PubMed

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice.

Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM.

Cell Metab. 2009 Nov;10(5):419-29.PMID: 19883619 [PubMed - in process]Related articles

Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment.

Patsouris D, Neels JG, Fan W, Li PP, Nguyen MT, Olefsky JM.

J Biol Chem. 2009 Nov 6;284(45):31223-35. Epub 2009 Sep 9.PMID: 19740750 [PubMed - in process]Related articles

IKKepsilon: a bridge between obesity and inflammation.

Olefsky JM.

Cell. 2009 Sep 4;138(5):834-6.PMID: 19737512 [PubMed - indexed for MEDLINE]Related articles

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.

Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM.

Am J Physiol Endocrinol Metab. 2009 Aug 25. [Epub ahead of print]PMID: 19706791 [PubMed - as supplied by publisher]Related articles

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.

Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky JM.

Diabetes. 2009 Jun;58(6):1275-82. Epub 2009 Mar 16.PMID: 19289458 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte CREB promotes insulin resistance in obesity.

Qi L, Saberi M, Zmuda E, Wang Y, Altarejos J, Zhang X, Dentin R, Hedrick S, Bandyopadhyay G, Hai T, Olefsky J, Montminy M.

Cell Metab. 2009 Mar;9(3):277-86.PMID: 19254572 [PubMed - indexed for MEDLINE]Related articles

FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes.

Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM.

J Biol Chem. 2009 May 1;284(18):12188-97. Epub 2009 Feb 26.PMID: 19246449 [PubMed - indexed for MEDLINE]Related articles

Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators.

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB.

J Med Chem. 2009 Feb 6. [Epub ahead of print]PMID: 19199480 [PubMed - as supplied by publisher]Related articles

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM.

Mol Cell Biol. 2009 Mar;29(5):1363-74. Epub 2008 Dec 22.PMID: 19103747 [PubMed - indexed for MEDLINE]Related articlesFree article

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis.

Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20021-6. Epub 2008 Dec 9.PMID: 19066220 [PubMed - indexed for MEDLINE]Related articlesFree article

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. Epub 2008 Oct 5.PMID: 18849969 [PubMed - indexed for MEDLINE]Related articlesFree article

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.

Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG.

Cell Metab. 2008 Oct;8(4):301-9.PMID: 18840360 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat talks, liver and muscle listen.

Olefsky JM.

Cell. 2008 Sep 19;134(6):914-6.PMID: 18805083 [PubMed - indexed for MEDLINE]Related articles

Insulin sensitivity: modulation by nutrients and inflammation.

Schenk S, Saberi M, Olefsky JM.

J Clin Invest. 2008 Sep;118(9):2992-3002. Review.PMID: 18769626 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.

Sonoda N, Imamura T, Yoshizaki T, Babendure JL, Lu JC, Olefsky JM.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6614-9. Epub 2008 Apr 29.PMID: 18445652 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity.

Féral CC, Neels JG, Kummer C, Slepak M, Olefsky JM, Ginsberg MH.

Diabetes. 2008 Jul;57(7):1842-51. Epub 2008 Apr 21.PMID: 18426864 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.

Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM.

Nature. 2008 Feb 21;451(7181):964-9.PMID: 18288188 [PubMed - indexed for MEDLINE]Related articles

Inflammation and insulin resistance.

de Luca C, Olefsky JM.

FEBS Lett. 2008 Jan 9;582(1):97-105. Epub 2007 Nov 29. Review.PMID: 18053812 [PubMed - indexed for MEDLINE]Related articlesFree article

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.PMID: 18046409 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes.

Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ.

Mol Endocrinol. 2008 Mar;22(3):760-71. Epub 2007 Nov 15.PMID: 18006641 [PubMed - indexed for MEDLINE]Related articlesFree article

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.

Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M.

Cell Metab. 2007 Nov;6(5):386-97.PMID: 17983584 [PubMed - indexed for MEDLINE]Related articles

Selective modulation of promoter recruitment and transcriptional activity of PPARgamma.

Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky JM.

Biochem Biophys Res Commun. 2007 Dec 21;364(3):515-21. Epub 2007 Oct 18.PMID: 17963725 [PubMed - indexed for MEDLINE]Related articlesFree article

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.

Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM.

J Biol Chem. 2007 Nov 30;282(48):35279-92. Epub 2007 Oct 4.PMID: 17916553 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex.

Kawamata Y, Imamura T, Babendure JL, Lu JC, Yoshizaki T, Olefsky JM.

J Biol Chem. 2007 Sep 28;282(39):28549-56. Epub 2007 Jul 30.PMID: 17664271 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.

Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M.

J Clin Invest. 2007 Jun;117(6):1658-69. Epub 2007 May 24.PMID: 17525798 [PubMed - indexed for MEDLINE]Related articlesFree article

Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation.

Yoshizaki T, Imamura T, Babendure JL, Lu JC, Sonoda N, Olefsky JM.

