PubMed

The evolution of the understanding of sepsis, infection, and the host response: a brief history.

Opal SM.

Crit Care Clin. 2009 Oct;25(4):637-63, vii.PMID: 19892245 [PubMed - in process]Related articles

Year in review 2008: Critical Care - sepsis.

Opal SM, Larosa SP.

Crit Care. 2009;13(5):224. Epub 2009 Oct 21.PMID: 19886974 [PubMed - in process]Related articles

Pathogenesis, treatment, and prevention of pneumococcal pneumonia.

van der Poll T, Opal SM.

Lancet. 2009 Oct 31;374(9700):1543-56. Review.PMID: 19880020 [PubMed - indexed for MEDLINE]Related articles

Coming soon to an ICU near you: severe pandemic influenza in ICU patients in Spain.

Opal SM.

Crit Care. 2009;13(5):196. Epub 2009 Oct 21.PMID: 19863761 [PubMed - in process]Related articles

Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions*

Vincent JL, Opal SM, Marshall JC.

Crit Care Med. 2009 Aug 27. [Epub ahead of print]PMID: 19730252 [PubMed - as supplied by publisher]Related articles

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

Tidswell M, Tillis W, Larosa SP, Lynn M, Wittek AE, Kao R, Wheeler J, Gogate J, Opal SM; Nd the Eritoran Sepsis Study Group.

Crit Care Med. 2009 Aug 5. [Epub ahead of print]PMID: 19661804 [PubMed - as supplied by publisher]Related articles

Swine flu, pandemics, and critical care.

Opal SM.

Crit Care. 2009;13(3):146. Epub 2009 May 15. No abstract available. PMID: 19490596 [PubMed - indexed for MEDLINE]Related articlesFree article

A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia.

Laterre PF, Opal SM, Abraham E, LaRosa SP, Creasey AA, Xie F, Poole L, Wunderink RG.

Crit Care. 2009;13(2):R36. Epub 2009 Mar 15.PMID: 19284881 [PubMed - indexed for MEDLINE]Related articlesFree article

Translational research in the development of novel sepsis therapeutics: logical deductive reasoning or mission impossible?

Opal SM, Patrozou E.

Crit Care Med. 2009 Jan;37(1 Suppl):S10-5.PMID: 19104207 [PubMed - indexed for MEDLINE]Related articles

Molecular biology of inflammation and sepsis: a primer.

Cinel I, Opal SM.

Crit Care Med. 2009 Jan;37(1):291-304. Review.PMID: 19050640 [PubMed - indexed for MEDLINE]Related articles

Bench-to-bedside review: Quorum sensing and the role of cell-to-cell communication during invasive bacterial infection.

Asad S, Opal SM.

Crit Care. 2008;12(6):236. Epub 2008 Nov 25. Review.PMID: 19040778 [PubMed - indexed for MEDLINE]Related articles

Sepsis strategies in development.

LaRosa SP, Opal SM.

Clin Chest Med. 2008 Dec;29(4):735-47, x-xi. Review.PMID: 18954707 [PubMed - indexed for MEDLINE]Related articles

Is the mortality rate for septic shock really decreasing?

Christaki E, Opal SM.

Curr Opin Crit Care. 2008 Oct;14(5):580-6. Review.PMID: 18787453 [PubMed - indexed for MEDLINE]Related articles

Sepsis: time to reconsider the concept.

Carlet J, Cohen J, Calandra T, Opal SM, Masur H.

Crit Care Med. 2008 Mar;36(3):964-6. Review.PMID: 18431286 [PubMed - indexed for MEDLINE]Related articles

Direct sequence detection of structured h5 influenza viral RNA.

Kerby MB, Freeman S, Prachanronarong K, Artenstein AW, Opal SM, Tripathi A.

J Mol Diagn. 2008 May;10(3):225-35. Epub 2008 Apr 10.PMID: 18403607 [PubMed - indexed for MEDLINE]Related articlesFree article

Communal living by bacteria and the pathogenesis of urinary tract infections.

Opal SM.

PLoS Med. 2007 Dec;4(12):e349. No abstract available. PMID: 18092887 [PubMed - indexed for MEDLINE]Related articlesFree article

Host-pathogen interactions in sepsis.

van der Poll T, Opal SM.

Lancet Infect Dis. 2008 Jan;8(1):32-43. Epub 2007 Dec 11. Review.PMID: 18063412 [PubMed - indexed for MEDLINE]Related articles

Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection.

