PubMed

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.

Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE.

Aging Cell. 2008 Oct;7(5):641-50.PMID: 18631321 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid.

Lazzarato L, Donnola M, Rolando B, Marini E, Cena C, Coruzzi G, Guaita E, Morini G, Fruttero R, Gasco A, Biondi S, Ongini E.

J Med Chem. 2008 Mar 27;51(6):1894-903. Epub 2008 Feb 23.PMID: 18293898 [PubMed - indexed for MEDLINE]Related articles

An Aging Interventions Testing Program: study design and interim report.

Miller RA, Harrison DE, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Strong R.

Aging Cell. 2007 Aug;6(4):565-75. Epub 2007 Jun 18. Erratum in: Aging Cell. 2008 Jun;7(3):445. PMID: 17578509 [PubMed - indexed for MEDLINE]Related articles

Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice.

Emanueli C, Monopoli A, Kraenkel N, Meloni M, Gadau S, Campesi I, Ongini E, Madeddu P.

Br J Pharmacol. 2007 Apr;150(7):873-82. Epub 2007 Mar 12.PMID: 17351667 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.

Neustadt BR, Hao J, Lindo N, Greenlee WJ, Stamford AW, Tulshian D, Ongini E, Hunter J, Monopoli A, Bertorelli R, Foster C, Arik L, Lachowicz J, Ng K, Feng KI.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1376-80. Epub 2006 Dec 3.PMID: 17236762 [PubMed - indexed for MEDLINE]Related articles

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.

Silverman LS, Caldwell JP, Greenlee WJ, Kiselgof E, Matasi JJ, Tulshian DB, Arik L, Foster C, Bertorelli R, Monopoli A, Ongini E.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1659-62. Epub 2007 Jan 8.PMID: 17234414 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy.

Brunelli S, Sciorati C, D'Antona G, Innocenzi A, Covarello D, Galvez BG, Perrotta C, Monopoli A, Sanvito F, Bottinelli R, Ongini E, Cossu G, Clementi E.

Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):264-9. Epub 2006 Dec 20.PMID: 17182743 [PubMed - indexed for MEDLINE]Related articlesFree article

A topical nitric oxide-releasing dexamethasone derivative: effects on intraocular pressure and ocular haemodynamics in a rabbit glaucoma model.

Galassi F, Masini E, Giambene B, Fabrizi F, Uliva C, Bolla M, Ongini E.

Br J Ophthalmol. 2006 Nov;90(11):1414-9. Epub 2006 Aug 16.PMID: 16914472 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages.

Ronchetti D, Impagnatiello F, Guzzetta M, Gasparini L, Borgatti M, Gambari R, Ongini E.

Eur J Pharmacol. 2006 Feb 17;532(1-2):162-9. Epub 2006 Jan 27.PMID: 16443213 [PubMed - indexed for MEDLINE]Related articles

Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases.

Bernardo A, Gasparini L, Ongini E, Minghetti L.

Neurobiol Dis. 2006 Apr;22(1):25-32. Epub 2005 Nov 22.PMID: 16307889 [PubMed - indexed for MEDLINE]Related articles

The nitrosteroid NCX 1015, a prednisolone derivative, improves recovery of function in rats after spinal cord injury.

Mallei A, Aden SA, Bachis A, Brandoli C, Ongini E, Mocchetti I.

Brain Res. 2005 Nov 16;1062(1-2):16-25. Epub 2005 Nov 2.PMID: 16263098 [PubMed - indexed for MEDLINE]Related articles

A novel nitric oxide-releasing statin derivative exerts an antiplatelet/antithrombotic activity and inhibits tissue factor expression.

Rossiello MR, Momi S, Caracchini R, Giannini S, Guglielmini G, Monopoli A, Ongini E, Semeraro N, Colucci M, Gresele P.

J Thromb Haemost. 2005 Nov;3(11):2554-62.PMID: 16241953 [PubMed - indexed for MEDLINE]Related articles

Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease.

Gasparini L, Ongini E, Wilcock D, Morgan D.

Brain Res Brain Res Rev. 2005 Apr;48(2):400-8. Epub 2005 Jan 28. Review.PMID: 15850679 [PubMed - indexed for MEDLINE]Related articles

Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen.

Bernardo A, Ajmone-Cat MA, Gasparini L, Ongini E, Minghetti L.

J Neurochem. 2005 Feb;92(4):895-903.PMID: 15686492 [PubMed - indexed for MEDLINE]Related articles

Glutamate efflux from human cerebrocortical slices during ischemia: vesicular-like mode of glutamate release and sensitivity to A(2A) adenosine receptor blockade.

Marcoli M, Bonfanti A, Roccatagliata P, Chiaramonte G, Ongini E, Raiteri M, Maura G.

Neuropharmacology. 2004 Nov;47(6):884-91.PMID: 15527822 [PubMed - indexed for MEDLINE]Related articles

Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action.