Mol Cell Biol. 2007 Jul;27(14):5172-83. Epub 2007 May 21.PMID: 17515613 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes.

Liao W, Nguyen MT, Yoshizaki T, Favelyukis S, Patsouris D, Imamura T, Verma IM, Olefsky JM.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E219-27. Epub 2007 Mar 27.PMID: 17389706 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion in a mouse model of ataxia telangiectasia.

Miles PD, Treuner K, Latronica M, Olefsky JM, Barlow C.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E70-4. Epub 2007 Mar 13.PMID: 17356010 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.

Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM.

Nat Med. 2007 Apr;13(4):455-62. Epub 2007 Mar 11.PMID: 17351624 [PubMed - indexed for MEDLINE]Related articles

The US's changing competitiveness in the biomedical sciences.

Olefsky JM.

J Clin Invest. 2007 Jan;117(1):270-6. No abstract available. PMID: 17200723 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins.

Hupfeld CJ, Olefsky JM.

Annu Rev Physiol. 2007;69:561-77. Review.PMID: 17002595 [PubMed - indexed for MEDLINE]Related articles

Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects.

Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

Diabetes. 2006 Aug;55(8):2277-85.PMID: 16873691 [PubMed - indexed for MEDLINE]Related articlesFree article

APPLied mechanics: uncovering how adiponectin modulates insulin action.

Hosch SE, Olefsky JM, Kim JJ.

Cell Metab. 2006 Jul;4(1):5-6. Review.PMID: 16814726 [PubMed - indexed for MEDLINE]Related articles

Cell signaling. A new way to burn fat.

Neels JG, Olefsky JM.

Science. 2006 Jun 23;312(5781):1756-8. No abstract available. PMID: 16794069 [PubMed - indexed for MEDLINE]Related articles

Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes.

Liao W, Nguyen MT, Imamura T, Singer O, Verma IM, Olefsky JM.

Endocrinology. 2006 May;147(5):2245-52. Epub 2006 Feb 23.PMID: 16497797 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARdelta regulates glucose metabolism and insulin sensitivity.

Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3444-9. Epub 2006 Feb 21.PMID: 16492734 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras.

Shin SY, Bahk YY, Ko J, Chung IY, Lee YS, Downward J, Eibel H, Sharma PM, Olefsky JM, Kim YH, Lee B, Lee YH.

EMBO J. 2006 Mar 8;25(5):1093-103. Epub 2006 Feb 2.PMID: 16456537 [PubMed - indexed for MEDLINE]Related articlesFree article

Stressed out about obesity and insulin resistance.

de Luca C, Olefsky JM.

Nat Med. 2006 Jan;12(1):41-2; discussion 42. No abstract available. PMID: 16397561 [PubMed - indexed for MEDLINE]Related articles

Inflamed fat: what starts the fire?

Neels JG, Olefsky JM.

J Clin Invest. 2006 Jan;116(1):33-5.PMID: 16395402 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes.

Huang J, Imamura T, Babendure JL, Lu JC, Olefsky JM.

J Biol Chem. 2005 Dec 23;280(51):42300-6. Epub 2005 Oct 20.PMID: 16239226 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.

Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY.

Nature. 2005 Sep 22;437(7058):569-73.PMID: 16177793 [PubMed - indexed for MEDLINE]Related articles

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes.

Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM.

J Biol Chem. 2005 Oct 21;280(42):35361-71. Epub 2005 Aug 5.PMID: 16085647 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.

Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

Diabetes. 2005 Aug;54(8):2351-9.PMID: 16046301 [PubMed - indexed for MEDLINE]Related articlesFree article

Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats.

Wilkes JJ, Nguyen MT, Bandyopadhyay GK, Nelson E, Olefsky JM.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1015-22. Epub 2005 Jul 19.PMID: 16030065 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.

Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM.

Mol Endocrinol. 2005 Nov;19(11):2760-8. Epub 2005 Jun 30.PMID: 15994203 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and evaluation of photolabile insulin prodrugs.

Li LS, Babendure JL, Sinha SC, Olefsky JM, Lerner RA.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3917-20.PMID: 15993597 [PubMed - indexed for MEDLINE]Related articles

VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data.

Hsiao A, Ideker T, Olefsky JM, Subramaniam S.

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W627-32.PMID: 15980550 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats.

Satoh H, Nguyen MT, Trujillo M, Imamura T, Usui I, Scherer PE, Olefsky JM.

Diabetes. 2005 May;54(5):1304-13.PMID: 15855314 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.

Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS.

Nat Med. 2005 May;11(5):567-71. Epub 2005 Apr 10.PMID: 15821749 [PubMed - indexed for MEDLINE]Related articles

Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait.

Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI.

Diabetes. 2005 Apr;54(4):1222-7.PMID: 15793265 [PubMed - indexed for MEDLINE]Related articlesFree article