Lutterloh EC, Opal SM, Pittman DD, Keith JC Jr, Tan XY, Clancy BM, Palmer H, Milarski K, Sun Y, Palardy JE, Parejo NA, Kessimian N.

Crit Care. 2007;11(6):R122.PMID: 18042296 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibodies against RAGE in sepsis and inflammation: implications for therapy.

Lutterloh EC, Opal SM.

Expert Opin Pharmacother. 2007 Jun;8(9):1193-6.PMID: 17563255 [PubMed - indexed for MEDLINE]Related articles

Endotoxin and cytokine detection systems as biomarkers for sepsis-induced renal injury.

Opal SM.

Contrib Nephrol. 2007;156:220-6. Review.PMID: 17464131 [PubMed - indexed for MEDLINE]Related articles

The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis.

Opal SM.

Int J Med Microbiol. 2007 Sep;297(5):365-77. Epub 2007 Apr 23. Review.PMID: 17452016 [PubMed - indexed for MEDLINE]Related articles

Can we RESOLVE the treatment of sepsis?

Opal SM.

Lancet. 2007 Mar 10;369(9564):803-4. No abstract available. PMID: 17350431 [PubMed - indexed for MEDLINE]Related articles

Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis.

Opal SM, Lim YP, Siryaporn E, Moldawer LL, Pribble JP, Palardy JE, Souza S.

Crit Care Med. 2007 Feb;35(2):387-92.PMID: 17205024 [PubMed - indexed for MEDLINE]Related articles

Coagulation abnormalities in critically ill patients.

Levi M, Opal SM.

Crit Care. 2006;10(4):222. Review.PMID: 16879728 [PubMed - indexed for MEDLINE]Related articlesFree article

WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock.

Cristofaro PA, Opal SM, Palardy JE, Parejo NA, Jhung J, Keith JC Jr, Harris HA.

Crit Care Med. 2006 Aug;34(8):2188-93.PMID: 16755255 [PubMed - indexed for MEDLINE]Related articles

Baseline severity of sepsis in subjects of the prowess and the Kybersept clinical trials on endogenous anticoagulants.

Wiedermann CJ, Keinecke HO, Jürs M, Opal SM.

Shock. 2006 Jun;25(6):657-8. No abstract available. PMID: 16721275 [PubMed - indexed for MEDLINE]Related articles

Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin.

Hoffmann JN, Wiedermann CJ, Juers M, Ostermann H, Kienast J, Briegel J, Strauss R, Warren BL, Opal SM; KyberSept investigators.

Thromb Haemost. 2006 May;95(5):850-6.PMID: 16676077 [PubMed - indexed for MEDLINE]Related articles

High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety.

Wiedermann CJ, Hoffmann JN, Juers M, Ostermann H, Kienast J, Briegel J, Strauss R, Keinecke HO, Warren BL, Opal SM; KyberSept Investigators.

Crit Care Med. 2006 Feb;34(2):285-92.PMID: 16424704 [PubMed - indexed for MEDLINE]Related articles

Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation.

Kienast J, Juers M, Wiedermann CJ, Hoffmann JN, Ostermann H, Strauss R, Keinecke HO, Warren BL, Opal SM; KyberSept investigators.

J Thromb Haemost. 2006 Jan;4(1):90-7.PMID: 16409457 [PubMed - indexed for MEDLINE]Related articles

Role of Toll-like receptors in infection and immunity: clinical implications.

Cristofaro P, Opal SM.

Drugs. 2006;66(1):15-29. Review.PMID: 16398566 [PubMed - indexed for MEDLINE]Related articles

The use of immunocompromised animals as models for human septic shock.

Opal SM, Cross AS.

Shock. 2005 Dec;24 Suppl 1:64-70.PMID: 16374375 [PubMed - indexed for MEDLINE]Related articles

The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels.

Kumar A, Haery C, Paladugu B, Kumar A, Symeoneides S, Taiberg L, Osman J, Trenholme G, Opal SM, Goldfarb R, Parrillo JE.

J Infect Dis. 2006 Jan 15;193(2):251-8. Epub 2005 Dec 13.PMID: 16362889 [PubMed - indexed for MEDLINE]Related articles

The activity of pathway-selective estrogen receptor ligands in experimental septic shock.

Opal SM, Palardy JE, Cristofaro P, Parejo N, Jhung JW, Keith JC Jr, Chippari S, Caggiano TJ, Steffan RJ, Chadwick CC, Harnish DC.

Shock. 2005 Dec;24(6):535-40.PMID: 16317384 [PubMed - indexed for MEDLINE]Related articles

Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei.

