197447 [PubMed - indexed for MEDLINE]Related articlesFree article

Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.

Piccard H, Van den Steen PE, Opdenakker G.

J Leukoc Biol. 2007 Apr;81(4):870-92. Epub 2006 Dec 21. Review.PMID: 17185359 [PubMed - indexed for MEDLINE]Related articlesFree article

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, McDonnell JM, Dwek RA, Rudd PM.

Biochemistry. 2006 Dec 26;45(51):15249-58. Epub 2006 Dec 6.PMID: 17176047 [PubMed - indexed for MEDLINE]Related articles

A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.

Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, Opdenakker G.

Biochim Biophys Acta. 2007 Feb;1770(2):178-86. Epub 2006 Oct 26.PMID: 17137715 [PubMed - indexed for MEDLINE]Related articles

Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.

Hu J, Dubois V, Chaltin P, Fiten P, Dillen C, Van den Steen PE, Opdenakker G.

Comb Chem High Throughput Screen. 2006 Sep;9(8):599-611.PMID: 17017880 [PubMed - indexed for MEDLINE]Related articles

Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice.

Andrei G, Gammon DB, Fiten P, De Clercq E, Opdenakker G, Snoeck R, Evans DH.

J Virol. 2006 Oct;80(19):9391-401.PMID: 16973545 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity.

Iwata M, Pillai M, Ramakrishnan A, Hackman RC, Joachim Deeg H, Opdenakker G, Torok-Storb B.

Blood. 2007 Jan 1;109(1):85-92.PMID: 16954500 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.

Van den Steen PE, Van Aelst I, Starckx S, Maskos K, Opdenakker G, Pagenstecher A.

Lab Invest. 2006 Sep;86(9):873-88. Epub 2006 Jul 24.PMID: 16865090 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis.

Loos T, Dekeyzer L, Struyf S, Schutyser E, Gijsbers K, Gouwy M, Fraeyman A, Put W, Ronsse I, Grillet B, Opdenakker G, Van Damme J, Proost P.

Lab Invest. 2006 Sep;86(9):902-16. Epub 2006 Jul 17.PMID: 16847431 [PubMed - indexed for MEDLINE]Related articlesFree article

Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies.

Proost P, Struyf S, Loos T, Gouwy M, Schutyser E, Conings R, Ronsse I, Parmentier M, Grillet B, Opdenakker G, Balzarini J, Van Damme J.

Arthritis Res Ther. 2006;8(4):R107.PMID: 16846531 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.

Winnepenninckx V, Debiec-Rychter M, Beliën JA, Fiten P, Michiels S, Lazar V, Opdenakker G, Meijer GA, Spatz A, van den Oord JJ.

Mod Pathol. 2006 Sep;19(9):1170-80. Epub 2006 Jun 23.PMID: 16799481 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis.

Calander AM, Starckx S, Opdenakker G, Bergin P, Quiding-Järbrink M, Tarkowski A.

Microbes Infect. 2006 May;8(6):1434-9. Epub 2006 Mar 29.PMID: 16697230 [PubMed - indexed for MEDLINE]Related articles

Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.

Kolaczkowska E, Scislowska-Czarnecka A, Chadzinska M, Plytycz B, van Rooijen N, Opdenakker G, Arnold B.

J Leukoc Biol. 2006 Jul;80(1):125-32. Epub 2006 May 9.PMID: 16684893 [PubMed - indexed for MEDLINE]Related articlesFree article

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.

Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, Opdenakker G.

J Biol Chem. 2006 Jul 7;281(27):18626-37. Epub 2006 May 3.PMID: 16672230 [PubMed - indexed for MEDLINE]Related articlesFree article

The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage.

Descamps FJ, Martens E, Kangave D, Struyf S, Geboes K, Van Damme J, Opdenakker G, Abu El-Asrar AM.

Exp Eye Res. 2006 Aug;83(2):401-7. Epub 2006 Apr 27.PMID: 16643893 [PubMed - indexed for MEDLINE]Related articles

Expression of chemokines and gelatinase B in sympathetic ophthalmia.

Abu El-Asrar AM, Struyf S, Van den Broeck C, Van Damme J, Opdenakker G, Geboes K, Kestelyn P.

Eye (Lond). 2007 May;21(5):649-57. Epub 2006 Apr 7.PMID: 16601741 [PubMed - indexed for MEDLINE]Related articles