Gasparini L, Ongini E, Wenk G.

J Neurochem. 2004 Nov;91(3):521-36. Review.PMID: 15485484 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.

Emanueli C, Van Linthout S, Salis MB, Monopoli A, Del Soldato P, Ongini E, Madeddu P.

Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2082-7. Epub 2004 Sep 2.PMID: 15345513 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties.

Ongini E, Impagnatiello F, Bonazzi A, Guzzetta M, Govoni M, Monopoli A, Del Soldato P, Ignarro LJ.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8497-502.PMID: 15173604 [PubMed - indexed for MEDLINE]Related articlesFree article

The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1.

Di Filippo C, Rossi F, Ongini E, Del Soldato P, Perretti M, D'Amico M.

J Pharmacol Exp Ther. 2004 Sep;310(3):1133-41. Epub 2004 Apr 27.PMID: 15113846 [PubMed - indexed for MEDLINE]Related articlesFree article

A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis.

Furlan R, Kurne A, Bergami A, Brambilla E, Maucci R, Gasparini L, Butti E, Comi G, Ongini E, Martino G.

J Neuroimmunol. 2004 May;150(1-2):10-9.PMID: 15081244 [PubMed - indexed for MEDLINE]Related articles

Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid.

Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E.

J Neurochem. 2004 Apr;89(2):484-93.PMID: 15056291 [PubMed - indexed for MEDLINE]Related articles

Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester].

Wallace JL, Muscará MN, de Nucci G, Zamuner S, Cirino G, del Soldato P, Ongini E.

J Pharmacol Exp Ther. 2004 May;309(2):626-33. Epub 2004 Jan 30.PMID: 14755007 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide.

Baraldi PG, Romagnoli R, Del Carmen Nuñez M, Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F, Ongini E.

J Med Chem. 2004 Jan 29;47(3):711-9.PMID: 14736251 [PubMed - indexed for MEDLINE]Related articles

A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure.

Iwanaga Y, Gu Y, Dieterle T, Presotto C, Del Soldato P, Peterson KL, Ongini E, Condorelli G, Ross J Jr.

FASEB J. 2004 Mar;18(3):587-8. Epub 2004 Jan 20.PMID: 14734637 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

Gasparini L, Rusconi L, Xu H, del Soldato P, Ongini E.

J Neurochem. 2004 Jan;88(2):337-48.PMID: 14690522 [PubMed - indexed for MEDLINE]Related articles

Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease.

Chen JF, Fredduzzi S, Bastia E, Yu L, Moratalla R, Ongini E, Schwarzschild MA.

Neurology. 2003 Dec 9;61(11 Suppl 6):S74-81.PMID: 14663016 [PubMed - indexed for MEDLINE]Related articles

Adenosine A(2A) receptors in nonlocomotor features of Parkinson's disease: introduction.

Ongini E.

Neurology. 2003 Dec 9;61(11 Suppl 6):S72-3. No abstract available. PMID: 14663015 [PubMed - indexed for MEDLINE]Related articles

A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.

Wu WP, Hao JX, Ongini E, Impagnatiello F, Presotto C, Wiesenfeld-Hallin Z, Xu XJ.

Br J Pharmacol. 2004 Jan;141(1):65-74. Epub 2003 Dec 8.PMID: 14662726 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity to selective adenosine A1 and A2A receptor antagonists of the release of glutamate induced by ischemia in rat cerebrocortical slices.

Marcoli M, Raiteri L, Bonfanti A, Monopoli A, Ongini E, Raiteri M, Maura G.

Neuropharmacology. 2003 Aug;45(2):201-10.PMID: 12842126 [PubMed - indexed for MEDLINE]Related articles

Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica.

Sannella A, Gradoni L, Persichini T, Ongini E, Venturini G, Colasanti M.

Antimicrob Agents Chemother. 2003 Jul;47(7):2303-6.PMID: 12821483 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival.

Ciccone R, Mariani F, Cavone A, Persichini T, Venturini G, Ongini E, Colizzi V, Colasanti M.

Antimicrob Agents Chemother. 2003 Jul;47(7):2299-302. Erratum in: Antimicrob Agents Chemother. 2004 Jan;48(1):368. PMID: 12821482 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin.

Chiroli V, Benedini F, Ongini E, Del Soldato P.

Eur J Med Chem. 2003 Apr;38(4):441-6.PMID: 12750033 [PubMed - indexed for MEDLINE]Related articles

Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.

Bertorelli R, Bastia E, Citterio F, Corradini L, Forlani A, Ongini E.

Peptides. 2002 Sep;23(9):1589-96.PMID: 12217419 [PubMed - indexed for MEDLINE]Related articles

Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury.

Briscini L, Corradini L, Ongini E, Bertorelli R.