LaRosa SP, Opal SM, Utterback B, Yan SC, Helterbrand J, Simpson AJ, Chaowagul W, White NJ, Fisher CJ Jr.

Int J Infect Dis. 2006 Jan;10(1):25-31. Epub 2005 Nov 11.PMID: 16290015 [PubMed - indexed for MEDLINE]Related articles

Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms.

Opal SM, Palardy JE, Chen WH, Parejo NA, Bhattacharjee AK, Cross AS.

J Infect Dis. 2005 Dec 15;192(12):2074-80. Epub 2005 Nov 10.PMID: 16288370 [PubMed - indexed for MEDLINE]Related articles

The immunopathogenesis of sepsis in elderly patients.

Opal SM, Girard TD, Ely EW.

Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S504-12. Review.PMID: 16237654 [PubMed - indexed for MEDLINE]Related articles

Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication.

Opal SM, Artenstein AW, Cristofaro PA, Jhung JW, Palardy JE, Parejo NA, Lim YP.

Infect Immun. 2005 Aug;73(8):5101-5.PMID: 16041026 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue factor pathway inhibitor and antithrombin trial results.

LaRosa SP, Opal SM.

Crit Care Clin. 2005 Jul;21(3):433-48. Review.PMID: 15992666 [PubMed - indexed for MEDLINE]Related articles

History of U.S. military contributions to the study of vaccines against infectious diseases.

Artenstein AW, Opal JM, Opal SM, Tramont EC, Peter G, Russell PK.

Mil Med. 2005 Apr;170(4 Suppl):3-11.PMID: 15916278 [PubMed - indexed for MEDLINE]Related articles

Concept of PIRO as a new conceptual framework to understand sepsis.

Opal SM.

Pediatr Crit Care Med. 2005 May;6(3 Suppl):S55-60. Review.PMID: 15857560 [PubMed - indexed for MEDLINE]Related articles

Intraabdominal infections in infants and children: descriptions and definitions.

Thompson AE, Marshall JC, Opal SM.

Pediatr Crit Care Med. 2005 May;6(3 Suppl):S30-5. Review.PMID: 15857555 [PubMed - indexed for MEDLINE]Related articles

Insights into severe sepsis in older patients: from epidemiology to evidence-based management.

Girard TD, Opal SM, Ely EW.

Clin Infect Dis. 2005 Mar 1;40(5):719-27. Epub 2005 Jan 28.PMID: 15714419 [PubMed - indexed for MEDLINE]Related articles

Sepsis associated with immunosuppressive medications: an evidence-based review.

Gea-Banacloche JC, Opal SM, Jorgensen J, Carcillo JA, Sepkowitz KA, Cordonnier C.

Crit Care Med. 2004 Nov;32(11 Suppl):S578-90. Review.PMID: 15542967 [PubMed - indexed for MEDLINE]Related articles

Chloroquine enhances survival in Bacillus anthracis intoxication.

Artenstein AW, Opal SM, Cristofaro P, Palardy JE, Parejo NA, Green MD, Jhung JW.

J Infect Dis. 2004 Nov 1;190(9):1655-60. Epub 2004 Sep 28.PMID: 15478072 [PubMed - indexed for MEDLINE]Related articles

Coagulation in sepsis.

Amaral A, Opal SM, Vincent JL.

Intensive Care Med. 2004 Jun;30(6):1032-40. Epub 2004 May 18. Review.PMID: 15148567 [PubMed - indexed for MEDLINE]Related articles

The nexus between systemic inflammation and disordered coagulation in sepsis.

Opal SM.

J Endotoxin Res. 2004;10(2):125-9. Review.PMID: 15120004 [PubMed - indexed for MEDLINE]Related articles

Unintended bias, clinical trial results, and the heparin post hoc crossover fallacy.

Opal SM.

Crit Care Med. 2004 Mar;32(3):874-5.PMID: 15090975 [PubMed - indexed for MEDLINE]Related articles

Advances in sepsis therapy.

Glück T, Opal SM.

Drugs. 2004;64(8):837-59. Review.PMID: 15059039 [PubMed - indexed for MEDLINE]Related articles

Interactions between coagulation and inflammation.

Opal SM.

Scand J Infect Dis. 2003;35(9):545-54. Review.PMID: 14620133 [PubMed - indexed for MEDLINE]Related articles

Severe sepsis and septic shock: defining the clinical problem.

Opal SM.

Scand J Infect Dis. 2003;35(9):529-34. Review.PMID: 14620131 [PubMed - indexed for MEDLINE]Related articles