Eur J Pharmacol. 2002 Jun 28;447(1):59-65. Erratum in: Eur J Pharmacol. 2002 Aug 16;450(1):113. PMID: 12106803 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide-releasing drugs: a novel class of effective and safe therapeutic agents.

Burgaud JL, Ongini E, Del Soldato P.

Ann N Y Acad Sci. 2002 May;962:360-71. Review.PMID: 12076987 [PubMed - indexed for MEDLINE]Related articles

Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

Marchi M, Raiteri L, Risso F, Vallarino A, Bonfanti A, Monopoli A, Ongini E, Raiteri M.

Br J Pharmacol. 2002 Jun;136(3):434-40. Erratum in: Br J Pharmacol. 2002 Sep;137(2):294.. PMID: 12023946 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.

Fredduzzi S, Moratalla R, Monopoli A, Cuellar B, Xu K, Ongini E, Impagnatiello F, Schwarzschild MA, Chen JF.

J Neurosci. 2002 Feb 1;22(3):1054-62.PMID: 11826134 [PubMed - indexed for MEDLINE]Related articlesFree article

7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.

Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Monopoli A, Ongini E, Varani K, Borea PA.

J Med Chem. 2002 Jan 3;45(1):115-26.PMID: 11754583 [PubMed - indexed for MEDLINE]Related articles

In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261.

El Yacoubi M, Ledent C, Parmentier M, Ongini E, Costentin J, Vaugeois JM.

Eur J Neurosci. 2001 Nov;14(9):1567-70.PMID: 11722618 [PubMed - indexed for MEDLINE]Related articles

Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice.

El Yacoubi M, Ledent C, Parmentier M, Bertorelli R, Ongini E, Costentin J, Vaugeois JM.

Br J Pharmacol. 2001 Sep;134(1):68-77.PMID: 11522598 [PubMed - indexed for MEDLINE]Related articlesFree article

The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats.

Corradini L, Briscini L, Ongini E, Bertorelli R.

Brain Res. 2001 Jun 29;905(1-2):127-33.PMID: 11423087 [PubMed - indexed for MEDLINE]Related articles

Selective adenosine A2A receptor antagonists.

Ongini E, Monopoli A, Cacciari B, Baraldi PG.

Farmaco. 2001 Jan-Feb;56(1-2):87-90. Review.PMID: 11347973 [PubMed - indexed for MEDLINE]Related articles

The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.

Chen JF, Moratalla R, Impagnatiello F, Grandy DK, Cuellar B, Rubinstein M, Beilstein MA, Hackett E, Fink JS, Low MJ, Ongini E, Schwarzschild MA.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1970-5.PMID: 11172060 [PubMed - indexed for MEDLINE]Related articlesFree article

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.

Grilli M, Diodato E, Lozza G, Brusa R, Casarini M, Uberti D, Rozmahel R, Westaway D, St George-Hyslop P, Memo M, Ongini E.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12822-7.PMID: 11070093 [PubMed - indexed for MEDLINE]Related articlesFree article

Nociceptin/orpanin FQ and its receptor: a potential target for drug discovery.

Bertorelli R, Calò G, Ongini E, Regoli D.

Trends Pharmacol Sci. 2000 Jul;21(7):233-4. No abstract available. PMID: 10979861 [PubMed - indexed for MEDLINE]Related articles

Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage.

Grilli M, Barbieri I, Basudev H, Brusa R, Casati C, Lozza G, Ongini E.

Eur J Neurosci. 2000 Jul;12(7):2265-72.PMID: 10947805 [PubMed - indexed for MEDLINE]Related articles

Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects.

Varani K, Portaluppi F, Gessi S, Merighi S, Ongini E, Belardinelli L, Borea PA.

Circulation. 2000 Jul 18;102(3):285-9.PMID: 10899090 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression.

Parker EM, Monopoli A, Ongini E, Lozza G, Babij CM.

Neuropharmacology. 2000 Jul 24;39(10):1913-9.PMID: 10884572 [PubMed - indexed for MEDLINE]Related articles

A(2A) adenosine receptors in human peripheral blood cells.

Gessi S, Varani K, Merighi S, Ongini E, Borea PA.

Br J Pharmacol. 2000 Jan;129(1):2-11. Review. No abstract available. PMID: 10694196 [PubMed - indexed for MEDLINE]Related articlesFree article

Nociceptin and the ORL-1 ligand [Phe1psi (CH2-NH)Gly2]nociceptin(1-13)NH2 exert anti-opioid effects in the Freund's adjuvant-induced arthritic rat model of chronic pain.

Bertorelli R, Corradini L, Rafiq K, Tupper J, Calò G, Ongini E.

Br J Pharmacol. 1999 Nov;128(6):1252-8.PMID: 10578139 [PubMed - indexed for MEDLINE]Related articlesFree article